Inhibition of Amyloid Fibrillation of HEWL by 4-Methylcoumarin and 4-Methylthiocoumarin Derivatives.

Background: Several human diseases like Parkinson's, Alzheimer's disease, and systemic amyloidosis are associated with the misfolding and aggregation of protein molecules.

Objective: The present study demonstrated the comparison of 4-methyl coumarin and 4-methylthiocoumarin derivative for their anti-amyloidogenic and disaggregation activities. The hen egg-white lysozyme is used as a model system to study protein aggregation and disaggregation under in vitro conditions.

Transpedal Approach in Failed Antegrade Attempt of Lower Limb Peripheral Arterial Disease-A Review with Different Treatment Strategies.

Transpedal access is an evolving technique primarily used in patients after failed femoral antegrade approach to revascularize complex tibiopedal lesions. In patients who are at high risk for surgery the transpedal access may be the only option in failed antegrade femoral access to avoid amputation of the limbs. In recent years transpedal access is used routinely to revascularize supra-popliteal lesions due to more success and less complications over femoral artery approach.

The Great Smog Month and Spatial and Monthly Variation in Air Quality in Ambient Air in Delhi, India.

Background: In recent years, poor urban air quality in Delhi, India has gained significant attention. Episodic events including crop stubble burning and Diwali celebrations are considered major factors in the worsening quality of ambient air.

Objective: This study aimed to investigate spatial and monthly variation as well as the role of episodic events in ambient air quality in Delhi, including the 'Great Smog' month of November 2017.

MicroRNAs: potential biomarkers for diagnosis and prognosis of different cancers.

A thorough understanding of the tumor environment and underlying genetic factors helps in the better formulation of cancer management strategies. Availability of efficient diagnostic and prognostic biomarkers facilitates early detection and progression of the disease. MicroRNAs affect different biological processes participating in tumorigenesis through regulation of their target genes.

Correction to: Statistical, time series and fractal analysis of full stretch of river Yamuna (India) for water quality management.

As corresponding author, while going through higher research in this area, it is found that the formula for Hurst exponent given in equation (13) on page no. 401 is wrongly written.

Transcriptome Analysis of and Identification of Superoxide Dismutase as a Novel Interactor of DNMT2 in the Moss .

is a DNA/tRNA cytosine methyltransferase that is highly conserved in structure and function in eukaryotes. In plants however, limited information is available on the function of this methyltransferase. We have previously reported that in the moss , plays a crucial role in stress recovery and tRNA transcription/stability under salt stress.

Suitability assessment of dumpsite soil biocover to reduce methane emission from landfills under interactive influence of nutrients.

Biocovers are known for their role as key facilitator to reduce landfill methane (CH) emission on improving microbial methane bio-oxidation. Methanotrophs existing in the aerobic zone of dumped wastes are the only known biological sinks for CH being emitted from the lower anaerobic section of landfill sites and even from the atmosphere. However, their efficacy remains under the influence of landfill environment and biocover characteristics.

A qualitative enquiry into strategic and operational responses to Covid-19 challenges in South Asia.

The Covid-19 epidemic is a public health emergency of international concern. It poses a massive risk for the human race across the planet, calling for the need to take measures at the local, regional, national, and global levels. South Asian countries stand more vulnerable to the pandemic due to their dense population, poor infrastructure, and low surveillance system.

Data driven estimation of novel COVID-19 transmission risks through hybrid soft-computing techniques.

Coronavirus genomic infection-2019 (COVID-19) has been announced as a serious health emergency arising international awareness due to its spread to 201 countries at present. In the month of April of the year 2020, it has certainly taken the pandemic outbreak of approximately 11,16,643 infections confirmed leading to around 59,170 deaths have been recorded world-over. This article studies multiple countries-based pandemic spread for the development of the COVID-19 originated in the China.

Removal of heavy metals and radionuclides from water using nanomaterials: current scenario and future prospects.

There is an increase in concern about the hazardous effects of radioactivity due to the presence of undesirable radioactive substances in our vicinity. Nuclear accidents such as Chernobyl (1986) and Fukushima (2011) have further raised concerns towards such incidents which have led to contamination of water bodies. Conventional methods of water purification are less efficient in decontamination of radioisotopes.

Solar Energy Harvesting using Candle-Soot-Coated Thermoelectric Materials.

This article reports the thermoelectric-based solar energy harvesting. The effect of candle soot (CS) coating on solar energy harvesting potential of thermoelectric modules is studied. To compare the performance, uncoated/coated modules are exposed to solar radiations (through Fresnel lens) and the other side is kept at lower temperature using continuous water flow.

Haar wavelet transform-based optimal Bayesian method for medical image fusion.

Image fusion (IF) attracts the researchers in the areas of the medical industry as valuable information could be afforded through the fusion of images that enable the clinical decisions to remain effective. With the aim to render an effective image fusion, this paper concentrates on the Bayesian fusion approach, which is tuned optimally using the proposed Fractional Bird Swarm Optimization (Fractional-BSA). The medical image fusion is progressed using the MRI brain image taken from the BRATS database, and the source images of multimodalities are fused effectively to present an information-rich fused image.

Withdrawal Notice: Lipid Carriers Mediated Targeted Delivery of Neurotherapeuticals: Challenges, Role of Blood Brain Barrier and Promises of Nanotechnology Based Approaches in Neuronal Disorders.

Unlabelled: The article has been withdrawn at the request of the editor of the journal Current Drug Metabolism due to incoherent content. Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused. The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.

Metal removal and recovery using bioelectrochemical technology: The major determinants and opportunities for synchronic wastewater treatment and energy production.

