Serotonin Regulates Lipogenesis and Endoplasmic Reticulum Stress in Alcoholic Liver Disease.

Background: Serotonin (5-hydroxytryptamine [5-HT]) is a monoamine neurotransmitter that has various functions in central and peripheral tissues. While 5-HT is known to regulate various biological processes in liver, direct role of 5-HT and its receptors, especially 5-HT receptor 2A (HTR2A) and HTR2B, in development and progression of alcoholic liver disease (ALD) in vivo is not well understood.

Methods: Blood 5-HT level was measured from both human ALD patients and ethanol (EtOH) diet-fed mouse models.

Characteristics of Plasmodium vivax apicomplexan amino acid transporter 8 (PvApiAT8) in the cationic amino acid transport.

Plasmodium vivax is the most widespread malaria parasite affecting humans, and its eradication is challenging due to the spread of drug-resistant parasites and their ability to remain in liver as a dormant stage. These parasites invade and multiply extensively within hepatocytes and erythrocytes in the host, relying on nutrient acquisition for their growth and replication. A promising new treatment aimed at targeting P.

Evidence-based Korean guidelines for the clinical management of multiple myeloma: addressing 12 key clinical questions.

Multiple myeloma (MM), a hematological malignancy, is characterized by malignant plasma cell proliferation in the bone marrow. Recent treatment advances have significantly improved patient outcomes associated with MM. In this study, we aimed to develop comprehensive, evidence-based guidelines for the diagnosis, prognosis, and treatment of MM.

Interrelation between hypoxic liver injury and Killip classification in ST-segment elevation myocardial infarction patients.

Introduction: Hypoxic liver injury (HLI) and Killip classification are poor prognostic factors in patients with ST-segment elevation myocardial infarction (STEMI). This study investigates the interrelationship between hypoxic liver injury (HLI) and Killip classification.

Method And Results: A total of 1,537 STEMI patients who underwent percutaneous coronary intervention (PCI) from 2007 to 2014 at four tertiary hospitals in the Incheon-Bucheon province were enrolled in this study.

Adiposity Rebound Timing in Small for Gestational Age Children Treated With Growth Hormone: Results From LG Growth Study Data.

Background: Adiposity rebound (AR) refers to the period during growth when the body mass index reaches its lowest point before increasing again. The timing of AR is associated with the development of obesity and puberty onset. Although studies have evaluated AR timing in Korean children, none has focused on children born small for gestational age (SGA).

Clinical practice guidelines for ovarian cancer: an update to the Korean Society of Gynecologic Oncology guidelines.

We updated the Korean Society of Gynecologic Oncology (KSGO) practice guideline for the management of ovarian cancer as version 5.1. The ovarian cancer guideline team of the KSGO published announced the fifth version (version 5.

Fuzzy multi-objective optimization model to design a sustainable closed-loop manufacturing system.

Republicans and Democrats practically everywhere have been demonstrating concerns about environmental conservation to achieve sustainable development goals (SDGs) since the turn of the century. To promote fuel (energy) savings and a reduction in the amount of carbon dioxide CO emissions in several enterprises, actions have been taken based on the concepts described. This study proposes an environmentally friendly manufacturing system designed to minimize environmental impacts.

Chemical Vapor Deposition Carbon Coating of SiO Anode for Li-Ion Batteries: Significance of Carbon Precursor Selection and Deposition Temperature.

Owing to the surge in the demand for lithium-ion batteries (LIBs) with high energy density, silicon suboxide (SiO )-based materials with impressive theoretical capacities have garnered significant attention. However, challenges such as poor electrical conductivity and substantial volume expansion must be overcome. A common strategy for addressing these issues involves coating SiO with carbon.

Diagnostic Decision Points of Specific Immunoglobulin E Concentrations for Seafood Allergies in Korean Children: A Nationwide Multicenter Study.

Shellfish and fish are common causes of food allergy (FA) in Asia, with significant prevalence rates reported across various countries. This study aimed to identify the diagnostic decision points (DDPs) for shrimp, crab, and cod allergies in Korean children. We enrolled participants aged 18 years or younger with suspected shrimp, crab, or cod allergies through a retrospective review of medical records from a nationwide 14-center study between January 2018 and March 2022.

Longitudinal Trajectories of Asthma and Allergic Comorbidities in the Korean Childhood Asthma Study.

Purpose: Studies on the longitudinal clinical features of asthma or allergic comorbidities in children are limited. We aimed to examine the trajectories of asthma and allergic comorbidities and determine whether these trajectories differ according to clinical asthma phenotypes from birth to adolescence.

Methods: We enrolled 958 children with physician-diagnosed asthma from the Korean childhood Asthma Study (KAS) cohort.

Exploring Barriers, Facilitators, and Needs Related to Mental Health Promotion for Police Officers: A Qualitative Approach.

Police officers are vulnerable to psychological distress and trauma since they are constantly exposed to significant physical and mental violence. Poor mental health can lead to increased healthcare costs for individuals, organizations, and nations and negatively impacts public safety. Mental health interventions tailored to the nature of police work are needed; however, a research gap exists regarding understanding the mental health of police officers.

Contact ion-pair S2 reactions activated by Lewis Base Phase transfer catalysts.

