Estimation of glacier-stored freshwater volume present in major tributaries of the Brahmaputra basin.

Estimation of the glacier-stored freshwater is important to understand the water security in the Himalayan region. While previous work has studied the western and central Himalayan glaciers, the eastern counterpart received less and more scattered attention. In this study, an attempt is made to quantify the total glacier-stored freshwater in the Brahmaputra basin and later compared with previous global models.

Nanomedicines as a cutting-edge solution to combat antimicrobial resistance.

Antimicrobial resistance (AMR) poses a critical threat to global public health, necessitating the development of novel strategies. AMR occurs when bacteria, viruses, fungi, and parasites evolve to resist antimicrobial drugs, making infections difficult to treat and increasing the risk of disease spread, severe illness, and death. Over 70% of infection-causing microorganisms are estimated to be resistant to one or several antimicrobial drugs.

Seismic monitoring of 2020 Baghjan oil-well blowout incident in Assam, India.

Characterization of a productive oil/gas well blowout through seismological methods is relatively uncommon. In this paper, we conduct an in-depth seismic evaluation of one of the world's most significant onshore oil well blowout incidents, which occurred in 2020 at the Baghjan oil field in Assam, northeast India. We show that the blowout and related on-site activities generated distinct signals that can be distinguished by their spectral characteristics, temporal variation in geometric spreading, and sharp attenuation of daytime noise in comparison to the nighttime.

Generation of patterns and higher harmonics in 1D quantum droplets in tilted and driven quasi-periodic confinements.

The generation of patterns by breaking the spatial symmetry in external confinement is a captivating area of physics. The emergence of patterns is a fundamental inquiry spanning various disciplines such as nonlinear optics, condensed matter physics, and fluid dynamics. The article investigates the generation of a variety of patterns in a one-dimensional binary mixture of Bose-Einstein condensate forming quantum droplets.

Synthesis of biaryl-based carbazoles C-H functionalization and exploration of their anticancer activities.

The synthesis of a library of new biaryl-based carbazoles bidentate directing group-assisted C-H functionalization and preliminary screening of the anticancer properties of biaryl-based carbazoles is reported. While various classes of modified carbazoles are known for their applications in materials and medicinal chemistry, to our knowledge, the biological activities of designed biaryl-based carbazoles have been rarely known. Given the prominence of carbazoles in research in medicinal chemistry, we envisioned the scope for new scaffolds of carbazole-based biaryl structures.

Machine Learning-Enabled Nanoscale Phase Prediction in Engineered Poly(Vinylidene Fluoride).

Engineered poly(vinylidene fluoride) (PVDF) with its diverse crystalline phases plays a crucial role in determining the performance of devices in piezo-, pyro-, ferro- and tribo-electric applications, indicating the importance of distinct phase-detection in defining the structure-property relation. However, traditional characterization techniques struggle to effectively distinguish these phases, thereby failing to offer complete information. In this study, multimodal data-driven techniques have been employed for distinguishing different phases with a machine learning (ML) approach.

Signature of a zonally symmetric semidiurnal tide during major sudden stratospheric warmings and plausible mechanisms: a case study.

Sudden Stratospheric Warming (SSW) is a winter phenomenon initiated primarily by the enhanced stationary planetary waves (SPWs), characterized by an increase in polar stratospheric temperature by a few tens of kelvin for a few days. Wave-wave non-linear interaction can produce secondary waves, with sum and difference frequencies of the primary wave frequencies. The sun-synchronous semidiurnal tide is a major component at mid and high latitude middle atmosphere, which non-linearly interacts with the dominant SPW in the stratosphere to produce the zonally symmetric semidiurnal tide component (S0), as observed during two boreal SSWs.

Statistical analysis of the unique characteristics of secondary structures in proteins.

Protein folding is a complex process influenced by the primary sequence of amino acids. Early studies focused on understanding whether the specificity or the conservation of properties of amino acids was crucial for folding into secondary structures such as α-helices, β-sheets, turns, and coils. However, with the advent of artificial intelligence (AI) and machine learning (ML), the emphasis has shifted towards the precise nature and occurrence of specific amino acids.

