777 results match your criteria: "Infertility Research Center[Affiliation]"

Background: Anxiety is considered a prevalent mental disorder during childhood. Due to the significance of child psychology in critical psychological and health conditions and the fact that parenting styles may affect child health and behavioral issues in prospective life, the present study intends to explore the association of parenting styles and anxiety level among children in the COVID-19 pandemic.

Materials And Methods: The present cross-sectional study used a convenient sampling of all mothers with 5 to 12 children in Bandar Abbas in southern Iran.

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Multipotent mesenchymal stromal/stem cells (MSCs) refer to a population of stem cells that exhibit distinct progenitor cell characteristics including the potential for differentiation into a wide range of cell types. MSCs have become a promising candidate for cell therapy and tissue regeneration due to their unique properties, such as their ability to differentiate into multiple cell types, their capacity for expansion, self-renewal, and immune-regulatory effects. However, reports have brought attention to thrombosis-related complications associated with MSCs therapy in the last decade.

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Objective: The choice between utilizing testicular or ejaculatory sperm for intracytoplasmic sperm injection (ICSI) in men with severe oligozoospermia or cryptozoospermia is a crucial aspect of managing male infertility. This study aimed to identify a predictive factor that could guide this decision-making process.

Methods: Seventy-five infertile men with severe oligozoospermia or cryptozoospermia were included in the analysis.

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Lycopene in male infertility.

Naunyn Schmiedebergs Arch Pharmacol

December 2024

Research Center for Traditional Medicine and History of Medicine, Department of Persian Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Male infertility is a major concern around the world, and efforts to find effective therapies to improve reproductive results are continuing. Factors such as genetics, hormonal disorders, lifestyle, and environmental pollutants have been mentioned as the pathoetiology of male infertility. The treatment of male infertility is far from optimal despite the recent signs of progress provided by assisted reproductive technology.

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Biological activities of astaxanthin in the treatment of neurodegenerative diseases.

Neurodegener Dis Manag

January 2025

Fertility and Infertility Research Center, Health Technology Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Introduction: Neurodegenerative diseases (NDs) develop with the gradual advancement of neuronal damage and dysfunction in the central nervous system (CNS). These disorders are mostly the outcomes of the improper sedimentation and accumulation of proteins, such as amyloid-β (Aβ), α-synuclein, and prions. Astaxanthin (AST) exists in different types of living organisms and displays antioxidant and anti-inflammatory functions.

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Placenta percreta, a rare variant of placenta accreta spectrum (PAS) disorders, poses a significant risk of life-threatening hemorrhage associated with the adherent placenta. Bladder involvement signifies an even rarer incidence and may sometimes present solely with gross hematuria. Therefore, it is imperative to consider both microscopic and gross hematuria during pregnancy as alarming signs.

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Article Synopsis
  • - This study explores how fucoidan, a natural polysaccharide, works alone and with antibiotics against biofilms formed by Methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii, particularly in cases related to diabetic foot ulcers (DFUs).
  • - The results showed that using fucoidan with antibiotics like gentamicin and imipenem significantly enhances antimicrobial effectiveness, especially in mixed-species biofilms, with low toxicity to human skin cells.
  • - The findings suggest that fucoidan could be a promising treatment to disrupt harmful biofilms in DFU patients, indicating the need for more clinical research in this area.
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Estradiol (E2) levels on the day progesterone starts may negatively impact implantation, ongoing pregnancy, and live birth rates in frozen embryo transfer (FET). Overall, while the picture isn't entirely clear, some evidence suggests maintaining estradiol levels within a specific range before starting progesterone might be beneficial for frozen transfer success. So we performed a systematic review and meta-analysis to find out the rate of pregnancy-related outcomes of frozen embryo transfer in different level of E2.

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Article Synopsis
  • * The combination of artificial intelligence (AI) and therapeutic peptides is revolutionizing drug development by speeding up processes and reducing costs while targeting a variety of pathogens.
  • * Machine learning techniques are essential for improving the synthesis and sustainability of peptide production, enabling better identification of active and harmful compounds in drug development.
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Article Synopsis
  • Infertility impacts 15% of couples, and male factor infertility is involved in half of those cases; this study focused on gene expression in oligospermic men compared to healthy controls.
  • The research utilized semen and blood samples from 36 oligospermic men and 30 healthy men, analyzing RNA to assess gene expression via real-time PCR and using statistical tools for evaluation.
  • Findings showed significant increases in certain gene expressions in infertile males, particularly in semen, while other genes showed decreased expressions; however, more extensive studies are needed to confirm these results and explore gene correlations in detail.
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Article Synopsis
  • Endometriosis is a condition affecting women with pelvic pain and infertility, linked to chronic inflammation, and the study tests the effects of soy isoflavones (SI) and broccoli extract (BE) on its pathology in a rat model.
  • The experimental study involved 45 rats with surgically induced endometriosis, divided into groups receiving different treatments and assessed based on histopathological scores and gene expression levels.
  • Results showed significant reductions in pathology scores for the groups treated with broccoli extract and soy isoflavones, suggesting that their combined use could be an effective therapy for endometriosis.
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Oocyte competence develops: nuclear maturation synchronously with cytoplasm maturation.

Zygote

December 2024

Reproductive Sciences and Technology Research Center, Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Human oocyte maturation is a lengthy process that takes place over the course of which oocytes gain the inherent ability to support the next developmental stages in a progressive manner. This process includes intricate and distinct events related to nuclear and cytoplasmic maturation. Nuclear maturation includes mostly chromosome segregation, whereas rearrangement of organelles, storage of mRNAs and transcription factors occur during cytoplasmic maturation.

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Plasma Glycated CD59 and Gestational Diabetes Mellitus: A Systematic Review.

