Cardiotoxicity evaluation of two-drug fixed-dose combination therapy under CiPA: a computational study.

The Comprehensive Proarrhythmia Assay (CiPA) evaluates drug-induced torsade de pointes (TdP) risk, with qNet commonly used to classify drugs into low-, intermediate-, and high-risk categories. While most studies focus on single-drug effects, 2-drug fixed-dose combination (FDC) therapy is widely used for cardiovascular disease management. We aimed to develop the CiPA-based methodology to predict adverse effects of FDC therapy.

Unilateral chylothorax in a renal transplant recipient: A case report.

Chylothorax is accumulated lymphatic fluid in the pleural space. It rarely happens in end-stage renal illness patients, but possible causes are hospital-related. This case describes a 40-year-old man experiencing unilateral chylothorax after a kidney transplant.

Noninvasive Detection of Alpha-Amylase in Saliva Using Screen-Printed Carbon Electrodes: A Promising Biomarker for Clinical Oral Diagnostics.

Background: Biomarkers are essential tools for diagnosing diseases. Saliva, as a human fluid, effectively reflects the body's condition due to its rich composition. Analyzing saliva components allows for noninvasive, cost-effective, and time-efficient screening and diagnosis.

Analysis of Circulating Plasma MicroRNA Profile in Low-Grade and High-Grade Glioma - A Cross-Sectional Study.

Background: Glioma is the second most common type of brain tumor, accounting for 24% of all brain tumor cases. The current diagnostic procedure is through an invasive tissue sampling to obtain histopathological analysis, however, not all patients are able to undergo a high-risk procedure. Circulating microRNAs (miRNAs) are considered as promising biomarkers for glioma due to their sensitivity, specificity, and non-invasive properties.

Plantar Fascia Thickness Difference Between Pregnant and Nulliparous in Indonesia.

Background: Pregnancy is associated with distinct risks of fascia thickness compared to nulliparous. Therefore, this study aimed to compare plantar fascia thickness between asymptomatic pregnant women and nulliparous, evaluating the relationship with age, body mass index (BMI), arch height index (AHI), gestational age, and number of pregnancies.

Methods: This cross-sectional study was conducted between January and March 2023, and subjects were through a simple random sampling method.

Three-year course of clinical high-risk symptoms for psychosis in the community: a latent class analysis.

Aims: Clinical high-risk for psychosis (CHR-P) states exhibit diverse clinical presentations, prompting a shift towards broader outcome assessments beyond psychosis manifestation. To elucidate more uniform clinical profiles and their trajectories, we investigated CHR-P profiles in a community sample.

Methods: Participants ( = 829; baseline age: 16-40 years) comprised individuals from a Swiss community sample who were followed up over roughly 3 years.

Immunoinformatics-guided design of a multiepitope peptide vaccine targeting the receptor-binding domain of SARS-CoV-2 spike glycoprotein: insights from Indonesian samples.

The emergence of new variants of SARS-CoV-2, including Alpha, Beta, Gamma, Delta, Omicron variants, and XBB sub-variants, contributes to the number of coronavirus cases worldwide. SARS-CoV-2 is a positive RNA virus with a genome of 29.9 kb that encodes four structural proteins: spike glycoprotein (S), envelope glycoprotein (E), membrane glycoprotein (M), and nucleocapsid glycoprotein (N).

The discovery of a new nonbile acid modulator of Takeda G protein-coupled receptor 5: An integrated computational approach.

The Takeda G protein-coupled receptor 5 (TGR5), also known as GPBAR1 (G protein-coupled bile acid receptor), is a membrane-type bile acid receptor that regulates blood glucose levels and energy expenditure. These essential functions make TGR5 a promising target for the treatment of type 2 diabetes and metabolic disorders. Currently, most research on developing TGR5 agonists focuses on modifying the structure of bile acids, which are the endogenous ligands of TGR5.

Overweight, obesity, and cardiovascular disease in heterozygous familial hypercholesterolaemia: the EAS FH Studies Collaboration registry.

