Harnessing RNA-Protein Interactions for Therapeutic Interventions.

Interactions between RNAs and proteins play a crucial role in various diseases, including viral infections and cancer. Hence, understanding and inhibiting these interactions are important for the development of novel therapeutics. However, the identification of drugs targeting RNA-protein interactions with high specificity and affinity is challenged by our limited molecular understanding of these interactions.

Photocatalytic nanomaterials and their implications towards biomass conversion for renewable chemical and fuel production.

Photocatalytic processes have recently gained popularity as a sustainable and energy-efficient method for converting biomass. This article gives a comprehensive overview of recent improvements in the photocatalytic conversion of biomass into useful chemicals and fuels utilizing various photocatalytic materials. The work delves into the assessment of diverse biomass sources and their preparation techniques, in addition to the synthesis of plasmonic nanoparticles as photocatalysts from biomass, offering a thorough examination.

Total synthesis of bicyclomahanimbine by Cu(ii)-promoted photoredox process.

Since the isolation of carbazole alkaloids, the synthetic chemists have witnessed an upsurge in research of them due to their potential pharmacological properties. Our approach shows the total syntheses of five such biorelevant pyrano-[3,2]-carbazole alkaloids, emphasizing biomimetic and innovative synthetic methodologies such as cascade reactions and strategic bond formations through sustainable electrochemical and photochemical conditions.

Total synthesis of (-)-2-oxo epimesembranol and (+)-dihydromaritidine a key Johnson-Claisen rearrangement.

A general approach to alkaloids of the family following a key Johnson (orthoester)-Claisen rearrangement of an enantioenriched allylic alcohol has been disclosed. The tricyclic core (1c) of -3-octahydroindoline skeleton was achieved an ester-aminolysis followed by an intramolecular aza-Michael reaction with amine under elevated temperature. Utilizing aforementioned strategy, a collective total syntheses of alkaloids, such as (-)-2-oxo-epimesembranol (1d) [the first total synthesis], (-)-6-epimesembranol (1b), and (-)-mesembrine (1a) were shown.

Total synthesis of (+)-oridamycins A and B.

We have accomplished a unified strategy to achieve the structurally intriguing indolosesquiterpene alkaloids with diverse biological activity, xiamycin A (1a), xiamycin A methyl ester (1b) and oridamycins A (2a), and B (2b), which possesses a complex 6/6/6/5/6-fused pentacyclic skeleton bearing a carbazole moiety fused with a highly functionalized -decalin motif. Lewis acid-mediated epoxy-ene cyclization establishes the required pentacyclic scaffold with the installation of the four contiguous stereogenic centers. Further oxidative cleavage of the vinyl functionality, followed by successive functional group interconversions, completed the total synthesis of the indolosesquiterpene alkaloids.

Total synthesis of naturally occurring abietane diterpenoids a late-stage Fe(iii)-TAML catalysed Csp-H functionalization.

The synthesis of diverse -fused decalins, including the abietane diterpenoids scaffold, using an efficient selective oxidation strategy is described. The abietane core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel oxidation strategy was showcased in a concise total synthesis of six abietane congeners.

Effects of PNA Sequence and Target Site Selection on Function of a 4.5S Non-Coding RNA.

Peptide nucleic acid (PNA) based antisense strategy is a promising therapeutic approach to specifically inhibit target gene expression. However, unlike protein coding genes, identification of an ideal PNA binding site for non-coding RNA is not straightforward. Here, we compare the inhibitory activities of PNA molecules that bind a non-coding 4.

Transition-Metal-Catalyzed C-H Bond Functionalization of Arenes/Heteroarenes via Tandem C-H Activation and Subsequent Carbene Migratory Insertion Strategy.

The past decade has witnessed tremendous developments in transition-metal-catalyzed C-H bond activation and subsequent carbene migratory insertion reactions, thus assisting in the construction of diverse arene/heteroarene scaffolds. Various transition-metal catalysts serve this purpose and provide efficient pathways for an easy access to substituted heterocycles. A brief introduction to metal-carbenes has been provided along with key mechanistic pathways underlying the coupling reactions.