Bipyridyl Functionalized NHC-Sulfenyl, Selenenyl Cations; Potential Species for Alkylation Reactions and Ligands in Copper(I) Catalysis.

Reactions of bipyridyl-functionalized imidazole-thiones and selones with MeX (X=I, OTf) afforded sulfenyl and selenenyl cations [(NNC)EMe]X (2/3, E=S, Se). Further reactions of these main-group cations with [Cu(CHCN)]BF, Cu(OTf) furnished dicationic [{Cu(μ-I)(NNC)EMe}][Y] (5/6, Y=BF, OTf) and tricationic copper(I) complexes [Cu{(NNC)EMe}](OTf)BF (7 a/7 b) when employed [(NNC)EMe]I and [(NNC)EMe]OTf respectively. All these cationic complexes were characterized by various spectroscopic techniques, including X-ray diffraction analysis.

Emerging Roles of Gossypol in Therapy: Innovations in Prodrug Design and Nanoformulation Frontiers.

Stimuli activatable systems have the potential to deliver drugs to targeted areas by releasing therapeutic agents in response to diseased specific microenvironments such as the acidic environment commonly found in diseased tissues. This review article focuses on gossypol, a bioactive compound with inherent toxicity attributed to various factors, including the presence of its formyl groups. It highlights the potential of imine-linked gossypol-based prodrugs and nanoparticle formulations for targeted delivery and controlled release.

A Three-Component Synthesis of Spiropyrrolines.

A rapid synthesis of medicinally important spiropyrrolines has been achieved by the reaction of 1,3-indanediones, benzaldehyde, and (1-azidovinyl)benzene under catalyst- and reagent-free conditions. This is the first report to synthesize diverse spiropyrroline compounds from readily available feedstock materials under metal-free conditions.

Ammonia synthesis by the reductive N-N bond cleavage of hydrazine using an air-stable, phosphine-free ruthenium catalyst.

The development of an effective molecular catalyst to reduce hydrazine efficiently to ammonia using a suitable reductant and proton source is demanding. Herein, an unprecedented air-stable, phosphine-free ruthenium complex is used as a potent catalyst for hydrazine hydrate reduction to generate ammonia using SmI and water under ambient reaction conditions. Maximizing the flow of electrons from the reductant to the hydrazine hydrate the metal centre results in a greater yield of ammonia while minimizing the evolution of H gas as a competing product.

Synthetically Tunable Suprahybrid Nanoparticle Platform for the Efficacious Delivery of Therapeutics.

The discovery of lipid-hybrid nanosystems has offered potential solutions to various drug delivery and theranostic challenges. However, in many instances, the commonly used lipids and other components in these systems often pose challenges related to their solubility, physicochemical properties, immune compatibility, and limited synthetic tunability. In this work, we introduce a synthetically tunable supramolecular scaffold with amphiphilic characteristics based on the calix[4]arene macrocyclic system.

New cationic coinage metal complexes featuring silyl group functionalized phosphine: syntheses, structures and catalytic studies in alkyne-azide cycloaddition reactions.

A series of coinage metal complexes bearing rarely explored -silylated phosphine is reported. The treatment of diphenyl(2-(trimethylsilyl)phenyl)phosphine (1) with CuCl and [Cu(CHCN)]BF furnished the corresponding neutral [(1)CuCl] (2) and mono-cationic [(1)Cu(CHCN)]BF (3) complexes, respectively. The reactions of 1 with AgX (X = BF, NO) in 2 : 1 ratio furnished the corresponding mono cationic dicoordinate silver(I) complexes of the type [(1)Ag]X (X = BF (4a), NO (4b)).

Dicationic copper(I) complexes bearing ENE (E = S, Se) pincer ligands; catalytic applications in regioselective cyclization of 1,6-diynes.

Two novel dicationic binuclear Cu(I) complexes of the type [{(BPPP)E}Cu][BF] (E = S (3a); Se (3b)) bearing (BPPP)E (BPPP = bis(diphenylphosphino)pyridine) pincer systems were isolated, and structurally characterized. The solid-state structures of 3a/3b display the presence of intermolecular cuprophilic (Cu⋯Cu) interactions between the two monocationic species, and consist of weak Cu⋯S bonding between the two cations. Besides, complex 3a was introduced as a molecular copper(I) catalyst in cyclization reactions, and new protocols were developed for the synthesis of a series of new oxazole and triazole derivatives bearing alkyne-phenyl propargylic ether substituents.

Injection Moulding into 3D-Printed Plastic Inserts Produced Using the Multi Jet Fusion Method.

Most injection-moulded plastics are injection moulded into moulds made from conventional materials such as steel or aluminium. The production costs of the mould are considerable. 3D printing from plastic can be used for injection moulds to save these costs.

