Identifying promising peptide targets for leprosy serological tests: From prediction to ELISA.

Leprosy remains a significant health concern, particularly in India, Brazil, and Indonesia. Early diagnosis is essential to prevent complications, highlighting the need for improved diagnostic tools. This study aimed to identify novel Mycobacterium leprae antigens and assess their effectiveness against human sera through immunotools for antibody response evaluation.

Genetic analysis of Gobiopterus brachyopterus (Oxudercidae) from Grati Lake and The genus potential misidentification.

The holotype of Gobiopterus brachyopterus originates from Grati Lake, Indonesia. It is locally called lempuk fish. The genus Gobiopterus has similar species, making identification difficult.

Factors associated with prehospital and in-hospital delays in acute ischaemic stroke care in Indonesia: a systematic review.

Objectives: This systematic review examines prehospital and in-hospital delays in acute stroke care in Indonesia.

Design: Systematic review adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Data Sources: We conducted a thorough search across 11 databases, ClinicalTrials.

Osteogenesis Potential of Polymethylmethacrylate-Hydroxyapatite and Stem Cells from Human Exfoliated Deciduous Teeth as Alveolar Bone Graft: An In Silico Study.

Objective:  The goal is to analyze the osteogenesis potential of polymethylmethacrylate (PMMA)-hydroxyapatite (HA) and stem cells from human exfoliated deciduous teeth (SHED) as a biomaterial candidate for alveolar bone defect therapy through a bioinformatic approach within an study.

Materials And Methods:  Three-dimensional (3D) ligand structures consisting of HA, PMMA, and target proteins of SHED were obtained from the PubChem database. STITCH was used for SHED target protein analysis, STRING was utilized for analysis and visualization of protein pathways related to osteogenesis, PASS Online was employed to predict biological functions supporting osteogenesis potential, PyRx 0.

Histological Assessment of the Anti-Inflammatory Effectiveness of Peperomia pellucida Extract Administered to the Gingival Sulcus in Rats Induced with Periodontitis.

This study aims to assess the impact of extract on periodontitis in rats, using the Papillary Bleeding Index (PBI), gingival index (GI), and histological evaluation of key inflammatory cells such as osteoclasts, osteoblasts, polymorphonuclear neutrophils (PMNs), macrophages, and fibroblasts to explore its potential in reducing inflammation and preserving periodontal tissue.The extract was prepared using the reflux method with 96% ethanol as a solvent, followed by phytochemical screening and antibacterial testing via the disk diffusion method. This study utilized a posttest control group experiment with 24 Wistar rats, divided into four groups: nonperiodontitis, no-treatment, chlorhexidine-treated (CHX), and extract-treated groups, with the latter three groups induced with periodontitis.

Bone Graft Paste Nanohydroxyapatite Chitosan-Gelatin (nHA/KG) for Periodontal Regeneration: Study on Three-Dimensional Cell Culture.

Objective:  Regenerative periodontal surgical approaches require scaffolds in a form that can fill narrow and irregular defects. Each scaffold must be specially designed to conform to the shape of the specific defect. The aim of this study was to fabricate nanohydroxyapatite chitosan-gelatin (nHA/KG) pastes with different composition percentages and to analyze the differences in physical, chemical, and biological characteristics in response to periodontal tissue regeneration .

Extraction and Characterization of Aceh Bovine Bone-Derived Hydroxyapatite for Applications in Dentistry.

Objective:  Bone grafts derived from natural hydroxyapatite (HA) are increasingly being explored because they are more economical in terms of production costs compared with commercial HA. HA can be obtained from local cattle slaughter waste in Aceh, Indonesia, which has not been widely studied for its potential for dental applications. This study examines the synthesis and characterization of bovine HA (BHA) derived from Aceh cattle femur through calcination for applications in dentistry.

Finger osteochondroma presenting as non-traumatic mallet finger in pediatric: A case report.

Introduction And Importance: A terminal extensor tendon disruption, with or without bony avulsion, may lead to a mallet deformity. In most cases, trauma precedes deformity. Non-traumatic causes are less probable.

Exercise-mediated modulation of autonomic nervous system and inflammatory response in sleep-deprived individuals: A narrative reviews of implications for cardiovascular health.

Sleep deprivation is a growing concern in cardiovascular risk, causing physiological disruptions like autonomic dysregulation and inflammation. Recent research indicates that sleep deprivation increases sympathetic nervous activity while decreasing parasympathetic activity, leading to increased blood pressure, impaired endothelial function, and heightened inflammation. Exercise has emerged as a non-pharmacological approach to increase cardiovascular health.

Determination of selection criteria for yield traits to improve okra (Abelmoschus esculentus L. Moench) breeding in Indonesia.

The Abelmoschus esculentus L. Moench, commonly known as okra, is increasingly cultivated in Indonesia due to its recognition as a functional food source. Current efforts in breeding new okra varieties are focused on high productivity, yet minimal information is available regarding selection criteria.

Genomic epidemiology of Plasmodium knowlesi reveals putative genetic drivers of adaptation in Malaysia.

Sabah, Malaysia, has amongst the highest burden of human Plasmodium knowlesi infection in the world, associated with increasing encroachment on the parasite's macaque host habitat. However, the genomic make-up of P. knowlesi in Sabah was previously poorly understood.

