136,518 results match your criteria: "Indiana; and Regenstrief Institute Center for Biomedical Informatics[Affiliation]"
J Am Chem Soc
January 2025
Radiation Laboratory, University of Notre Dame, Notre Dame, Indiana 46556, United States.
Modulation of singlet and triplet energy transfer from excited semiconductor nanocrystals to attached dye molecules remains an important criterion for the design of light-harvesting assemblies. Whereas one can consider the selection of donor and acceptor with favorable energetics, spectral overlap, and kinetics of energy transfer as a means to direct the singlet and triplet energy transfer pathways, it is not obvious how to control the singlet and triplet characteristics of the donor semiconductor nanocrystal itself. By doping CsPb(ClBr) nanocrystals with Mn, we have now succeeded in increasing the triplet characteristics of semiconductor nanocrystals.
View Article and Find Full Text PDFOptom Vis Sci
January 2025
Indiana University School of Optometry, Bloomington, Indiana.
Purpose: This study investigated how obstacle contrast altered gait behavior of healthy younger and older adults.
Methods: Twenty normally sighted adults, 11 older (mean [standard deviation] age, 68.1 [5.
Science
January 2025
Department of Biology, Indiana University, Bloomington, IN, USA.
Testosterone is controlled while it circulates in the bloodstream.
View Article and Find Full Text PDFScience
January 2025
Center for Pulmonary Vascular Biology and Medicine, Pittsburgh, Heart, Lung, and Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Vascular inflammation regulates endothelial pathophenotypes, particularly in pulmonary arterial hypertension (PAH). Dysregulated lysosomal activity and cholesterol metabolism activate pathogenic inflammation, but their relevance to PAH is unclear. Nuclear receptor coactivator 7 () deficiency in endothelium produced an oxysterol and bile acid signature through lysosomal dysregulation, promoting endothelial pathophenotypes.
View Article and Find Full Text PDFJNCI Cancer Spectr
January 2025
Department of Epidemiology and Biostatistics, University of California, Irvine, CA, USA.
Background: Obesity, classified by body mass index (BMI), is associated with higher postmenopausal breast cancer (BCa) risk. Yet, the associations between abdominal visceral (VAT) and subcutaneous adipose tissue (SAT) with BCa are unclear.
Methods: We assessed BCa associations with abdominal VAT and SAT in a prospective cohort of postmenopausal women without a history of cancer and with 27 years follow-up (N = 9950), during which all new cancers were adjudicated.
Curr Cardiol Rep
January 2025
John Ochsner Heart and Vascular Institute, Ochsner Clinical School University of Queensland School of Medicine, New Orleans, LA, USA.
Purpose Of Review: To provide a narrative overview of trends and disparities in the cardiometabolic profiles of U.S. adults by synthesizing findings from nationally representative studies conducted between 1999 and 2020.
View Article and Find Full Text PDFVirchows Arch
January 2025
Department of Pathology, Université de Tours, Centre Hospitalier Universitaire de Tours, 37044, Tours, France.
A case of cutaneous adnexal neoplasm with unusual squamoid morphology and harboring an in frame ACTB::ZMIZ2 fusion transcript was recently described. Herein, we report a second case of adnexal carcinoma harboring similar morphology and an identical in frame ACTB::ZMIZ2 fusion transcript. This 2.
View Article and Find Full Text PDFMemorializes Arthur (Andy) M. Horne (1942-2024), esteemed counseling psychologist, lauded for his contributions to group counseling, bullying prevention, violence reduction, and prevention. Andy served the University of Georgia in the Department of Counseling and Human Development Services from 1989 to 2012 as training director, department chair, distinguished research professor, and dean (2008-2012).
View Article and Find Full Text PDFNucleic Acid Ther
January 2025
Global Preclinical Safety, AbbVie Inc., North Chicago, Illinois, USA.
The Oligonucleotide Nonclinical Working Group (WG) of the European Federation of Pharmaceutical Industries and Associations conducted an industry survey to understand current practices and regulatory expectations for genotoxicity and carcinogenicity assessment of oligonucleotide therapeutics (ONTs), along with historical genotoxicity testing results. The survey, involving 29 pharmaceutical and biotechnology companies, revealed a consistent absence of genotoxicity across a diverse range of oligonucleotide classes and chemistries, consistent with previous observations. Despite the lack of genotoxicity, companies continue to follow standard testing guidelines, with only limited divergence.
View Article and Find Full Text PDFImmunohorizons
January 2025
Department of Microbiology/Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
J Anat
January 2025
NSF-Simons Center for Quantitative Biology, Northwestern University, Evanston, Illinois, USA.
We have read with great interest the paper published by the Journal of Anatomy [244(5), 2024, 861-872] on Is human height based on a Lucas sequence relationship between the foot height, tibial length, femur length and upper body length? by Paley et al. The authors show that foot height, tibial length, femur length and upper body length follow a generalized Lucas sequence. Our letter demonstrates that their result is indeed stronger, as their data follow the original, homogeneous Lucas sequence.
View Article and Find Full Text PDFJ Dent Educ
January 2025
Division of Pediatric Dentistry and Orthodontics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Objectives: From January 2020 to the end of August 2020, preliminary research gathered data about the need for and the feasibility of an ADEA-led joint Climate Study of dental schools and allied dental programs in the United States and Canada. Informed by these findings, the first ever ADEA-led joint Climate Study took place in 2022. The objectives of this manuscript were to describe the timeline of this climate study and provide information about its methodology, specifically about (a) who participated in this research, (b) what was assessed, (c) how the study was conducted, and (d) how the results were communicated.
