Constructing Multiresonance Thermally Activated Delayed Fluorescence Emitters for Organic LEDs: A Computational Investigation.

Multiple resonance thermally activated delayed fluorescence (MR-TADF) materials have acquired substantial attention due to their high electroluminescence efficiency with narrow emission spectra. However, the existing MR-TADF emitters suffer from substantial efficiency roll-off due to insufficient rate constants of the reverse intersystem crossing () process compared to the traditional TADF materials. Herein, we employ the DLPNO-STEOM-CCSD method, which is computationally less expensive than the wave function-based EOM-CCSD method, to evaluate the electronic and photophysical properties of MR-TADF materials accurately.

Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis in vitro and in vivo models.

Nintedanib (NIN) and pirfenidone are the only approved drugs for the treatment of Idiopathic Pulmonary Fibrosis (IPF). However, NIN and pirfenidone have low oral bioavailability and limited therapeutic potential, requiring higher dosages to increase their efficacy, which causes significant liver and gastrointestinal toxicities. In this study, we aimed to develop nintedanib-loaded solid lipid nanoparticles (NIN-SLN) to improve the oral bioavailability and therapeutic potential against TGF-β-induced differentiation in IPF fibroblasts and bleomycin (BLM)-induced lung fibrosis in rat models.

Effective electronic waste valorization via microwave-assisted pyrolysis: investigation of graphite susceptor and feedstock quantity on pyrolysis using experimental and polynomial regression techniques.

Waste printed circuit board (WPCB) was subjected to microwave-assisted pyrolysis (MAP) to investigate the energy and pyrolysis products. In MAP, pyrolysis experiments were conducted, and the effects of WPCB to graphite mass ratio on three-phase product yields and their compositions were analyzed. In addition, the role of the initial WPCB mass (10, 55, and 100 g) and susceptor loading (2, 22, and 38 g) on the quality of product yield was also evaluated.

Banana Peel Derived Chitosan-Grafted Biocomposite for Recovery of NH and PO.

Biomass-derived adsorbents afford accessible and inexpensive harvesting of nitrogen and phosphorus from wastewater sources. Human urine is widely accepted as a rich source of nitrogen and phosphorus. However, direct use of urine in agriculture is untenable because of its unpleasant smell, pathogen contamination, and pharmaceutical residues.

Cultural adaptation and psychometric evaluation of Childbirth Experience Questionnaire 2 in Karnataka state, India.

Background: Women's birthing experience is a sensitive indicator of the quality of childbirth care and can impact the physical and mental health of both women and their neonates. Negligible evidence exists on Indian women's birth experiences and-to the best of authors' knowledge-no questionnaire has been tested in India for measuring women's birthing experiences. This study aimed to test the construct validity and reliability of the Kannada-translated Revised Childbirth Experience Questionnaire.

Genomic profiling and characteristics of a C1 degrading heterotrophic fresh-water bacterium Paracoccus sp. strain DMF.

Paracoccus species are metabolically versatile gram-negative, aerobic facultative methylotrophic bacteria showing enormous promise for environmental and bioremediation studies. Here we report, the complete genome analysis of Paracoccus sp. strain DMF (P.

A DNA aptamer-based assay for the detection of soluble ST2, a prognostic biomarker for monitoring heart failure.

Heart failure (HF) is emerging as a leading cause of death worldwide. Estimation of BNP levels is a routine diagnosis in these patients. However, in patients having high body-mass index (BMI), renal disease or in geriatric patients, BNP level is reported to be noisy and leads to incongruous conclusion.

Contribution of fossil and biomass-derived secondary organic carbon to winter water-soluble organic aerosols in Delhi, India.

Delhi, among the world's most polluted megacities, is a hotspot of particulate matter emissions, with high contribution from organic aerosol (OA), affecting health and climate in the entire northern India. While the primary organic aerosol (POA) sources can be effectively identified, an incomplete source apportionment of secondary organic aerosol (SOA) causes significant ambiguity in the management of air quality and the assessment of climate change. Present study uses positive matrix factorization analysis on the water-soluble organic aerosol (WSOA) data from the offline-aerosol mass spectrometry (AMS).

