Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance.

Increasing reports of chloroquine resistance (CQR) in Plasmodium vivax endemic regions have led to several countries, including Indonesia, to adopt dihydroarteminsin-piperaquine instead. However, the molecular drivers of CQR remain unclear. Using a genome-wide approach, we perform a genomic analysis of 1534 P.

The translational potential of inflammation-induced skin blister human models in exploring the pathogenesis of periodontitis and its systemic health implications.

Periodontitis is a highly prevalent chronic disease. Despite decades of extensive research on the topic, a complete understanding of its immunopathogenesis, especially when linked to other inflammatory comorbidities, is lacking. human and animal experiments have shown the host inflammatory response's crucial role in both the disease's onset and its systemic implications.

Women in gender equality movement: a systematic literature review.

This study employs a rigorous Systematic Literature Review (SLR) methodology to examine the role of women's leadership in advancing social movements for gender equality. Utilizing Scopus-indexed articles, we provide a comprehensive review of the relevant literature, analyzing factors contributing to the success of women leaders, effective leadership strategies, and the impacts of these efforts on communities and structural change. The findings indicate that women's leadership plays a crucial role in fostering sustainable social change by enhancing women's participation in decision-making, increasing public awareness of gender issues, and advocating for policies that promote gender equity.

Potency of anti-trematode in inhibiting cathepsin-2L and cathepsin-5L of using homology, docking, and molecular dynamics.

Background: Cathepsin-L (FhCL) is a group of enzymes that most flukes express and secreted significantly in parasite-host interactions. Researches are focusing on antigens released by as one of the keys to understanding immunologic pathways in parasite infection and targets for anthelmintics. Efforts to suppress FhCL function through vaccination or therapy using anthelmintic drugs are key factors in controlling field-level trematode infections.

Effect of leaf extract and its active components on heart muscle cell apoptosis induced by hyperglycemia.

Background: Hyperglycemia is a condition in which blood sugar levels increase excessively due to a variety of factors, one of which is the body's inability to regulate insulin properly. Diabetes closely relates to this condition, which significantly contributes to premature death and disability. Long-term diabetes treatment accompanied by a strict diet provides real results in controlling blood glucose levels but can cause side effects.

Detection of the methicillin-resistant gene encoding in nasal swabs of cats in Surabaya, Indonesia.

Background: The most susceptible group of people to spread methicillin-resistant (MRSA) among domestic cats is their owners' relatives.

Aim: Considering the aforementioned, research at the Surabaya City Animal Hospital is necessary to determine whether the A gene may be detected in cat nasal swabs.

Methods: Samples were taken using a sterile cotton swab, and the transport medium was buffered peptone water.

Investigating the effect of quail egg supplementation enriched with marine macroalgae on hematological indices, lipid profile parameters, and blood glucose level of Sprague Dawley rats during lactation and offspring growth.

Background: The lactation period is a crucial period where the nutritional status and the mother's environment influence milk production, impacting organ differentiation, function, and structure in the baby's body.

Aim: The study aimed to determine the impact of providing lactating rats with quail egg supplements enriched with marine macroalgae on their physiological condition (blood cells, lipids, blood glucose, antioxidant activity, and prolactin hormone levels) and the growth of their offspring.

Methods: The study involved 25 lactating Sprague Dawley white rats aged 3 months old and weighing approximately 200 g divided into five treatment groups thus; T0 as the control, T1 with quail eggs enriched with commercial feed, T2 with quail eggs enriched with 3% of marine macroalgae, T3 with quail eggs enriched with 4% of marine macroalgae, and T4 with quail eggs enriched with 5% of marine macroalgae, which received one quail egg for 21 days.

A comprehensive review of paratuberculosis in animals and its implications for public health.

Paratuberculosis is an infectious disease caused by subspecies (MAP). Typically, ruminant animals including cattle, buffalo, goats, and sheep are infected with MAP. Animals get infected with MAP in a number of ways, such as by eating or drinking contaminated food or water, or by nursing from an infected mother who may have contaminated teats or directly shed the organism in milk or colostrum.

Effect of nano curcumin administration on IL-6 expression in placental organs and fetal weight exposed to stress during pregnancy in mice.

Background: Stress can cause an increase in proinflammatory cytokines, IL-6, which plays a role in the inflammatory response and causes changes in the placenta, causing a low risk of the fetus being born. Giving nanocurcumin, which functions as an anti-inflammatory and antioxidant, is expected to reduce cortisol levels which increase during pregnancy.

Aim: This study aims to determine the effect of stress during pregnancy on pregnant mice, namely IL-6 expression and fetal body weight.

Bovine trichomoniasis: A hidden threat to reproductive efficiency.

Bovine trichomoniasis is a reproductive illness that affects cattle causing pyometra, early to mid-pregnancy miscarriages, and lower birth rates. is a flagellated protozoan which first discovered in France in 1888 and composts three phases during its lifecycle including trophozoite, cyst, and pseudocyst. In addition, several factors contributed to the prevalence of trichomoniasis and fall into three categories are management, cow, and bull-related factors.

Ultrastructural morphology of second and third-stage larvae of inside paratenic host tissue.

