Enhanced therapeutic action of Trastuzumab loaded ZnMnFeO nanoparticles using a pre-treatment step for hyperthermia treatment of HER2+ breast cancer.

In this study, Ferrites (FeO, MnFeO, ZnFeO) and different stoichiometric ratios of ZnMnFeO (x = 0.2, 0.4, 0.

Methanol assisted water electrooxidation on noble metal free perovskite: RRDE insight into the catalyst's behaviour.

In this work, we have hypothesized that noble metal-free perovskites are an essential class of oxygen evolution reaction (OER) catalysts in an alkaline medium and thus, they are a suitable candidate for the assisted water oxidation catalysts. Herein, we demonstrate that the origin of the methanol-assisted OER activity at near thermodynamic potential on perovskite electrode arises due to the involvement of additional hydroxyls as a result of dissociative chemisorption of methanol. When the perovskite electrode is screened for methanol electrooxidation reaction in 0.

Interfacial band offset engineering with barium-doping towards enhanced performance of all inorganic CsPbIBr perovskite solar cells.

This study investigates the incorporation of Ba at a low concentration into CsPbIBr, resulting in the formation of mixed CsPbBaIBr perovskite films. Photovoltaic devices utilizing these Ba-doped CsPbIBr (Ba-CsPbIBr) perovskite films achieved a higher stabilized power conversion efficiency of 14.07% compared to 11.

Improved lipophilic probe for visualizing lipid droplets in erastin-induced ferroptosis.

Studying the viscosity of lipid droplets (LDs) provides insights into various diseases associated with LD viscosity. Ferroptosis is one such process in which LD viscosity increases due to the abnormal accumulation of lipid ROS (reactive oxygen species) caused by peroxidation. For investigating the LD imaging and ferroptosis, we developed two molecules (NNS and DNS) that show significant Stokes shifts (182-232 nm) and utilized them for sub-cellular imaging.

Hydrological model-based streamflow reconstruction for Indian sub-continental river basins, 1951-2021.

Streamflow is a vital component of the global water cycle. Long-term streamflow observations are required for water resources planning and management, hydroclimatic extremes analysis, and ecological assessment. However, long-term streamflow observations for the Indian-Subcontinental (ISC) river basins are lacking.

Understanding the Microscopic Origin of the Contact Resistance at the Polymer-Electrode Interface.

Contact resistance () in organic devices originates from a mismatch in energy levels between injecting electrodes and organic semiconductors (OSCs). However, the microscopic effects governing charge transfer between electrodes and the OSCs have not been analyzed in detail. We fabricated transistors with different OSCs (PTB7, PCDTBT, and PTB7-Th) and electrodes (MoO, Au, and Ag) and measured their contact resistance.

Effect of mutations on the folding and stability of D-crystallin protein.

Interprotein interactions between the partially unfolded states of D-crystallin (D-crys) protein are known to cause cataracts. Therefore, understanding the unfolding pathways of native D-crys is extremely crucial to delineate their aggregation mechanism. In this study, we have performed extensive all-atom Molecular Dynamics simulations with explicit solvent to understand the role of the critical residues that drive the stability of the motifs and domains of D-crys in its wild type and mutant forms.

Interplay of bulk soluble surfactants and interfacial kinetics governs the stability of two-layer channel flows.

The linear stability of two-layer channel flows in the presence of bulk-soluble surfactants is investigated here, taking into account the rheological properties of the interface. The interfacial stresses are quantified using the Boussinesq-Scriven model, while the surfactant kinetics is assumed to follow the Frumkin isotherm, which accounts for their non-ideal behavior. Our results show that in general, the bulk solubility of surfactants has a stabilizing effect on the interface, both with and without the presence of inertia.

Fluorescent styryl pyridine--oxide probes for imaging lipid droplets.

Lipid droplets (LDs) have emerged as major regulators of cellular metabolism, encompassing lipid storage, membrane synthesis, viral replication, and protein degradation. Exclusive studies have suggested a direct link between LDs and cancer, as a notable abundance of LDs is found in cancerous cells. Therefore, monitoring the location, distribution, and movements of LDs is of paramount importance for understanding their involvement in biological processes.

Ligand-mediated electron transport channels enhance photocatalytic activity of plasmonic nanoparticles.

Photoexcitation of noble metal nanoparticles creates surface plasmons which further decay to form energetic charge carriers. These charge carriers can initiate and/or accelerate various chemical processes at nanoparticle surfaces, although the efficiency of such processes remains low as a large fraction of these carriers recombine before they can reach the reaction sites. Thus efficient utilization of these charge carriers requires designing nanostructures that promote the separation of charges and their transport toward the reaction sites.

Exploration of probiotic attributes in lactic acid bacteria isolated from fermented fruit using techniques.

Probiotics are known for their health-promoting properties and are recognized as beneficial microorganisms. The current investigation delves into the isolation and comprehensive characterization of lactic acid bacteria (LAB) obtained from the Indian-origin Forastero variety to assess their potential as probiotic candidates. Eleven LAB isolates were obtained, and among them, five exhibited classical LAB traits.

TiB-Derived Nanosheets Enhance the Tensile Strength and Controlled Drug Release of Biopolymeric Films Used in Wound Healing.

Wound healing using an alginate-based biopolymeric film is one of the most preferred treatments. However, these films lack mechanical strength (elasticity and tensile strength), show higher initial burst release, and exhibit high vapor permeability. The present study reports the development of nanosheets derived from titanium diboride (10 nm) (NTB)-incorporated biopolymeric films (0.

Dog-bone shaped gold nanoparticle-mediated chemo-photothermal therapy impairs the powerhouse to trigger apoptosis in cancer cells.

