Unravelling viral ecology and evolution over 20 years in a freshwater lake.

As freshwater lakes undergo rapid anthropogenic change, long-term studies reveal key microbial dynamics, evolutionary shifts and biogeochemical interactions, yet the vital role of viruses remains overlooked. Here, leveraging a 20 year time series from Lake Mendota, WI, USA, we characterized 1.3 million viral genomes across time, seasonality and environmental factors.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Designing lysyl hydroxylase inhibitors for oral submucous fibrosis - Insights from molecular dynamics.

Alpha-ketoglutarate (αKG) dependent Lysyl hydroxylase (LH) is a critical enzyme in the post-translational conversion of lysine into hydroxylysine in collagen triple helix and telopeptide regions. Overexpression of LH increases collagen hydroxylation and covalent cross-linkage, causing fibrosis. Currently, no drugs are available to inhibit LH potentially.

Quartz-Enhanced Photoacoustic Spectroscopy-Based Acetone and Ammonia Measurements from Human Breath Near 8 μm Wavelength Band.

Human breath gas analysis is a noninvasive disease diagnostic approach used to identify different pathological conditions in the human body. Monitoring breath acetone (CHO) and ammonia (NH) as biomarkers is vital in diagnosing diabetes mellitus and liver disorders, respectively. In this article, the quartz-enhanced photoacoustic spectroscopy (QEPAS) technique is proposed and demonstrated for measuring CHO and NH in human exhaled breath samples.

Radiomics for differentiating adenocarcinoma and squamous cell carcinoma in non-small cell lung cancer beyond nodule morphology in chest CT.

Distinguishing between primary adenocarcinoma (AC) and squamous cell carcinoma (SCC) within non-small cell lung cancer (NSCLC) tumours holds significant management implications. We assessed the performance of radiomics-based models in distinguishing primary there is from SCC presenting as lung nodules on Computed Tomography (CT) scans. We studied individuals with histopathologically proven adenocarcinoma or SCC type NSCLC tumours, detected as lung nodules on Chest CT.

Deep-learning enabled generalized inverse design of multi-port radio-frequency and sub-terahertz passives and integrated circuits.

Millimeter-wave and terahertz integrated circuits and chips are expected to serve as the backbone for future wireless networks and high resolution sensing. However, design of these integrated circuits and chips can be quite complex, requiring years of human expertise, careful tailoring of hand crafted circuit topologies and co-design with parameterized and pre-selected templates of electromagnetic structures. These structures (radiative and non-radiative, single-port and multi-ports) are subsequently optimized through ad-hoc methods and parameter sweeps.

Uniform dipole resonance and suppressed quadrupole resonance for constant transmittivity full phase control plasmonic metasurfaces.

Transmission-type plasmonic phase metasurfaces utilizing the Pancharatnam-Berry (PB) phase require constant transmittivity with complete phase variation from 0 to 2π. Usually, this is achieved by rotating metallic nanoparticles in an otherwise uniform lattice arrangement. However, this rotation and the chosen lattice structure cause a significant change in the transmittivity, resulting in a lower intensity of light with certain phases and a higher intensity for other phases.

Revolutionizing lung cancer treatment: Introducing PROTAC therapy as a novel paradigm in targeted therapeutics.

This comprehensive review explores the transformative potential of PROTAC (Proteolysis-Targeting Chimeras) therapy as a groundbreaking approach in the landscape of lung cancer treatment. The introduction provides a succinct overview of current challenges in lung cancer treatment, emphasizing the significance of targeted therapies. Focusing on PROTAC therapy, the article elucidates its mechanism of action, comparing it with traditional targeted therapies and highlighting the key components and design principles of PROTAC molecules.

Histopathology-based near-realistic arterial wall reconstruction of a patient-specific cerebral aneurysm for fluid-structure interaction studies.

Background And Objective: Cerebral aneurysms occur as balloon-like outpouchings in an artery, which commonly develop at the weak curved regions and bifurcations. When aneurysms are detected, understanding the risk of rupture is of immense clinical value for better patient management. Towards this, Fluid-Structure Interaction (FSI) studies can improve our understanding of the mechanics behind aneurysm initiation, progression, and rupture.

