705 results match your criteria: "Inner Ear Meniere Disease Surgical Treatment"

The living human inner ear is challenging to study because it is encased within dense otic capsule bone that limits access to biological tissue. Traditional temporal bone histopathology methods rely on lengthy, expensive decalcification protocols that take 9-10 months and reduce the types of tissue analysis possible due to RNA degradation. There is a critical need to develop methods to access fresh human inner ear tissue to better understand otologic diseases, such as Ménière's disease, at the cellular and molecular level.

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Introduction: Triple semicircular canal plugging is effective in controlling vertigo in patients with Meniere's disease, however, whether the rate of causing hearing loss during treatment is still not uniform. This study aimed to evaluate the effects of Triple semicircular canal plugging (TSCP) on hearing in Meniere's disease (MD) patients.

Methods: Databases Reviewed were PubMed, EMBASE, Scopus, Clinical Trials, Web of Science, Cochrane Library, CNKI, Wanfang, and VIP.

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Semicircular canal and vestibular plugging in patients with Meniere's disease: a preliminary study.

Acta Otolaryngol

October 2024

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.

Article Synopsis
  • A study aimed to evaluate the safety and effectiveness of simultaneous semicircular canal and vestibular plugging for treating patients with intractable Meniere's disease suffering from vertigo and drop attacks.
  • Five patients were observed over six months post-surgery; none experienced recurring drop attacks, and four had no vertigo episodes, indicating promising results.
  • The procedure shows potential in alleviating symptoms of Meniere's disease while maintaining hearing function, but more research is needed to validate these findings.
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Efficacy of endolymphatic duct blockage in treating Ménières disease.

Zhong Nan Da Xue Xue Bao Yi Xue Ban

May 2024

Department of Otolaryngology-Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.

Article Synopsis
  • Ménière's disease (MD) is an inner ear disorder causing vertigo, hearing loss, tinnitus, and ear fullness, primarily treated through endolymphatic sac (ES)-related surgery for patients not responding to medications.
  • This study analyzed 33 patients who underwent endolymphatic duct blockage (EDB) surgery, comparing outcomes based on the morphology of their ES (normal vs. atrophic types).
  • Results showed that patients with normal-type ES had significantly better control of vertigo and improved cochlear function, along with a notable reversal of endolymphatic hydrops, indicating different disease mechanisms between the two types.
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Purpose: The precise location of the endolymphatic sac (ES) may be difficult during surgical approaches. This morphometric study aimed to determine the exact location of ES in adult human cadavers for the management of pathologies such as Meniere's disease.

Methods: Twenty temporal bones of 10 adult cadavers (mean age: 70 ± 13.

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Objectives: The aim was to evaluate endolymphatic hydrops in patients with severe Ménière's disease (MD) before and after vestibular neurectomy to verify if vestibular denervation results in hydrops regression.

Methods: Magnetic resonance imaging was performed after intravenous gadolinium injection in twenty patients with unilateral definite MD before and after the vestibular neurectomy. Clinical symptoms and audiovestibular tests were evaluated.

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Purpose: To compare the effectiveness of the Endolymphatic duct blockage (EDB) and intratympanic methylprednisolone(ITMP) injection to control refractory Ménière's disease(MD) symptoms and evaluate their impact on hearing level.

Study Design: Retrospective study in a tertiary care center.

Methods: 36 received ITMP injection and 52 EDB.

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Introduction: We present a series of six cases whose clinical presentations exhibited audiovestibular manifestations of a third mobile window mechanism, bearing a reasonable resemblance to Ménière's disease and otosclerosis. The occurrence of these cases in such a short period has prompted a review of the underlying causes of its development. Understanding the pathophysiology of third mobile window syndrome and considering these entities in the differential diagnosis of conditions presenting with vertigo and hearing loss with slight air-bone gaps is essential for comprehending this group of pathologies.

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Functional outcomes and caloric response changes after endolymphatic sac decompression.

Am J Otolaryngol

June 2024

Istanbul University, Istanbul Faculty of Medicine, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey.

Objective: To evaluate caloric response changes after endolymphatic sac decompression (ESD), together with hearing outcomes and the functional benefit of the operation.

Methods: A retrospective chart review of subjects who underwent endolymphatic sac decompression at a tertiary referral centre was performed. Data on audiological results, caloric testing, and functional level scale of the patients were analysed.

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Introduction: Surgical treatment of Ménière's disease (MD) and deafness aims to treat vertigo and hearing disabilities. Current treatment options like labyrinthectomy and cochlear implantation (CI) have shown acceptable results but are destructive. Less destructive procedures, like the occlusion of the lateral semicircular canal and endolymphatic sac surgery, have been shown to be successful in vertigo control.

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Semicircular canal occlusion(SCO) is a surgical technique widely used for treating vertigo symptoms. It is primarily aimed at treating benign paroxysmal positional vertigo(BPPV), Ménière's disease(MD), labyrinthine fistula, and superior semicircular canal dehiscence syndrome, among others. This review aims to comprehensively summarize the development, evolution, relevant basic research, and clinical applications of semicircular canal occlusion, especially the application of endoscopic technology in recent years, and explore its practical value in the field of surgical treatment for vertigo.

