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The Xpc gene markedly affects cell survival in mouse bone marrow.
Mutagenesis
July 2009
Department of Microbiology and Walther Oncology Center, Indiana University Simon Cancer Center and Walther Cancer Institute, Indianapolis, 46202, USA.
The XPC protein (encoded by the xeroderma pigmentosum Xpc gene) is a key DNA damage recognition factor that is required for global genomic nucleotide excision repair (G-NER). In contrast to transcription-coupled nucleotide excision repair (TC-NER), XPC and G-NER have been reported to contribute only modestly to cell survival after DNA damage. Previous studies were conducted using fibroblasts of human or mouse origin.
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