1 results match your criteria: "India. jayanti.roy@dbuniversity.ac.in.[Affiliation]"
Phytocompounds as potential inhibitors of mycobacterial multidrug efflux pump Rv1258c: an in silico approach.
AMB Express
February 2024
Department of Microbiology, Assam Don Bosco University, Tapesia Gardens, Sonapur, Assam, 782402, India.
Article Synopsis
- The rise of multidrug resistant tuberculosis (MDR-TB) is a growing global concern, driven by factors like the efflux pump Rv1258c, which contributes to antibiotic resistance and poor treatment outcomes.
- In our research, we employed rational drug design and in silico techniques to identify potential efflux pump inhibitors (EPIs) aimed at Rv1258c, utilizing 210 phytocompounds for docking studies.
- Our findings highlighted two promising compounds, ellagic acid and baicalein, which not only showed excellent docking scores but also demonstrated better drug-like properties compared to traditional EPIs, suggesting their potential for further development in combatting MDR-TB.