A review on digital transformation in healthcare waste management: Applications, research trends and implications.

At present, both emerging and developed economies have faced the challenge of higher healthcare waste generation. Developed countries are using these technologies to manage healthcare waste and cope with the challenge. Emerging economies are still struggling to understand and implement digital technologies in healthcare waste management, posing a danger to partners handling toxic and hazardous waste.

Low-Cost, High-Efficiency Aluminum Zinc Oxide Synaptic Transistors: Blue LED Stimulation for Enhanced Neuromorphic Computing Applications.

Neuromorphic devices are electronic devices that mimic the information processing methods of neurons and synapses, enabling them to perform multiple tasks simultaneously with low power consumption and exhibit learning ability. However, their large-scale production and efficient operation remain a challenge. Herein, we fabricated an aluminum-doped zinc oxide (AZO) synaptic transistor via solution-based spin-coating.

Efficient synthesis of indole-chalcones based glycohybrids and their anticancer activity.

Indole based glycosides belong to the class of pharmacologically active molecules and found in diverse natural compounds. Herein, we report the synthesis of 1,2,3-triazole bridged chirally enriched diverse indole-chalcones based glycohybrids. Three series of glycohybrids were designed and efficiently synthesized using d-glucose, d-galactose and d-mannose derived 1-azido glycosides.

An Aqueous Route to Oxygen-Deficient Wake-Up-Free La-Doped HfO Ferroelectrics for Negative Capacitance Field Effect Transistors.

The crucial role of nanocrystalline morphology in stabilizing the ferroelectric orthorhombic (o)-phase in doped-hafnia films is achieved via chemical solution deposition (CSD) by intentionally retaining carbonaceous impurities to inhibit grain growth. However, in the present study, large-grained (>100 nm) La-doped HfO (HLO) films are grown directly on silicon by adopting engineered water-diluted precursors with a minimum carbonaceous load and excellent shelf life. The o-phase stabilization is accomplished through a well-distributed La dopant, which generates uniformly populated oxygen vacancies, eliminating the need for oxygen-scavenging electrodes.

Se-Vacancy Healing with Substitutional Oxygen in WSe for High-Mobility p-Type Field-Effect Transistors.

Transition-metal dichalcogenides possess high carrier mobility and can be scaled to sub-nanometer dimensions, making them viable alternative to Si electronics. WSe is capable of hole and electron carrier transport, making it a key component in CMOS logic circuits. However, since the p-type electrical performance of the WSe-field effect transistor (FET) is still limited, various approaches are being investigated to circumvent this issue.

NASICON-structured NaFePO(SO): a potential cathode material for rechargeable sodium-ion batteries.

The cost-effective and abundant availability of sodium offers an opportunity for rechargeable Na-ion batteries as an ideal replacement for rechargeable Li-ion batteries. However, the larger size and strong Na-Na interaction create multidimensional phase instability and transformation problems, especially in layer-structured NaMO (Mn, Co, Fe, and Ni) that inhibit the direct transformation of rechargeable Li-ion battery technology to Na-ion batteries. However, framework structures offer superior structural stability due to the interconnection of polyanions or polyhedra forming cationic octahedra.

Modeling the blockchain readiness challenges for product recovery system.

Product Recovery System (PRS) transfers products from their typical final place to their source to arrest some value on the product. There are obstructions, such as costs, associated with the modification of accounts and assessment of products and refunds associated with the implementation of PRS. Blockchain Technology (BCT) emerged as an innovative approach to constructing trust in a trust less environment and assures the availability, traceability, and security in data management.

CycleGAN for interpretable online EMT compensation.

Purpose: Electromagnetic tracking (EMT) can partially replace X-ray guidance in minimally invasive procedures, reducing radiation in the OR. However, in this hybrid setting, EMT is disturbed by metallic distortion caused by the X-ray device. We plan to make hybrid navigation clinical reality to reduce radiation exposure for patients and surgeons, by compensating EMT error.

Evaluation of seasonal variation and the optimization of reducing sugar extraction from Ulva prolifera biomass using thermochemical method.

Green macroalgae comprise significant amount of structural carbohydrates for their conversion to liquid biofuels. However, it generally relies on species characteristics and the variability in seasonal profile to determine its route for bioprocessing. Hence, this study was conducted to analyze the indigenous marine macroalgal strain (Ulva prolifera) with respect to periodic trend and reducing sugar extraction.

The molecular mechanism of vernalization in Arabidopsis and cereals: role of Flowering Locus C and its homologs.

Winter varieties of plants can flower only after exposure to prolonged cold. This phenomenon is known as vernalization and has been widely studied in the model plant Arabidopsis thaliana as well as in monocots. Through the repression of floral activator genes, vernalization prevents flowering in winter.

Cardenolide and pregnatriene compounds from the roots of .