Background And Aims: Overweight and obesity are modifiable risk factors for atherosclerotic cardiovascular disease (ASCVD) in the general population, but their prevalence in individuals with heterozygous familial hypercholesterolaemia (HeFH) and whether they confer additional risk of ASCVD independent of LDL cholesterol (LDL-C) remains unclear.

Methods: Cross-sectional analysis was conducted in 35 540 patients with HeFH across 50 countries, in the EAS FH Studies Collaboration registry. Prevalence of World Health Organization-defined body mass index categories was investigated in adults (n = 29 265) and children/adolescents (n = 6275); and their association with prevalent ASCVD.

Roadside Dining: The Collective Movement Behavior of Sulawesi Moor Macaques in a Provisioning Context.

How group-living primates come to a consensus about navigating their environment is a result of their decision-making processes. Although decision-making has been examined in several primate taxa, it remains underexplored for primates living in anthropogenic landscapes. To shed light on consensus decision-making and flexibility in this process, we examined collective movement behavior in a group of wild moor macaques (Macaca maura) experiencing a risk-reward tradeoff as a result of roadside provisioning within Bantimurung Bulusaraung National Park in South Sulawesi, Indonesia.

High Glucose Inhibits O-GlcNAc Transferase Translocation in Early Osteoblast Differentiation by Altering Protein Phosphatase 2A Activity.

Our previous study revealed a link between O-GlcNAc transferase (OGT) localization and protein phosphatase 2A (PP2A) activity in osteoblast. Given the association of PP2A downregulation with osteoblast differentiation, we hypothesized that OGT localization changes during this process. We examined OGT localization in MC3T3-E1 cells undergoing differentiation under normal and high glucose conditions.

Alginate coated mesoporous silica nanoparticles as oral delivery carrier of curcumin and quercetin to colon cancer: preparation, optimization, characterization, and anticancer activity.

The synergistic bioactive effect of polyphenols can enhance the development of functional foods to prevent chronic diseases such as cancer. Curcumin and quercetin have been shown to possess anticancer properties. The combination of curcumin and quercetin has been shown to provide synergistic effects against cancer cell proliferation.

Seroprevalence, incidence estimates, and environmental risk factors for dengue, chikungunya, and Zika infection amongst children living in informal urban settlements in Indonesia and Fiji.

Background: The burden of Aedes aegypti-transmitted viruses such as dengue, chikungunya, and Zika are increasing globally, fueled by urbanization and climate change, with some of the highest current rates of transmission in Asia. Local factors in the built environment have the potential to exacerbate or mitigate transmission.

Methods: In 24 informal urban settlements in Makassar, Indonesia and Suva, Fiji, we tested children under 5 years old for evidence of prior infection with dengue, chikungunya, and Zika viruses by IgG serology.

The potency of ethyl acetate fraction of cempedak (Artocarpus champeden) leaves in attenuating the nephrotoxic effect in gentamicin-piroxicam-induced rat models.

Background: Nephrotoxicity is a condition characterized by a decline in kidney function due to the toxic effects of medications and substances, such as the nephrotoxic antibiotic gentamicin. Artocarpus champeden is a traditional medicinal plant that is commonly found in Indonesia.

Objective: This study aims to evaluate the potential of the ethyl acetate fraction of Artocarpus champeden leaves (FEC) in improving kidney function in an animal model of nephrotoxicity induced by gentamicin and piroxicam.

Uncertainties around net-zero climate targets have major impact on greenhouse gas emissions projections.

Globally, more than 100 countries have adopted net-zero targets. Most studies agree on how this increases the chance of keeping end-of-century global warming below 2°C. However, they typically make assumptions about net-zero targets that do not capture uncertainties related to gas coverage, sector coverage, sinks, and removals.

Role of antioxidative stress activity of Fucoxanthin nanoparticle as hepatoprotective in diabetic rats.