Sustainable environmental practices of tea waste-a comprehensive review.

Tea, the major beverage worldwide, is one of the oldest commercial commodities traded from ancient times. Apart from many of its advantages, including health, socio-economic, climatic, and agro-ecological values, FAO has recognized that the tea value chain covering its growth in the field, processing and marketing, and finally, the hot cup at the user's hand needs to be made sustainable during all these stages. Tea generates a lot of waste in different forms in different stages of its growth and processing, and these wastes, if not managed properly, may cause environmental pollution.

Pathophysiology to advanced intra-articular drug delivery strategies: Unravelling rheumatoid arthritis.

Rheumatoid arthritis (RA) is one of the most prevalent life-long autoimmune diseases with an unknown genesis. It primarily causes chronic inflammation, pain, and synovial joint-associated cartilage and bone degradation. Unfortunately, limited information is available regarding the etiology and pathogenesis of this chronic joint disorder.

Recent advances in dosage form design for the elderly: a review.

Introduction: With the increase in the elderly population and the prevalence of multiple medical conditions, medication adherence, and efficacy have become crucial for the effective management of their health. The aging population faces unique challenges that need to be addressed through advancements in drug delivery systems and formulation technologies.

Areas Covered: The current review highlights the recent advances in dosage form design for older individuals, with consideration of their specific physiological and cognitive changes.

Fine-grained domain counting and percolation analysis in two-dimensional lattice systems with linked lists.

We present a fine-grained approach to identify clusters and perform percolation analysis in a two-dimensional (2D) lattice system. In our approach, we develop an algorithm based on the linked-list data structure whereby the members of a cluster are nodes of a path. This path is mapped to a linked-list.

Enhancing Medical Diagnosis with AI: A Focus on Respiratory Disease Detection.

Background: Artificial intelligence (AI) is revolutionizing medical diagnosis and healthcare, providing constant support to medical practitioners. Intelligent systems alleviate workload pressure while optimizing practitioner performance. AI and deep learning have also improved medical imaging and audio analysis.

Unveiling DNA Translocation in Pristine Graphene Nanopores: Understanding Pore Clogging via Polarizable Simulations.

Graphene has garnered remarkable attention in recent years as an attractive nanopore membrane for rapid and accurate sequencing of DNA. The inherent characteristics of graphene offer exquisite experimental control over pore dimensions, encompassing both the width (pore diameter) and height. Despite these promising prospects, the practical deployment of pristine graphene nanopores for DNA sequencing has encountered a formidable challenge in the form of pore clogging, which is primarily attributed to hydrophobic interactions.

Efficacy of amorphous TiOcoated surfaces against micro- and macrofouling through laboratory microcosms and field studies.

In this study, Soda Lime Glass (SLG) and Stainless Steel (SS316L) substrata coated with Titanium oxide (TiOx) were tested for their efficacy in the laboratory microcosms and in field against micro- and macrofouling. Laboratory microcosm studies were conducted for five days using natural biofilms, single-species diatom ( sp.), and bacterial biofilms, whereas field observations were conducted for 30 days.

Small-Molecule Endoplasmic Reticulum Stress Inducer Triggers Apoptosis in Cancer Cells.

Endoplasmic reticulum (ER) is highly critical for the sub-cellular protein synthesis, post-translational modifications and myriads of signalling pathways to maintain cellular homeostasis. Consequently, dysregulation in the ER functions leads to the ER stress in different pathological situations including cancer. Hence, exploring small molecules to induce ER stress emerged as one of the unorthodox strategies for future cancer therapeutics.

Improved Efficiency and Stability in 1,5-Diaminonaphthalene Iodide-Passivated 2D/3D Perovskite Solar Cells.

