136,518 results match your criteria: "Indiana; and Regenstrief Institute Center for Biomedical Informatics[Affiliation]"

Modulation of singlet and triplet energy transfer from excited semiconductor nanocrystals to attached dye molecules remains an important criterion for the design of light-harvesting assemblies. Whereas one can consider the selection of donor and acceptor with favorable energetics, spectral overlap, and kinetics of energy transfer as a means to direct the singlet and triplet energy transfer pathways, it is not obvious how to control the singlet and triplet characteristics of the donor semiconductor nanocrystal itself. By doping CsPb(ClBr) nanocrystals with Mn, we have now succeeded in increasing the triplet characteristics of semiconductor nanocrystals.

View Article and Find Full Text PDF

Purpose: This study investigated how obstacle contrast altered gait behavior of healthy younger and older adults.

Methods: Twenty normally sighted adults, 11 older (mean [standard deviation] age, 68.1 [5.

View Article and Find Full Text PDF

Adaptations in surprising places.

Science

January 2025

Department of Biology, Indiana University, Bloomington, IN, USA.

Testosterone is controlled while it circulates in the bloodstream.

View Article and Find Full Text PDF

Lysosomal dysfunction and inflammatory sterol metabolism in pulmonary arterial hypertension.

Science

January 2025

Center for Pulmonary Vascular Biology and Medicine, Pittsburgh, Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.

Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 () deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes.

View Article and Find Full Text PDF

Background: Obesity, classified by body mass index (BMI), is associated with higher postmenopausal breast cancer (BCa) risk. Yet, the associations between abdominal visceral (VAT) and subcutaneous adipose tissue (SAT) with BCa are unclear.

Methods: We assessed BCa associations with abdominal VAT and SAT in a prospective cohort of postmenopausal women without a history of cancer and with 27 years follow-up (N = 9950), during which all new cancers were adjudicated.

View Article and Find Full Text PDF

Purpose Of Review: To provide a narrative overview of trends and disparities in the cardiometabolic profiles of U.S. adults by synthesizing findings from nationally representative studies conducted between 1999 and 2020.

View Article and Find Full Text PDF

A case of cutaneous adnexal neoplasm with unusual squamoid morphology and harboring an in frame ACTB::ZMIZ2 fusion transcript was recently described. Herein, we report a second case of adnexal carcinoma harboring similar morphology and an identical in frame ACTB::ZMIZ2 fusion transcript. This 2.

View Article and Find Full Text PDF

Memorializes Arthur (Andy) M. Horne (1942-2024), esteemed counseling psychologist, lauded for his contributions to group counseling, bullying prevention, violence reduction, and prevention. Andy served the University of Georgia in the Department of Counseling and Human Development Services from 1989 to 2012 as training director, department chair, distinguished research professor, and dean (2008-2012).

View Article and Find Full Text PDF

The Oligonucleotide Nonclinical Working Group (WG) of the European Federation of Pharmaceutical Industries and Associations conducted an industry survey to understand current practices and regulatory expectations for genotoxicity and carcinogenicity assessment of oligonucleotide therapeutics (ONTs), along with historical genotoxicity testing results. The survey, involving 29 pharmaceutical and biotechnology companies, revealed a consistent absence of genotoxicity across a diverse range of oligonucleotide classes and chemistries, consistent with previous observations. Despite the lack of genotoxicity, companies continue to follow standard testing guidelines, with only limited divergence.

View Article and Find Full Text PDF

Give the grant-writing monkeys another banana.

Immunohorizons

January 2025

Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States.

View Article and Find Full Text PDF

We have read with great interest the paper published by the Journal of Anatomy [244(5), 2024, 861-872] on Is human height based on a Lucas sequence relationship between the foot height, tibial length, femur length and upper body length? by Paley et al. The authors show that foot height, tibial length, femur length and upper body length follow a generalized Lucas sequence. Our letter demonstrates that their result is indeed stronger, as their data follow the original, homogeneous Lucas sequence.

View Article and Find Full Text PDF

Objectives: From January 2020 to the end of August 2020, preliminary research gathered data about the need for and the feasibility of an ADEA-led joint Climate Study of dental schools and allied dental programs in the United States and Canada. Informed by these findings, the first ever ADEA-led joint Climate Study took place in 2022. The objectives of this manuscript were to describe the timeline of this climate study and provide information about its methodology, specifically about (a) who participated in this research, (b) what was assessed, (c) how the study was conducted, and (d) how the results were communicated.

View Article and Find Full Text PDF

Background: Stigma is emerging as an important social contributor to migraine-related disability and other outcomes. Currently, there are no published validated measures of migraine-specific measures of stigma.

Objectives: This secondary post hoc analysis of a cross-sectional cohort study aimed to develop a questionnaire to evaluate migraine-related stigma.

