Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity.

Piperazine derivatives were screened using the ChEMBL database, paving the way for the design, synthesis, and evaluation of a novel series of dual COX-2/5-LOX inhibitors and identifying their role in mitigating cancer cell proliferation. Compound 9d with 4-Cl substitution at the terminal phenyl ring showed promising inhibition of COX-2 (IC = 0.25 ± 0.

Effect of Mndoping and DDAB-assisted postpassivation on the structural and optical properties of CsPb(Cl/Br)halide perovskite nanocrystals.

Cesium lead halide perovskite (CsPbX; X = Cl, Br, I) nanocrystals showing intense band-edge emission and high photoluminescence quantum yield are known to be a potential candidate for application in optoelectronic devices. However, controlling toxicity due to the presence of Pbin lead-based halide perovskites is a major challenge for the environment that needs to be tackled cautiously. In this work, we have partially replaced Pbwith Mnions in the CsPb(Cl/Br)nanocrystals and investigated their impact on the structural and optical properties.

Design, synthesis, and biological evaluation of 3,3'-diindolylmethane -linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity.

Leishmaniasis, one of the neglected diseases, ranks second to malaria in the cause of parasitic mortality and morbidity. The present chemotherapeutic regimen faces the limitations of drug resistance and toxicity concerns, raising a great need to develop new chemotherapeutic leads that are orally administrable, potent, non-toxic, and cost-effective. Several research groups came forward to fill this therapeutic gap with new classes of active compounds against leishmaniasis, one such being 3,3'-diindolylmethane (DIM) derivatives.

Impact of crystal structure on optical properties and temperature sensing behavior of NaYF:Yb/Er nanoparticles.

We report a comprehensive study of the structural, morphological, and optical properties, and UC-based ratiometric temperature sensing behavior of (α) cubic and (β) hexagonal phases of NaYF:Yb/Er nanoparticles. The α-NaYF:Yb/Er and β-NaYF:Yb/Er nanoparticles were synthesized using co-precipitation and hydrothermal methods, respectively. Powder X-ray diffraction studies confirmed the phase purity of the samples.

Morphological dependent exciton dynamics and thermal transport in MoSe films.

Thermal transport and exciton dynamics of semiconducting transition metal dichalcogenides (TMDCs) play an immense role in next-generation electronic, photonic, and thermoelectric devices. In this work, we synthesize distinct morphologies (snow-like and hexagonal) of a trilayer MoSe film over the SiO/Si substrate the chemical vapor deposition (CVD) method and investigated their morphological dependent exciton dynamics and thermal transport behaviour for the first time to the best of our knowledge. Firstly, we studied the role of spin-orbit and interlayer couplings both theoretically as well as experimentally first-principles density functional theory and photoluminescence study, respectively.

Enhancing the temperature sensing property of a CaBiErYbMoO phosphor local symmetry distortion and reduction in non-radiative channels.

We demonstrate an enhancement in the upconversion (UC) emission and temperature sensing property of a CaMoO:Er/Yb phosphor distortion of the local symmetry environments and reduction in no-radiative channels. Bi ion co-doping creates a local distortion while the average tetragonal structure of CaMoO remains intact. This creates asymmetry around the Er ions which improves the UC emission.

Effect of Cr doping on structural and optical properties of Eu doped LaVO phosphor.

In this work, the Eu, Cr doped and co-doped LaVO phosphors have been prepared through a high temperature solid-state reaction method. The powder XRD patterns of phosphors are very sharp and intense, which reflects a highly crystalline nature of phosphors. The XRD data were also refined by a Rietveld refinement method.

Cd-doped AgO/BiVO visible light Z-scheme photocatalyst for efficient ciprofloxacin degradation.

Foreign element doping can produce new photocatalysts with different band edge positions and adsorption properties. A composite of such a doped semiconductor with another component should enhance its photocatalytic properties towards a target substrate. The present investigation used a simple hydrothermal protocol to prepare Cd-doped AgO nanoparticles.

Temperature sensing using bulk and nanoparticles of CaErYbMoOphosphor.

Optical temperature sensing is widely realized by using upconversion (UC) emission in lanthanide-doped phosphors. There are various parameters that are responsible for UC intensity of the phosphor like particle shape and size, type of symmetry that exist at the site position, distribution of lanthanide ions in the phosphor, and so on. However, a comparative study of the bulk and nanostructure on the temperature sensing ability of such phosphor is rare.

Reinforcement of nanoporous lanthanum-doped zinc borate by vanadium selenide nanosheets for improved tribological activity.

Nanoporous zinc borate (ZB) and 10% lanthanum-doped porous zinc borate (LZB) were synthesized to explore the role of porosity and doping in zinc borate during lubrication. HR-SEM, TEM, and HR-TEM authenticated nanoporous structures. The tribological properties of their blends with paraffin oil (PO) were compared by employing ASTM D4172 and ASTM D5183 norms on a four-ball tester.

Electro-mechanical and Polarization-Induced Antibacterial Response of 45S5 Bioglass-Sodium Potassium Niobate Piezoelectric Ceramic Composites.

