Recent progress on nanomaterial-based electrochemical sensors for glucose detection in human body fluids.

In the modern age, half of the population is facing various chronic illnesses due to glucose maintenance in the body, major causes of fatality and inefficiency. The early identification of glucose plays a crucial role in medical treatment and the food industry, particularly in diabetes diagnosis. In the past few years, non-enzymatic electrochemical glucose sensors have received a lot of interest for their ability to identify glucose levels accurately.

A study on red potato peel ( Red Holland): characterization, composition and formulation of tablet using different drying techniques.

Unlabelled: Potato peels are one of the most under-utilized wastes which can be highly beneficial to mankind. The red potato peel powder was prepared by using tray drying and vacuum-oven drying method. The proximate analysis of red potato peel powder was conducted followed by its characterization which includes FT-IR, XRD, TGA, DSC, and SEM.

Untargeted Metabolomics and Bioactivities Assessment of Xylaria ellisii, an Endophytic Fungus Isolated from the Leaf of the Plant Acorus calamus Linn.

Introduction: Fungal endophytes have mutualistic associations with the plant's host, communicating through genetic and metabolic processes. As a result, they gain the ability to generate therapeutically effective metabolites and their derivatives.

Methods: The current study aims to assess antioxidant potential along with the identification of robust metabolites within the crude extract of a potent endophytic fungus Xylaria ellisii isolated from leaf tissues of the Acorus calamus Linn plant.

A Novel Model Using ML Techniques for Clinical Trial Design and Expedited Patient Onboarding Process.

Introduction: Clinical trials are critical for drug development and patient care; however, they often need more efficient trial design and patient enrolment processes. This research explores integrating machine learning (ML) techniques to address these challenges. Specifically, the study investigates ML models for two critical aspects: (1) streamlining clinical trial design parameters (like the site of drug action, type of Interventional/Observational model, etc) and (2) optimizing patient/volunteer enrolment for trials through efficient classification techniques.

Formulation and Evaluation of Lipid/Soluplus-Stabilized Nanocrystals of Paclitaxel and Bosutinib for a Synergistic Effect in Non-Small Cell Lung Cancer Therapy.

Tyrosine kinase inhibitors have been employed for the treatment of lung cancer, owing to their role in regulating irregulated pathways or mutated genes. Bosutinib, a nonreceptor tyrosine kinase, has been recently investigated for lung cancer treatment. Bosutinib can also be used with paclitaxel as a combinatorial approach to receive a synergistic effect for the effective management of lung cancer.

Transition Metal Complexes Containing Selenium Ligands for Catalytic Reduction, Oxidation, and Hydrofunctionalization Reactions.

Transition metal-mediated catalytic reduction, oxidation, and hydrofunctionalization reactions are important organic reactions and are considered highly atom-economical. Owing to their unique properties, selenium ligated several transition metals-based complexes have been reported for several catalytic applications. This review presents the synthesis of various selenium-supported transition metal complexes and their catalytic applications in reduction, oxidation, N-alkylation of amines, and hydrofunctionalization reactions.

Voices of Nanomedicine: Blueprint Guidelines for Collaboration in Addressing Global Unmet Medical Needs.

The "" under this Perspective underline the importance of interdisciplinary collaboration and partnerships across several disciplines, such as medical science and technology, medicine, bioengineering, and computational approaches, in bridging the gap between research, manufacturing, and clinical applications. Effective communication is key to bridging team gaps, enhancing trust, and resolving conflicts, thereby fostering teamwork and individual growth toward shared goals. Drawing from the success of the COVID-19 vaccine development, we advocate the application of similar collaborative models in other complex health areas such as nanomedicine and biomedical engineering.

Introducing Sulfur in VNi-Layered Double Hydroxide Enables Efficient Electrocatalytic Oxidation of Benzylamine with High Current Densities.

The replacement of the thermodynamically unfavorable anodic oxygen evolution reaction (OER) with a more favorable organic oxidation reaction, such as the anodic oxidation of benzylamine, has garnered significant interest in hybrid water electrolyzer cells. This approach promises the production of value-added chemicals alongside hydrogen fuel generation, improving overall energy efficiency. However, achieving high current density for benzylamine oxidation without interference from OER remains a challenge, limiting the practical efficiency of the electrolyzer cell.

