Molecular dynamics simulations to decipher the hotspots at the allosteric site of human 5-lipoxygenase.

Human 5-lipoxygenase (LOX) is a non-heme, Fe-containing LOX which catalyses the conversion of arachidonic acid (AA) to leukotriene A (LTA). LTA is subsequently converted to cysteinyl-LTs and LTB that cause bronchoconstriction and act as chemotactic and chemokinetic agent on human leukocytes, respectively. Leukotrienes play significant roles in inflammation in asthma, cardiovascular diseases, allergic rhinitis, atopic dermatitis, inflammatory bowel disease, rheumatoid arthritis, psoriasis and many more.

Machine learning-based monitoring and design of managed aquifer rechargers for sustainable groundwater management: scope and challenges.

Managed aquifer recharge (MAR) replenishes groundwater by artificially entering water into subsurface aquifers. This technology improves water storage, reduces over-extraction, and ensures water security in water-scarce or variable environments. MAR systems are complex, encompassing various components such as water storage, soil, meteorological factors, groundwater management (GWM), and receiving bodies.

Formulation of Dual-Functional Nonionic Cetomacrogol Creams Incorporated with Bacteriophage and Human Platelet Lysate for Effective Targeting of MDR and Enhanced Wound Healing.

Successful development of phage-based therapeutics and their utility predominantly depend on the mode and route of phage administration. Topical and site-directed phage application evokes minimal immune clearance and allows more phage-host adsorption, thereby ensuring higher phage efficacy. However, a notable drawback of conventional topical phage applications is the absence of sustained release.

Waste biomass-based 3D graphene aerogels for high performance zinc-ion hybrid supercapacitors.

Biomass-based 3D graphene aerogels were explored as cathode materials for the fabrication of high-performance zinc-ion hybrid supercapacitors. These hybrid supercapacitors delivered a high specific capacitance of ∼353.1 F g at a current density of 0.

Graphene Incorporated Sugar Derived Carbon Aerogel for Pyridine Adsorption and Oil-Water Separation.

Herein, we have synthesized a three-dimensional and hydrophobic graphene incorporated carbon aerogel (G-SCA) derived from sugar. G-SCA is being used as a multifunctional sorbent material for removing various advanced water-soluble and insoluble pollutants. Initially, G-SCA is being explored for the adsorption of nitroarenes (nitrophenols, 3-nitroaniline), an insecticide (Phoskill), an antibiotic (ciprofloxacin), and a pharmaceutical drug precursor (pyridine).

Waste-Derived Carbon Nano-Onions for the Removal of Organic Dye from Wastewater and Phytotoxicity Studies.

Dyes are extensively employed in industries, namely, textiles, cosmetics, paper, pharmaceuticals, tanning, etc. The effluent released from these industries contains various kinds of harmful dyes that adversely impact living beings and the environment due to their recalcitrant and toxic nature. In this study, an effort has been made to eliminate the methylene blue (MB) from wastewater using carbon nano-onions (CNOs) produced from waste frying oil (WFO) using an economical and eco-friendly wick pyrolysis method.

Enhanced biodegradation of 2, 4-dichlorophenol in packed bed biofilm reactor by impregnation of polyurethane foam with FeO nanoparticles: Bio-kinetics, process optimization, performance evaluation and toxicity assessment.

In this work, an effort has been made to enhance the efficacy of biological process for the effective degradation of 2, 4-dichlorophenol (2, 4-DCP) from wastewater. The polyurethane foam was modified with FeO nanoparticles and combined with polyvinyl alcohol, sodium alginate, and bacterial consortium for biodegradation of 2, 4-DCP in a packed bed biofilm reactor. The maximum removal efficiency of 2, 4-DCP chemical oxygen demand, and total organic carbon were found to be 92.

A critical review on the influence of operating parameters and feedstock characteristics on microwave pyrolysis of biomass.

Biomass pyrolysis is the most effective process to convert abundant organic matter into value-added products that could be an alternative to depleting fossil fuels. A comprehensive understanding of the biomass pyrolysis is essential in designing the experiments. However, pyrolysis is a complex process dependent on multiple feedstock characteristics, such as biomass consisting of volatile matter, moisture content, fixed carbon, and ash content, all of which can influence yield formation.

Digitalization of phosphorous removal process in biological wastewater treatment systems: Challenges, and way forward.

Phosphorus in wastewater poses a significant environmental threat, leading to water pollution and eutrophication. However, it plays a crucial role in the water-energy-resource recovery-environment (WERE) nexus. Recovering Phosphorus from wastewater can close the phosphorus loop, supporting circular economy principles by reusing it as fertilizer or in industrial applications.

Role of plasma process gas on permeate flux augmentation of cellulose nitrate membrane for mud water treatment.

A comparative study between Nitrogen (N) and Argon (Ar) plasma is carried out to investigate its effect on surface morphology, hydrophilicity, permeate flux and ageing of cellulose nitrate polymeric membranes in the present work. Langmuir probe and Optical Emission Spectroscopy are used to characterize the plasma. The SEM analysis reveals the noticeable macro-void creations and pore enlargement for both N and Ar plasma.

Nanocarbon-based sensors for the structural health monitoring of smart biocomposites.

Structural health monitoring (SHM) is a critical aspect of ensuring the safety and durability of smart biocomposite materials used as multifunctional materials. Smart biocomposites are composed of renewable or biodegradable materials and have emerged as eco-friendly alternatives of traditional non-biodegradable glass fiber-based composite materials. Although biocomposites exhibit fascinating properties and many desirable traits, real-time and early stage SHM is the most challenging issue to enable their long-term use.

