Documentation of International Staging System (ISS) and Revised International Staging System (R-ISS) for Multiple Myeloma at a Tertiary Care Center: A Clinical Audit.

Multiple myeloma (MM) is a highly heterogeneous disease characterised by neoplastic clonal plasma cell proliferation and a wide range of clinical manifestations including skeletal destruction, hypercalcemia, anaemia, renal failure, and immune suppression. Currently accepted and widely used staging criteria for MM patients are the International staging system (ISS) and the Revised International staging system (R-ISS). In order to anticipate outcomes for these patients and to select a risk-adapted therapy, a staging approach that can classify MM patients based on risk at the time of diagnosis itself may be helpful.

Diagnostic Utility of Serum Ferritin in Identifying Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD): A Cross-Sectional Study Using National Health and Nutrition Examination Survey (NHANES-2017-2020) Data.

Unlabelled: Non-alcoholic fatty liver disease (NAFLD) is one of the major causes of chronic liver disease worldwide. There are conflicting reports on the association of serum ferritin levels and its utility in discriminating various stages of liver fibrosis in patients with NAFLD. This study is done to address the conflicts by analysing the National Health and Nutritional Examination Survey 2017-2020 (NHANES 2017-2020) data.

Redefining the Reference Interval and Cut-Off Values of the Hematological and Biochemical Parameters and Deriving a Sensitive Predictive Marker for Crisis Events in Sickle Cell Disease.

Unlabelled: The heterogeneity in clinical presentations in sickle cell disease (SCD) alters between crisis and steady state phases. Considering the pathophysiology, it is crucial to establish a disease-specific reference interval for hematological and biochemical parameters and identify the sensitive predictive markers for crisis. The case-control study included fifty-four healthy control, forty SCD cases in crisis state, and forty-six steady state cases.

Incredible use of plant-derived bioactives as anticancer agents.

Cancer is a major global concern. Despite considerable advancements in cancer therapy and control, there are still large gaps and requirements for development. In recent years, various naturally occurring anticancer drugs have been derived from natural resources, such as alkaloids, glycosides, terpenes, terpenoids, flavones, and polyphenols.

Mitochondrial DNA variants in the pathogenesis and metabolic alterations of diabetes mellitus.

Mitochondrial DNA (mtDNA) variants considerably affect diabetes mellitus by disturbing mitochondrial function, energy metabolism, oxidative stress response, and even insulin secretion. The m.3243 A > G variants is associated with maternally inherited diabetes and deafness (MIDD), where early onset diabetes and hearing loss are prominent features.

Efficacy and Safety of F-Biotic™ in Combination With Metformin for Type 2 Diabetes Mellitus: Results From a Randomized, Double-Blind Clinical Trial.

Introduction: This study evaluated the effectiveness, safety, and tolerability of F-Biotic™ (Arishina Life Sciences, Karnataka, IND), a prebiotic containing 60% resistant starch derived from natural sources, in patients with Type 2 diabetes mellitus (T2DM) on stable metformin therapy.

Methods: Seventy participants with T2DM, aged 25-70 years, were randomized into two groups: one receiving F-Biotic™ and the other a placebo, both administered daily for 12 weeks. Key outcomes included fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), fasting insulin, insulin resistance (HOMA-IR), GLP-1 levels, lipid profile, and quality of life.

Bibliometric Analysis of Research on Lip Prints.

Lip prints, or cheiloscopy, are unique patterns of grooves and wrinkles, gaining prominence in forensic science as reliable tools for personal identification, akin to fingerprints and DNA profiling. Advances in imaging techniques have enhanced their forensic applicability. This study conducts a bibliometric analysis to explore global research trends, key contributors, and thematic developments in lip print research.

Evaluation of the Safety and Efficacy of Trastuzumab Emtansine (T-DM1) Biosimilar in Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer: Findings From a Single-Center Retrospective Analysis in India.

