1,399 results match your criteria: "Inje University Ilsan-Paik Hospital[Affiliation]"

Advances in Intrathecal Nanoparticle Delivery: Targeting the Blood-Cerebrospinal Fluid Barrier for Enhanced CNS Drug Delivery.

Pharmaceuticals (Basel)

August 2024

Department of Biomedical Science, Graduate School of Medicine, Inje University, 75, Bokji-ro, Busanjingu, Busan 47392, Republic of Korea.

Article Synopsis
  • The blood-cerebrospinal fluid barrier (BCSFB) regulates how drugs move between the bloodstream and cerebrospinal fluid, complicating drug delivery to the central nervous system (CNS).
  • The review focuses on intrathecal nanoparticle (NP) delivery systems designed to bypass the BCSFB, discussing their advantages over traditional methods that address the blood-brain barrier (BBB).
  • Key insights include the ability of engineered nanoparticles to enhance drug retention in the CNS, their prolonged presence in the cerebrospinal fluid, and ongoing challenges related to their clearance and targeted delivery.
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Optimizing Therapeutic Strategies for Syringomyelia Associated with Tethered Cord Syndrome: A Comprehensive Review.

Children (Basel)

August 2024

Department of Medicine, Graduate School of Medicine, Inje University, 75 Bokji-ro, Busanjin-gu, Busan 47392, Republic of Korea.

This review highlights the need for therapeutic guidelines for syringomyelia associated with tethered cord syndrome (TCS) caused by spinal dysraphism (SD). A comprehensive literature review was conducted, selecting twelve articles to analyze common therapeutic strategies. Surgical cord untethering alone has recently become a preferred treatment, with 45 ± 21.

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Article Synopsis
  • The study focuses on suture tape implantation as a treatment for anterior talofibular ligament (ATFL) insufficiency, which can occur due to frequent sprains or insufficient ligament tissue for repair.
  • It evaluated 68 patients retrospectively over a minimum two-year follow-up to determine the incidence of post-operative re-sprains and identify risk factors associated with them.
  • Results showed a 27.9% incidence of post-operative re-sprains, with higher risk linked to smoking, generalized ligament laxity, and physically demanding occupations.
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Aim: Ankylosing spondylitis (AS) predominantly affects the spine and sacroiliac joints, with rare renal involvement. We investigated the incidence rate and risk factors for chronic kidney disease (CKD) in patients with AS and its relationship with long-term nonsteroidal anti-inflammatory drug (NSAID) use.

Methods: We retrospectively analyzed data of patients diagnosed with AS from the Korean National Health Insurance service.

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Radiofrequency ablation (RFA) offers a minimally invasive treatment for small hepatocellular carcinoma (HCC), but it faces challenges such as high local recurrence rates. This prospective study, conducted from January 2020 to July 2022, evaluated a novel approach using a three-channel, dual radiofrequency (RF) generator with separable clustered electrodes to improve RFA's efficacy and safety. The study employed a high-power, gradual, stepwise RFA method on HCCs (≤ 4 cm), utilizing real-time ultrasound-computed tomography (CT)/magnetic resonance imaging (MRI) fusion imaging.

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Objective: This study aimed to evaluate the prevalence of urinary incontinence (UI) and its associated risk factors among pregnant Korean women, as UI significantly impacts their quality of life.

Methods: A cross-sectional study involving singleton pregnant women was conducted between April and December 2023. Data were collected using a questionnaire assessing demographic information and UI symptoms.

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Diagnostic value of serum vascular endothelial growth factor-D in Korean patients with lymphangioleiomyomatosis.

Ther Adv Respir Dis

August 2024

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu, Seoul 05505, Republic of Korea.

Article Synopsis
  • Lymphangioleiomyomatosis (LAM) is a rare disorder marked by the growth of abnormal smooth muscle-like cells, and the effectiveness of serum VEGF-D as a diagnostic tool in Korean patients needs evaluation.
  • This study collected serum samples from 40 LAM patients and 24 controls to measure VEGF-D levels and analyze its diagnostic potential using ROC curve analysis.
  • Results indicated that serum VEGF-D levels were significantly elevated in LAM patients, showing strong predictive value for diagnosis, making it a potentially useful biomarker for this condition in the Korean population.
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A Life-Stage Approach to Precision Nutrition: A Narrative Review.

