The Effect of Autologous Dendritic Cell Immunotherapy on Kidney Function and Endothelial Dysfunction of Patients with Diabetic Kidney Disease (DKD): An Open Label Clinical Trial.

This study aimed to evaluate the effects of autologous dendritic cell (DC) immunotherapy on clinical outcomes (glomerular filtration rate/GFR and urine creatinine albumin ratio/UACR) and endothelial dysfunction (ICAM, VCAM, VEGF) in patients with diabetic kidney disease (DKD). Endothelial dysfunction induced by inflammation is one of the key factors in the pathogenesis of DKD. In this one-group pretest-posttest quasi-experimental study, 69 subjects with DKD were administered a single dose of autologous DC immunotherapy ex vivo.

Reducing the Radioactive Surface Contamination Level of Cobalt-60-Contaminated Material with PVA-Glycerol-EDTA Combination Gel.

Decommissioning of nuclear facilities can be performed in stages. One of the stages and processes in decontamination is the decontamination process before dismantling or facility area recovery activities. Decontamination can be performed using various methods, primarily physical and chemical.

Polydeoxynucleotide-Loaded Visible Light Photo-Crosslinked Gelatin Methacrylate Hydrogel: Approach to Accelerating Cartilage Regeneration.

Articular cartilage faces challenges in self-repair due to the lack of blood vessels and limited chondrocyte concentration. Polydeoxyribonucleotide (PDRN) shows promise for promoting chondrocyte growth and cartilage regeneration, but its delivery has been limited to injections. Continuous PDRN delivery is crucial for effective cartilage regeneration.

-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology.

is a medicinal mushroom widely utilized in traditional East Asian medicine, recognized for its diverse therapeutic properties. This review explores the potential of -derived bioactive gels for applications in dermatology and skincare, with a particular focus on their therapeutic and anti-aging benefits. In response to the rising incidence of skin cancers and the growing demand for natural bioactive ingredients, has emerged as a valuable source of functional compounds, including cordycepin, polysaccharides, and adenosine.

Thermosensitive In Situ Ophthalmic Gel for Effective Local Delivery and Antifungal Activity of Ketoconazole Nanoparticles.

Fungal keratitis is a severe ocular infection caused by pathogenic fungi, leading to potential vision loss if untreated. Current antifungal treatments face limitations such as low solubility, poor corneal penetration, and limited therapeutic options. This study aimed to develop a thermosensitive in situ gel incorporating ketoconazole nanoparticles (NPs) to enhance drug solubility, stability, and antifungal activity.

Environmental Performance, Financial Constraints, and Tax Avoidance Practices: Insights from FTSE All-Share Companies.

Through its initiative known as the Climate Change Act (2008), the Government of the United Kingdom encourages corporations to enhance their environmental performance with the significant aim of reducing targeted greenhouse gas emissions by the year 2050. Previous research has predominantly assessed this encouragement favourably, suggesting that improved environmental performance bolsters governmental efforts to protect the environment and fosters commendable corporate governance practices among companies. Studies indicate that organisations exhibiting strong corporate social responsibility (CSR), environmental, social, and governance (ESG) criteria, or high levels of environmental performance often engage in lower occurrences of tax avoidance.

Ononin's Antagonistic Activity towards TRPV1: Insights from Molecular Dynamics and Capsaicin-Evoked Calcium Response in DRG Neurons.

Background: The search for effective painkillers has led to intensive research, with a particular focus on the transient receptor potential vanilloid-1 (TRPV1) channel as a possible target.

Methods: One promising candidate is ononin, which is investigated for its binding with TRPV1 through a 200-ns molecular dynamic simulation and analysed via root-meansquare deviation (RMSD), root-mean-square fluctuation (RMSF), hydrogen-bond interactions, radius of gyration (RadGyr), and MM-PBSA energy calculations. The results were further validated experimentally via calcium imaging studies.

Unveiling the electrochemical nitrogen reduction reaction mechanism in heteroatom-decorated-MoCS-MXene: the synergistic effect of single-atom Fe and heteroatom.

