Dual-Sided Superhydrophobic Laser-Induced Graphene Evaporator for Efficient Desalination and Brine Treatment under High Salinity.

The immense energy footprint of desalination and brine treatment is a barrier to a green economy. Interfacial evaporation (IE) offers a sustainable approach to water purification by efficient energy conversion. However, conventional evaporators are susceptible to fluctuations in solar radiation and the salinity of handling liquid.

Voices of Nanomedicine: Blueprint Guidelines for Collaboration in Addressing Global Unmet Medical Needs.

The "" under this Perspective underline the importance of interdisciplinary collaboration and partnerships across several disciplines, such as medical science and technology, medicine, bioengineering, and computational approaches, in bridging the gap between research, manufacturing, and clinical applications. Effective communication is key to bridging team gaps, enhancing trust, and resolving conflicts, thereby fostering teamwork and individual growth toward shared goals. Drawing from the success of the COVID-19 vaccine development, we advocate the application of similar collaborative models in other complex health areas such as nanomedicine and biomedical engineering.

Comparative analysis of brain volumetric measurements between contrast-enhanced and non-contrast MRI images.

Background: Clinical brain MRI scans, including contrast-enhanced (CE-MR) images, represent an underutilized resource for neuroscience research due to technical heterogeneity.

Purpose: To evaluate the reliability of morphometric measurements from CE-MR scans compared to non-contrast MR (NC-MR) scans in normal individuals.

Methods: T1-weighted CE-MR and NC-MR scans from 59 normal participants (aged 21-73 years) were compared using CAT12 and SynthSeg+ segmentation tools.

Solvent-Driven Self-Assembly of Discrete Ni(II)-Azide Complexes: Unraveling Unusual Behavior in Mimicking Jack Bean Urease.

The well-known inhibitory strength of 3d metal Schiff base complexes against urease enzymes has long been acknowledged, but their untapped potential to act as ureolytic mimics of active metallobiosites remained unexplored. To break the new ground, we present pyrrolidine-based mononuclear Ni(II)-azide complex {[NiL(HL)(N)]·1.5(HO)} using the N,N,O donor ligand, namely ()-4-bromo-2-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)phenol.

Protein Based Hybrid Materials of Metal Phosphate Nanoflowers and Gels for Water Remediation: Perspectives and Prospects.

Water pollution is a critical environmental issue affecting ecosystems and human health worldwide. Contaminants such as heavy metals, dyes, antibiotics, and microplastics enter water bodies from the disposals of industrial, agricultural, and domestic waste. The development of new and advanced technologies for addressing water remediation has turned out to be a dire need.

Deciphering the Seed Size-Dependent Cellular Internalization Mechanism for α-Synuclein Fibrils.

Aggregation of α-synuclein (α-Syn) and Lewy body (LB) formation are the key pathological events implicated in Parkinson's disease (PD) that spread in a prion-like manner. However, biophysical and structural characteristics of toxic α-Syn species and molecular events that drive early events in the propagation of α-Syn amyloids in a prion-like manner remain elusive. We used a neuronal cell model to demonstrate the size-dependent native biological activities of α-Syn fibril seeds.

Sequence and biochemical analysis of vaccinia virus A32 protein: Implications for in vitro stability and coiled-coil motif mediated regulation of the DNA-dependent ATPase activity.

Nucleocytoplasmic large DNA viruses (NCLDVs) have massive genome and particle sizes compared to other known viruses. NCLDVs, including poxviruses, encode ATPases of the FtsK/HerA superfamily to facilitate genome encapsidation. However, their biochemical and structural characteristics are yet to be discerned.

Triazolyl-phosphole and triazolyl-azaphosphole: synthesis, transition metal complexes and catalytic studies.

Phosphole and azaphosphole derivatives with triazole functionalities, [CH{1,2,3-NCCHC(PPh)}] (L1) and [CH{1,2,3-NC(Ph)C(PPh)}] (L2) were synthesized by reacting [(CH)(1,2,3-NC = CH--Br-CH)] and [(-Br-CH)(1,2,3-NC = CHCH)] with BuLi followed by the addition of dichlorophenylphosphine. The reactions of L1 and L2 with an excess of 30% HO afforded phosphole oxides [CH{1,2,3-NCCHC(P(O)Ph)}] (L1O) and [CH{1,2,3-NC(Ph)C(P(O)Ph)}] (L2O) as white crystalline solids. Stoichiometric reactions of L1 and L2 with [Ru(η--cymene)Cl] in CHCl yielded [RuCl(η--cymene)(L1-κ-)] (1) and [RuCl(η--cymene)(L2-κ-)] (2), respectively.