Effective electronic waste valorization via microwave-assisted pyrolysis: investigation of graphite susceptor and feedstock quantity on pyrolysis using experimental and polynomial regression techniques.

Waste printed circuit board (WPCB) was subjected to microwave-assisted pyrolysis (MAP) to investigate the energy and pyrolysis products. In MAP, pyrolysis experiments were conducted, and the effects of WPCB to graphite mass ratio on three-phase product yields and their compositions were analyzed. In addition, the role of the initial WPCB mass (10, 55, and 100 g) and susceptor loading (2, 22, and 38 g) on the quality of product yield was also evaluated.

A detailed review on various aspects of inverted solar still desalination systems proposed for clean water production.

Rapid degradation of quality and quantity of the available limited fresh water reserves has forced nations around the globe to search for alternate fresh water sources. This has led to the development of various desalination technologies to generate potable water from abundantly available sea and brackish water. Desalination sector has undergone various upgradations to meet the rising fresh water demand in a sustainable way.

Bony Fish Arachidonic Acid 15-Lipoxygenases Exhibit Different Catalytic Properties than Their Mammalian Orthologs, Suggesting Functional Enzyme Evolution during Vertebrate Development.

The human genome involves six functional arachidonic acid lipoxygenase () genes and the corresponding enzymes (ALOX15, ALOX15B, ALOX12, ALOX12B, ALOXE3, ALOX5) have been implicated in cell differentiation and in the pathogenesis of inflammatory, hyperproliferative, metabolic, and neurological disorders. In other vertebrates, ALOX-isoforms have also been identified, but they occur less frequently. Since bony fish represent the most abundant subclass of vertebrates, we recently expressed and characterized putative ALOX15 orthologs of three different bony fish species (, , ).

3D Porous MoS-Decorated Reduced Graphene Oxide Aerogel as a Heterogeneous Catalyst for Reductive Transformation Reactions.

The MoS-based reduced graphene oxide aerogel (MoS-rGOA)-assisted organic transformation reactions are presented. MoS-rGOA is used as a heterogeneous catalyst for the reduction of benzene derivatives such as benzaldehyde, nitrobenzene, and benzonitrile to benzyl alcohol, aniline, and benzamide and their derivatives, respectively, in green solvents (water/methanol) and green reducing agents (hydrazine hydrate having N and H as byproducts). The mechanistic features of the reduction pathway, substrate scope, and the best suitable conditions by varying the temperature, solvent, reducing agent, catalyst loading, time, etc.

A synergistic approach combining Adsorption and Biodegradation for effective treatment of Acid Blue 113 dye by Klebsiella grimontii entrapped Graphene Oxide-Calcium Alginate Hydrogel Beads.

This study investigated the degradation of Acid Blue 113 (AB 113) dye using Klebsiella grimontii entrapped Graphene Oxide-Calcium Alginate Hydrogel beads (KG-GO-CA) in a Fluidized Bed Bioreactor (FBBR) under varying inlet loading rates. The minimum fluidization velocity of the KG-GO-CA hydrogel beads in FBBR was found to be 0.15 mm/s.

An experimental workflow to assess the applicability of microemulsions for conformance improvement in oil-bearing reservoir.

A comprehensive workflow approach is necessary to link multiple experimental tasks and identify microemulsion (ME) formulations with 'optimal' stability, displacement behavior and technical feasibility in the petroleum industry. In this paper, a systematic approach is described with the aid of a case study which involves the formulation of an anionic sodium dodecyl sulfate-based microemulsion. The design of such ME systems requires a proper methodology, substantial laboratory work, and functional assessment from research/industrial viewpoints.

Sulphonated poly(ethersulfone)/carbon nano-onions-based nanocomposite membranes with high ion-conducting channels for salt removal via electrodialysis.

Herein, we are reporting the carbon nano onions (CNO)-based sulphonated poly(ethersulfone) (SPES) composite membranes by varying CNO content in SPES matrix for water desalination applications. CNOs were cost-effectively synthesized using flaxseed oil as a carbon source in an energy efficient flame pyrolysis process. The physico- and electrochemical properties of nanocomposite membranes were evaluated and compared to pristine SPES.

Assessment of biodegradation kinetics and mass transfer aspects in attached growth bioreactor for effective treatment of brilliant green dye from wastewater.

In this study, Bacillus licheniformis immobilized with low-density polyethylene (LDPE) was employed to degrade Brilliant Green (BG) dye from wastewater in a packed bed bioreactor (PBBR). Bacterial growth and extracellular polymeric substance (EPS) secretion were also assessed under different concentrations of BG dye. The impacts of external mass transfer resistance on BG biodegradation were also evaluated at different flow rates (0.

Biodegradation of Congo Red Dye Using Lysinibacillus Species in a Moving Bed Biofilm Reactor: Continuous Study and Kinetic Evaluation.

The objective of this work was to develop a low-cost and efficient biocarrier for biodegradation of azo dye (i.e., Congo red (CR) dye).

Biodegradation and detoxification study of triphenylmethane dye (Brilliant green) in a recirculating packed-bed bioreactor by bacterial consortium.

In the last few decades, Brilliant green (BG) dye is widely employed to colour the fabric materials in various industries (e.g. textile, pulp and paper, etc.

Techno-enviro-economic assessment of novel hybrid inclined-multi-effect vertical diffusion solar still for sustainable water distillation.

A novel hybrid inclined-multi effect vertical diffusion (Hybrid I-MEVD) solar still has been proposed and its viability for sustainable water distillation has been assessed based on detailed techno-enviro-economic aspects. The optimum number of diffusion chambers and recommended diffusion gap of integrated MEVD still was estimated to be 4 and 0.01 m, respectively.