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Nondiagnostic Percutaneous Transthoracic Needle Biopsy of Lung Lesions: A Multicenter Study of Malignancy Risk.

Radiology

March 2019

From the Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea (K.H.L.); Department of Radiology, National Cancer Center, Gyeonggi-do, South Korea (K.Y.L.); Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea (Y.J.S., J.H.); Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea (J.H.); Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea (D.H.H.); Department of Radiology, Inje University Sanggyepaik Hospital, Seoul, South Korea (M.J.K.); Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Gyeonggi-do, South Korea (J.Y.C., C.K.); Department of Radiology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, South Korea (J.I.K.); Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea (S.H.Y., C.M.P.); Department of Statistics, Inha University, Incheon, South Korea (W.L.); and Institute of Radiation Medicine, Seoul National University Medical Research Center, 101 Daehak-ro, Jongno-gu, Seoul 03080, South Korea (C.M.P.).

Purpose To evaluate the malignancy risk of lung lesions that show nondiagnostic results at transthoracic needle biopsy (PTNB) of the lung and to identify any malignancy-associated risk factors in each nondiagnostic category. Materials and Methods In this retrospective study, 9384 initial PTNBs (9239 patients [mean age, 65 years; age range, 20-99 years] consisting of 5729 men [mean age, 66 years; age range, 20-99 years] and 3510 women [mean age, 63 years; age range, 20-94 years]) were performed in eight institutions between January 2010 and December 2014. PTNB results were categorized as diagnostic (malignant or specifically benign) or nondiagnostic (nonspecific benign pathologic findings, atypical cells, or insufficient specimen), and the proportion of final malignant diagnoses per nondiagnostic category was obtained.

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Children with autism are often medicated to manage emotional and behavioral symptoms; yet, data on such pharmacotherapy is insufficient. In this study, we investigated the Korean National Health Insurance Claims Database (NHICD) information related to autism incidence and psychotropic medication use. From the 2010-2012 NHICD, we selected a total of 31,919,732 subjects under 19 years old.

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We report a human parechovirus-3 (HPeV-3) infection in 2 neonates who had prolonged fever (>5 days) with palmar-plantar erythema. This distinctive rash was observed 4-5 days after fever onset, just before defervescence. Elevated aspartate aminotransferase, lactate dehydrogenase, and ferritin levels were characteristic laboratory findings in the 2 cases, suggesting tissue damage caused by hypercytokinemia.

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Objectives: To identify the most common frequency of food-purchasing patterns and relate this pattern to characteristics of individuals and families.

Design: A customer-intercept survey was conducted in the greater Houston area, Texas, USA, in 2002. The frequency of food shopping at supermarkets, convenience stores and restaurants to buy food for eating at home was assessed.

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