7 results match your criteria: "India. Electronic address: biswajit.mukherjee@jadavpuruniversity.in.[Affiliation]"
H-ras-targeted genetic therapy remarkably surpassed docetaxel treatment in inhibiting chemically induced hepatic tumors in rats.
Life Sci
July 2024
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:
Aims: Hepatocellular carcinoma (HCC) is still a leading cause of cancer-related death worldwide. But its chemotherapeutic options are far from expectation. We here compared H-ras targeted genetic therapy to a commercial docetaxel formulation (DXT) in inhibiting HCC in rats.
View Article and Find Full Text PDFAssessment of superiority of HSP70-targeting aptamer-functionalized drug-nanocarrier over non-targeted commercially available counterpart in HCC therapy: in vitro and in vivo investigations and molecular modeling.
Life Sci
March 2023
Pharmaceutics Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Aims: This research aims to compare the therapeutic potential of target-specific phosphorothioate backbone-modified aptamer L5 (TLS9a)-functionalized paclitaxel (PTX)-loaded nanocarrier (PTX-NPL5) that we formulated with that of non-targeted commercial formulation, protein albumin-bound nanoparticles of PTX, Abraxane® (CF) against hepatocellular carcinoma (HCC) through a myriad of preclinical investigations.
Main Methods: A variety of in vitro and in vivo assays have been executed to compare the therapeutic effects of the formulations under investigation, including the investigation of the degree of apoptosis induction and its mechanism, cell cycle analysis, the level of ROS production, and redox status, the morphological and histological characteristics of malignant livers, and in vivo imaging. The formulations were also compared concerning pharmacokinetic behaviors.
Inhibitory potential of iRGD peptide-conjugated garcinol-loaded biodegradable nanoparticles in rat colorectal carcinoma.
Biomater Adv
March 2022
Infectious Diseases and Immunology Division, CSIR - Indian Institute of Chemical Biology, Kolkata 700032, West Bengal, India.
Article Synopsis
- Targeted drug delivery has gained traction in chemotherapy, aiming to maximize treatment effects at cancer sites while minimizing side effects elsewhere.
- Plant-derived compounds and their derivatives have shown promise in enhancing chemotherapy's effectiveness, particularly for colorectal carcinoma (CRC).
- The study introduces a novel peptide-conjugated nanoparticle (iRGD-GAR-NP) that significantly outperforms standard treatments in targeting CRC cells, showing improved cytotoxicity and tumor reduction in both lab and animal models.
Aptamer-Functionalized Drug Nanocarrier Improves Hepatocellular Carcinoma toward Normal by Targeting Neoplastic Hepatocytes.
Mol Ther Nucleic Acids
June 2020
Pharmaceutics Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India; Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India.
Article Synopsis
- Site-specific delivery of chemotherapeutics to neoplastic hepatocytes (cancerous liver cells) aims to treat hepatocellular carcinoma (HCC) without harming normal liver cells.
- The study investigates a novel drug nanocarrier, PTX-NPL5, which uses the aptamer TLS 9a designed to induce apoptosis (cell death) specifically in cancerous cells, and compares it with other known targeting methods.
- Results showed PTX-NPL5 was the most effective at selectively causing apoptosis in cancer cells while sparing healthy cells, and identified specific proteins that facilitate its targeted delivery, suggesting promise for clinical application in improving HCC treatment.
Therapeutic potential of andrographolide-loaded nanoparticles on a murine asthma model.
Nanomedicine
August 2019
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Corticosteroids commonly prescribed in asthma show several side-effects. Relatively non-toxic andrographolide (AG) has an anti-asthmatic potential. But its poor bioavailability and short plasma half-life constrain its efficacy.
View Article and Find Full Text PDFApigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats.
Nanomedicine
August 2018
Division of Molecular Medicine, Bose Institute, Kolkata, West Bengal, India.
Hepatocellular carcinoma (HCC) is one of the major causes of cancer related death globally. Apigenin, a dietary flavonoid, possesses anti-tumor activity against HCC cells in-vitro. Development, physicochemical characterization of apigenin loaded nanoparticles (ApNp), biodistribution pattern and pharmacokinetic parameters of apigenin upon intravenous administration of ApNp, and effect of ApNp treatment in rats with HCC were investigated.
View Article and Find Full Text PDFPreferential hepatic uptake of paclitaxel-loaded poly-(d-l-lactide-co-glycolide) nanoparticles - A possibility for hepatic drug targeting: Pharmacokinetics and biodistribution.
Int J Biol Macromol
June 2018
School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.
Liver cancer is a leading cause of death related to cancer worldwide. Poly(d-l-lactide-co-glycolide) (PLGA) nanoparticles provide prolonged blood residence time and sustained drug release, desirable for cancer treatment. To achieve this, we have developed paclitaxel-loaded PLGA nanoparticles by emulsification solvent evaporation method and evaluated by in vitro and in vivo studies.
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