Understanding flux switching in metabolic networks through an analysis of synthetic lethals.

Biological systems are robust and redundant. The redundancy can manifest as alternative metabolic pathways. Synthetic double lethals are pairs of reactions that, when deleted simultaneously, abrogate cell growth.

A comprehensive review of 3D cancer models for drug screening and translational research.

The 3D cancer models fill the discovery gap of 2D cancer models and play an important role in cancer research. In addition to cancer cells, a range of other factors include the stroma, density and composition of extracellular matrix, cancer-associated immune cells (e.g.

Molecular Property Diagnostic Suite for COVID-19 (MPDS): an open-source disease-specific drug discovery portal.

Unlabelled: Molecular Property Diagnostic Suite (MPDS) was conceived and developed as an open-source disease-specific web portal based on Galaxy. MPDS was developed for COVID-19 as a one-stop solution for drug discovery research. Galaxy platforms enable the creation of customized workflows connecting various modules in the web server.

Selective Targeting of Lung Cancer Cells with Methylparaben-Tethered-Quinidine Cocrystals in 3D Spheroid Models.

The development and design of pharmaceutical cocrystals for various biological applications has garnered significant interest. In this study, we have established methodologies for the growth of the methylparaben-quinidine cocrystal (MP-QU), which exhibits a well-defined order that favors structure-property correlation. To confirm the cocrystal formation, we subjected the cocrystals to various physicochemical analyses such as powder X-ray diffraction (PXRD), single-crystal X-ray diffraction (SCXRD), Raman, and IR spectroscopy.

StressNet: a spatial-spectral-temporal deformable attention-based framework for water stress classification in maize.

In recent years, monitoring the health of crops has been greatly aided by deploying highthroughput crop monitoring techniques that integrate remotely captured imagery and deep learning techniques. Most methods rely mainly on the visible spectrum for analyzing the abiotic stress, such as water deficiency in crops. In this study, we carry out experiments on maize crop in a controlled environment of different water treatments.

Palladium-Catalyzed [3 + 2] Annulation of Substituted Iodoarenes with Maleimides via a Consecutive Double Heck-type Strategy.

Herein, we report an efficient [3 + 2] annulation of -substituted iodoarenes with maleimides a palladium-catalyzed consecutive double Heck-type strategy, leading to fused tricyclic frameworks of pharmaceutical relevance. The protocol ensued through consecutive inter- and intramolecular Heck couplings effectively. This approach was compatible with a large variety of substrates and functional groups, and it was remarkably tolerated with unprotected maleimide.

A TBADT photocatalyst-enabled radical-induced cyclization pathway to access functionalized dihydrobenzofurans.

Herein, this work describes a photoinduced visible light-mediated radical cyclization for constructing dihydrobenzofuran (DHB) scaffolds. Notably, this cascade photochemical process is tolerable with various aromatic aldehydes and diverse alkynyl aryl ethers and proceeds an intramolecular 1,5-hydrogen atom transfer (HAT) pathway. Significantly, acyl C-H activation under mild conditions has been achieved without the use of additives or reagents.

Accounting of the Use and Emissions of Polychlorinated Biphenyl Compounds (PCBs) in India, 1951-2100.

Polychlorinated biphenyl compounds (PCBs) are highly toxic organic chemicals still prevalent in the environment. While global inventories of the use and emissions of PCBs have been developed, estimates for individual countries determined using bottom-up approaches are few and often show different trends from the global inventory. Here, we determine the past, present, and future consumption and emissions of PCBs in India.

Skyrmion based 3D low complex runtime reconfigurable architecture design methodology of universal logic gate.

In this study, we introduce the area efficient low complex runtime reconfigurable architecture design methodology based on Skyrmion logic for universal logic gate (ULG) i.e. NOR/NAND implementation using micromagnetic simulations.

Intermolecular Sonogashira Coupling and Intramolecular 5-- Cycloisomerization Cascade: A One-Pot Pathway for Accessing (3-Benzylbenzofuran-2-yl)(phenyl)methanones.