Background Human epidermal growth factor receptor 2 (HER2)-positive breast cancer is a highly aggressive subtype characterized by a high recurrence rate. Trastuzumab emtansine (T-DM1), an antibody-drug conjugate targeting HER2, has shown improved outcomes; however, its effectiveness in cases with brain metastases remains unclear. The T-DM1 biosimilar has emerged as a cost-effective treatment option.

Antimicrobial Utilization, Adverse Drug Reactions, and Associated Cost of Care in a Tertiary Care Hospital in Eastern India.

Background Antimicrobials considerably reduce infectious conditions, but their overuse and misuse contribute to various adverse drug reactions (ADRs) and antimicrobial resistance. In 2019, India adopted a national program to reduce antibiotic resistance for 2019-2021. Assessing antibiotic consumption among the out-patient and in-patient departments is paramount because it is the foundation for implementing and assessing antibiotic stewardship initiatives.

Seronegative Autoimmune Encephalitis With Rapidly Progressive Parkinsonism.

Seronegative autoimmune encephalitis is an infrequent entity in older patients, and its presentation as rapidly progressive parkinsonism is rarely seen in cases of autoimmune encephalitis. We present a case report of an older patient who presented with worsening Parkinson's-like symptoms over a month. We highlight the importance of considering autoimmune encephalitis as a potential cause of rapidly progressive parkinsonism and the importance of radiological findings when the entire autoimmune panel is negative in such patients.

Neuromodulatory Effect of Lactate on Visual Evoked Potential After Acute Exercise in Healthy Adult Males.

Background Lactate, once considered merely a byproduct of anaerobic metabolism, is now recognized as a crucial neuromodulator in the brain, particularly during high-energy demands. Recent studies have explored its role in neuroprotection, cognitive enhancement, and neural plasticity. This study investigates the effects of elevated blood lactate levels, induced by acute exercise, on visual evoked potentials (VEPs), which reflect neural activity in the visual cortex.

Analgesic Efficacy Comparison Between Ultrasound-Guided Erector Spinae Plane Block and Retrolaminar Block in Patients Undergoing Modified Radical Mastectomy: A Randomized Controlled Trial.

Introduction: Breast cancer is the most common cancer in females. Surgery is the gold standard therapy, with modified radical mastectomy (MRM) being the most commonly performed procedure for breast cancer. Management of postoperative pain after MRM poses a clinical challenge and hence receives utmost priority.

A Comparative Study Between Posterolateral Lumbar Fusion and Transforaminal Lumbar Interbody Fusion for Degenerative Lumbar Spondylolisthesis.

Introduction Degenerative spondylolisthesis (DS) is a degenerative condition characterized by subluxation of one vertebral body anterior to the adjacent inferior vertebral body with an intact pars. Conservative treatment approaches, such as steroid injections and physical therapy, may work well at first, but in resistant situations, surgery is frequently necessary. Posterolateral lumbar fusion (PLF) has been widely used, but transforaminal lumbar interbody fusion (TLIF) offers theoretical advantages such as improved alignment and enhanced fusion rates.

Developing a Discrete Choice Experiment Questionnaire to Design Health Policy Interventions for Rural Retention of Specialist Physicians in Rajasthan, India.

Background: Understanding the preferences of specialist physicians is essential to mitigate their critical deficiency in the Indian rural healthcare system. This necessitates an urgent focus to inform health policy interventions imperative to address and strengthen the vacancies of specialist physicians in the Indian rural healthcare system. The policy interventions should address the preferences of specialists, leading to their intention to stay in rural postings.

Beyond Classic Leprosy: Exploring Atypical Manifestations and Their Diagnostic Challenges.

Leprosy, or Hansen's disease, is an ancient infectious disease characterized by varied clinical presentations influenced by the host's immune response. This study aimed to explore the atypical manifestations of Hansen's disease in a cohort of 15 biopsy-confirmed patients admitted to the Department of Dermatology, Venereology & Leprosy at a tertiary care center in Andhra Pradesh, India. There were 14 male patients and one female patient, with a mean age of 42.

Night Eating Syndrome and Its Association With Depression Among College Students: A Cross-Sectional Study.