Cascade Nucleophilic Addition-Cyclic Michael Addition of Arynes and Indoles Bearing Michael Acceptor: A Strategy to Construct Pyrroloacridines and Study of Their Physicochemical Properties.

A facile synthetic approach to 6-pyrrolo[3,2,1-]acridines has been developed by using cascade -nucleophilic addition-cyclic Michael addition process of arynes and indoles substituted with Michael acceptors under metal-free conditions. Additionally, photophysical studies of a few of the newly synthesized pyrroloacridine compounds indicated good fluorescence emission properties.

Physical Fitness and Body Composition of Youth Referees in Invasion Games.

Background: Referees' activity can be an instrument for training students with an impact on health-related physical fitness (PF). This study aimed to investigate the differences in PF and body composition between students without sports practice (G1), students with regular sports practice (G2), and student referees in team invasion games (G3).

Methods: This study followed a cross-sectional design.

A Method to Access Highly Functionalized Dibenzobicyclo[3.2.1]octadienones: Application to the Construction of the 6/6/5/6/6 Carbon Skeleton of Rubialatin A.

The dibenzobicyclo[3.2.1]octadienone scaffold, which has been found in naphthocyclinones, engelharquinones, rubialatin A, etc.

Issues and solutions of electronic waste urban mining for circular economy transition: An Indian context.

The rapid consumption of advanced e-products has intensified problems for the linear economy; constantly diminishing natural resources employed in production processes have created a need of recycle and reuse. Although the transition to a circular economy proposes to end the loop of e-products, it needs the application of processes such as urban mining to recover resources as secondary raw material. The present study intends to examine the issues and challenges of electronic waste urban mining (EWUM) in India that need to be assessed for the development of a sustainable economy.

Leisure Time Physical Activity and Risk of Developing Depression among the Youth of Kangra District, Himachal Pradesh, India.

Background: Physical inactivity during adolescence and youth has been considered as potential risk factor for future mental health problems. The present study was conducted with the aim to examine whether an association exists between leisure-time physical activity (PA) and depression among the youth of Kangra district, studying in professional or degree colleges.

Methodology: A cross-sectional study was conducted among the students of Medical College (MC), Central University (CU) and Industrial Training Institute (ITI) of Kangra district.

Approximation properties of Chlodowsky variant of [Formula: see text] Bernstein-Stancu-Schurer operators.

In the present paper, we introduce the Chlodowsky variant of [Formula: see text] Bernstein-Stancu-Schurer operators which is a generalization of [Formula: see text] Bernstein-Stancu-Schurer operators. We also discuss its Korovkin-type approximation properties and rate of convergence.

Novel combination of salinomycin and resveratrol synergistically enhances the anti-proliferative and pro-apoptotic effects on human breast cancer cells.

Resveratrol (RES) is a natural polyphenol having anti-proliferative activity against breast cancer cells. RES in combination with other chemo modulatory agents, minimizes toxicity and increases efficacy of the treatment. Salinomycin (SAL), a monocarboxylic polyether ionophore is known for selectively targeting breast cancer stem cells.

Vitamin B12 functionalized layer by layer calcium phosphate nanoparticles: A mucoadhesive and pH responsive carrier for improved oral delivery of insulin.

Unlabelled: The present study investigates the potential of layer by layer coated calcium phosphate nanoparticles - for oral delivery of insulin where Vitamin B12 grafted chitosan and sodium alginate have been used as cationic and anionic polyelectrolyte respectively. The major emphasis has been given on the role Vitamin B12 conjugated chitosan as cationic polyelectrolyte (VitB12-Chi) in the delivery system. VitB12-Chi conjugate was prepared by carbodiimide reaction.

Impact of a multi-method promotional package on awareness and knowledge about STD and AIDS among the trainees of an industrial training institute in a resettlement colony of Delhi, India.

To design and apply a multi-method promotional package for enhancing awareness and knowledge on STD and AIDS among ITI trainees, and evaluate its impact, an intervention study, using pre and post assessment of the subjects for comparison was carried out. The study was carried out in the Industrial Training Institute (ITI), in a resettlement colony of Delhi. Urethral/vaginal discharge, genital ulcer and pain on micturition were identified as symptoms of STD by a significantly higher number of respondents in the post package sample.

The development of the ITI Dental Implant System as a model for the cooperation between research and industry.

For thirty years now oral implants and methods for implantation have been developed further to assure a lifetime stability of these devices and to optimize function and esthetics. Coming from osteosynthesis the Institut Straumann in cooperation with leading clinicians had a considerable share in this development. Out of this longtime cooperation an institutionalized form was devised, where clinicians, material scientists and engineers were united in the International Team for oral Implantology (ITI).