Conversion of nitrogen (N) to ammonia (NH) is a significant process that occurs in environment and in the field of chemistry, but the traditional NH synthesis method requires high energy and pollutes the environment. In this work, the charge, orbital and spin order of the single-atom Fe loaded on heteroatom (X) doped-MoCS (X = B, N, O, F, P and Se) and its synergistic effect on electrochemical nitrogen reduction reaction (eNRR) were investigated using well-defined density functional theory (DFT) calculations. Results revealed that the X-element modified the charge loss capability of Fe atoms and thereby introduced a net spin through heteroatom doping, resulting in the magnetic moment modulation of Fe.

Unravelling the case of suspected ectopic ureter in a young adult patient.

An ectopic ureter (EU) opens outside the bladder's trigone, a rare condition with an incidence of 0.05%-0.025%.

The potential of mangrove leaves extract as a bioactive food ingredient using various water extract.

Background: , known as the red pidada, has been widely utilized by the Indonesian. leaves contain various active compounds, contributing to their popularity in the treatment of various diseases. Mangrove leaves are also known to exhibit very high antioxidant activity.

Protective effects of against hepatocyte apoptosis and liver fibrosis induced by high palmitic acid diet.

Background: Fatty Liver Disease (FLD) progresses from steatosis to steatohepatitis and, if left untreated, can lead to irreversible conditions such as cirrhosis and hepatocarcinoma. The etiology of FLD remains unclear, but factors such as overconsumption, poor diet, obesity, and diabetes contribute to its development. Palmitic acid (PA) plays a significant role in FLD progression by inducing apoptosis, inflammation, oxidative stress, and endoplasmic reticulum (ER) stress in hepatocytes.

Survival Analysis of Anaplastic Thyroid Carcinoma With Various Therapeutic Modalities: Twenty-Seven Years' Experience in a Single Cancer Center.

Background: Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid gland malignancy. Several consensuses support the concept of multimodal therapy that combines surgery, radiation, chemotherapy, and targeted therapy. However, patient's comorbidity, poor performance status, and metastasis often make it impossible for patients to undergo multimodal therapy.

Diagnostic challenges of arboviral infections and dengue virus serotype distribution in febrile patients in East Java, Indonesia.

Objectives: Arboviruses pose significant public health threats worldwide, with Southeast Asia being a hotspot for these infections. This study aimed to reassess the incidence of dengue, Zika, and chikungunya viruses in patients clinically diagnosed with dengue in East Java, Indonesia in 2023.

Methods: The study included 108 patients admitted to hospitals in Jember, with blood samples collected on admission.

Severe knowlesi malaria with acute neurocognitive impairment: A case report.

infection in Indonesia has been reported from Sumatera and Kalimantan Island. has the shortest asexual replication cycle of all species, leading to rapidly increased parasitemia levels; however, it usually does not cause high parasitemia. It was reported a severe knowlesi malaria case in a 41-year-old male patient in Samarinda, East Kalimantan Province, Indonesia.

Anemia prevention measures in female students in the Islamic Boarding School of Al-Junaidiyah Biru, Indonesia.

Background: Anemia in adolescent girls in particular will have a more serious impact, given that they are future mothers. Therefore, the purpose of preventive measure is to reduce the risk of maternal mortality, stunting, wasting, and low birth weight. This study aimed to determine the relationship between knowledge, attitudes, sources of information, perceived susceptibility, and perceived benefits in relation to anemia prevention measures.

Video role-play versus powerpoint lecture in the knowledge domain among medical students during the COVID-19 pandemic era: A systematic review and meta-analysis.

The coronavirus disease 2019 (COVID-19) pandemic disrupted conventional teaching methodologies, forcing educational institutions to swiftly adapt to remote learning. This study aimed to compare the effectiveness of video- and powerpoint-based teaching methods in the knowledge of medical students using a systematic review and meta-analysis. A systematic review of the literature was conducted to identify relevant studies that compared the efficacy of video-based and PowerPoint-based teaching methods in medical students during the COVID-19 pandemic.

Bibliometric analysis of teen pregnancy research in Asia-Africa: Explore the future scope.