We present experimental probes of contact ion-pair (CIP) S2 reactions for simplest prototype systems by F-NMR spectroscopy. This study provides crucial evidences for the reactions of CIP metal salts facilitated by Lewis base phase transfer catalysts (PTCs) [2,2,2]-cryptand, 18-crown-6, pentaethylene glycols (pentaEGs) and BINOL-based pentaEG. The F-NMR spectra of MF (M = K, Cs) ion-pairs in various solvents are used as fingerprinting tools to identify the CIP CsF/PTC/substrate complexes in S2 reactions.

Influence of Workplace Bullying and Bystander Types on Speaking Up for Patient Safety Among Hospital Nurses: A Cross-Sectional Study.

Aims: To explore the influences of workplace bullying experiences, witnessing workplace bullying and bystander types on Speaking up for patient safety (SUPS) among hospital nurses.

Design: Cross-sectional study.

Methods: A survey was conducted in September 2021 using a structured questionnaire about workplace bullying experiences, witnessing workplace bullying, bystander types, and SUPS.

Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis.

Background: Remote ischemic conditioning (RIC) has been implicated in cross-organ protection in cerebrovascular disease, including stroke. However, the lack of a consensus protocol and controversy over the clinical therapeutic outcomes of RIC suggest an inadequate mechanistic understanding of RIC. The current study identifies RIC-induced molecular and cellular events in the blood, which enhance long-term functional recovery in experimental cerebral ischemia.

First record of Serban, 2000 (Bathynellacea, Bathynellidae) from subterranean waters of South Korea, with the description of a new species.

This study describes , the first new species of Bathynellidae family reported in East Asia since 2000, and it presents the first molecular analysis using CO1 and 18S gene sequences. Morphological analysis reveals that the new species and previously known species uniquely share key characteristics in the male and female thoracopods VIII. However, the presence or absence of the median seta on the antenna exopod, along with the length differences between the four spines in the furca, distinguish the new species from , 2000.

Carbon dioxide, global boiling, and climate carnage, from generation to assimilation, photocatalytic conversion to renewable fuels, and mechanism.

The increasing CO concentration in the atmosphere has substantial impacts on the global temperature. For energy sustainability and minimization of the effects of global warming, an approach to understand CO capturing and a carbon neutral culture is extremely essential in the present circumstances. The CO emission from vehicles and industries can be minimized using energy cost-effective techniques and can be converted more selectively into reusable fuels via thermochemical, electrochemical, photochemical, photocatalytic, electrocatalytic, biological and inorganic carbonate-based approaches.

Cross-cultural validation of plasma p-tau217 and p-tau181 as precision biomarkers for amyloid PET positivity: An East Asian study in Taiwan and Korea.

Introduction: Plasma phosphorylated tau (p-tau) biomarkers have improved Alzheimer's disease (AD) diagnosis, but data from diverse Asian populations are limited. This study evaluated plasma p-tau217 and p-tau181 levels in Korean and Taiwanese populations.

Methods: All participants (n = 270) underwent amyloid positron emission tomography (PET) and blood tests.

Nelonemdaz and Patients With Acute Ischemic Stroke and Mechanical Reperfusion: The RODIN Randomized Clinical Trial.

Importance: Nelonemdaz selectively antagonizes the 2B subunit of the N-methyl-d-aspartate glutamate receptor and scavenges free radical species.

Objective: To evaluate whether nelonemdaz enhances the clinical outcomes of patients with acute ischemic stroke undergoing emergent reperfusion therapy.

Design, Setting, And Participants: This multicenter double-blind placebo-controlled randomized phase 3 trial (December 25, 2021, to June 30, 2023, in South Korea) recruited patients with acute ischemic stroke who met the following criteria: National Institutes of Health Stroke Scale score greater than or equal to 8, Alberta Stroke Program Early Computed Tomography score greater than or equal to 4, and endovascular thrombectomy within 12 hours after stroke onset.

Establishing freshwater sediment sample pretreatment methods for monitoring microplastics and its challenges.

Microplastics (MPs) have been detected in various environmental matrices, drinking water, and food, and their presence is an ecological and human health concern. Most research on MPs has focused solely on their detection and analysis. However, sample pretreatment methods are critical for accurate MP analysis and must be properly established.

SEPO-FI: Deep-learning based software to calculate fusion index of muscle cells.

The fusion index is a critical metric for quantitatively assessing the transformation of in vitro muscle cells into myotubes in the biological and medical fields. Traditional methods for calculating this index manually involve the labor-intensive counting of numerous muscle cell nuclei in images, which necessitates determining whether each nucleus is located inside or outside the myotubes, leading to significant inter-observer variation. To address these challenges, this study proposes a three-stage process that integrates the strengths of pattern recognition and deep-learning to automatically calculate the fusion index.

Relationship Between Poor Sleep and Depressive Symptoms in Korean Elite Youth Athletes.

: Sleep and mental health are crucial to elite youth athletes, who face combined pressures of training, competition, school, and social commitments. We examined the association between sleep and depression in elite youth athletes. : We analyzed data of 248 Korean world-class youth athletes (aged 13-19 years).

Ellagic Acid from and Antimalarial Activity of Korean Medicinal Plants.

This study investigates the antimalarial potential of extracts and compounds from various plants used in traditional Korean medicine, in response to the increasing resistance of to standard treatments such as chloroquine and artemisinin. The antimalarial activity screening was conducted on 151 extracts, identifying the top seven candidates, including (50% ethanol and 100% methanol extract), , (hot water and 50% ethanol extract), , and . Among these, was identified as the top priority for further analysis due to its high antimalarial activity and high yield of bioactive compounds.