"Exploring the Potential of Ferulic Acid loaded Nanostructured Lipid Carriers: Angiotensin Inhibition via Docking, Formulation, and Pharmacokinetic and Pharmacodynamics Studies".

Ferulic acid (FA) is a phenolic compound obtained naturally and is a versatile antioxidant identified for its potential in managing hypertension. However, its application is constrained due to its classification as a BCS Class IV moiety. To address this, we concentrated on improving its solubility and permeability by developing nanostructured lipid carriers (NLCs) of FA using emulsification probe sonication technique.

Unfolding the Potential of Pyrrole- and Indole-Based Allylidene Hydrazine Carboximidamides as Antimicrobial Agents.

Antimicrobial drug resistance is a significant global health challenge, causing hundreds of thousands of deaths annually and severely impacting healthcare systems worldwide. Several reported antimicrobial compounds have a guanidine motif, as the positive charge on guanidine promotes cell lysis. Therefore, pyrrole- and indole-based allylidene hydrazine carboximidamide derivatives with guanidine motifs are proposed as antimicrobial agents that mimic cationic antimicrobial peptides (CAMPs).

Innovations in RNA therapeutics: a review of recent advances and emerging technologies.

The field of biomedical science has witnessed another milestone with the advent of RNA-based therapeutics. This review explores three major RNA molecules, namely: messenger RNA (mRNA), RNA interference technology (RNAi), and Antisense Oligonucleotide (ASO), and analyses U.S.

Predictors of mortality in patients with Gram-Negative Bacilli (GNB) blood stream infections (BSI): multicentre data from India.

Background: This study was done with objectives of determining the predictors of mortality in patients with Gram-Negative Bacilli (GNB) Blood stream Infection (BSI) along with estimating mortality attributable to carbapenem resistance (CR).

Methods: In this prospective cohort study (January 2023-September 2024), done in 3 tertiary care centres in India, patients found to have mono-microbial GNB BSI were included. Primary outcome was crude mortality at day 30 of onset of BSI.

Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity.

Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage is limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via a solvent casting method and cross-linked in an alkaline solution. Sodium hydroxide facilitated deprotonation, leading to increased intramolecular hydrogen bonding and mechanical properties.

Deciphering stakeholder voice on the challenges of transformative healthcare 5.0 ecosystem: a quality function deployment analyses.

Purpose: The healthcare ecosystem continues to evolve with new technological developments with the support of its stakeholders. The technology-driven and patient-centric Healthcare 5.0 (H5.

Global Minimization of Electronic Hamiltonian 1-Norm via Linear Programming in the Block Invariant Symmetry Shift (BLISS) Method.

The cost of encoding a system Hamiltonian in a digital quantum computer as a linear combination of unitaries (LCU) grows with the 1-norm of the LCU expansion. The Block Invariant Symmetry Shift (BLISS) technique reduces this 1-norm by modifying the Hamiltonian action on only the undesired electron-number subspaces. Previously, BLISS required a computationally expensive nonlinear optimization that was not guaranteed to find the global minimum.

Green-Emitting AIEgen for Fluorescent Switch-Off Detection of Multi-Cations and Applications.

An easy-to-synthesize aggregation-induced emission (AIE) active Schiff base HNSA was obtained by condensing equimolar amount of 3-hydroxy-2-naphthohydrazide and salicylaldehyde. In pure DMSO, HNSA is non-fluorescent, but increasing the HEPES (HO, 10 mM, pH 7.4) fraction (f) ≥ 90% showed an intense green fluorescence with maximum fluorescence intensity at 515 nm.

Real-time ultrasound for umbilical venous catheter insertion in neonates- a systematic review and meta-analysis.

Objective: There has been an increase in real-time ultrasonography use in central venous catheterisation. This systematic review and meta-analysis aimed to assess the role of real-time ultrasound use in umbilical venous catheterisation in neonates.

Data Sources: PubMed, Embase, Web of Science and Cochrane Library were searched on July 11, 2024.

Emerging Trends in Neuroblastoma Diagnosis, Therapeutics, and Research.

This review explores the current understanding and recent advancements in neuroblastoma, one of the most common extracranial solid pediatric cancers, accounting for ~ 15% of childhood cancer-related mortality. The hallmarks of NBL, including angiogenesis, metastasis, apoptosis resistance, cell cycle dysregulation, drug resistance, and responses to hypoxia and ROS, underscore its complex biology. The tumor microenvironment's significance in disease progression is acknowledged in this study, along with the pivotal role of cancer stem cells in sustaining tumor growth and heterogeneity.

Diversity and Plant Growth-Promoting Activities of Culturable Seed Endophytes in Abies pindrow (Royle ex D. Don) Royle: Their Role in Seed Germination and Seedling Growth.

Abies pindrow, a vital conifer in the Kashmir Himalayan forests, faces threats from low regeneration rates, deforestation, grazing, and climate change, highlighting the urgency for restoration efforts. In this context, we investigated the diversity of potential culturable seed endophytes in A. pindrow, assessed their plant growth-promoting (PGP) activities, and their impact on seed germination and seedling growth.

