20,197 results match your criteria: "Indian Institute Of Science[Affiliation]"

Raman signatures of inversion symmetry breaking structural transition in quasi-1D compound, (TaSe4)3I.

J Phys Condens Matter

January 2025

School of Physical Sciences, Indian Association for the Cultivation of Science, 2A & B Raja S C Mullick Road, Kolkata 700032, INDIA, Kolkata, 700032, INDIA.

The breaking of inversion symmetry combined with spin-orbit coupling, can give rise to intrigu- ing quantum phases and collective excitations. Here, we report systematic temperature dependent Raman scattering and theoretical calculations of phonon modes across the inversion symmetry- breaking structural transitions in a quasi-one-dimensional compound (TaSe4)3I. Our investigation revealed the emergence of three additional Raman-active modes in Raman spectra of the low- temperature (LT) non-centrosymmetric (NC) structure of the material.

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Groundwater is often used directly by the public in several river basins of India. Hence, this study was carried out with the objective of assessing the quality of groundwater in the Amaravathi basin, India, using a multiple indices approach. Groundwater quality data from 96 monitoring wells were obtained from the Central Groundwater Board and used in this study.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: In the face of increasing Mild Cognitive Impairment(MCI) and Dementia rates among aging populations, understanding the factors shaping the non-normal cognitive decline is crucial. Leveraging the Clinical Dementia Rating (CDR) data, this study has a dual focus. (1) It utilizes CDR to aid early MCI diagnosis by investigating factors contributing to transition from Questionable- to Low- AD.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research (CBR), Indian Institute of Science, Bengaluru, Karnataka, India.

Background: Data-driven methods, particularly deep learning, are transforming neuroimaging by accurately estimating Brain Age using diverse modalities. Discrepan- cies between predicted and actual age unveil potential health risks. Utilizing a training set of healthy subjects, a regression algorithm correlates brain features to age, allowing inference for unseen patients.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research (CBR), Indian Institute of Science, Bengaluru, Karnataka, India.

Background: Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the brain resulting gradual decline in a cognitive function, memory impairment, alterations in behavior, potentially resulting in the inability to engage in a conversation and react to the surroundings. Corpus callosum (CC) is the principal white fabric matter present in the center of the brain that connects the left and right cerebral hemispheres. Neurodegenerative diseases can impact the size and structure of the CC, leading to its atrophy and dysfunction.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research (CBR), Indian Institute of Science, Bengaluru, Karnataka, India.

Background: Deep Neural Networks (DNNs) have emerged as powerful tools in the biomedical field, particularly for the early detection of neurodegenerative diseases. Despite their complexity and data-intensive nature, simpler fully connected Convolutional Neural Network (SFCN) architectures have shown effectiveness in accurately discerning between subjects affected by Alzheimer's disease (AD) and healthy controls (HC). This model draws inspiration from the work of Peng H et al.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Musical activity is known to act as a cognitive reserve and protect the brain against age-related cognitive decline. The neural correlates of music perception and processing has been linked to the cerebellum, which is also known to be implicated in musical-training related plasticity. These insights led us to explore the differences in cerebellar volumes between musicians and non-musicians.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Thyroid disorders is one of the most common endocrine disorders. It is estimated that 42 million people suffer from thyroid disorders in India. The imbalance in thyroid hormone levels can significantly impact cognitive health of older population.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Physiological and mental functions decline as the person ages. However, studies have found that a group of people who are more than 80 years have better cognitive functioning than their peers and also similar to 2-3 decades younger counterpart group. These people are termed as "Superagers".

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: In the scientific literatures, C-reactive protein (CRP), a well-known inflammatory biomarker, has been closely examined in connection to cognitive function. However, less knowledge on correlation study between the serum CRP level and different cognitive domain. Therefore, we aimed to study the relation between CRP level and cognition performance in TLSA cohort.

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Public Health.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Previous studies have reported that poor sleep quality is associated with several adverse outcomes including multimorbidity, particularly in the aging population. Another common occurrence in the elderly is frailty. We aim to study the mediating effect of objective physical frailty parameters on the association between sleep quality and multimorbidity in an aging rural Indian population.

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Public Health.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: The phenotype model of frailty, initially proposed by Fried, is primarily confined to the physical dimension. This study seeks to expand this model by integrating the psychological dimension. We hypothesize that this psychological frailty model is strongly associated with cognitive functional impairment (CFI) in an aging Indian population.

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Public Health.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Worsening pulmonary health may be independently associated with declining cognitive function. However, the association between specific types of pulmonary impairment with cognitive function is not well understood. The present study aims to determine the differential impact of Chronic Obstructive Pulmonary Disease (COPD) and Preserved Ratio Impaired Spirometry (PRISm) in a rural Indian aging cohort METHOD: Data from participants (n = 1223) of the Srinivaspura Aging, Neuro Senescence and COGnition (SANSCOG) cohort were analyzed.