Introduction Night eating syndrome (NES) is categorized as an eating disorder characterized by a delayed circadian rhythm of food intake and involves evening hyperphagia and/or nighttime awakening and food consumption two or more times per week. Young adults showed a higher prevalence of night eating, and students who reported high stress, irregular sleep patterns, and disordered eating may be more likely to develop NES symptoms. Objective This study aimed to assess the prevalence of Night Eating Syndrome among college students in Chengalpattu district of Tamil Nadu (India) and to find out the association between NES and socio-demographic variables and depression among the students.

Early Identification of Low Scorers: The Role of Formative Assessments and Summative Assessments.

Background Identifying students who are low scorers is essential for providing timely interventions and support. Traditional methods of identifying such students often rely on summative assessments, such as end-of-term exams. However, formative assessments offer valuable insights into students' understanding, strengths, and weaknesses.

A Pilot Study of the Anthropometric Growth Pattern of the Human Auricle of the North Indian Region.

Objectives To assess the dimensions of external ear (pinna) in different age groups in the North Indian population. To assess the mean dimensions of external ear (pinna) in different age groups in North Indian males and females. Methods The study area was Lucknow/Barabanki, Uttar Pradesh, and the study center was Era's Lucknow Medical College, Uttar Pradesh, India.

Molecular Assay Versus Serology for Diagnosis of Scrub Typhus Among Patients With Acute Febrile Illness: A Retrospective Study.

Background And Objectives: The epidemiology of scrub typhus caused by has been growing in Odisha, India. The most common symptoms include fever, cough, lymphadenopathy, eschar, and rash. In India, enzyme-linked immunosorbent assays (ELISA) and DNA real-time polymerase chain reaction (DNA RT-PCR) are the most commonly used methods to diagnose scrub typhus.

The Role of Nasal Microbiota and Sensitivity in Patients With Chronic Rhinosinusitis at a Rural Tertiary Care Hospital.

Background and aim Etiopathogeneses of chronic rhinosinusitis are poorly understood. Recent research emphasizes culture-independent molecular sequencing to identify clusters of flora that may function as drivers of inflammation. Studies also indicate that macrolides are as effective as corticosteroids in controlling chronic rhinosinusitis.

Comparison of the Effectiveness and Safety of Segmental Thoracic Spinal Anesthesia Using Isobaric Levobupivacaine 0.5% Versus Hyperbaric Levobupivacaine 0.5% in Performing Laparoscopic Cholecystectomy: A Prospective Randomized Controlled Trial.

Introduction: Laparoscopic cholecystectomy has evolved into a daycare procedure thanks to advancements in both surgical and anesthetic techniques. Regional anesthesia, specifically segmental thoracic spinal anesthesia (TSA), offers distinct benefits over general anesthesia, such as enhanced hemodynamic stability and quicker recovery, especially in high-risk patients. This study aims to compare the sensory and motor block characteristics, hemodynamic stability, and incidence of adverse effects between isobaric and hyperbaric 0.

Exploring the antifungal potential of -derived stilbenoids and cannabinoids against novel targets through protein interaction profiling.

Cannabinoid and stilbenoid compounds derived from were screened against eight specific fungal protein targets to identify potential antifungal agents. The proteins investigated included Glycosylphosphatidylinositol (GPI), Enolase, Mannitol-2-dehydrogenase, GMP synthase, Dihydroorotate dehydrogenase (DHODH), Heat shock protein 90 homolog (Hsp90), Chitin Synthase 2 (CaChs2), and Mannitol-1-phosphate 5-dehydrogenase (M1P5DH), all of which play crucial roles in fungal survival and pathogenicity. This research evaluates the binding affinities and interaction profiles of selected cannabinoids and stilbenoids with these eight proteins using molecular docking and molecular dynamics simulations.

Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations.

The natural world is a vast reservoir of exceptionally varied and inventive chemical compositions. Natural products are used as initial compounds to create combinatorial libraries by targeted modifications and then by analyzing their structure-activity connections. This stage is regarded as a crucial milestone in drug discovery and development.