Oral delivery of dihydroartemisinin for the treatment of melanoma via bovine milk exosomes.

Cancer, particularly skin cancer, is a major cause of mortality worldwide, with melanoma being one of the most aggressive and challenging to treat types. Current therapeutic options, such as dacarbazine (DTIC), have limitations due to dose-related toxicities like liver toxicity. Therefore, there is a need for new and effective treatments for melanoma.

Reinvestigating atomic ordering inK0.5Na0.5NbO3and its impact on ferroelectric properties.

In the present work, we reinvestigate the atomic ordering of a Pb-free morphotropic phase boundary (MPB) compositionviz.,K0.5Na0.

An overview of additive manufacturing strategies of enzyme-immobilized nanomaterials with application incatalysis and biomedicine.

Meticulous and bespoke fabrication of structural materials with simple yet innovative outlines along with on-demand availability is the imperative aspiration for numerous fields. The alliance between nanotechnology and enzymes has led to the establishment of an inimitable and proficient class of materials. With the advancement in the field of additive manufacturing, the fabrication of some complex biological architects is achievable with similitude to the instinctive microenvironment of the biological tissue.

Comparative photocatalytic performance of iron nanoparticles biosynthesized from aqueous extracts of potato, potato peels, and leaves.

This study presents an eco-friendly, cost-effective approach for synthesizing highly efficient nanocatalysts with the help of organic waste. Iron nanoparticles (INPs) were synthesized from aqueous extracts of potato, potato peel, and potato leaf and were evaluated for their photocatalytic efficiency for the degradation of methylene blue dye. X-ray Diffraction (XRD) confirmed FeO nanoparticles cubic crystal structure with the smallest crystallite size (9.

A facile approach for the synthesis of solketal, a fuel additive, from biowaste glycerol using transition metal-based solid acid catalysts.

The rise in global biodiesel production leads to the surplus of glycerol as a byproduct, necessitating its industrial application in various chemicals to sustain the biodiesel industry economically. Solketal is one of the value-added chemicals in the biodiesel industry with numerous applications in the food, polymer, and chemical industries and as a fuel additive. Nowadays, researchers mainly focus on synthesizing solketal using biowaste glycerol obtained from the biodiesel industry due to its immense applications.

Deciphering adsorption behaviour and mechanisms of enhanced phosphate removal via optimized cetyltrimethylammonium bromide-modified nanofibrillated cellulose.

To combat the persistent environmental issues resulting from eutrophication, it is necessary to scavenge excess phosphorous levels from aquatic ecosystems. In response, a cationic adsorbent was prepared by modifying agrowaste-derived natural biomacromolecule; nanofibrillated cellulose (NFC) using cetyltrimethylammonium bromide (CTAB) surfactant. Comprehensive characterization through XRD, FTIR, HR-SEM, SEM-EDX, BET and XPS demonstrated that quaternizing NFC significantly improved its surface chemistry by introducing substantial quaternary ammonium groups.

Discovery of novel hybrid tryptamine-rivastigmine molecules as potent AChE and BChE inhibitors exhibiting multifunctional properties for the management of Alzheimer's disease.

Contemporary research evidence has corroborated a gradual loss of central cholinergic neurons in Alzheimer's Disease (AD). This progressive deterioration leads to cognitive dysfunction and impaired motor activity, culminating in the brain cell's death in the disease. The approved drugs for AD treatment can only offer relief from symptoms without addressing the underlying pathological hallmarks of the disease.

Dinuclear Ru(II) Complexes Containing Tetrapyrido[3,2-a : 2,3-c : 3,2-h : 2''',3'''-j]Phenazine Ligand for Biomedical Applications.

Ruthenium complexes are among the most extensively studied and developed luminescent transition-metal complexes for anticancer applications. Dinuclear Ru(II) complexes have caught significant interest for larger size, higher charge, and variable complex shapes. In this concept, we have explored past and recent works on the possible biological applications of versatile tetrapyrido[3,2-a : 2,3-c : 3,2-h : 2''',3'''-j]phenazine (tppz)-based dinuclear Ru(II) complexes with a focus on their use as quadruplex DNA probes, organelle imaging, and phototherapeutic agents.

Isolation and characterization of novel bacterial strain from sewage sludge and exploring its potential for hydrogen production.