View Article and Find Full Text PDF

All species must partition resources among the processes that underly growth, survival, and reproduction. The resulting demographic trade-offs constrain the range of viable life-history strategies and are hypothesized to promote local coexistence. Tropical forests pose ideal systems to study demographic trade-offs as they have a high diversity of coexisting tree species whose life-history strategies tend to align along two orthogonal axes of variation: a growth-survival trade-off that separates species with fast growth from species with high survival and a stature-recruitment trade-off that separates species that achieve large stature from species with high recruitment.

View Article and Find Full Text PDF

Comparative Foliar Atmospheric Mercury Accumulation across Functional Types in Temperate Trees.

Environ Sci Technol

January 2025

State Key Laboratory of Cryospheric Science and Frozen Soil Engineering, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.

Vegetation assimilation of atmospheric gaseous elemental mercury (GEM) represents the largest dry deposition pathway in global terrestrial ecosystems. This study investigated Hg accumulation mechanisms in deciduous broadleaves and evergreen needles, focusing on how ecophysiological strategies─reflected by δC, δO, leaf mass per area, and leaf dry matter content-mediated Hg accumulation. Results showed that deciduous leaves exhibited higher total Hg (THg) concentrations and accumulation rates (THg), which were 85.

View Article and Find Full Text PDF

Forest canopy complexity (i.e., the three-dimensional structure of the canopy) is often associated with increased species diversity as well as high primary productivity across natural forests.

View Article and Find Full Text PDF

Although cognitions have predicted COVID-19 protective behaviors in cancer populations, theory suggests that emotions may be more predictive of these behaviors. This study examined Health Belief Model (HBM) variables as correlates of COVID-19 protective behaviors in lung cancer patients and whether worry about COVID-19 was associated with these behaviors beyond the effects of HBM variables. From 2021 to 2022, 191 patients (62.

View Article and Find Full Text PDF

Using a Serious Game to Teach Central Line Care in Pediatric Critical Care Nursing.

Am J Nurs

February 2025

Mouhammad Yabrodi, Kamal Abulebda, and Riad Lutfi are associate professors and physicians at the Indiana University School of Medicine and Riley Hospital for Children, IU Health, Indianapolis, IN, where Mara E. Nitu is a professor and chief medical officer and Colin M. Rogerson is an assistant professor and physician. Kellie J. Pearson is a critical care respiratory therapist at IU Health, Indianapolis, IN, and Tracy Spitzer is a clinical nurse specialist at Riley Hospital for Children, IU Health, Indianapolis, IN. Nathanael Thomas Tavares is chief executive officer at Flyover Zone, Indianapolis, IN. Contact author: Mouhammad Yabrodi, The authors have disclosed no potential conflicts of interest, financial or otherwise.

Background: Central venous catheters (CVCs) are used in pediatric patients to deliver IV fluids, blood products, medications, and nutrients. Potential complications include central line infection, which carries a high risk of morbidity and mortality in this population. Pediatric critical care nurses play a crucial role in helping to reduce the risk of infection.

View Article and Find Full Text PDF

Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.

View Article and Find Full Text PDF

The effectiveness of state-of-the-art cross-linking strategies and mass spectrometry (MS) detection was explored in an important biological context, namely, the ubiquitin-proteasome system, which is responsible for most of the regulated protein degradation in eukaryotic cells. The locations of possible binding sites on the 19S proteasome regulatory particle for Lys linked polyubiquitin chains were examined using cross-linking strategies and MS based detection by comparing two types of cross-linkers: a (bis)-sulfosuccinimidyl suberate (BS) and diethyl suberothioimidate (DEST). The well-established BS-based strategy produced 328 cross-linked peptides; however, no ubiquitin-19S cross-links were observed.

View Article and Find Full Text PDF

Promotion or inhibition? This is a question in gene editing.

Mol Ther

January 2025

Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Electronic address:

View Article and Find Full Text PDF

Assessing post-COVID-19 functional recovery in healthcare workers: Insights from the 6-minute walking test and DLCO analysis.

J Infect Public Health

January 2025

Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

Introduction: The COVID-19 pandemic has impacted healthcare workers (HCWs) worldwide, necessitating an understanding of its effects on their health and functional capacity. This study utilized the 6-Minute Walk Test (6MWT) and pulmonary function test (PFT) to evaluate post-infection recovery of HCWs, and analyzed the results in relation to comorbidities, symptoms, and healthcare admission.

Methods: HCWs who previously tested positive for SARS-CoV-2 were recruited, and the 6MWT and PFT were conducted.

View Article and Find Full Text PDF

Twisted halide perovskite bilayers, a type of moiré material, show square moiré patterns with exciting optical properties. Atomic-scale structure analysis and its correlation with properties are difficult to achieve due to the extreme sensitivity of organic-inorganic halide perovskites to the illuminated electron beam in conventional/scanning transmission electron microscopy. Here, we developed a low-dose exit wave reconstruction methodology with a real-space resolution of one angstrom at ∼50 e/Å, which recovers the phase information on the moiré fringes in CHNHPbI (MAPbI) twisted perovskite bilayers at atomic scale, enabling detailed structural analysis of defects and corresponding strain distribution in such moiré materials.

View Article and Find Full Text PDF