Endocrinol Diabetes Metab

November 2024

Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Aims: Gestational diabetes mellitus (GDM) is a common complication of pregnancy worldwide. The standard method for screening GDM is the 75 g oral glucose tolerance test (OGTT). However, the OGTT is difficult, time-consuming and requires fasting, making it an inconvenient test for GDM.

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Introduction: Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin production or utilization, leading to severe health complications. Diabetic foot ulcers (DFUs) represent a major complication, often exacerbated by polymicrobial infections involving Staphylococcus aureus and Acinetobacter baumannii. These pathogens, notorious for their resistance to antibiotics, complicate treatment efforts, especially due to biofilm formation, which enhances bacterial survival and resistance.

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Millions globally suffer from visual impairment, complicating the management of eye diseases due to various ocular barriers. The eye's complex structure and the limitations of existing treatments have spurred interest in tissue engineering (TE) as a solution. This approach offers new functionalities and improves therapeutic outcomes over traditional drug delivery methods, creating opportunities for treating various eye disorders, from corneal injuries to retinal degeneration.

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Platelet-rich plasma (PRP) has been suggested for the improvement of endometrial growth and receptivity in the patients with recurrent implantation failure (RIF). The aim of present study was to investigate the impact of different concentration of PRP on the expression of genes involved in the endometrial receptivity in the human endometrial cells from RIF and controls with thin and normal endometrium in vitro. In this cross-sectional study, endometrial biopsies were obtained from 14 healthy fertile women and 14 women with RIF.

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Exploring microbial diversity in Kermanshah province's Kermanshahi oil through DGGE and sequencing analysis.

J Health Popul Nutr

October 2024

Department of Microbiology, School of Medicine, Medical Technology Research Center, Research Institute for Health Technology, Kermanshah University of Medical Sciences, Kermanshah, 6714415333, Iran.

Background: Ghee, known as "roghane heiwâni," or "Kermanshahi oil" is a traditional fermented butter-like product highly esteemed for its nutritional value. Ghee is prepared using traditional methods and has substantial potential as a reservoir of probiotic microorganisms. Previous research delved into isolating and identifying lactic acid bacteria (LAB) in Kermanshahi through culture and PCR sequencing.

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Background: Routine Doppler study is a common tool for early diagnosis of Fetal Growth Restriction (FGR) and Small for Gestational Age (SGA) patients. It aimed to determine the role of the Foramen Ovale Pulsatility Index (FOPI) study beside routine Doppler study among patients with FGR and SGA fetuses.

Methods: This prospective study was conducted on 35 FGR, 32 SGA, and 33 Appropriate for Gestational Age (AGA) fetuses.

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Coronary artery disease (CAD) is the most common cardiovascular disease and the main cause of mortality in developing countries. Since physical activity and nutritional behaviors are modifiable risk factors in people at risk of CAD, the present study aims to explore the effect of an intervention based on the social cognitive theory (SCT) on physical activity and nutritional behaviors in middle-aged population at risk of CAD in the city of Bandar Abbas. The present cross-sectional study was conducted on 519 middle-aged subjects who visited the healthcare centers in Bandar Abbas, southern Iran, in 2023.

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Designing a novel multi-epitope antigen for diagnosing human cytomegalovirus infection: An immunoinformatics approach.

Biotechnol Appl Biochem

October 2024

Department of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Shiraz, Iran.

Article Synopsis
  • Human cytomegalovirus (HCMV) can cause severe health issues, especially in those with weakened immune systems, and current diagnostic tests for HCMV have limitations in sensitivity and specificity.
  • Researchers aimed to create a new, more accurate multi-epitope antigen for diagnosing HCMV infections using immunoinformatic methods, selecting five key proteins based on their antigenic properties.
  • The designed antigen showed promising stability and antigenicity without cross-reactivity and is a potential candidate for better HCMV diagnosis, although further lab testing is needed to confirm its effectiveness.*
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Decellularization of various tissues and organs through chemical methods.

Tissue Cell

December 2024

Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Article Synopsis
  • * Decellularization technology is a notable technique that removes cells from the extracellular matrix while preserving its structural and functional components.
  • * This process creates a biocompatible 3D structure that reduces the risk of immune rejection and inflammatory responses, highlighting its potential in regenerative medicine and tissue engineering.
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Fabrication and characterization of nanohydroxyapatite/chitosan/decellularized placenta scaffold for bone tissue engineering applications.

Int J Biol Macromol

November 2024

Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address:

Article Synopsis
  • Novel biomaterials like nanohydroxyapatite/chitosan/decellularized placenta (nHA.Cs.dPL) are being developed to create effective scaffolds for bone tissue engineering.
  • The human placenta was processed to form a hydrogel, and the resulting scaffolds were analyzed for various mechanical and biological properties, including porosity and biocompatibility.
  • The study found that the nHA.Cs.dPL scaffolds supported the growth and bone-forming activity of Saos-2 cells, making them promising candidates for enhancing bone regeneration.
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Glioblastomas (GBMs) are the most common and aggressive malignant brain tumors, presenting significant challenges for treatment due to their invasive nature and localization in critical brain regions. Standard treatment includes surgical resection followed by radiation and adjuvant chemotherapy with temozolomide (TMZ). Recent advances in immunotherapy, including the use of mRNA vaccines, offer promising alternatives.

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Background: Malaria disease is one of the most dangerous protozoan parasitic infections with a high mortality rate in developing countries. Malaria is a public health issue, especially in Hormozgan province, and is highly affected by foreign immigrants (Pakistani and Afghani); thus, the present study aimed to evaluate the effect of an intervention based on the health belief model (HBM) on the promotion of malaria prevention behaviors in Afghani immigrants over the age of 18. The participants resided in Persian city in Hormozgan province.

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