9 results match your criteria: "Indian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis[Affiliation]"
Lighting up with membrane-targeting peptides.
Org Biomol Chem
November 2024
Precision Healthcare University Research Institute, Queen Mary University of London, Empire House, Whitechapel, London, E1 1HH, UK.
Article Synopsis
- - The study focuses on fluorescent probes designed from membrane-disrupting peptides from mycobacteria, which can contain either L- or D-amino acids.
- - These probes feature "always on" and environmentally sensitive fluorescent markers, allowing them to effectively label specific targets.
- - The effectiveness of two specific probes in labeling was demonstrated, showcasing their potential application in research.
Cytokine and chemokine profiles in pulmonary tuberculosis with pre-diabetes.
Front Immunol
September 2024
International Center for Excellence in Research, National Institute of Allergy and Infectious Diseases (NIAID), Chennai, India.
Article Synopsis
- Tuberculosis (TB) is a major health issue in India, especially in patients with diabetes mellitus (DM), creating a serious challenge known as TB-PDM.
- The study analyzed the effects of DM on the immune response in patients with pulmonary TB by measuring various cytokine and chemokine levels in blood samples.
- Results revealed that coexisting TB and PDM lead to higher mycobacterial loads and increased cytokine and chemokine levels, suggesting that glycemic control is crucial for managing this complicated relationship between the two diseases.
Operational feasibility and multi-centric evaluation of 'TB sputum microscopy kit' for the direct detection of in field settings.
Infect Dis (Lond)
December 2024
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Background: India relies primarily on direct smear microscopy for tuberculosis (TB) diagnosis. However, the low sensitivity of smear microscopy emphasizes the need to improve its performance. We recently described the development of 'TB' kit which showed improved performance over direct smear microscopy at National Reference Laboratories (NRLs) in India.
View Article and Find Full Text PDFDownregulation of monocyte miRNAs: implications for immune dysfunction and disease severity in drug-resistant tuberculosis.
Front Immunol
July 2023
Department of Immunology, Indian Council of Medical Research (ICMR)-National Institute for Research in Tuberculosis (NIRT), Chennai, India.
Article Synopsis
- This study investigates how monocyte miRNAs are involved in the immune responses during tuberculosis (TB), focusing on their expression profiles in different TB conditions, including drug-resistant TB, drug-sensitive TB, and latent TB, as well as in healthy individuals.* -
- Using flow cytometry and NanoString profiling, researchers identified significant differences in miRNA expression, particularly noting downregulation in active TB cases and specific miRNA changes unique to drug-resistant and drug-sensitive TB.* -
- The findings suggest that these miRNA signatures could serve as biomarkers for TB severity and drug resistance, highlighting the need for further research on their role in the immune response to tuberculosis.*
Early diagnosis of drug-resistant TB (DR-TB) is crucial in preventing the spread of the disease in the community. Introduction of upfront decentralised drug susceptibility testing to district-level as part of universal drug susceptibility testing (UDST) policy increased the feasibility of rapid and early testing for drug resistance closer to the patient and has resulted in reduced circumstances for transmission. The introduction of the first-line line-probe assay (FL-LPA), GenoType MTBDR v2, has had an extensive impact on the management of multidrug-resistant TB (MDR-TB) in India.
View Article and Find Full Text PDFCurrent knowledge on resistance-conferring determinants in Mycobacterium tuberculosis is biased toward globally dominant lineages 2 and 4. In contrast, lineages 1 and 3 are predominant in India. In this study, we performed whole-genome sequencing of 498 MDR M.
View Article and Find Full Text PDFSystemic inflammation is a characteristic feature of pulmonary tuberculosis (PTB). Whether systemic inflammation is associated with treatment failure in PTB is not known. Participants, who were newly diagnosed, sputum smear and culture positive individuals with drug-sensitive PTB, were treated with standard anti-tuberculosis treatment and classified as having treatment failure or microbiological cure.
View Article and Find Full Text PDFCovaxin/BBV152 is a whole virion inactivated SARS-CoV-2 vaccine. The effect of prime-boost vaccination with Covaxin on systemic immune responses is not known. We investigated the effect of Covaxin on the plasma levels of a wide panel of cytokines and chemokines at baseline (M0) and at months 1 (M1), 2 (M2) and 3 (M3) following prime-boost vaccination in healthy volunteers.
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