O,S-Chelated bis(pentafluorophenyl)boron and diphenylboron-β-thioketonates: synthesis, photophysical, electrochemical and NLO properties.

Boron-β-diketonates are classical emissive materials that have been utilized in various fields, however, boron monothio-β-thioketonates, where one oxygen atom is exchanged for a sulphur atom, have not been explored in detail. To gain a better understanding of this class of materials, we synthesised various aryl substituted monothio-β-diketonate boron complexes with two different aryl substitutions on the boron center and studied their structural, optical and electrochemical properties. Single crystal X-ray analysis revealed that there is considerable deviation in B-O and B-S bond lengths for bis(pentafluorophenyl)boron complexes against diphenyl boron complexes.

Unveiling fungal strategies: Mycoremediation in multi-metal pesticide environment using proteomics.

Micropollutants, such as heavy metals and pesticides, inhibit microbial growth, threatening ecosystems. Yet, the mechanism behind mycoremediation of the pesticide lindane and multiple metals (Cd, Total Cr, Cu, Ni, Pb, Zn) remains poorly understood. In our study, we investigated cellular responses in Aspergillus fumigatus PD-18 using LC-MS/MS, identifying 2190 proteins, 1147 of which were consistently present under both stress conditions.

Rational design based on multi-monomer simultaneous docking for epitope imprinting of SARS-CoV-2 spike protein.

Among biomimetic strategies shaping engineering designs, molecularly imprinted polymer (MIP) technology stands out, involving chemically synthesised receptors emulating natural antigen-antibody interactions. These versatile 'designer polymers' with remarkable stability and low cost, are pivotal for in vitro diagnostics. Amid the recent global health crisis, we probed MIPs' potential to capture SARS-CoV-2 virions.

A virulence-associated small RNA MTS1338 activates an ABC transporter CydC for rifampicin efflux in .

The efficacy of the tuberculosis treatment is restricted by innate drug resistance of and its ability to acquire resistance to all anti-tuberculosis drugs in clinical use. A profound understanding of bacterial ploys that decrease the effectiveness of drugs would identify new mechanisms for drug resistance, which would subsequently lead to the development of more potent TB therapies. In the current study, we identified a virulence-associated small RNA (sRNA) MTS1338-driven drug efflux mechanism in .

Deciphering Asymmetric Brønsted Base-Aminocatalytic Mode in Pudovik/[1,2]-Phospha-Brook Rearrangement/Michael Cascade Reaction.

An approach involving the use of a bifunctional aminocatalyst containing Brønsted base and iminium activation sites for asymmetric multicomponent reactions involving [1,2]-phospha-Brook rearrangement has yet to be realized. Herein, we present an aminocatalytic enantioselective conjugate addition of α-phosphonyloxy enolates formed [1,2]-phospha-Brook rearrangement to α,β-unsaturated ketones. The methodology unfolds a simple one-pot operation consisting of a robust additive-free catalytic system providing a series of oxindole derivatives having two contiguous stereocenters in high yields with excellent stereoselectivities.

Colon or semicolon: gut sampling microdevices for omics insights.

Ingestible microdevices represent a breakthrough in non-invasive sampling of the human gastrointestinal (GI) tract. By capturing the native spatiotemporal microbiome and intricate biochemical gradients, these devices allow a non-invasive multi-omic access to the unperturbed host-microbiota crosstalk, immune/nutritional landscapes and gut-organ connections. We present the current progress of GI sampling microdevices towards personalized metabolism and fostering collaboration among clinicians, engineers, and data scientists.

Synthesis of anionic alkaline earth metal methanesulfonates bearing photo-responsive methylviologen.