Exploring the Effect of Hydrocarbon Cross-Linkers on the Structure and Binding of Stapled p53 Peptides.

Short-length peptides are used as therapeutics due to their high target specificity and low toxicity; for example, peptides are designed for targeting the interaction between oncogenic protein p53 and E3 ubiquitin ligase MDM2. These peptide therapeutics form a class of successful inhibitors. To design such peptide-based inhibitors, stapling is one of the methods in which amino acid side chains are stitched together to get conformationally rigid peptides, ensuring effective binding to their partners.

Synthesis of -dA Damaged DNAs to Probe the Replication Ability of Human Translesion Polymerases.

The DNA adducts formed by the alkenylbenzene natural products, safrole (SF) and methyleugenol (MEG) are primarily attributed to their reported carcinogenic properties. Herein, we report a concise strategy to access -Ac-SF/MEG-dA phosphoramidites, which were selectively incorporated into DNA oligonucleotides by solid-phase DNA synthesis. The replication studies using human polymerases hpolκ and hpolη showed that both polymerases replicate these adducts error-free, which indicates that these polymerases do not contribute to the adduct-induced mutagenicity.

From Self-Assembly to Drug Delivery: Understanding and Exploring Protein Fibrils.

It is crucial to comprehend protein misfolding and aggregation in the domains of biomedicine, pharmaceuticals, and proteins. Amyloid fibrils are formed when proteins misfold and assemble, resulting in the debilitating illness known as "amyloidosis". This work investigates lysozyme fibrillation with pluronics (F68 and F127).

Unravelling the Role of Sterically Encumbered Ligands in Tuning the Magnetic Properties of Lanthanide-Based D5h Single-Ion Magnets.

Isostructural Dy(III) and Er(III) complexes [L12Ln(H2O)5][I]3·L12·(CH2Cl2) (Ln = Dy (1), Er (3)) and [L22Ln(H2O)5][I]3·L22·(CH2Cl2)2 (Ln = Dy (2), Er (4)), with distorted pentagonal bipyramidal geometry (D5h) around the central metal were synthesized by utilizing two bulky phosphonamide ligands, adamantyl phosphonamide, (Ad)P(O)(NHiPr)2 (L1) and carbazolyl phosphoramide (Cz)P(O)(NHiPr)2 (L2). The resultant complexes were investigated for their magnetic properties in order to elucidate the impact of modification of the coordinating P-O bond environment either by increasing steric bulk and/or introduction of a third P-N bond at the central phosphorus atom. Magnetic studies revealed substantial energy barriers (Ueff) of 640 K and 560 K for Dy compounds 1 and 2, respectively, rendering them as some of the best-performing air-stable SIMs amongst the class of SIMs with D5h symmetry.

Unravelling the Relaxation Pathway and Excited State Dynamics of Ruthenium(II) Polypyridyl Complexes Incorporating Phosphorus-Based Monodentate Ligands.

Herein, the photophysical, photochemical properties and photogenerated excited state dynamics of two new Ru(II) complexes, viz. [Ru(p-ttp)(bpy)(PTA)]2+ [1]2+, [Ru(p-ttp)(phen)(PTA)]2+ [2]2+ having a phosphorus-based ligand PTA [p-ttp = p-tolyl terpyridine; bpy = 2,2'-bipyridyl; phen = 1,10-phenthroline and PTA = 1,3,5-triaza-7-phosphaadamantane] are reported. Upon excitation with 470 nm LED, [1]2+ and [2]2+ neither undergo ligand release nor exhibit room temperature luminescence/1O2 generation.

Deep Learning Predicts Subtype Heterogeneity and Outcomes in Luminal A Breast Cancer Using Routinely Stained Whole Slide Images.

Intratumor heterogeneity (ITH) presents challenges for precision oncology, but methods for its spatial quantification, scalable at population levels, do not exist. Based on previous work showing that admixture of PAM50 subtype can be measured from bulk tissue using transcriptomic data, we trained a deep neural network (DNN) to quantify subtype ITH in Luminal A (LumA) breast cancer from routinely-stained whole slide images. We tested the hypothesis that subtype admixture detected in images was associated with tumor aggressiveness and adverse outcome.