Automated characterisation of cerebral microbleeds using their size and spatial distribution on brain MRI.

Cerebral microbleeds (CMBs) are small, hypointense hemosiderin deposits in the brain measuring 2-10 mm in diameter. As one of the important biomarkers of small vessel disease, they have been associated with various neurodegenerative and cerebrovascular diseases. Hence, automated detection, and subsequent extraction of clinically useful metrics (e.

Helminths infection of Schizothorax niger in Kashmir, India: morphological and molecular characterization.

Background: The identification of helminth parasites in Schizothorax spp. from Kashmir, including Schyzocotyle acheilognathi, Pomphorhynchus kashmirensis, and Adenoscolex oreini, is hindered by morphological limitations and high intraspecific variation. While previous studies have relied on morphological diagnosis, a comprehensive molecular characterization is lacking.

Pulmonary Dysfunction in Children with Dystrophinopathy: A Cross-Sectional Study.

Objectives: To observe the prevalence of impaired pulmonary function during various phases of the disease course in children aged 5-18 y with dystrophinopathy. The correlation between different parameters of pulmonary dysfunction and motor function was also studied.

Methods: One hundred and thirty-three confirmed cases of Duchenne muscular dystrophy (DMD), fulfilling predefined inclusion and exclusion criteria were evaluated.

The Future of Parenthood? Examining the Promise and Complexity of Pregnancy Robots in Reproductive Health.

Advancements in reproductive technology are now approaching an unprecedented frontier: the pregnancy robot, a potential artificial womb capable of carrying a fetus from fertilization to birth. This innovation, by simulating the natural uterine environment, could redefine pregnancy and parenthood, offering transformative benefits for maternal and infant health. The pregnancy robot promises safer pathways for individuals with medical risks, LGBTQ + couples, and single parents, while also reducing the risks of complications like preeclampsia and preterm birth.

Integration of silver nanostructures in wireless sensor networks for enhanced biochemical sensing.

Integrating noble metal nanostructures, specifically silver nanoparticles, into sensor designs has proven to enhance sensor performance across key metrics, including response time, stability, and sensitivity. However, a critical gap remains in understanding the unique contributions of various synthesis parameters on these enhancements. This study addresses this gap by examining how factors such as temperature, growth time, and choice of capping agents influence nanostructure shape and size, optimizing sensor performance for diverse conditions.

Insights on the role of cryoprotectants in enhancing the properties of bioinks required for cryobioprinting of biological constructs.

Preservation and long-term storage of readily available cell-laden tissue-engineered products are major challenges in expanding their applications in healthcare. In recent years, there has been increasing interest in the development of off-the-shelf tissue-engineered products using the cryobioprinting approach. Here, bioinks are incorporated with cryoprotective agents (CPAs) to allow the fabrication of cryopreservable tissue constructs.

A Non-Benzenoid Route to Thio-Oxybenzone Analogs: Superior UV Protection with Reduced Cytotoxicity.

A one-pot methodology for the tandem acylation and oxidative aromatization of vinylogous thioesters to 2-acyl-5-(alkyl/arylthio)phenols is presented. Initially, cyclohexane-1,3-diones were converted to vinylogous thioesters through FeCl3-mediated thioenolization. This was followed by LiTMP-mediated acylation and DDQ-mediated aromatization, which resulted in the synthesis of sulphur derived oxybenzone analogs.

Role of local structural distortions in the variation of martensitic transformation temperature with / ratio in NiMnZ (Z = In, Sn or Sb) alloys.

NiMnZ (Z = In, Sn or Sb) undergo martensitic transformation with transformation temperature () scaling with the average valence electron per atom (/) ratio. However, the rate of increase of depends on the type of Z atom, with the slope of / curve increasing from Z = In to Z = Sb. Local structural distortions are believed to be the leading cause of martensitic transformation in these alloys.

Structurally programmable, functionally tuneable dendrimers in biomedical applications.

The application of nanotechnology in medical biology has seen a significant rise in recent years because of the introduction of novel tools that include supramolecular systems, complexes, and composites. Dendrimers are one of the remarkable examples of such tools. These spherical, regularly branching structures with enhanced cell compatibility and bioavailability have shown to be an excellent option for gene or drug administration.

Exploring the Role of [Ga]Ga-DOTAGA-IAC and Comparison of Its Diagnostic Performance with [F]F-FDG PET/CT in Radioiodine Refractory Differentiated Thyroid Carcinoma.

Integrin antagonist complex (IAC), a novel αvβ3 integrin antagonist peptidomimetic, has emerged as a promising agent for molecular imaging of tumor angiogenesis. This study evaluates the biodistribution and clinical efficacy of [Ga]Ga-DOTAGA-IAC PET/CT in detecting radioiodine-refractory differentiated thyroid carcinoma (RAIR-DTC), comparing its diagnostic performance with [F]F-FDG PET/CT. In this prospective pilot study, RAIR-DTC patients underwent whole-body imaging with [F] F-FDG PET/CT, followed by [Ga]Ga-DOTAGA-IAC PET/CT.