Gemini surfactant-like peptide-based nanocages with β-sheet-enhanced stability and encapsulation efficiency of hydrophobic anticancer drugs.

Peptide-based scaffolds have been widely applied to drug delivery because of their ease and high yields of synthesis, well-defined structure, biocompatibility, diversity, tunability of properties, and molecular recognition abilities. However, the stability of peptide-based nanostructures highly depends on the intermolecular assembling manner, , α-helix based coiled coils, β-sheet. Inspired by the robust protein fibril structures in amyloidosis, herein we constructed a β-sheet-forming gemini surfactant-like peptide to self-assemble into nanocages with the help of molecular dynamics simulation.