1 results match your criteria: "Indiana University Bloomington IN 47405 USA zaleski@iu.edu.[Affiliation]"
Pronounced electronic modulation of geometrically-regulated metalloenediyne cyclization.
Chem Sci
December 2024
Department of Chemistry, Indiana University Bloomington IN 47405 USA
Article Synopsis
- Researchers developed new cisplatin-like platinum metalloenediynes using thermally resistant phosphine enediyne ligands, demonstrating how different ligand substituents affect cyclization kinetics.
- The first crystallographic studies of these complexes revealed they have short inter alkyne distances, indicating a potential for spontaneous cyclization at room temperature, influenced by their electronic properties.
- Kinetic studies showed that complexes with electron-donating groups cyclized much faster than those with electron-withdrawing groups due to their unique electronic effects on bond formation and cyclization barriers.