Microwave catalytic treatment using magnetically separable CoFeO spinel catalyst for high-rate degradation of malachite green dye.

The release of toxic chemical dyes from the industrial effluent poses huge challenges for the environmental engineers to treat it. Azo dyes encompass the huge part of textile discharges which are difficult to degrade due to their complex chemical aromatic structures and due to the presence of strong bonds (-N=N-). Thus, the removal of a carcinogenic azo dye (i.

Computer simulations of entropic cohesion in reversibly crosslinked polymers.

Reversibly crosslinked polymer networks - polymer networks that can undergo bond association and dissociation reactions - rearrange their structures while maintaining their overall integrity, thus resulting in unique properties such as self-healing, reprocessability, shape memory and adaptability. Here, we show that the introduction of crosslinks, whether reversible or permanent, directly impacts the equilibrium polymer density and hence the material's surface tension. For a limiting case where the bonds are the same size as the polymer chain bonds, simulations, Flory hypotheses and thermodynamic calculations show that the crosslinks induce an increased entropic cohesion in the liquid.

Selective photoreduction of carbon dioxide to formic acid using CsBiCl-Ir/IrO hybrid materials.

Tuning the selectivity and improving the activity of photocatalysts are among the main bottlenecks for the conversion of CO to value-added chemicals. Recently, lead-free halide perovskites have been extensively investigated as photocatalysts for the photoreduction of CO. Herein, we report a composite photocatalyst using CsBiCl and Ir/IrO for the photoreduction of CO.

Causal contextual bandits with one-shot data integration.

We study a contextual bandit setting where the agent has access to causal side information, in addition to the ability to perform multiple targeted experiments corresponding to potentially different context-action pairs-simultaneously in one-shot within a budget. This new formalism provides a natural model for several real-world scenarios where parallel targeted experiments can be conducted and where some domain knowledge of causal relationships is available. We propose a new algorithm that utilizes a novel entropy-like measure that we introduce.

Photophysical behavior of meso-N-butylcarbazole-substituted BODIPY in different nano-scale organized media.

The present work focuses on the photophysical behavior of meso-N-butylcarbazole-substituted BODIPY (CBZ-BDP) in different organized media towards exploring the possible use of the dye as a molecular sensor and imaging agent. The molecule shows an appreciable change in absorption and emission spectra at 75% water-acetonitrile mixture compared to pure acetonitrile. In water-acetonitrile mixture, it displays aggregate-induced emission (AIE) bands.

Effects of Congestion in Human Lung Investigated Using Dual-Scale Porous Medium Models.

Chronic obstructive pulmonary disease (COPD) is a primary chronic respiratory disease associated with pulmonary congestion that restricts airflow and thereby affects the exchange of gases between the alveoli and the blood capillaries in the lungs. Dual scale-global and local-porous medium models have been developed and reported in this work, to study the effects of air-side congestion on the blood-oxygen content in the alveolar region of the human lung. The human lung is model as a global, equivalent, heterogeneous porous medium comprising three zones with distinct permeabilities related to their progressively complex branching structure.

Diet-Modifiable Redox Alterations in Ageing and Cancer.

With ageing comes some of life's best and worst moments. Those lucky enough to live out into the seventh, eighth, and nineth decades and perhaps beyond have more opportunities to experience the wonders and joys of the world. As the world's population shifts towards more and more of these individuals, this is something to be celebrated.

Metal Nanoclusters for Interface Engineering and Improved Photovoltaic Performance in Organic Solar Cells.

Copper nanoclusters (Cu NCs), synthesized by a one-pot synthesis method, were theoretically shown to exhibit a dipole moment and cause work function modification on a surface as observed from Kelvin probe measurement. Here, Cu NCs were used as an interfacial modifier in organic solar cells (OSCs). The effective engineering of the electron transporting layer/active layer interface using Cu NCs resulted in improved photovoltaic performance in fullerene and non-fullerene based OSCs.

A Pair of Dinuclear Fe(II) Enantiomers: Syntheses and Structures of ΛΔ/ΔΛ-Bis(Dihydridoborate) Complexes.

