9,291 results match your criteria: "Infectious Mononucleosis"

Background: Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a severe hyperinflammatory disorder induced by overactivation of macrophages and T cells. This study aims to identify the risk factors for the progression from infectious mononucleosis (EBV-IM) to EBV-HLH, by analyzing the laboratory parameters of patients with EBV-IM and EBV-HLH and constructing a clinical prediction model. The outcome of this study carries important clinical value for early diagnosis and treatment of EBV-HLH.

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Epstein-Barr virus strains present in South-East Asia are tightly associated with nasopharyngeal carcinomas. We report the case of a Caucasian female who presented with an infectious mononucleosis syndrome. Sequencing demonstrated that she had been infected with a virus of Chinese origin that is thus spreading into European countries.

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The molecular diversity of Epstein-Barr virus (EBV) is defined by mutations in specific EBV genes and has been insufficiently studied in infectious mononucleosis (IM). The aim of this study was to determine all variations of the EBV latency genes EBNA-1, EBNA-2 and LMP-1 in pediatric patients with EBV-associated IM in Croatia, including previously defined SNPs and indels as well as previously undocumented polymorphisms. The vast majority of EBV isolates (71/72) were determined as EBV type 1 while EBNA-1 genes were classified exclusively as previously defined EBNA-1 prototypes, with 22/72 sequences categorized as P-Ala and 50/72 sequences as P-Thr.

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One of the main clinical manifestations of infection by the Epstein-Barr virus (EBV) is infectious mononucleosis. In this clinical syndrome, mild hepatitis with a slight elevation of aminotransferases is common. However, cholestasis is rare and usually occurs alongside a more severe, cytolytic hepatitis.

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A Rare Complication of Atraumatic Splenic Rupture in Infectious Mononucleosis: A Case Report.

Br J Hosp Med (Lond)

November 2024

Department of Surgery, General Hospital of Syros, "Vardakeio and Proïo", Hermoupolis, Syros, Greece.

Atraumatic splenic rupture is a very rare and potentially life-threatening event usually associated with underlying pathological conditions. Splenic rupture in infectious mononucleosis occurs only in 0.1%-0.

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Article Synopsis
  • A new viral species called human circovirus (HCirV) has been identified, potentially linked to hepatitis in people with weakened immune systems.
  • A study tested 278 hepatitis patients and 184 healthy individuals, finding HCirV in 2.9% of the hepatitis patients but none in healthy individuals.
  • The virus appears to have a preference for liver cells, indicated by its ability to bind to liver cancer cell lines but not to lung cells, suggesting it may play a role in hepatitis, especially in immunocompromised patients.
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The diagnostic value of peripheral blood lymphocyte testing in children with infectious mononucleosis.

BMC Pediatr

November 2024

Hematology Laboratory, Suqian First Hospital, No. 120, Suzhi Road, Sucheng District, Suqian City, Jiangsu Province, 223800, China.

Objective: To investigate the diagnostic value of peripheral blood lymphocyte testing in children with infectious mononucleosis (IM).

Methods: A total of 135 children with IM as the IM group and 100 healthy volunteers as the healthy group were included in this retrospective study. Peripheral blood lymphocyte subsets marked as CD3+, CD4+, CD8+, CD16 + CD56+, and CD19 + in the peripheral blood were quantified using flow cytometry.

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Background: Timely identification of the etiology of transaminitis is critical in informing subsequent management as strategies can vary from supportive care to urgent transplant assessment. This is especially important in returning travelers as there may be multiple causes of injury that need to be addressed.

Case Report: We present a case of severe transaminitis secondary to non-hepatitis viral co-infections.

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Large diagnostic panels allow for pathogens with high or low likelihood of causing attributable illness to be tested simultaneously. Infectious mononucleosis (IM) due to primary infection with Epstein-Barr virus (EBV) is a common cause of acute febrile illness (AFI) in case series from high-income countries, though its contribution to AFI in tropical low-income settings is unclear. As part of a case-control study using multiplex quantitative polymerase chain reaction (qPCR) diagnostics, we set out to determine if primary EBV infection was an underrecognized cause of AFI in the Peruvian Amazon.

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An insect cell-derived extracellular vesicle-based gB vaccine elicits robust adaptive immune responses against Epstein-Barr virus.

Sci China Life Sci

October 2024

State Key Laboratory of Vaccines for Infectious Diseases, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, National Innovation Platform for Industry-Education Integration in Vaccine Research, School of Life Sciences, School of Public Health, Xiang An Biomedicine Laboratory, Xiamen University, Xiamen, 361005, China.

Epstein-Barr virus (EBV), the first identified human tumor virus, is implicated in various human malignancies, infectious mononucleosis, and more recently, multiple sclerosis. Prophylactic vaccines have the potential to effectively prevent EBV infection. Glycoprotein B (gB) serves as the fusogen and plays a pivotal role in the virus entry process, making it a critical target for EBV vaccine development.

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Langerhans cell histiocytosis (LCH) is a rare disorder predominantly affecting children and is characterized by a wide range of clinical presentations, which can make early identification of the disease difficult and result in the delay of appropriate treatment. The challenge is further compounded by the fact that diagnostic confirmation typically requires a biopsy of the bone or skin lesion, as well as immunohistochemical identification of molecular markers, which may not be readily available in all settings. This case report describes a two-year-old female who was initially misdiagnosed with infectious mononucleosis due to her non-specific presentation, highlighting the diagnostic challenges of LCH, particularly in resource-limited settings.