Engineering multidimensional two-dimensional/three-dimensional (2D/3D) perovskite interfaces as light harvesters has recently emerged as a potential strategy to obtain a higher photovoltaic performance in perovskite solar cells (PSCs) with enhanced environmental stability. In this study, we utilized the 1,5-diammonium naphthalene iodide (NDAI) bulky organic spacer for interface modification in 3D perovskites for passivating the anionic iodide/uncoordinated Pb vacancies as well as facilitating charge carrier transfer by improving the energy band alignment at the perovskite/HTL interface. Consequently, the NDAI-treated 2D/3D PSCs showed an enhanced open-circuit voltage and fill factor with a remarkable power conversion efficiency (PCE) of 21.

β-Carotene laden antibacterial and antioxidant gelatin/polyglyceryl stearate nano-hydrogel system for burn wound healing application.

Worldwide, burn wounds are severe health issues prone to bacterial infections and challenging to treat with traditional wound dressings. Therefore, a highly desirable biological macromolecules-based wound dressing with good antioxidant, antibacterial, biocompatible, and a large surface area is required. Herein, aim to develop a biological macromolecules-based physically cross-linked gelatin/polyglyceryl stearate/graphene oxide (GPGO) hydrogel to treat burn wounds.

Multicomponent decellularized extracellular matrix of caprine small intestine submucosa based bioactive hydrogel promoting full-thickness burn wound healing in rabbits.

Effective treatment for full-thickness burn wounds has remained challenging for clinicians. Among various strategies, extracellular gel-based dressing materials have gained attention to promote effective and rapid wound healing. These gel-based materials are porous and have antioxidant, antibacterial, hydrophilic, biodegradation, and biocompatible properties and hence can be used to alleviate burn wound healing.

Chimeric Small Molecules for Detouring Drugs into Mitochondria to Engender Apoptosis in Cancer Cells.

Mitochondrion has appeared as one of the important targets for anti-cancer therapy. Subsequently, small molecule anti-cancer drugs are directed to the mitochondria for improved therapeutic efficacy. However, simultaneous imaging and impairing mitochondria by a single probe remained a major challenge.

Performance evaluation of an active headrest system using a filtered-x least mean square/fourth algorithm with virtual sensing.

In an active headrest system virtual sensing tends to transfer the spatial zone of quiet from the residual error microphone to the ear canal. An attempt has been made in this paper to develop an auxiliary filter based virtual sensing scheme integrated with the filtered-x least mean square/fourth algorithm for an active headrest. The performance of the proposed method has been evaluated experimentally using periodic and band limited white noise.

Effect of shape anisotropy on the precipitation of dimeric nanoparticles.

We use grand canonical transition matrix Monte Carlo simulations to study the precipitation of dimeric nanoparticles. The dimers are composed of two particles having different chemical features and separated by a fixed distance. The non-attractive and attractive parts of the dimer are modeled using hard-sphere and square-well potentials, respectively.

Technological Interventions Enhancing Curcumin Bioavailability in Wound-Healing Therapeutics.

Wound healing has been a challenge in the medical field. Tremendous research has been carried out to expedite wound healing by fabricating various formulations, some of which are now commercially available. However, owing to their natural source, people have been attracted to advanced formulations with herbal components.

Lipid Droplets Specific Fluorophore for Demarcation of Normal and Diseased Tissues.

Using high-fidelity, permeable, lipophilic, and bright fluorophores for imaging lipid droplets (LDs) in tissues holds immense potential in diagnosing conditions such as diabetic or alcoholic fatty liver disease. In this work, we utilized linear and Λ-shaped polarity-sensitive fluorescent probes for imaging LDs in both cellular and tissue environments, specifically in rats with diabetic and alcoholic fatty liver disease. The fluorescent probes possess several key characteristics, including high permeability, lipophilicity, and brightness, which make them well-suited for efficient LD imaging.

An MXene-Grafted Terpolymer Hydrogel for Adsorptive Immobilization of Toxic Pb(II) and Post-Adsorption Application of Metal Ion Hydrogel.

Toxic metal ions present in industrial waste, such as Pb(II), introduce deleterious effects on the environment. Though the adsorptive removal of Pb(II) is widely reported, there is a dearth of research on the suitable utilization and disposal of the Pb(II)-adsorbed adsorbent. In this work, an MXene-grafted terpolymer () hydrogel has been designed for the adsorption of Pb(II) under ambient conditions of pH and temperature.