Estimation of a parameter and its exact confidence interval following sequential sample size reestimation trials.

For confirmatory trials of regulatory decision making, it is important that adaptive designs under consideration provide inference with the correct nominal level, as well as unbiased estimates, and confidence intervals for the treatment comparisons in the actual trials. However, naive point estimate and its confidence interval are often biased in adaptive sequential designs. We develop a new procedure for estimation following a test from a sample size reestimation design.

Systemic lupus erythematosus.

Systemic lupus erythematosus is a challenging diagnosis. This article provides an overview of this disorder and what nurses need to know to provide care to patients with this potentially life-threatening disorder.

The electrical properties of the anterior stomach of the larval mosquito (Aedes aegypti).

The electrical properties of the anterior stomach of the larval mosquito (Aedes aegypti) were determined. At late times after cannulation, the intraluminal space constant was 936 microm, which is almost as long as the isolated tissue itself. At this time, the resistance of the apical cell membranes dominates the transcellular resistance; it is approximately 14 times the resistance of the basal cell membrane.

The control of blood pressure during external hypercapnia in the rainbow trout (Oncorhynchus mykiss).

Adult freshwater rainbow trout (Oncorhynchus mykiss) were exposed acutely (approximately 20 min) in a stepwise manner to increasing levels of environmental carbon dioxide ranging between 1.7 and 9.0 mmHg (0.

Differences in perceptions of hospital marketing orientation between administrators and marketing officers.

Hospital administrators have been struggling for more than a decade to determine the role and proper position for marketing and marketers within their organizations. Results of a study now confirm the expected--administrators and their chief marketing officers do not see the same marketing actions being conducted for their hospitals. The consequence of such perceptual differences in marketing orientation for the role of marketers within the hospital are significant and are discussed in this article.

An economic evaluation of the market for physicians' services: shortage versus surplus.

The paper examines the existence of a shortage or surplus in the market for physicians' services over time. The assessment is carried out within a framework provided by economic theory, and three basic indicators are utilized: earnings, rates of return to education, and quantity of work. The third indicator is examined in various forms including vacancies, weeks of work, and hours of work.

Studies of 7-hydroxycoumarins.

Spectral studies of a series of 7-hydroxycoumarins substituted at positions 3 and 4 with methyl and phenyl groups are reported. Rates of ring opening in 0.7M potassium hydroxide at 25.

Constant Calcein Blue: An indicator for spectrofluorometric calcium determination.

A new fluorescent indicator for metal ions, called Constant Calcein Blue, has been synthesized by condensing 7-hydroxy-2,3-dimethylchromone, iminodiacetic acid and formaldehyde. The indicator exhibits extraordinary resistance to alkaline hydrolysis and is recommended for spectrofluorometric determinations of metal ions, such as calcium, that must be performed at pH 10.5 and higher.

Studies of 7-hydroxybenzo-4-pyrones.

Spectral data and rates of hydrolysis in 0.7M potassium hydroxide are reported for a series of nine 7-hydroxybenzo-4-pyrones differing in substitution at positions 2 and 3. The results reveal that 2,3-dimethyl substitution produces a molecule, 7-hydroxy-2,3-dimethylchromone, sufficiently fluorescent and resistant to alkaline hydrolysis to warrant its use as the fluorescent moiety in a metallofluorescent indicator of the Calcein Blue type.