Besides the excellent osteoconductivity and biocompatibility of 45S5 bioglass (BG), poor mechanical and electrical properties as well as susceptibility toward bacterial adhesion limit its widespread clinical applications. In this context, the present study investigates the effect of addition of piezoelectric sodium potassium niobate (NaKNbO; NKN) on mechanical, dielectric, and antibacterial response of BG. BG-NKN ( = 0, 10, 20, and 30 vol%) composites were synthesized at 800 °C for 30 min.

Robust spin-ice freezing in magnetically frustrated HoGeTiOpyrochlore.

Structural analysis of spin frustrated HoGeTiO(= 0, 0.1, 0.15 & 0.

Tetrahydropyrazolopyridines as antifriction and antiwear agents: experimental and DFT calculations.

Some tetrahydropyrazolopyridines (THPP-H) with the methoxy (THPP-OMe) and methyl (THPP-Me) substituents were synthesized by a one-pot multi-component reaction. NMR spectroscopy (H and C) was used to authenticate the synthesis. According to the results of tribological tests ASTM D4172, and ASTM D5183 on a four-ball tester in paraffin oil (PO) at a concentration of 0.

Challenges and opportunities in the recovery of gold from electronic waste.

Rapid global technological development has led to the rising production of electronic waste that presents both challenges and opportunities in its recycling. In this review, we highlight the value of metal resources in the printed circuit boards (PCBs) commonly found in end-of-life electronics, the differences between primary (ore) mining applications and secondary ('urban') mining, and the variety of metallurgical separations, in particular those that have the potential to selectively and sustainably recover gold from waste PCBs.

Probing structural transformation and optical and magnetic properties in Cr doped GdMnO: Jahn-Teller distortion, photoluminescence and magnetic switching effect.

The systematic evolution of structure, photoluminescence and different magnetic transitions in GdMnO is reported after Cr doping. With increasing the Cr concentration from 10 to 40 at%, Rietveld refinement of X-ray diffraction patterns demonstrates that an O' type orthorhombic structure transforms to O type, manifesting a reduction in lattice volume. The noticeable reduction in lattice volume is ascribed to the smaller size of the Cr ion compared to Mn.

Ag-Cu Bimetallic Nanoparticles as Efficient Oxygen Reduction Reaction Electrocatalysts in Alkaline Media.

The alkaline medium oxygen reduction reaction (ORR) activities of Ag-Cu bimetallic nanoparticles (BNPs), consisting of neighboring Ag and Cu domains, were studied and compared with those of pure Ag and Cu nanoparticles prepared by the same polyol route. Three variations of Ag-Cu BNPs viz. Ag-Cu (4:1), Ag-Cu (2:1), Ag-Cu (1:1) BNPs were considered.

Retracted Article: A bio-based piezoelectric nanogenerator for mechanical energy harvesting using nanohybrid of poly(vinylidene fluoride).

A bio-based piezoelectric egg shell membrane (ESM) is used for energy harvesting applications in the form of two and three-component nanohybrids. A bio-waste piezo-filler in a piezoelectric polymer matrix was designed through an induced β-phase nucleation in the matrix using an organically modified two-dimensional nanoclay. Structural alteration (α to β-phase) in the presence of the nanoparticles was also manifested by morphological changes over spherulite to a needle-like morphology; thus, these nanohybrid materials are suitable for energy harvesting applications.

Multiple 3D-QSAR modeling, e-pharmacophore, molecular docking, and study to explore novel AChE inhibitors.

Ligand-based and energy-optimized structure-based approaches were considered to obtain excellent candidates as AChE inhibitors. The known AChE inhibitors were utilized to develop a pharmacophore hypothesis, HPRRR and X-ray crystallographic structures of AChE were used to produce three e-pharmacophore hypotheses . AHHRR, AHRR, and DHRR.

Effect of Bi ion on upconversion-based induced optical heating and temperature sensing characteristics in the Er/Yb co-doped LaO nano-phosphor.

The upconversion-based optical heating and temperature sensing characteristics are investigated in the Er/Yb/Bi tri-doped LaO nano-phosphor synthesized through a solution combustion method. The structural measurements reveal an increase in lattice parameters and particles size of the phosphor on increasing the concentrations of Bi ions. The energy dispersive spectroscopic (EDS) measurements confirm the presence of La, Er, Yb, Bi and O elements in the tri-doped phosphor.

Effect of cold working on biocompatibility of Ni-free high nitrogen austenitic stainless steels using Dalton's Lymphoma cell line.

The aims of the present work are to explore the effect of cold working on in-vitro biocompatibility of indigenized low cost Ni-free nitrogen containing austenitic stainless steels (HNSs) and to compare it with conventionally used biomedical grade, i.e. AISI 316L and 316LVM, using Dalton's Lymphoma (DL) cell line.

Chalcone and curcumin derivatives: a way ahead for malarial treatment.

Malaria has been a major cause of morbidity and mortality in developing countries, particularly in Sub-Saharan Africa and South Asia. The global malaria situation is increasingly being challenging owing to lack of credible malaria vaccine and the emergence of drug resistance to most of the available antimalarials. They demand search for novel generation of drugs.