Hydrogen (H) energy has garnered significant attention due to its numerous advantages. Nonetheless, for future commercialization, it is imperative to screen and identify strains with enhanced H-producing capacities. In order to attain a high and consistent production performance, the conversion of biomass sources into H requires careful selection of the most appropriate H-producing bacteria.

Curcumin-Derived (3-Aminopropyl)trimethoxysilane-Functionalized Carbon Quantum Dots: A Fluorometric and Colorimetric Nanoprobe for Picric Acid Detection, Antioxidant Activity, and Liposome Encapsulation.

Creating an analytical probe to track extremely mutagenic picric acid (PA) is essential for human health and the environment. Here, we developed a straightforward and quick fluorescence analytical method utilizing 3-aminopropyltrimethoxysilane (3-APTMS)-functionalized curcumin carbon quantum dots (CQDs) for the fast and selective detection of PA. Solvothermal carbonization and functionalization of curcumin with 3-APTMS were used to create multifunctional CQDs, which were then characterized using UV-vis spectroscopy, Fourier transform infrared (FTIR), X-ray diffraction (XRD), ζ-potential, transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS).

Multilevel Resistive Switching Dynamics by Controlling Phase and Self-Assembled Nanochannels in HfO.

A resistive switching device with precise control over the formation of conductive filaments (CF) holds immense potential for high-density memory arrays and atomic-scale in-memory computing architectures. While ion migration and electrochemical switching mechanisms are well understood, controlling the evolution of CF remains challenging for practical resistive random-access memory (RRAM) deployment. This study introduces a systematic approach to modulate oxygen vacancies (OV) in HfO films of Ag/HfO/Pt-based RRAM devices by controlling the substrate temperature.

Molecular Engineering of Ultrabright Biomimetic NanoGhost for Site-Selective Tumor Imaging and Biodistribution.

Optically active ultrabright imaging agents are shown to delineate tumor location with deep tissue visualization in pre noclinical tumor models. NanoGhosts (NGs) particles are reconstructed from the cell membrane and integrated with organic fluorophores to attain ultra-brightness for solid tumor imaging. Moreover, the integration of amphiphilic and lipophilic molecules reveals structural characteristics of NGs (≈70 nm), which also alter their brightness.

Pristine NiMOF Sandwiched between 1D and 3D Engineered Au Particles and Dendrites for Ultraswift Folic Acid Sensing in Cellular Microenvironment.

Catalytic metal-organic frameworks (MOFs)-based sensor matrices can act synergistically with Au metallic nanostructures to generate amplified signal readouts by causing the electro-oxidation of the target analyte. Folic acid (FA), an essential water-soluble vitamin and a precursor for enzymes, requires timely and precise monitoring in the serum of individuals with varying clinical diagnoses. An attempt has been made in this direction through our work, where the rapid detection of FA through its oxidation at metal centers from hybrid nanomaterials is deployed for signal generation.

Strip electrodes: a novel, effective and minimally invasive therapeutic option for correcting DNS electromechanical reshaping.

Deviated nasal septum (DNS) is a common condition affecting nasal breathing, which is generally treated using septoplasty. However, this invasive surgical method carries potential risks of post-surgical complications. Alternatively, electromechanical reshaping (EMR) is a novel method that has evolved as a non-thermal, minimally invasive option to reshape the cartilage using mechanical pressure and direct current (DC) without significant tissue damage.

Molecular Mechanisms of Cell Death in Leishmania donovani Induced by Selected Steroidal Alkaloids.

We have earlier reported novel anti-leishmanial molecules, veratramine and hupehenine, targeting dephospho-coenzyme A kinase of the parasite. In our current investigation, we assessed the efficacy of these two steroidal alkaloids, veratramine and hupehenine, in combating the parasite. Contrary to expectations, our study did not detect the typical signs of apoptosis such as mitochondrial membrane potential loss and phosphatidylserine externalization.

Pharmacological Evaluation of Bakuchiol From Psoralea corylifolia L. as Potent Antimicrobial Agent Against Staphylococcus aureus.

The surge in multidrug resistance in Staphylococcus aureus is the pressing need to identify novel alternatives to combat antimicrobial resistance effectively. Bakuchiol is a bioactive prenylated phenolic meroterpene largely abundant in the seeds of Psoralea corylifolia. In this study, we present the biological assessment of bakuchiol derived from P.