Preserving the Biologically Coherent Generic Concept of , 'Plant Destroyer'.

is a long-established, well known and globally important genus of plant pathogens. Phylogenetic evidence has shown that the biologically distinct, obligate biotrophic downy mildews evolved from at least twice. Since, cladistically, this renders 'paraphyletic', it has been proposed that evolutionary clades be split into multiple genera (Runge et al.

Relationship and Determinants of Breastfeeding Self-Efficacy Among Postpartum Mothers and Fathers in Malawi: A Cross-Sectional Study.

Background: Breastfeeding self-efficacy among both mothers and fathers is critical in enhancing exclusive breastfeeding rates. However, the interrelationship between maternal and paternal breastfeeding self-efficacy and their determinants remains unknown.

Research Aims: We aimed to (a) investigate the relationship between breastfeeding self-efficacy scores postpartum for mothers and fathers; (b) explore factors associated with breastfeeding self-efficacy in this group; and (c) examine determinants of combined self-efficacy scores among breastfeeding parents in Malawi.

Vitamin D receptor FokI polymorphism as a risk factor for painful diabetic neuropathy in type 2 diabetes mellitus patients.

Painful diabetic neuropathy (PDN) is a common complication in patients with type 2 diabetes mellitus (T2DM) with disruption of vitamin D (VD) activity as one of the risk factors. Active VD exerts its biological functions through the vitamin D receptor (VDR), which polymorphisms in the VDR gene can impair. This study aims to establish VDR FokI and ApaI polymorphisms as risk factors for PDN.

Placenta Accreta Spectrum Care in Middle-Resource Settings.

Management of the placenta accreta spectrum (PAS) in resource-limited settings poses significant challenges. Traditional approaches, which often involve hysterectomy and extensive technology in all the patients are being replaced by individualized treatment plans considering each patient's specific clinical situation, available resources, and team expertise. Using ultrasonographic and surgical staging based on PAS topographic classification can help design tailored surgical plans and optimize resource use.

Recent Advances in Paper-Based Nano-Biosensors for Water-Borne Pathogen Detection: Challenges and Solutions.

Ensuring access to safe water and public health necessitates sensitive, quick, and dependable detection instruments. Conventional techniques frequently have prolonged detection durations, intricate processes, and the requirement for skilled staff. Biosensors augmented with nanomaterials provide enhanced sensitivity, specificity, and rapid detection of waterborne pathogens.

Community preparedness for earthquake disasters: A preliminary assessment of awareness and disaster infrastructure response in Cianjur, West Java-Indonesia.

Background: The danger of earthquakes poses a serious threat to people worldwide. One of the most significant challenges is preparing communities to cope effectively with this disaster. Therefore, understanding earthquake hazards is critically important for preparedness, mitigation, and an effective response to this threat.

Cost-Effectiveness Analysis of Multiple Micronutrient Supplementation (MMS) Compared to Iron Folic Acid (IFA) in Pregnancy: A Systematic Review.

Introduction: Multiple micronutrient deficiencies might increase the adverse outcome during pregnancy and after birth. Considering the WHO recommendations since 2016 and scientific evidence from previous studies that multiple-micronutrient supplementation (MMS) is more effective than iron folic acid (IFA) in improving pregnant women's health, it is imperative to conduct an economic evaluation to assess the cost-effectiveness of MMS compared with IFA.

Methods: We conducted a systematic review from PubMed and Scopus to identify the cost-effectiveness analyses of MMS compared to IFA for pregnant women up to January 2024.

Threatened synanthropes depend on intact forests: a critical evaluation of Moore et al. (2023).

Synanthropes are known for their remarkable adaptability to coexist with humans, yet increased visibility exposes them to significant threats, such as hunting or conflict over resources. Moore et al.'s review 'The rise of hyperabundant native generalists threatens both humans and nature' (https://doi.

Impact of combined high-intensity bodyweight interval training and breathing exercise on cardiometabolic health in normal-weight middle-aged adults with hypertension.

Background: High-intensity interval training and breathing exercises alone have well-documented health benefits in people with hypertension. This study aimed to investigated the effects of combining the two methods on physical health among adults with hypertension.

Methods: Ninety-six adults (59.

eHealth Literacy 3.0: Updating the Norman and Skinner 2006 Model.

This paper advances the "eHealth Literacy 3.0" model following Norman and Skinner's 2006 original eHealth literacy 1.0 model and Norman's 2011 2.

Hippocampal volume asymmetry in Alzheimer disease: A systematic review and meta-analysis.

Background: Biomarkers play an important role in the diagnosis of early-stage Alzheimer disease (AD), with the hippocampal emerging as the most reliable indicator of AD pathology. Elucidation of the patient's left and right hippocampal volumes warrants further consideration. Therefore, caution should be exercised regarding the constraints inherent in the measurement method.

The impact of political assassinations on turnout: Evidence from Colombia.

Although a growing literature has investigated the effects of various types of civil war violence on political behavior, no study has examined the impact of assassinations targeting politicians. This is a critical omission, as violence against local politicians is prevalent across civil war contexts and may be the most consequential form of violence for political participation by affecting both candidate supply and voter demand. Using an original dataset of nearly 2,000 killings of Colombian local politicians between 1980 and 2023, we estimate the impact of this violence on voter turnout.

Characterizing the genetic diversity and population structure of Plasmodium knowlesi in Aceh Province, Indonesia.

As in other parts of Southeast Asia, efforts to achieve or sustain malaria elimination in Indonesia have been threatened by the emergence of human infection with the primate species P. knowlesi. To understand the transmission dynamics of this species, investigation of P.