2 results match your criteria: "India. sandip@seramporecollege.ac.in.[Affiliation]"
Individual and combined antagonism of aryl hydrocarbon receptor (AhR) and estrogen receptors (ERs) offers distinct level of protection against Bisphenol A (BPA)-induced pancreatic islet cell toxicity in mice.
Naunyn Schmiedebergs Arch Pharmacol
October 2024
Department of Physiology, Serampore College, 9 William Carey Road, Serampore, Hooghly, 712201, West Bengal, India.
Article Synopsis
- - BPA disrupts pancreatic islet function by interacting with estrogen receptors and activating the aryl hydrocarbon receptor, suggesting potential toxic effects on insulin regulation.
- - In experiments, treating isolated pancreatic islet cells and live mice with BPA demonstrated that AhR plays a critical role in BPA's impact on insulin release and cell viability, with antagonists for both AhR and ER mitigating these effects.
- - The study suggests that targeting both AhR and ER could be a therapeutic strategy to counteract the negative effects of BPA, particularly regarding insulin dysfunction and related diabetic conditions.
Centella asiatica mitigates the detrimental effects of Bisphenol-A (BPA) on pancreatic islets.
Sci Rep
April 2024
Department of Physiology, Serampore College, 9 William Carey Road, Serampore, Hooghly, West Bengal, 712201, India.
Bisphenol-A (BPA) is widely used in food packaging and household products, leading to daily human exposure and potential health risks including metabolic diseases like type 2 diabetes mellitus (T2DM). Understanding BPA's mechanisms and developing intervention strategies is urgent. Centella asiatica, a traditional herbal medicine containing pentacyclic triterpenoids, shows promise due to its antioxidant and anti-inflammatory properties, utilized for centuries in Ayurvedic therapy.
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