View Article and Find Full Text PDFActa Biochim Biophys Sin (Shanghai)
January 2025
Medical Sciences Program, Indiana University School of Medicine, Bloomington, IN 47405, USA.
Headache
January 2025
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA.
Background: Stigma is emerging as an important social contributor to migraine-related disability and other outcomes. Currently, there are no published validated measures of migraine-specific measures of stigma.
Objectives: This secondary post hoc analysis of a cross-sectional cohort study aimed to develop a questionnaire to evaluate migraine-related stigma.
All species must partition resources among the processes that underly growth, survival, and reproduction. The resulting demographic trade-offs constrain the range of viable life-history strategies and are hypothesized to promote local coexistence. Tropical forests pose ideal systems to study demographic trade-offs as they have a high diversity of coexisting tree species whose life-history strategies tend to align along two orthogonal axes of variation: a growth-survival trade-off that separates species with fast growth from species with high survival and a stature-recruitment trade-off that separates species that achieve large stature from species with high recruitment.
View Article and Find Full Text PDFEnviron Sci Technol
January 2025
State Key Laboratory of Cryospheric Science and Frozen Soil Engineering, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China.
Vegetation assimilation of atmospheric gaseous elemental mercury (GEM) represents the largest dry deposition pathway in global terrestrial ecosystems. This study investigated Hg accumulation mechanisms in deciduous broadleaves and evergreen needles, focusing on how ecophysiological strategies─reflected by δC, δO, leaf mass per area, and leaf dry matter content-mediated Hg accumulation. Results showed that deciduous leaves exhibited higher total Hg (THg) concentrations and accumulation rates (THg), which were 85.
View Article and Find Full Text PDFForest canopy complexity (i.e., the three-dimensional structure of the canopy) is often associated with increased species diversity as well as high primary productivity across natural forests.
View Article and Find Full Text PDFAlthough cognitions have predicted COVID-19 protective behaviors in cancer populations, theory suggests that emotions may be more predictive of these behaviors. This study examined Health Belief Model (HBM) variables as correlates of COVID-19 protective behaviors in lung cancer patients and whether worry about COVID-19 was associated with these behaviors beyond the effects of HBM variables. From 2021 to 2022, 191 patients (62.
View Article and Find Full Text PDFAm J Nurs
February 2025
Mouhammad Yabrodi, Kamal Abulebda, and Riad Lutfi are associate professors and physicians at the Indiana University School of Medicine and Riley Hospital for Children, IU Health, Indianapolis, IN, where Mara E. Nitu is a professor and chief medical officer and Colin M. Rogerson is an assistant professor and physician. Kellie J. Pearson is a critical care respiratory therapist at IU Health, Indianapolis, IN, and Tracy Spitzer is a clinical nurse specialist at Riley Hospital for Children, IU Health, Indianapolis, IN. Nathanael Thomas Tavares is chief executive officer at Flyover Zone, Indianapolis, IN. Contact author: Mouhammad Yabrodi, The authors have disclosed no potential conflicts of interest, financial or otherwise.
Background: Central venous catheters (CVCs) are used in pediatric patients to deliver IV fluids, blood products, medications, and nutrients. Potential complications include central line infection, which carries a high risk of morbidity and mortality in this population. Pediatric critical care nurses play a crucial role in helping to reduce the risk of infection.
View Article and Find Full Text PDFNature
January 2025
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFJ Am Soc Mass Spectrom
January 2025
Department of Molecular Biosciences, University of Texas, Austin, Texas 78712, United States.
The effectiveness of state-of-the-art cross-linking strategies and mass spectrometry (MS) detection was explored in an important biological context, namely, the ubiquitin-proteasome system, which is responsible for most of the regulated protein degradation in eukaryotic cells. The locations of possible binding sites on the 19S proteasome regulatory particle for Lys linked polyubiquitin chains were examined using cross-linking strategies and MS based detection by comparing two types of cross-linkers: a (bis)-sulfosuccinimidyl suberate (BS) and diethyl suberothioimidate (DEST). The well-established BS-based strategy produced 328 cross-linked peptides; however, no ubiquitin-19S cross-links were observed.
View Article and Find Full Text PDFMol Ther
January 2025
Center for Advanced Models Translational Sciences and Therapeutics, University of Michigan Medical School, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Electronic address:
J Infect Public Health
January 2025
Infectious Disease Division, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Infectious Disease Unit, Specialty Internal Medicine, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Infectious Disease Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Introduction: The COVID-19 pandemic has impacted healthcare workers (HCWs) worldwide, necessitating an understanding of its effects on their health and functional capacity. This study utilized the 6-Minute Walk Test (6MWT) and pulmonary function test (PFT) to evaluate post-infection recovery of HCWs, and analyzed the results in relation to comorbidities, symptoms, and healthcare admission.
Methods: HCWs who previously tested positive for SARS-CoV-2 were recruited, and the 6MWT and PFT were conducted.
ACS Nano
January 2025
School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Twisted halide perovskite bilayers, a type of moiré material, show square moiré patterns with exciting optical properties. Atomic-scale structure analysis and its correlation with properties are difficult to achieve due to the extreme sensitivity of organic-inorganic halide perovskites to the illuminated electron beam in conventional/scanning transmission electron microscopy. Here, we developed a low-dose exit wave reconstruction methodology with a real-space resolution of one angstrom at ∼50 e/Å, which recovers the phase information on the moiré fringes in CHNHPbI (MAPbI) twisted perovskite bilayers at atomic scale, enabling detailed structural analysis of defects and corresponding strain distribution in such moiré materials.
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