This study attempts to prove that the antioxidant effect of fucoxanthin nanoparticles can prevent streptozotocin-induced rat liver damage. Fucoxanthin nanoparticles are synthesized using the high-energy ball milling method. Dynamic Light Scattering (DLS) was then used to describe the sizes of the fucoxanthin nanoparticles.

Development and Validation of the Spiritual and Religious Needs Inventory for Muslim Psychiatric Inpatients: A Study in the Indonesian Context.

Spirituality care plays an important role in holistic healthcare. Our previous study found Muslim psychiatric inpatients encounter significant obstacles that hinder their ability to engage in a formal prayer practice in the hospital. To address this gap, we aimed to develop a spirituality and religious needs inventory specifically for Muslim psychiatric inpatients.

Disposal practices, risk perceptions, and quantification of potential active pharmaceutical ingredients (APIs) from used human medicine in Upper Citarum River Basin.

This paper highlights potential active pharmaceutical ingredients (APIs) generations from improper disposal of medicines and captures the perceptions of key stakeholders - households and pharmaceutical actors in Upper Citarum River Basin (UCRB). Most pharmaceutical waste is disposed of with household waste, suggesting landfills are the most significant APIs contamination sources. We highlight the complex relationship between knowledge, risk perception, and behavioural intentions, stressing the relevance of risk perception as a mediator when studying how knowledge affects behaviour.

Microalgae-based membrane bioreactor for wastewater treatment, biogas production, and sustainable energy: A review.

Managing wastewater and using renewable energy sources are challenges in achieving sustainable development goals. This study provides an overview of the factors influencing the performance of algae-based membrane bioreactors (AMBRs) for contaminant removal from wastewater and biogas production. This review highlights that the performance of AMBRs in removing total phosphorus (TP) and nitrogen (N) from wastewater can reach up to 93% and 97%, respectively, depending on parameters such as pH, hydraulic retention time (HRT), and algae concentration.

A comparative study of transforaminal and interlaminar approaches in percutaneous endoscopic lumbar discectomy for L5-S1 disc Herniation: Systematic review.

Background: Percutaneous Endoscopic Lumbar Discectomy (PELD) is a leading minimally invasive technique for lumbar disc herniation (LDH). The two primary approaches, transforaminal (PETD) and interlaminar (PEID), each present distinct advantages and challenges in treating L5-S1 LDH. This study aims to compare the efficacy and safety of these two approaches.

Second Versus First Molar Extractions in Class II Division 1 Malocclusion Treatment: A Retrospective Longitudinal Outcome Study into Maxillary Canine, Premolar, and Molar Movement.

This retrospective longitudinal outcome study comparing orthodontic extraction modalities, including extraction of maxillary first or second molars, aimed to compare the three-dimensional tooth movement of maxillary canines (C), premolars (P1, P2), and molars (M1, M2) in Class II division 1 malocclusion treatment with fixed appliances. A sample of 98 patients (mean age 13.20 ± 1.

The Construction of a Stream Service Application with DeepStream and Simple Realtime Server Using Containerization for Edge Computing.

This paper addresses the increasing demand for efficient and scalable streaming service applications within the context of edge computing, utilizing NVIDIA Jetson Xavier NX hardware and Docker. The study evaluates the performance of DeepStream and Simple Realtime Server, demonstrating that containerized applications can achieve performance levels comparable to traditional physical machines. The results indicate that WebRTC provides superior low-latency capabilities, achieving delays of around 5 s, while HLS typically experiences delays exceeding 10 s.

Maternal Long-Chain Polyunsaturated Fatty Acids Status in Pregnancy and Newborn Body Composition.

Background: A number of clinical studies have shown a positive association between the maternal -3 PUFA status during pregnancy and fetal and newborn development and health. Despite this well-documented role of -3 PUFAs in pregnancy, data on maternal the LC-PUFAs status during pregnancy in the Indonesian population, to our knowledge, are not yet available. This study reports on the LC-PUFA dietary intake among pregnant women in a suburban population of Bogor City, West Java, Indonesia.