The mitochondrion has emerged as one of the uncommon targets in cancer therapeutics due to its involvement in cancer generation and progression. Consequently, nanoplatform mediated delivery of anti-cancer drugs into the mitochondria of cancer tissues demonstrated immense potential in cancer treatment. In the last couple of decades, gold nanoparticles have gained incredible attention in biomedical applications due to their easy synthesis, size-shape tenability, optical properties and outstanding photothermal ability.

Bacteria-derived topologies of CuO nanozymes exert a variable antibacterial effect.

The ability of bacteria to facilitate fabrication of nanomaterials has been adapted towards bacterial sensing applications. In this work, we fabricate spherical, cubic and truncated octahedron topologies of CuO nanoparticles -facilitated redox reaction in an electrochemical setup. The CuO nanoparticles exhibit cytochrome c oxidase-like activity with the spherical topology displaying higher catalytic rate compared to the other geometries.

Enhanced activity of lipase B in cholinium aminoate ionic liquids: a combined experimental and computational analysis.

As a class of ionic liquids with higher biocompatibility, cholinium aminoates ([Cho][AA]) hold potential as solvation media for enzymatic bioprocessing. Herein, solvation effect of [Cho][AA] on structural stability and enzymatic activity of lipase B (CALB) was evaluated using experimental and computational approaches. Influence of [Cho][AA] on CALB stability was investigated using amino acid anions ([AA]) with varying hydrophobicity levels.

Synthesis of novel zinc porphyrins with bioisosteric replacement of Sorafenib: Efficient theranostic agents for anti-cancer application.

Novel zinc porphyrins (trans-AB and AB type) are reported containing pharmacophoric groups derived from Sorafenib at the meso-positions. The pharmacophoric and bioisosteric modification of Sorafenib was done with 2-methyl-4-nitro-N-phenylaniline. The in-vitro photo-cytotoxicity studies of zinc porphyrins on HeLa cells revealed excellent PDT based autophagy inhibition of cancer cells, with IC values between 6.

Insight into the environmental fate, hazard, detection, and sustainable degradation technologies of chlorpyrifos-an organophosphorus pesticide.

Pesticides play a critical role in terms of agricultural output nowadays. On top of that, pesticides provide economic support to our farmers. However, the usage of pesticides has created a public health issue and environmental hazard.

Tracing spatiotemporal changes in agricultural and non-agricultural trade networks of India.

The evolving international economic instability and international trade relationship demand a nation to move towards a self-reliant integrated system at a sub-national scale to address the growing human needs. Given India's role in the global trade network, it is critical to explore the underlying extensive complex trade network at the domestic scale. The potential advantages of complex interaction among the different commodities remain unexplored despite the known importance of trade networks in maintaining food security and industrial sustainability.

Contribution of socio-economic and demographic factors to maternal and child malnutrition in Bangladesh: Insights from a nationwide survey.

Malnutrition is a major global public health issue, especially for under five children and their mothers. This study examined the relationships between socio-economic and demographic characteristics and under- and over-nutrition in mothers and children of Bangladesh. Using the Nationally representative Bangladesh Demographic and Health Survey (2017-18) data, we performed the multiple logistic regression analysis to assess the relationships between key outcome variables and predictors.

Green Synthesis of Pristine and Ag-Doped TiO and Investigation of Their Performance as Photoanodes in Dye-Sensitized Solar Cells.

Dye-sensitized solar cells (DSSCs) have emerged as a potential candidate for third-generation thin film solar energy conversion systems because of their outstanding optoelectronic properties, cost-effectiveness, environmental friendliness, and easy manufacturing process. The electron transport layer is one of the most essential components in DSSCs since it plays a crucial role in the device's greatest performance. Silver ions as a dopant have drawn attention in DSSC device applications because of their stability under ambient conditions, decreased charge recombination, increased efficient charge transfer, and optical, structural, and electrochemical properties.

Hypoxia Modulates Cellular Endocytic Pathways and Organelles with Enhanced Cell Migration and 3D Cell Invasion.

Hypoxia, a decrease in cellular or tissue level oxygen content, is characteristic of most tumors and has been shown to drive cancer progression by altering multiple subcellular processes. We hypothesized that the cancer cells in a hypoxic environment might have slower proliferation rates and increased invasion and migration rates with altered endocytosis compared to the cancer cells in the periphery of the tumor mass that experience normoxic conditions. We induced cellular hypoxia by exposing cells to cobalt chloride, a chemical hypoxic mimicking agent.

Structural, kinetic, and thermodynamic aspects of insulin aggregation.

Given the significance of protein aggregation in proteinopathies and the development of therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the aggregation kinetics has been observed. Quantitative analysis of aggregation includes data of gradual monomeric depletion followed by the formation of subvisible particles. Kinetic and thermodynamic studies are essential to gain key insights into the aggregation process.

The synergy between electrochemical substrate oxidation and the oxygen reduction reaction to enable aerobic oxidation.

Aerobic substrate oxidation reactions catalyzed by a heterogeneous catalyst can be looked upon as two independent half-cell reactions, anodic substrate oxidation and the cathodic oxygen reduction reaction (ORR). In this context, Fe PANI/C, a well-known catalyst for the ORR, is chosen to validate this hypothesis, wherein the anodic reaction is hydrazine oxidation. Fe PANI/C shows excellent activity in terms of the electrochemical ORR and hydrazine oxidation in both alkaline aqueous and non-aqueous media and taken together the aerobic oxidation efficacy of hydrazine-like small organic molecules is correlated with the electrochemical outcomes.