Cardenolide and pregnatriene compounds were isolated from the chloroform fraction of the 95% aqueous ethanolic extract of dried roots of . The stereochemical structure of the cardenolide and pregnatriene compounds was determined to be 3β--(D-diginosyl)-14β-hydroxy card-20(22)-enolide and 12β-hydroxy pregna-4,6,16-triene-3,20-dione using spectroscopic methods including IR, HRMS and NMR spectroscopy.

Activation of µ-δ opioid receptor heteromers inhibits neuropathic pain behavior in rodents.

Several reports support the idea that µ- and δ-opioid receptors (ORs) may exist as heterodimers in brain regions involved in pain signaling. The unique pharmacology of these heteromers may present a novel analgesic target. However, the role of µ-δ heteromers in sensory neurons involved in pain and opioid analgesia remains unclear, particularly during neuropathic pain.

Raman spectroscopic study of ZnO/NiO nanocomposites based on spatial correlation model.

The effect of nickel concentration has been investigated in ZnO/NiO nanocomposites synthesized using the co-precipitation method. The X-ray diffraction and TEM measurements confirm the distinct phase of NiO in the ZnO/NiO samples. Furthermore, the Raman study shows the sharp modes at 99 cm and 438 cm corresponding to E , E of hexagonal wurtzite ZnO structure and, 1080 cm associated to the two-phonon (2P) mode of NiO, respectively.

Antibiofilm Potential of Silver Sulfadiazine-Loaded Nanoparticle Formulations: A Study on the Effect of DNase-I on Microbial Biofilm and Wound Healing Activity.

Biofilm resistance is one of the severe complications associated with chronic wound infections, which impose extreme microbial tolerance against antibiotic therapy. Interestingly, deoxyribonuclease-I (DNase-I) has been empirically proved to be efficacious in improving the antibiotic susceptibility against biofilm-associated infections. DNase-I hydrolyzes the extracellular DNA, a key component of the biofilm responsible for the cell adhesion and strength.

Alginate lyase immobilized chitosan nanoparticles of ciprofloxacin for the improved antimicrobial activity against the biofilm associated mucoid P. aeruginosa infection in cystic fibrosis.

Dense colonization of mucoid Pseudomonas aeruginosa within the self-secreted extracellular matrix (mainly alginate), called biofilm, is a principal reason for the failure of antimicrobial therapy in cystic fibrotic patients. Alginate is a key component in the biofilm of mucoid P. aeruginosa and responsible for surface adhesion and stabilization of biofilm.

Gene expression profiling of spontaneously occurring canine mammary tumours: Insight into gene networks and pathways linked to cancer pathogenesis.

Spontaneously occurring canine mammary tumours (CMTs) are the most common neoplasms of unspayed female dogs leading to thrice higher mortality rates than human breast cancer. These are also attractive models for human breast cancer studies owing to clinical and molecular similarities. Thus, they are important candidates for biomarker studies and understanding cancer pathobiology.

Formulation, optimization, hemocompatibility and pharmacokinetic evaluation of PLGA nanoparticles containing paclitaxel.

Objective: Paclitaxel (PTX)-loaded polymer (Poly(lactic-co-glycolic acid), PLGA)-based nanoformulation was developed with the objective of formulating cremophor EL-free nanoformulation intended for intravenous use.

Significance: The polymeric PTX nanoparticles free from the cremophor EL will help in eliminating the shortcomings of the existing delivery system as cremophor EL causes serious allergic reactions to the subjects after intravenous use.

Methods And Results: Paclitaxel-loaded nanoparticles were formulated by nanoprecipitation method.

Exploring temple floral refuse for biochar production as a closed loop perspective for environmental management.

Religious faith and ritual activities lead to significant floral offerings production and its disposal as waste to the nearby open lands and water bodies. These activities result into various social and environmental nuisances because of their high organic content. Alternatively, it can be used as valuable resources for various biochemical and thermo-chemical processes.

Implication of linker length on cell cytotoxicity, pharmacokinetic and toxicity profile of gemcitabine-docetaxel combinatorial dual drug conjugate.

The present study investigates effect of linkers [zero length (without linker), short length linker (glycine and lysine) and long length linker (PEG1000, PEG2000 and PEG3500)] on pharmacokinetics and toxicity of docetaxel (DTX) and gemcitabine (GEM) bio-conjugates. Conjugates were synthesized via carbodiimide chemistry and characterized by H NMR and FTIR. Conjugation of DTX and GEM via linkers showed diverse physiochemical and plasma stability profile.

Application of nanocarrier-based drug delivery system in treatment of oral cancer.

Oral cancer includes cancer of lips, oral cavity and oropharynx. Oral cancer is the sixth most life-threatening disease affecting 65% of population. The delivery of cytotoxic chemotherapeutic anticancer drugs is a challenging task due to unfavorable properties.

Emerging trends in photodegradation of petrochemical wastes: a review.

Various human activities like mining and extraction of mineral oils have been used for the modernization of society and well-beings. However, the by-products such as petrochemical wastes generated from such industries are carcinogenic and toxic, which had increased environmental pollution and risks to human health several folds. Various methods such as physical, chemical and biological methods have been used to degrade these pollutants from wastewater.