Herein, we present an efficient and straightforward strategy enabling access to 2,3-disubstituted benzo[]furans. The whole synthetic process proceeds a domino intermolecular Sonogashira coupling of 2-(2-bromophenoxy)-1-phenylethan-1-ones/alkyl 2-(2-bromophenoxy)acetates/2-(2-bromophenoxy)acetonitrile/1-(2-bromophenoxy)propan-2-one with terminal acetylenes followed by an intramolecular carbanion-yne cyclization in a 5-- manner and subsequent double-bond isomerization. Notably, two C-C bonds have been constructed in a one-pot manner and a wide variety of (3-benzylbenzofuran-2-yl)(phenyl)methanones were accomplished with good functional group tolerance.

Lignin Residue-Derived Carbon-Supported Nanoscale Iron Catalyst for the Selective Hydrogenation of Nitroarenes and Aromatic Aldehydes.

Heterogeneous iron-based catalysts governing selectivity for the reduction of nitroarenes and aldehydes have received tremendous attention in the arena of catalysis, but relatively less success has been achieved. Herein, we report a green strategy for the facile synthesis of a lignin residue-derived carbon-supported magnetic iron (γ-FeO/LRC-700) nanocatalyst. This active nanocatalyst exhibits excellent activity and selectivity for the hydrogenation of nitroarenes to anilines, including pharmaceuticals (e.

Mercury in the Environment Around Industrially Impacted Locations in India: A Mini-Review.

India is a major emitter of mercury to the environment. This mini-review condenses the information available since 2008 on mercury in air, soil, sediment, biota and human biomarkers near industrial locations. Information from eight regions was analyzed.

A Hybrid Bipolar Active Charge Balancing Technique with Adaptive Electrode Tissue Interface (ETI) Impedance Variations for Facial Paralysis Patients.

Functional electrical stimulation (FES) is a safe, effective, and general approach for treating various neurological disorders. However, in the case of FES usage for implantable applications, charge balancing is a significant challenge due to variations in the fabrication process and electrode tissue interface (ETI) impedance. In general, an active charge balancing approach is being used for this purpose, which has limitations of additional power consumption for residual voltage calibration and undesired neurological responses.

Modelling the pedestrian dilemma zone at uncontrolled midblock sections.

Introduction: Pedestrians at high-speed midblock crossings with the intention to cross the road usually face safety risks due to difficulty in judging the available gaps. The risk to pedestrians is high in developing nations like India since priorities are not respected by road users. Moreover, the non-yielding vehicular traffic puts pedestrians at further risk.

Unsaturated Sulfur Crown Ethers Can Extract Mercury(II) and Show Promise for Future Copernicium(II) Studies: A Combined Experimental and Computational Study.

The unsaturated hexathia-18-crown-6 (UHT18C6) molecule was investigated for the extraction of Hg(II) in HCl and HNO media. This extractant can be directly compared to the recently studied saturated hexathia-18-crown-6 (HT18C6). The default conformation of the S lone pairs in UHT18C6 is endodentate, where the pocket of the charge density, according to the crystal structures, is oriented toward the center of the ring, which should allow better extraction for Hg(II) compared to the exodentate HT18C6.

Modelling work- and non-work-based trip patterns during transition to lockdown period of COVID-19 pandemic in India.

COVID-19 pandemic has significantly affected the transportation sector across the world. Implementation of lockdown (that includes restricted travel activities) is a prevention strategy executed by various governments to minimize the spread of COVID-19. India went into complete lockdown from 25th March 2020; however, change in commuter's travel behavior was observed from the third week of March (termed as transition to lockdown) due to pandemic fear.

Portable X-ray Fluorescence as a Rapid Determination Tool to Detect Parts per Million Levels of Ni, Zn, As, Se, and Pb in Human Toenails: A South India Case Study.