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Public Health.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Emerging evidence suggests environmental factors, such as chronic pesticide exposure, may influence cognitive functioning, yet research in this area remains limited, particularly in rural Indian settings. Our objective was to investigate the potential link between pesticide exposure and cognitive performance in an aging population from rural India.

Method: This cross-sectional analysis included 4320 participants from the Srinivasapura Aging NeuroSenescence and COGnition (SANSCOG) cohort.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research (CBR), Indian Institute of Science, Bengaluru, Karnataka, India.

Background: Mild Cognitive Impairment (MCI), a transitional stage between healthy aging and Alzheimer's disease, offers a critical intervention window (Vega and Newhouse, 2014). Diagnosing MCI proves challenging due to subtle neurodegenerative changes. Our study employs graph representations of fMRI time-series, emphasizing connectivity between brain regions (Stam and Reijneveld, 2007).

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Social isolation among the elderly is increasing and its detrimental effect on cognition is not fully understood. We aimed to study the effects of social isolation on cognitive performance and brain morphology among the urban elderly.

Method: In this cross-sectional analysis of 1484 participants from the Tata Longitudinal Study of Aging (TLSA) based in urban Bangalore, we administered the social network index questionnaire to identify participants experiencing social isolation.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Though frailty is common in aging, its impact on varied health outcomes has been grossly understudied among rural Indians. We aimed to cross-sectionally examine the impact of physical frailty on 13 health outcomes and brain structure in this population.

Method: Participants (n=5302) were non-demented, aging individuals (≥45 years) from the ongoing Srinivaspura Aging Neuro Senescence and Cognition (SANSCOG) cohort in rural southern India.

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Biomarkers.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Metabolic Syndrome (MetS) is a significant health concern, characterized by a combination of cardio- vascular risk factors, influenced by genetic factors including the apolipoprotein E (ApoE). This study examines the sex- specific association between ApoE genotypes and MetS in a rural Southern Indian population METHOD: This cross- sectional study included 3741 participants aged ≥ 45 years from the rural Srinivaspura Aging, Neuro Senescence and COGnition (SANSCOG) cohort in Karnataka, India. All participants were measured for blood pressure, anthropometric measurements, and fasting concentrations of glucose, triglycerides, cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

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Alzheimer's Imaging Consortium.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: Though frailty is common in aging, its impact on varied health outcomes has been grossly understudied among rural Indians. We aimed to cross-sectionally examine the impact of physical frailty on 13 health outcomes and brain structure in this population.

Method: Participants (n=5302) were non-demented, aging individuals (=45 years) from the ongoing Srinivaspura Aging Neuro Senescence and Cognition (SANSCOG) cohort in rural southern India.

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Dementia Care Research and Psychosocial Factors.

Alzheimers Dement

December 2024

Relecura, Bangalore, karnataka, India.

Background: Clinical Dementia Rating (CDR) and its evaluation have been important nowadays as its prevalence in older ages after 60 years. Early identification of dementia can help the world to take preventive measures as most of them are treatable. The cellular Automata (CA) framework is a powerful tool in analyzing brain dynamics and modeling the prognosis of Alzheimer's disease.

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Dementia Care Practice.

Alzheimers Dement

December 2024

Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.

Background: India is unfortunately the "Diabetes Capital" of the world with estimated 101 million and 136 million patients suffering from diabetes and prediabetes respectively. Prediabetes is a transition state between euglycemia and diabetes. Although diabetes is associated with cognitive decline, studies that link prediabetes and cognition have been scarce and inconclusive especially from the Low and Middle Income (LMIC) countries.

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Chiral allyl amines are important structural components in natural products, pharmaceuticals, and chiral catalysts. Herein, we report a cobalt-catalyzed enantioselective reductive coupling of imines with internal alkynes to synthesize chiral allyl amines. The reaction is catalyzed by a cobalt complex derived from commercially available bisphosphine ligand utilizing zinc as the electron donor.

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Hexaanionic cyclophosphazenate ligands [(RN)PN] provide versatile platforms for the assembly of multinuclear metal arrays due to their multiple coordination sites and highly flexible ligand core structure. This work investigates the impact of incrementally increasing the steric demand of the ligand periphery on the coordination behavior of ethylzinc arrays. It shows that the increased congestion around the ligand sites is alleviated by progressive condensation with the elimination of diethylzinc.

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Under changing climatic conditions, plant exposure to high-intensity UV-B can be a potential threat to plant health and all plant-derived human requirements, including food. It's crucial to understand how plants respond to high UV-B radiation so that proper measures can be taken to enhance tolerance towards high UV-B stress. We found that BBX22, a B-box protein-coding gene, is strongly induced within one hour of exposure to high-intensity UV-B.

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In this study, we present a protecting group photocleavage method to investigate both covalent and noncovalent interactions between a squaraine dye (PSq) and Bovine Serum Albumin (BSA). This approach allows for the photoinduced activation and deactivation of PSq fluorescence, providing valuable insights into the dual-mode interaction of the dye with the protein.

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