Background: is a known cause of a zoonotic infectious illness called toxocariasis. Parathenic hosts are important as they can transmit larvae 2 (L) through direct transmission. Scanning electron microscope (SEM) techniques are needed to provide a three-dimensional image of each stage of larvae.

evaluation of the antimicrobial efficacy of ethanol extract against Gram-positive and Gram-negative bacterial strains.

Background: (EO) L (Siam weed) is a highly invasive species that contains various beneficial active compounds. This study was conducted to explore the antibacterial properties of EO ethanol extract against Gram-positive and Gram-negative bacteria.

Aim: The aim of this study was to evaluate the antibacterial activity of EO ethanolic extract against various Gram-positive and Gram-negative bacteria to assess its potential as an antimicrobial agent.

Prospects of e-Coaching as a Platform for Empowering Families of Person With Mental Disorder: A Qualitative Study.

Introduction: In all countries, the burden of mental disorders (MDs) spans the entire life course. Smartphones are currently widely used by families with a history of MD looking for the required mental health information. The use of digital media is an alternative to improving the ability of families to care for person with MD at home.

An improved electrocardiogram arrhythmia classification performance with feature optimization.

Background: Automatic classification of arrhythmias based on electrocardiography (ECG) data faces several significant challenges, particularly due to the substantial volume of clinical data involved in ECG signal analysis. The volume of clinical data has increased considerably, especially with the emergence of new clinical symptoms and signs in various arrhythmia conditions. These symptoms and signs, which serve as distinguishing features, can number in the tens of thousands.

From the depths of the Java Trench: genomic analysis of Priestia flexa JT4 reveals bioprospecting and lycopene production potential.

Background: The marine environment boasts distinctive physical, chemical, and biological characteristics. While numerous studies have delved into the microbial ecology and biological potential of the marine environment, exploration of genetically encoded, deep-sea sourced secondary metabolites remains scarce. This study endeavors to investigate marine bioproducts derived from deep-sea water samples at a depth of 1,000 m in the Java Trench, Indonesia, utilizing both culture-dependent and whole-genome sequencing methods.

Social frailty in older adults: A concept analysis.

Background: Social frailty has been increasingly prevalent due to the aging populations. This concept is a relatively new topic in the gerontology. Older adults experiencing social isolation because of social frailty remain in a state of loneliness or depression.

Development of peptone-based serum-free media to support Vero CCL-81 cell proliferation and optimize SARS-CoV2 viral production.

Background: Developing an optimal media for Vero cell lines is crucial as it directly influences cell survival, proliferation, and virus production. The use of serum in cell culture raises safety concerns in biological production. The United States Food and Drug Administration (FDA) and the European Medicines Agency have implemented stricter regulations on the use of animal-derived components in commercial protein manufacturing to ensure patient safety.

Antiplatelet Effects of a Combination of Sappan Wood ( L.) and Red Ginger () Extracts in a High-Fat Diet-Induced Rat Model.

Antithrombotic medications, including antiplatelet agents, are standard treatments for patients with hyperlipidemia who have a high risk of developing cardiovascular disease (CVD). The ongoing exploration of new antiplatelet agents with minimal bleeding effects is crucial, including the investigation of potential compounds derived from natural products. This study intended to evaluate the antiplatelet effects of a combined extract of sappan wood ( L.

In silico study of bioactive compounds derived from Indonesian marine invertebrates as a novel antituberculosis agent.

Background/aim: Tuberculosis (TB) has become the world's deadliest disease. The lack of an effective therapeutic drug to treat it is one of the obstacle for doctors. Today, multidrug-resistant TB cases are increasing.

Seizing tumor factors for mortality and survival outcomes following liver resection in Indonesia's hepatocellular carcinoma patients.

Backgrounds/aims: The 3-year mortality rate for hepatocellular carcinoma (HCC) in Indonesia was 94.4%. This underscores a significant health issue in Southeast Asia, particularly in Indonesia due to its large population.

International consensus on research priorities in hypospadias using a Delphi study approach.

Introduction: Hypospadias is a common congenital anomaly of the male genitalia that poses significant management and treatment challenges. Gaining a comprehensive understanding of priority research questions in hypospadiology will be essential to reach agreement on the optimal approach to assessment, treatment, and outcome prediction for affected patients.

Methods: We employed a consensus-building Delphi method to identify and prioritize research questions in the hypospadias field.

Prrx2, the paired-related homeobox transcription factor, functions as a potential regulator of pannexin 3 expression in odontoblast differentiation.

Objectives: This study aimed to elucidate the roles of Prrx1 and Prrx2, homeobox transcription factors, in tooth development and determine whether Prrx2 regulates pannexin 3 (Panx3) expression, which is important in preodontoblasts.

Methods: Tooth sections were prepared from 13.5-, 15.

Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders.

Psychiatric disorders pose a significant global health challenge, exacerbated by the COVID-19 pandemic and insufficiently addressed by the current treatments. This review explores the emerging role of bile acids and the TGR5 receptor in the pathophysiology of psychiatric conditions, emphasizing their signaling within the gut-brain axis. We detail the synthesis and systemic functions of bile acids, their transformation by gut microbiota, and their impact across various neuropsychiatric disorders, including major depressive disorder, general anxiety disorder, schizophrenia, autism spectrum disorder, and bipolar disorder.