Anionic coordination frameworks stabilized by methylviologen (MV; 1,1'-dimethyl 4,4'-bipyridinium) as a photochromic module are a distinct class of functional materials. Herein, we report the first examples of alkaline earth metal methanesulfonates [MV{Mg(OSOMe)(HO)}] (1), [MV{Ca(OSOMe)(HO)}] (2), [2{Mg(OSOMe)(HO)}MV·2OSOMe] (3), and [Me-pip{Ca(OSOMe)(HO)}] (4) incorporating methylviologen or tetra--methylpiperazinium (Me-pip) as a charge-balancing cation. X-ray crystallographic studies of 1-3 emphasize the role of isolated ion-pairs for the construction of hydrogen-bonded supramolecular assemblies and the ability of methanesulfonates to donate electrons (centroid⋯O = 3.

Propagation of transient explosive synchronization in a mesoscale mouse brain network model of epilepsy.

Generalized epileptic attacks, which exhibit widespread disruption of brain activity, are characterized by recurrent, spontaneous, and synchronized bursts of neural activity that self-initiate and self-terminate through critical transitions. Here we utilize the general framework of explosive synchronization (ES) from complex systems science to study the role of network structure and resource dynamics in the generation and propagation of seizures. We show that a combination of resource constraint and adaptive coupling in a Kuramoto network oscillator model can reliably generate seizure-like synchronization activity across different network topologies, including a biologically derived mesoscale mouse brain network.

Designer pseudopeptides: autofluorescent polygonal tubes Phe-zipper and triple helix.

Chemists are increasingly turning to biology for inspiration to develop novel and superior synthetic materials. Here, we present an innovative peptide design strategy for tubular assembly. In this simple design, a phenylene urea unit is introduced as an aglet at the N-terminus of the peptide.

Reproducibility of spatial penalty-based methodologies for intravoxel incoherent motion analysis with diffusion MRI.

Objective was to assess the precision and reproducibility of spatial penalty-based intravoxel incoherent motion (IVIM) methods in comparison to the conventional bi-exponential (BE) model-based IVIM methods. IVIM-MRI (11 b-values; 0-800 s/mm) of forty patients (N = 40; Age = 17.7 ± 5.

Employing Machine Learning Models to Predict Potential α-Glucosidase Inhibitory Plant Secondary Metabolites Targeting Type-2 Diabetes and Their Validation.

The need for new antidiabetic drugs is evident, considering the ongoing global burden of type-2 diabetes mellitus despite notable progress in drug discovery from laboratory research to clinical application. This study aimed to build machine learning (ML) models to predict potential α-glucosidase inhibitors based on the data set comprising over 537 reported plant secondary metabolite (PSM) α-glucosidase inhibitors. We assessed 35 ML models by using seven different fingerprints.

Aggregation in Deep Eutectic Solvents (DESs): Formation of Polar DES-in-Nonpolar DES Microemulsions.

The versatility of environmentally benign and inexpensive deep eutectic solvents (DESs) lies in their widely varying physicochemical properties. Depending on its constituents, a DES may be highly polar or nonpolar in nature. This offers an enticing possibility of formation of novel nonaqueous microemulsions (MEs).

Retraction: Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections.

Retraction of 'Cytocompatible, soft and thick brush-modified scaffolds with prolonged antibacterial effect to mitigate wound infections' by Shaifali Dhingra , , 2022, , 3856-3877, https://doi.org/10.1039/D2BM00245K.

A sustainable recycling process and its life cycle assessment for valorising post-consumer textile materials for thermal insulation applications.

The textile industry along with construction, electronics and plastic generate huge amounts of waste posing challenges to the adoption of the circular economy. This research presents a sustainable and low-cost recycling technology for conversion of post-consumer textile (denim) wastes to useful insulation materials. To accomplish the objective, nonwoven materials were produced using varying proportions of post-consumer recycled denim (r-denim) fibre and hollow polyester (PET) fibre using different punch densities in the needle punching process.

The safety impacts of paved shoulder width in Indian four-lane rural highways.

The shoulder width, as a geometric element, plays a crucial role in enhancing highway safety. Research from high-income countries indicates that improving shoulders on highways leads to substantial safety benefits. However, the safety effectiveness of paved shoulders for low- and middle-income countries (LMICs) highway contexts has limited evidence.