Spatial variability in residence time of Beryllium in the Indian Ocean.

Residence time of an element in the ocean is a consequence of its chemical behaviour and the various biogeochemical processes governing its distribution, sources, and sinks. Precise estimation of the residence time of beryllium(Be) is necessary for its application as a tracer for understanding present and paleo-environmental processes. We utilise cosmogenic Be and terrestrially derived Be measurements from surface sediments to estimate the residence time of Be in the Indian Ocean.

Tunable Coassembly of Octaarginine with Thiazolyl Benzenesulfonamides Exerts Variable Antibacterial Activity.

The cationic peptide octaarginine (R8) is a prominent cell-penetrating peptide and has been extensively researched as a carrier of diverse cell-destined cargo. In this work, we describe the coassembly of R8 with small molecule thiazolyl benzenesulfonamide (TBS) derivatives. Physical complexation of R8 with three TBS derivatives across a range of weight ratios results in the formation of a distinctive set of nano- and microstructures.

Refinement of the Drude Polarizable Force Field for Hexose Monosaccharides: Capturing Ring Conformational Dynamics with Enhanced Accuracy.

We present a revised version of the Drude polarizable carbohydrate force field (FF), focusing on refining the ring and exocyclic torsional parameters for hexopyranose monosaccharides. This refinement addresses the previously observed discrepancies between calculated and experimental NMR coupling values, particularly in describing ring dynamics and exocyclic rotamer populations within major hexose monosaccharides and their anomers. Specifically, α-MAN, β-MAN, α-GLC, β-GLC, α-GAL, β-GAL, α-ALT, β-ALT, α-IDO, and β-IDO were targeted for optimization.

Can Microcavitated Slippery Surfaces Outperform Micropillared and Untextured?

Surface features' morphology is crucial in designing lubricant-infused slippery surfaces (LIS). Microcavities were hypothesized to provide lower physical pinning, reduced droplet normal adhesion, and superior lubricant retention as compared to micropillars and untextured surfaces. Micropillars and microcavities ( = 10 ± 3 μm, = 8 ± 1 μm, = 17 ± 3 μm, = 1.

Small molecules for impairing endoplasmic reticulum in cancer.

The endoplasmic reticulum plays an important role in maintaining the protein homeostasis of cells as well as regulating Ca storage. An increased load of unfolded proteins in the endoplasmic reticulum due to alterations in the cell's metabolic pathway leads to the activation of the unfolded protein response, also known as ER stress. ER stress plays a major role in maintaining the growth and survival of various cancer cells, but persistent ER stress can also lead to cell death and hence can be a therapeutic pathway in the treatment of cancer.

Investigating the nonlinear dynamics of photosensitive Belousov-Zhabotinsky gels via bifurcation analyses.

Controlling the dynamics of active stimuli-responsive smart materials is essential to replicate the biomimetic functionalities at different length scales for a variety of biological systems-based applications. Photosensitive Belousov-Zhabotinsky (BZ) gels, powered by a nonlinear chemical oscillator, called a BZ reaction are one of the stimuli-responsive smart materials in demand due to their ability to continuously transduce chemical oscillations into mechanical deformations. The chemical oscillations in a BZ reaction and subsequent mechanical oscillations in photosensitive BZ gels occur due to the redox cycle of photosensitive ruthenium complex-based catalysts.

Small Molecular Approaches for Cellular Reprogramming and Tissue Engineering: Functions as Mediators of the Cell Signaling Pathway.

Utilizing induced pluripotent stem cells (iPSCs) in drug screening and cell replacement therapy has emerged as a method with revolutionary applications. With the advent of patient-specific iPSCs and the subsequent development of cells that exhibit disease phenotypes, the focus of medication research will now shift toward the pathology of human diseases. Regular iPSCs can also be utilized to generate cells that assess the negative impacts of medications.