Background: Adolescent pregnancy is prevalent in Asian-African countries. Hence, it is critical to track the progress of research and development trends related to the topic. The study aimed to characterize published articles on teen pregnancy by measuring the authors' country and affiliation, most relevant and cited journals, thematic research, and growth trends.

Neutrophil Extracellular Traps Contribute to the Disease Severity of Dengue Virus Infection.

Background: The spectrum of dengue infection ranges from asymptomatic or mild to severe disease. The pathogenic mechanisms are not fully understood. A viral infection can induce the neutrophil extracellular traps (NETs), and the excessive NETs lead to increased vascular permeability, coagulopathy, and platelet dysfunction, a hallmark of severe dengue.

Correlation Between Indoxyl Sulfate in Chronic Kidney Disease and Olfactory Dysfunction.

Introduction: Olfactory dysfunction is prevalent among individuals with chronic kidney disease (CKD), with prevalence escalating alongside disease severity. The uremic toxin we observed in this study is Indoxyl sulfate (IS), a potent uremic toxin that markedly accumulates in the plasma of patients with chronic insufficiency. Olfactory damage may occur in the setting of neuronal damage due to renal failure.

Enhancing dermal collagen density towards youthfulness: A comparative study of PCL, PLLA, and PDO thread implantation in aging rats model.

Objectives: Both intrinsic and extrinsic factors cause skin aging. Intrinsic aging is characterized by decreased collagen density, particularly collagen types I (COL1A1) and III (COL3A1), and an increase in the COL1/COL3 ratio. Extrinsic aging, primarily due to ultraviolet light exposure, leads to photoaging, which causes collagen fragmentation and reduced production, leading to skin sagging.

Sleep Disturbances and Depression Levels among General Indonesian Population: A National Survey.

Background: The correlation between sleep disturbance and depression is widely recognized in developed countries but relevant evidence is lacking in developing countries.

Objective: This study aims to assess the correlation between sleep disturbance and depression levels among the general Indonesian population.

Methods: This national cross-sectional survey was conducted using the Indonesian Family Life Survey.

Integrating finite element analysis in total hip arthroplasty for childhood hip disorders: Enhancing precision and outcomes.

Total hip arthroplasty for adults with sequelae from childhood hip disorders poses significant challenges due to altered anatomy. The paper published by Oommen reviews the essential management strategies for these complex cases. This article explores the integration of finite element analysis (FEA) to enhance surgical precision and outcomes.

Cross-cultural adaptation and validation of a teaching questionnaire measuring facilitator competencies and characteristics of interprofessional clinical educators in an Asian setting.

This study aimed to validate an Indonesian version of the teaching questionnaire measuring the competencies of interprofessional education (IPE) facilitators and the characteristics of good clinical educators described by Kerry et al. (2021). A cross-cultural adaptation was developed and consisted of the following steps: forward-backward translation, content validity index measurement, cognitive interviews and a pilot study to measure content validity and reliability, exploratory factor analysis (EFA) to identify the new dimensionality, and confirmatory factor analysis (CFA) to confirm the measurement model.

Implementation of an information system for tuberculosis in healthcare facilities in Indonesia: evaluation of its effectiveness and challenges.

Background: Tuberculosis (TB) surveillance in Indonesia is currently supported by the recording and reporting technology Tuberculosis Information System (Sistem Informasi Tuberkulosis [SITB]). SITB is used by all health workers responsible for TB programs in health facilities or hospitals throughout Indonesia. The satisfaction and ease of use of SITB affect the speed and accuracy of TB case reporting.

Effect of selected Indonesian plants on Giardia intestinalis in an experimental in vitro model.

Background: This study evaluated in vitro antigiardial activity in four Indonesian plants (Archidendron fagifolium, Diospyros sumatrana, Piper betle and Shorea sumatrana) extracted in methanol, methanol-tetrahydrofuran, and water. These plants exhibiting promising anti-parasitic activity were selected on the basis of collected behavioral data and their ability to decrease parasite load in Sumatran orangutans. Extracts of Arabidopsis thaliana, a plant routinely used as a laboratory model in research, were used as a negative control.