Cureus

August 2024

Department of Family Medicine, Center for Obesity, Metabolism, and Nutrition, Dongguk University Ilsan Hospital, Goyang, KOR.

The concept of precision nutrition highlights the customization of nutrition to specific needs, emphasizing that a one-size-fits-all approach is not sufficient for either optimal nutrition or optimal health. Precision nutrition encompasses a range of factors, from broad strata of age and sex categories to personal characteristics such as lifestyle to an individual's unique genotype. This breadth of scope requires us to consider how precision nutrition can be implemented in an inclusive and appropriate way for individuals and groups within real-life populations.

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Clinical Implications of a Proteomics-Based Approach for Cardiomyopathy and Heart Failure.

Korean Circ J

August 2024

Division of Cardiology, Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

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Article Synopsis
  • - The study aimed to compare the efficacy of drug-coated balloon (DCB) PCI versus drug-eluting stent (DES)-only PCI in patients with complex coronary artery lesions.
  • - A total of 126 patients received DCB-based PCI, which was compared with 234 patients who underwent DES-only PCI, focusing on the rate of target vessel failure (TVF) over 2 years.
  • - Results showed that DCB-based PCI had similar risks for TVF and other complications compared to DES-only PCI, suggesting that DCB could be a viable alternative in complex cases.
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Article Synopsis
  • The study assessed the effectiveness of conservative treatments for atraumatic medial sesamoid pain (MSP) in 27 patients involved in sports, focusing on treatment outcomes and underlying pathologies.
  • Nearly half (48.1%) of the patients reported pain relief after treatment, but factors like age, body weight, and the type of sport influenced their recovery outcomes.
  • MRI revealed that 42.8% of patients had no notable abnormalities, with common issues identified being soft tissue signal changes and intraosseous signal changes in the medial sesamoid bone.*
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Blood pressure control in diabetic kidney disease: a post-hoc analysis of the FANTASTIC trial.

Clin Hypertens

August 2024

Department of Internal Medicine, Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul, Republic of Korea.

Article Synopsis
  • The study investigated the impact of strict blood pressure (BP) control on health outcomes in patients with diabetic kidney disease (DKD), focusing on whether targeting systolic BP (SBP) below 130 mmHg has benefits compared to below 140 mmHg.
  • A total of 341 DKD patients were split into standard and strict BP control groups, with cardiovascular and renal events being monitored over a follow-up period of 2.8 years.
  • Results showed that while strict BP control didn't significantly lower the risk of health events, maintaining achieved SBP levels between 130-139 mmHg was linked to a reduced risk of cardiovascular and renal complications.
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Damage control surgery for life-threatening blunt chest trauma.

J Surg Case Rep

July 2024

Department of Thoracic and Cardiovascular Surgery, Inje University Ilsan Paik Hospital, 170 Juwha-ro, Ilsansu-gu, Goyang-si 10394, Gyeonsgi-Do, South Korea.

A 31-year-old male sustained life-threatening chest contusions and recovered after damage control surgery. The patient was in an unwitnessed accident where his motorcycle was struck by a car. Upon admission, blood pressure was 69/58 mmHg, heart rate was 126 bpm, and oxygen saturation was 85%.

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Objective: This study investigated the application of a deep learning-based object detection model for accurate localization and orientation estimation of spinal fixation surgical instruments during surgery.

Methods: We employed the You Only Look Once (YOLO) object detection framework with oriented bounding boxes (OBBs) to address the challenge of non-axis-aligned instruments in surgical scenes. The initial dataset of 100 images was created using brochure and website images from 11 manufacturers of commercially available pedicle screws used in spinal fusion surgeries, and data augmentation was used to expand 300 images.

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Automated Segmentation of MRI White Matter Hyperintensities in 8421 Patients with Acute Ischemic Stroke.