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Objective: Report three cases of simultaneous triple semicircular canal occlusion (TSCO) and cochlear implantation (CI) as the treatment of intractable Meniere's disease (MD).

Case Reports: Patients with MD can present occasionally with intractable vertigo and profound sensorineural hearing loss (SNHL). TSCO and CI have been proposed to control vertigo and restore profound deafness in patients with MD separately.

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Redox Modulation of Meniere Disease by Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential.

Curr Neuropharmacol

September 2024

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania, Italy.

Background: Meniere's disease (MD) is a cochlear neurodegenerative disease. Hearing loss appears to be triggered by oxidative stress in the ganglion neurons of the inner ear.

Objective: Here, we confirm the variation of markers of oxidative stress and inflammation in patients with Meniere and hypothesize that chronic treatment with Coriolus mushroom helps in the response to oxidative stress and acts on α-synuclein and on NF-kB-mediated inflammatory processes Methods: Markers of oxidative stress and inflammation were evaluated in MD patients with or without Coriolus treatment for 3 or 6 months.

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Purpose: Meniere's disease (MD), a disorder of the inner ear, presents numerous therapeutic challenges, and intratympanic (IT) gentamicin has been proposed for intractable cases. However, controversy regarding dosage and method persists. The purpose of this study was to assess the efficacy and safety of low-dose IT gentamicin on vertigo attacks in MD using a clinical symptomatology-based method, wherein administration was repeated only if vertigo attacks recurred, with a 2-week interval between injections.

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Purpose: Meniere's disease (MD) is a disabling condition with symptoms, such as hearing loss, dizziness, and tinnitus. Surgery is the last resort option for managing MD when other treatments are not effective. Surgical labyrinthectomy (SL) is less commonly performed than vestibular neurectomy or chemical labyrinthectomy.

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Article Synopsis
  • The study aimed to analyze nystagmus and balance characteristics in patients experiencing vertigo after cochlear implantation.
  • Twenty-one patients were recruited for both retrospective and prospective examinations, involving video recordings during vertigo attacks and vestibular function tests.
  • Main findings included high-velocity nystagmus linked to vertigo, with a significant portion diagnosed with conditions like secondary endolymphatic hydrops and Ménière's disease, indicating potential underlying vestibular issues after cochlear implantation.
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Article Synopsis
  • The study aimed to identify factors that predict the efficacy of endolymphatic sac decompression (ESD) surgery in patients with Meniere's disease, particularly focusing on post-surgery vertigo outcomes.
  • A cohort of 56 patients who underwent ESD was analyzed using logistic regression to determine which variables could reliably predict the likelihood of experiencing vertigo after the procedure.
  • Key predictors identified were the patient's audiogram type and the average pure-tone threshold at speech frequency, leading to a predictive model that showed good discrimination and calibration for assessing ESD efficacy.
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Purpose: The focus on treating patients with Menière's Disease (MD) lies on the reduction of vertigo attacks and the preservation of sensory function. Endolympathic hydrops is considered as an epiphenomenon in MD, which can potentially be altered by endolymphatic sac surgery (ESS). Purpose of the study was to investigate the influences on vertigo control through manipulation of the perilymphatic system with or without ESS.

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Iatrogenic inner ear dehiscence associated with lateral skull base surgery: a systematic analysis of drilling injuries and their causal factors.

Acta Neurochir (Wien)

October 2023

Department of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, 45 Francis Street, Boston, MA, 02115, USA.

Purpose: Drilling injuries of the inner ear are an underreported complication of lateral skull base (LSB) surgery. Inner ear breaches can cause hearing loss, vestibular dysfunction, and third window phenomenon. This study aims to elucidate primary factors causing iatrogenic inner ear dehiscences (IED) in 9 patients who presented to a tertiary care center with postoperative symptoms of IED following LSB surgery for vestibular schwannoma, endolymphatic sac tumor, Meniere's disease, paraganglioma jugulare, and vagal schwannoma.

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Purpose Of Review: Meniere's disease is caused by hydropic changes in the endolymphatic system, and manifests as a collection of vertigo, hearing loss, tinnitus, and aural fullness. Although high-quality clinical practice guidelines exist for the diagnosis and initial management of Meniere's disease, there is no strong consensus for treatment of medically refractory Meniere's disease. This review summarizes treatment options and highlights controversies surrounding surgical treatment of Meniere's disease.

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Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease.

J Vis Exp

April 2023

Department of Otorhinolaryngology, Haga Hospital; Department of Otorhinolaryngology, Leiden University Medical Centre; Department of Otorhinolaryngology, Antwerp University Hospital.

Article Synopsis
  • - Endolymphatic duct blockage is a new treatment for Ménière's disease designed to reduce vertigo attacks while preserving hearing and balance.
  • - The surgical process involves identifying and blocking the endolymphatic duct with a titanium clip after a mastoidectomy, with confirmation through CT scans.
  • - Preliminary results show a 96.5% rate of patients being free from vertigo 2 years post-surgery, but more research is still needed to validate these findings.
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