Groundwater contaminant source identification using swarm intelligence-based simulation optimization models.

In this study, a linked simulation optimization (SO) model is presented for identification of groundwater contaminant sources. The SO model consists of two steps namely, simulation and optimization. The simulation step entails developing a groundwater contaminant transport model in which the advection-dispersion-reaction equation (ADRE) is solved for predicting the concentration of the contaminant.

Doppler weather radars as a game changer in desert locust swarm tracking.

Desert locusts, notorious for their ruinous impact on agriculture, threaten over 20% of Earth's landmass, prompting billions in losses and global food scarcity concerns. With billions of these locusts invading agrarian lands, this is no longer a thing of the past. Recent invasions, such as those in India, where losses reached US$ 3 billion in 2019-20 alone, underscore the urgency of action.

Revealing exchange bias in spin compensated systems for spintronics applications.

Antiferromagnetic materials offer potential for spintronic applications due to their resilience to magnetic field perturbations and lack of stray fields. Achieving exchange bias in these materials is crucial for certain applications; however, discovering such materials remains challenging due to their compensated spin structure. The quest for antiferromagnetic materials with exchange bias became a reality through our experimental study and theoretical simulation on and .

pH-responsive supramolecular switch of a rationally designed dipyrroethene-based chromophore.

Herein, we present a strategy to access a novel class of pH-responsive, dual-state emissive (DSE), highly fluorescent pyrrole-based chromophores diformylation of dipyrroethenes (DPE) followed by condensation with various aniline derivatives. The DPE-based chromophores exhibit a large Stokes shift and maintain good fluorescence quantum yields. Remarkably, these chromophores demonstrate reversible colourimetric changes and a fluorometric 'on-off-on' switch in response to pH variations.

Design and development of Vaginal wall mimicking Poly (ε-caprolactone) based nanofibrous prosthetic mesh for pelvic organ prolapse: Evaluation of biocompatibility and antibacterial ability.

Mechanical non-conformance of conventionally used transvaginal non-degradable meshes has led to complications like organ perforation, dyspareunia caused by mesh stiffness, and stress shielding. In this study, we have solved the dire need of mimicking the mechanical properties of vaginal wall by designing and developing a soft and elastic mesh made of polycaprolactone (PCL), citric acid modified polyethylene glycol (PEGC) and zinc oxide (ZnO) prepared through electrospinning and is tested in-vitro and in-vivo. Mesh containing 90:10:0.

Triazine-Functionalized Nitrogen-Rich Covalent Organic Framework as an Electrode Material for Aqueous Symmetric Supercapacitor.

Covalent triazine frameworks, with their ordered pores and crystalline structure that exhibit heteroatom impacts, demonstrate outstanding chemical stability, making them designable for charge storage applications. In this study, the triazine-based covalent organic frameworks (TPT@BDA-COF) was synthesized using 4',4''',4'''''-(1,3,5-Triazine-2,4,6-triyl) tris (([1,1'-biphenyl]-4-amine)) (TPT) and 4,4'-Oxydibenzaldehyde (BDA) following polycondensation process. Interestingly, these resulted in the fabrication of a well-connected, orderly porous crystalline structure, redox-active moiety, and significantly high doping atomic percentages of N (~13.

Cooling Performance of TiO-Based Radiative Cooling Coating in Tropical Conditions.

The cooling power of radiative cooling (RC) coatings depends not only on the radiative properties of the coating but also on environmental variables. In tropical environments, the cooling performance of RC coatings deteriorates due to high humidity and high solar radiation. Previous studies focused on developing high solar-reflective coatings to achieve subambient cooling in tropical environments.

Theta-Gamma Decoupling - A neurophysiological marker of impaired reward processing in Parkinson's disease.

Individuals with Parkinson's disease (PD) exhibit altered reward processing, reflected by a decreased amplitude of an event-related potential (ERP) marker called reward positivity (RewP). Most studies have used RewP to investigate reward behavior due to the high temporal resolution of EEG and its high sensitivity. However, traditional single-electrode ERP analyses often overlook the intricate dynamics of non-phase-locked oscillatory activity and the complex interactions within these neural oscillatory patterns.