Aggregation of therapeutic monoclonal antibodies due to thermal and air/liquid interfacial agitation stress: Occurrence, stability assessment strategies, aggregation mechanism, influencing factors, and ways to enhance stability.

Therapeutic proteins, such as monoclonal antibodies (mAbs) are known to undergo stability related issues during various stages of product life cycle resulting in the formation of aggregates and fragments. Aggregates of mAb might result in reduced therapeutic activity and could cause various adverse immunogenic responses. Sample containing mAb undergo aggregation due to various types of stress factors, and there is always a continuous interest among researchers and manufacturers to determine the effect of different factors on the stability of mAb.

Auriferous nanozymes: advances in diagnostic and therapeutic applications.

Nanozymes are a group of nanomaterials that garnered significant attention due to their enzyme-mimicking properties and their catalytic activities comparable to those of natural enzymes. The ability of nanozymes to emulate crucial biological processes which can conquer the drawbacks of natural enzymes, such as their restricted thermostability as well as substrate range. Auriferous (gold) nanozymes possess remarkable enzyme-like properties, such as reductase, peroxidase, superoxide dismutase, oxidase, and catalase.

Surface-engineered vertically-aligned ZnO nanorod for sensitive non-enzymatic electrochemical monitoring of cholesterol.

Developing highly sensitive and selective non-enzymatic electrochemical biosensors for disease biomarker detection has become challenging in healthcare applications. However, advances in material science are opening new avenues for creating more dependable biosensing technologies. In this context, the present work introduces a novel approach by engineering a hybrid structure of zinc oxide nanorod (ZnO NR) modified with iron oxide nanoparticle (FeO NP) on an FTO electrode.

-Difluoroallene (DFA): an emerging versatile synthetic precursor to enable diverse fluorinated molecules.

Organofluorine compounds are increasingly found in diverse fields, such as pharmaceuticals, agrochemicals, and materials science. -Difluoroallenes, which have -difluoro alkenes and allenes-like properties, offer a distinct and adaptable platform for novel synthetic transformations. Their distinctiveness is highlighted by various strategies, where the -difluoro group's presence plays a pivotal role in successful reactions.

Silane-mediated, facile C-H and N-H methylation using formaldehyde.

The use of ()-formaldehyde for the methylation/alkylation of C(sp)-H and N-H bonds, utilizing a combination of silane and hexafluoroisopropanol (HFIP) as activators, is reported. Overcoming the complexity of C(sp)-H methylation on aryl and indole substrates, the process utilizes a Friedel-Crafts alkylation, followed by silane as a hydride donor, under a mild acidic medium. The method has been employed for the synthesis of the antifungal drug butenafine and a derivative of the non-steroidal anti-inflammatory drug (NSAID) flurbiprofen.

O and Base Assisted Oxidative Conversion of β-Enaminoesters to α-Acyloxy-β-ketoesters under Visible Light Irradiation.

Singlet oxygen (O) and base assisted conversion of βenaminoesters to α-acyloxy-β-ketoesters is demonstrated under visible light irradiation. The reaction involves formation of an imine intermediate via ene-type pathway initiated by O followed by base promoted dimerization and hydrolysis steps. The method is mild, environmentally friendly, requires air as the oxidant, and gives the products in moderate to high yields.

Gallium recovery from red mud: Integration of solvent extraction and siderophore assisted technologies.

Gallium (Ga) recovery from the red mud, though important has never been successful due to several technical and economic reasons such as contaminant interference and the high cost of membranes due to their faster saturation resulting in the clogging of membranes with contaminants. This study demonstrated the recovery of Ga by a combination of HCl-based leaching, Fe/Al/Ti separation, and recovery of Ga using Cyphos IL 104-based solvent extraction and complexation of Ga with desferrioxamine B as a proof-of-principle of the GaLIophore technology. The main leaching parameters such as concentrations of acids, time and temperature of the reaction, and solid-to-liquid ratio have been systematically investigated.