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EBV infects more than 90% of people globally, causing lifelong infection. The phases of the EBV life cycle encompass primary infection, latency, and subsequent reactivation or lytic phase. The primary infection usually happens without noticeable symptoms, commonly in early life stages.

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Introduction: We aimed to evaluate the efficacy of measuring transaminase levels to determine the resolution of splenomegaly in athletes diagnosed with infectious mononucleosis (IM).

Methods: We collected serial aspartate aminotransferase (AST) and alanine transaminase (ALT) levels and ultrasound-measured spleen sizes in university athletes who had been diagnosed with IM. Our study included seven university-aged athletes from a single institution.

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Viral infection leads to heterogeneous cellular outcomes ranging from refractory to abortive and fully productive states. Single cell transcriptomics enables a high resolution view of these distinct post-infection states. Here, we have interrogated the host-pathogen dynamics following reactivation of Epstein-Barr virus (EBV).

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Objective: To develop a prediction model based on peripheral blood signs to distinguish between infectious mononucleosis and chronic active EBV infection.

Methods: Retrospective data was collected for 60 patients with IM (IM group) and 20 patients with CAEBV infection (CAEBV group) who were hospitalized and diagnosed at the General Hospital of Tianjin Medical University between December 2018 and September 2022. The analyses used were univariate and LASSO (least absolute shrinkage and selection operator) logistic regression.

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Biological false-positive reactions to non-treponemal syphilis tests occur under various conditions, including in patients with infectious mononucleosis. However, false-positive treponemal test results are rarely reported. We present three cases of Epstein-Barr virus-associated infectious mononucleosis that exhibited concurrent false-positive results in both treponemal and non-treponemal tests, effectively imitating syphilis serology.

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Article Synopsis
  • * Initial diagnosis suggested infectious mononucleosis, but further biopsies confirmed systemic EBV DLBCL; the patient underwent successful treatment with R-CHOP chemotherapy, resulting in complete remission.
  • * Despite remission, the patient developed hemophagocytic lymphohistiocytosis (HLH) after the fifth treatment cycle and ultimately received allogeneic stem cell transplantation, but died 14 months later, highlighting the
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Chronic active Epstein-Barr Virus infection in a teenage girl with suspect autoimmune Hepatitis.

BMC Pediatr

October 2024

Division of Pediatric Gastroenterology, Department of Pediatrics, Linkou Branch, Chang Gung Children's Medical Center, Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan Dist, Taoyuan City, 33305, Taiwan.

Article Synopsis
  • Chronic active Epstein-Barr virus (CAEBV) disease can mimic autoimmune hepatitis (AIH) due to similar symptoms and liver enzyme elevations, complicating diagnosis.
  • A case is presented of a 14-year-old girl misdiagnosed with AIH who was later found to have CAEBV after testing positive for EBV markers and DNA, leading to diverse treatment options that were ultimately refused by her family.
  • The study highlights the importance of considering CAEBV in patients with AIH-like symptoms, especially when they do not respond to standard treatment methods.
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Objective: Infectious mononucleosis (IM) or mono is typically caused by primary infection with Epstein-Barr virus (EBV) and may have a months-long, complicated course. We utilized population-based data to add to the limited literature on health care utilization following EBV infection.

Methods: The Rochester Epidemiology Project includes medical records for ∼60% of residents living in 27 counties of Minnesota (MN) and Wisconsin (WI).

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Objective: This study aimed to investigate the prevalence of Epstein-Barr virus (EBV) infection in patients with and without cancer.

Methods: A total of 26,648 participants who underwent whole-blood EBV DNA (WBEBV) assays between January 1, 2020, and August 31, 2023, were included. The chi-square test was used for categorical data analysis, and R software was used to analyze the differences in EBV DNA load levels and the diagnostic capabilities of WBEBV.

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Background: Exanthematous drug eruption and infectious mononucleosis (IM) are both exanthematous diseases. Current research on exanthematous drug eruption and IM mainly targets identifying these disorders, the resulting differences at the metabolism level have not yet been systematically analyzed.

Materials And Methods: A total of 30 cases of exanthematous drug eruption and IM, 10 patients without exanthema and 10 healthy volunteers were enrolled, 3 mL of fasting venous blood was collected, the serum metabolite content was detected by gas chromatography-mass spectrometry metabolomics.

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Article Synopsis
  • Spontaneous splenic rupture is a rare condition usually related to diseases like infectious mononucleosis caused by the Epstein-Barr virus, and it typically lacks an identifiable cause.* -
  • The article discusses a case of a 73-year-old woman who experienced sudden left-sided flank pain, leading to the discovery of a splenic injury requiring emergency surgery and splenectomy.* -
  • Early diagnosis and treatment of spontaneous splenic rupture are crucial, as delays can increase the risk of serious complications, and while some stable patients might be treated non-operatively, long-term outcomes remain uncertain.*
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Article Synopsis
  • - A 24-year-old South Asian male had an unusual case of Epstein-Barr virus (EBV) infectious mononucleosis, showing liver-related symptoms like cholestatic hepatitis and high bilirubin levels.
  • - Initially, he presented with common symptoms such as sore throat, fever, and malaise, which later included nausea and vomiting.
  • - Laboratory tests confirmed EBV infection, highlighting the need to consider EBV in young adults with infectious symptoms and liver issues, aiding in effective management and reducing unnecessary tests.
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