Microbial fuel cell (MFC) technology has emerged as a new and attractive bioelectrochemical approach in the last one and a half decade that offers an alternative to conventional treatment methods to remove and recover heavy metals and organics from wastewaters with simultaneous energy production. This technique has advantage over the conventional wastewater treatment techniques, which are energy intensive, sludge producing and with little effectivity at high concentrations. Significant work has been done in the recent years on MFC principle, electrode configuration, biofilm composition, application of MFC in wastewater treatment, metal removal or recovery and energy production.

Transcriptomic and network analyses reveal distinct nitrate responses in light and dark in rice leaves (Oryza sativa Indica var. Panvel1).

Nitrate (N) response is modulated by light, but not understood from a genome-wide perspective. Comparative transcriptomic analyses of nitrate response in light-grown and etiolated rice leaves revealed 303 and 249 differentially expressed genes (DEGs) respectively. A majority of them were exclusive to light (270) or dark (216) condition, whereas 33 DEGs were common.

Scopoletin: Antiamyloidogenic, Anticholinesterase, and Neuroprotective Potential of a Natural Compound Present in Roots by In Vitro and In Silico Study.

Alzheimer's disease (AD) is characterized by depositions of amyloid β (Aβ) peptides aggregates resulting in plaques formation in the central nervous system (CNS). This study evaluates the disease-modifying potential of scopoletin against multiple factors associated with AD such as cholinesterase enzymes, Aβ peptides, and neuroprotective properties against Aβ- and HO-induced cytotoxicity under in vitro conditions. Scopoletin was identified and quantified using UPLC-QTOF (ultra-high performance liquid chromatography-quadrupole time-of-flight) and high-performance liquid chromatography (HPLC), respectively.

Ion beam modified TiO nanotubular bio-interface for electrochemical detection of L-tyrosine towards smart bandage application.

One of the common complications diagnosed in Diabetes Mellitus (DM) patients is Diabetic Foot Ulcers (DFUs). It is a condition wherein the deep tissues located in the lower limb undergo inflammation and infection due to neurological abnormalities (neuropathy) and various degrees of vascular diseases (angiopathy). The concentration of l-tyrosine (Tyr) rises abruptly in DFUs, and therefore may be used as an indicator for early monitoring of the patient's condition during the onset of diabetic foot disease.

Role and influence of growth factors on early osseointegration in animal jaw bone: A meta-analysis.

Aim: Growth factors (GFs) are polypeptides, which are intricately involved in the regulation of bone formation, preservation, and regeneration through gene expression. However, the role of these bioactive agents in osseointegration of dental implants has not been substantially proven. The objective of this systematic review (SR) and meta-analysis was to explore the effect of GFs on early osseointegration of dental implants in animal jaws.

Synthesis of silver nanoparticles utilizing various biological systems: mechanisms and applications-a review.

The evolving technology of nanoparticle synthesis, especially silver nanoparticle (AgNPs) has already been applied in various fields i.e., electronics, optics, catalysis, food, health and environment.

Nitrogen futures in the shared socioeconomic pathways 4.

Humanity's transformation of the nitrogen cycle has major consequences for ecosystems, climate and human health, making it one of the key environmental issues of our time. Understanding how trends could evolve over the course of the 21 century is crucial for scientists and decision-makers from local to global scales. Scenario analysis is the primary tool for doing so, and has been applied across all major environmental issues, including nitrogen pollution.

Energy consumption, FDI, and urbanization linkage in coastal Mediterranean countries: re-assessing the pollution haven hypothesis.

Foreign direct investment (FDI) and the consumption of non-renewable energy have been on the increase in the coastal Mediterranean countries (CMCs) over the last few decades. Both trigger growth, but the environmental impact could be far-reaching as environmental distortions are mainly human-induced. This study examines the environmental issues facing CMCs.

Dataset on aqueous solid-liquid extraction of gossypol from defatted cottonseed in acidic medium using green solvent, its kinetics and thermodynamics study and mass transfer effects.

Extraction of gossypol from cottonseed is essentially required to produce cottonseed free from gossypol for animal feed and or human applications. The focus of the present research was to determine the percentage gossypol extraction after extracting the defatted cottonseed using environment friendly green solvent ethanol-water (95:5 v/v) acidified with 0.5 M oxalic acid.

Case Series on Four Treated Cases of Embryonal Rhabdomyosarcoma in Children.

We report four cases of embryonal rhabdomyosarcoma treated successfully with multimodality therapy which included surgery, chemotherapy and radiotherapy. Our first case was a 2 year old who admitted with the chief complaint of swelling of the upper lip. Biopsy was taken, which showed embryonal rhabdomyosarcoma.

Design and screening of aryl allyl mercaptan analogs as potential histone deacetylases (HDAC) inhibitors.

The Zn HDACIs show promising anticancer activity. Allyl mercaptan (AM), a metastabilzed monomeric form of diallyl disulphide (DADS) shows better HDACI activity. The present work screens a dataset of aryl AM derivatives for potential HDACI action models.

Development of cost effective metal oxide semiconductor based gas sensor over flexible chitosan/PVP blended polymeric substrate.

In the present work, biodegradable and flexible chitosan/polyvinylpyrrolidone (CHP) polymeric substrate was fabricated by solvent casting method. This is a novel demonstration of the combination of natural polymer (chitosan) and synthetic polymer (PVP) for next-generation semiconductor device applications. The ZnO thin films were successfully synthesized on these polymeric substrates by facile drop-casting method for gas sensing applications.