AJNR Am J Neuroradiol

December 2024

National Priority Research Center for Stroke and Department of Neurology (W.-S.R, J.C., S.-W.J., D.-S.G., D.-E.K.), Dongguk University Ilsan Hospital, Goyang, Republic of Korea

Article Synopsis
  • A study was conducted to develop deep learning algorithms for the automatic segmentation of white matter hyperintensity (WMH) lesions in patients with cerebral infarction, involving a large dataset of 8,421 patients from multiple hospitals in Korea.
  • Two models, 2D UNet and SE-Unet, were trained and validated using FLAIR MRI images, with performance measured against a human-segmented gold standard using various statistical metrics.
  • Results showed that while both models had good performance, the SE-Unet outperformed the UNet with higher average Dice Similarity Coefficients (DSCs) in both internal and external validations, indicating it was more reliable for WMH segmentation.
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Medication overuse headache (MOH) is a chronic headache disorder that results from excessive use of acutely symptomatic headache medications, leading to more frequent and severe headaches. This study aims to assess the 3-month treatment outcomes in MOH patients, focusing on the types and usage of overused medications, as well as preventive treatments. This prospective cross-sectional study analyzed the treatment outcomes of 309 MOH patients from April 2020 to March 2022.

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Introduction: Cytomegalovirus (CMV) infection is a major cause of transplantation-related morbidity and mortality. This study assessed the utility of the QuantiFERON monitor (QFM; Qiagen) for the prediction of early CMV infection and viral burden.

Methods: QuantiFERON-CMV (QF-CMV; Qiagen) and QFM were measured at the post-allogeneic hematopoietic stem cell transplantation (HSCT) week 4.

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Background: Oral retinoids are used to treat various dermatological conditions, and their use is increasing in women of childbearing age. However, there is limited knowledge on the incidence of adverse outcomes after retinoid exposure during pregnancy. We aimed to evaluate the risk of adverse outcomes associated with oral retinoid exposure during pregnancy.

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International liver societies recommend hepatocellular carcinoma (HCC) surveillance for those at high-risk of developing HCC. While previous studies have shown the benefits of surveillance for middle-aged patients, but its necessity for elderly patients is unclear. This study aimed to assess the benefits of HCC surveillance in the elderly by comparing diagnosis mode of HCC.

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Background And Objectives: Angiographic assessment of coronary stenosis severity using quantitative coronary angiography (QCA) is often inconsistent with that based on fractional flow reserve (FFR) or intravascular ultrasound (IVUS). We investigated the incidence of discrepancies between QCA and FFR or IVUS, and the outcomes of FFR- and IVUS-guided strategies in discordant coronary lesions.

Methods: This study was a post-hoc analysis of the FLAVOUR study.

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Background: Many people struggle with the choice in a series of processes, from prostate cancer (PCa) diagnosis to treatment. We investigated the degree of regret after the prostate biopsy (PBx) and relevant factors in patients recommended for biopsy for suspected PCa.

Methods: From 06/2020 to 05/2022, 198 people who performed PBx at three institutions were enrolled and analyzed through a questionnaire before and after biopsy.

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Clinical Aspects of Chronic Idiopathic Postnasal Drip: An Entity Not to Be Overlooked.

In Vivo

June 2024

Department of Otorhinolaryngology-Head and Neck Surgery, Inje University Ilsan Paik Hospital, Inje University School of Medicine, Goyang, Republic of Korea

Background/aim: Postnasal drip may be related to several diseases, but not all patients are clearly diagnosed. Patients with chronic, idiopathic postnasal drip symptoms are easily overlooked, and their clinical features are yet to be identified. This study aimed to analyze the clinical features and response to first generation antihistamine-decongestant therapy in patients with chronic idiopathic postnasal drip, suggesting it as a distinct entity.

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: The European Association of Urology guidelines on urolithiasis highlight the limited evidence supporting the superiority of percutaneous nephrostomy (PCN) over retrograde ureteral stent placement for the primary treatment of infected hydronephrosis secondary to urolithiasis. We, therefore, conducted a systematic review and meta-analysis comparing the effects of PCN and retrograde ureteral stent in patients with severe urinary tract infections secondary to obstructive urolithiasis. : Meta-analyses were performed to compare four outcomes: time for the temperature to return to normal; time for the white blood cell (WBC) count to return to normal; hospital length of stay; and procedure success rate.

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