Chronic exposure to inorganic pollutants adversely affects human health. Inductively coupled plasma mass spectrometry (ICP-MS) is the most common method used for trace metal(loid) analysis of human biomarkers. However, it leads to sample destruction, generation of secondary waste, and significant recurring costs.

Impact of physical distancing due to novel coronavirus (SARS-CoV-2) on daily travel for work during transition to lockdown.

The outbreak of COVID-19 pandemic has resulted in change in both commute and personal travel patterns. Though, in India, lockdown was implemented from 25th March 2020, due to self-awareness and pandemic risk perception, change in commuter behavior was observed from the beginning of March 2020. The period from 15th to 24th March 2020 is considered as the transition phase of COVID-19 outbreak in India (i.

Lewis Acid Mediated Domino Intramolecular Cyclization: Synthesis of Dihydrobenzo[]fluorenes.

An efficient and facile method for the regioselective synthesis of novel dihydrobenzo[]fluorenes from readily accessible alkynols is presented. The current strategy triggers the formation of a dual C-C bond intramolecularly via Lewis acid catalysis under mild reaction conditions. Notably, secondary as well as tertiary alcohols bearing an alkyne moiety have been smoothly transformed into the corresponding products.

Development of robust, ultra-smooth, flexible and transparent regenerated silk composite films for bio-integrated electronic device applications.

Regenerated Silk Fibroin (RSF) films are considered promising substrate candidates primarily in the field of bio-integrated electronic device applications. The key issues that ought to be addressed to exploit the inherent advantages of silk thin films include enhancing their flexibility and chemical durability. Such films find a plethora of applications, the significant one being conformal, transparent microelectrode arrays.

Mercury in skin-care products in India and consumer exposure risks.

We report concentrations of mercury in skin-care products in India and the associated health risks. Mercury concentrations were 0.11 μg/kg (median; 5th percentile-95th percentile = 0.

Photocatalytic Visible-Light-Induced Nitrogen Insertion via Dual C(sp)-H and C(sp)-H Bond Functionalization: Access to Privileged Imidazole-based Scaffolds.

Here we have demonstrated a visible-light-mediated metal-free organic-dye-catalyzed dehydrogenative N-insertion leading to highly substituted imidazoles and privileged dihydroisoquinoline-based imidazole derivatives via C(sp)-H and C(sp)-H bond functionalization. A sustainable, convenient, metal-free azidation/C-H aminative cyclization approach in the absence of stoichiometric oxidants is presented. This protocol involves a rare photoinduced iminyl radical as a key intermediate for the "N" insertion.

Curcumin-Loaded Nanostructure Hybrid Lipid Capsules for Co-eradication of Breast Cancer and Cancer Stem Cells with Enhanced Anticancer Efficacy.

Co-eradication of cancer stem cells (CSCs) along with cancer cells have emerged as an immediate necessity to combat the rapid progression, therapeutic resistance, and relapse of cancer. Curcumin (CMN) has been well established for anticancer activity against a variety of cancers with an ability to eliminate CSCs. In spite of its extensive therapeutic potential, clinical applicability is impeded due to its highly hydrophobic nature.

Modulated Linear Tellurium Chains in BaScTe: Synthesis, Crystal Structure, Optical and Resistivity Studies, and Electronic Structure.

A new ternary telluride, BaScTe, with a pseudo-one-dimensional structure, was synthesized at 1173 K by standard solid-state methods. A single-crystal X-ray diffraction study at 100(2) K shows the structure to be modulated. The structure of the subcell of BaScTe crystallizes with two formula units in the hexagonal space group -6/ with unit cell dimensions of = = 10.

Nanomagnetic logic based runtime Reconfigurable area efficient and high speed adder design methodology.

In this study, we present a runtime reconfigurable nanomagnetic (RRN) adder design offering significant area efficiency and high speed operations. Subsequently, it is implemented using a micromagnetic simulation tool, by exploiting the reversal magnetization and energy minimization nature of the nanomagnets. We compute the carry and sum of the 1-bit full adder using only two majority gates comprising a total of 7 nanomagnets and single design layout.