In our effort to establish a direct synthetic approach for bis(dihydridoborate) complexes of first-row transition metals, we have investigated the reactivity of [Cp*Fe(dppe)Cl] (dppe =1,2-bis(diphenylphosphino)ethane) with Na[BHL] (L =2-mercaptopyridine (mp) and 2-mercaptobenzothiazole (mbz)) that led to the formation of iron(II) dihydridoborate complexes, [Cp*Fe{κ-S,H,H-(HBH(L))}] 1 a-b (L=mp (1 a) and L=mbz (1 b)). Further, in an attempt to isolate the bis(dihydridoborate) complex of iron by the insertion of borane into the κ-N,S-chelated iron complex, [(dppe)Fe{κ-N,S-(mp)}] (2), we have isolated and structurally characterized a rare example of dimeric iron bis(dihydridoborate) complex, [Fe{κ-S,H,H-(HBH(mp))}], ΛΔ/ΔΛ-3 as pair of enantiomers. Interestingly, these enantiomers ΛΔ/ΔΛ-3 have two trans-[Fe{κ-S,H,H-(HBH(mp))}] moieties bridged through sulfur atoms of 2-mercaptopyridinyl ligands, where the iron centres are hepta-coordinated.

Oligomerization-mediated phase separation in the nucleoid-associated sensory protein H-NS is controlled by ambient cues.

H-NS, a nucleoid-associated protein (NAP) from enterobacteria, regulates gene expression by dynamically transducing environmental cues to conformational assembly and DNA binding. In this work, we show that H-NS from Escherichia coli, which can assemble into octameric and tetrameric oligomerization states, forms spontaneous micron-sized liquid-like condensates with DNA at sub-physiological concentrations in vitro. The heterotypic condensates are metastable at 298 K, partially solubilizing with time, while still retaining their liquid-like properties.

The theragnostic advances of exosomes in managing leukaemia.

Leukaemia, a group of haematological malignancies, presents ongoing diagnosis, prognosis, and treatment challenges. A major obstacle in treating this disease is the development of drug resistance. Overcoming drug resistance poses a significant barrier to effective leukaemia treatment.

A generalized model for predicting different morphologies of bacterial swarming on a porous solid surface.

In this study, we develop a comprehensive two-phase model to analyze the dynamics of bacterial swarming on porous substrates. The two distinct phases under consideration are the cell and aqueous phases. We use the thin-film approximation, as the characteristic height of the swarm is significantly lower than its characteristic radius.

Facile control of giant green-emission in multifunctional ZnO quantum dots produced in a single-step process: femtosecond pulse ablation.

Controlling both UV and visible emissions in ZnO quantum dots (QDs) poses a significant challenge due to the inherent introduction of defects during the growth process. We have refined the photoluminescence (PL) emission characteristics of ZnO QDs through a single-step, reagent-free femtosecond pulsed laser ablation in liquid (fs-PLAL) technique. The ratio of the near band edge (NBE) to deep-level emission (DLE), which determines the shape of the QDs' optical emission spectrum, is precisely controlled by the ablation laser pulse parameters-namely, pulse energy and temporal duration.

Facile preparation of solid gelatin foams by a water-lean batch foaming process.

Existing polystyrenic and polyolefinic packaging foams are non-biodegradable, and persist in the environment for hundreds of years. Gelatin foams are an interesting alternative, given their biodegradability, biocompatibility, solution-based processability, low cost, and non-toxicity. However, current methods for preparing gelatin foams, such as freeze-drying, microfluidic foaming, and batch foaming, are not suitable for high-volume production.

Advanced synthetic aperture technique to enhance image quality in ultrasound elastography: A novel strategy.

Quasi-static elastography (QSE) is a well-established technique used in medical imaging, where ultrasound data is collected both, before and after applying a slight compression on a tissue. This data is then analyzed to create image frames that reveal the stiffness parameter of the underlying tissue medium. Previous studies have focused on assessing how the Conventional Focused Beam (CFB) transmit method impacts the ultrasound elastography image quality.