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The ATP-Dependent Protease ClpP Inhibits Biofilm Formation by Regulating Agr and Cell Wall Hydrolase Sle1 in .

Front Cell Infect Microbiol

January 2018

Department of Microbiology and Immunology, Indiana University School of Medicine-NorthwestGary, IN, USA.

Qian Liu Xing Wang Juanxiu Qin Sen Cheng Won-Sik Yeo

Biofilm causes hospital-associated infections on indwelling medical devices. In , Biofilm formation is controlled by intricately coordinated network of regulating systems, of which the ATP-dependent protease ClpP shows an inhibitory effect. Here, we demonstrate that the inhibitory effect of ClpP on biofilm formation is through Agr and the cell wall hydrolase Sle1.

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