Chiral and Quantum Plasmonic Sensors: New Frontiers in Selective and Ultra-Sensitive Sensing.

Surface Plasmon Polaritons (SPPs) and Localized Surface Plasmon Resonances (LSPRs) are fundamental phenomena in plasmonics that enable the confinement of electromagnetic waves beyond the diffraction limit. This confinement results in a significant enhancement of the electric field, making this phenomenon particularly beneficial for sensitive detection applications. However, conventional plasmonic sensors face several challenges, notably their difficulty in distinguishing chiral molecules, which are vital in drug development.

Solitary Rectal Ulcer Syndrome - A Rare Entity in the Pediatric Population.

Objective: To study and correlate the clinicopathological findings of Solitary Rectal Ulcer Syndrome (SRUS) in 10 pediatric patients.

Material And Methods: This study is a retrospective study of patients from January 2017 to June 2024. The clinical records were reviewed for details of the clinical presentation, colonoscopic findings, associated local and systemic diseases, and other investigations.

Electrochemical Deconstruction of Waste Polyvinylidene Chloride (PVDC) to Value-Added Products in Batch and Flow.

Chlorinated polymers have made enormous contributions to materials science and are commercially produced on a large scale. These chlorinated polymers could be recycled as chlorine sources to efficiently produce valuable chlorinated compounds owing to their facile release of HCl. Although the thermal stability of PVDC is low compared to PVC, this can be advantageous in terms of easy and fast dehydrochlorination.

Navigating Tumor Microenvironment Barriers with Nanotherapeutic Strategies for Targeting Metastasis.

Therapeutic strategy for efficiently targeting cancer cells needs an in-depth understanding of the cellular and molecular interplay in the tumor microenvironment (TME). TME comprises heterogeneous cells clustered together to translate tumor initiation, migration, and proliferation. The TME mainly comprises proliferating tumor cells, stromal cells, blood vessels, lymphatic vessels, cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), and cancer stem cells (CSC).

Smart Mesoporous Silica Nanoparticles in Cancer: Diagnosis, Treatment, Immunogenicity, and Clinical Translation.

In cancer research and personalized medicine, mesoporous silica nanoparticles (MSNs) have emerged as a significant breakthrough in both cancer treatment and diagnosis. MSNs offer targeted drug delivery, enhancing therapeutic effectiveness while minimizing adverse effects on healthy cells. Due to their unique characteristics, MSNs provide targeted drug delivery, maximizing therapeutic effectiveness with minimal adverse effects on healthy cells.

Leveraging Long-Life Alkaline Redox Flow Batteries Using Durable and High-Hydroxide Exchange N-Bridged Triazine Framework Membranes.

Fluorine-free organic framework polyelectrolyte membranes showing near frictionless ionic conductivities are gaining cognitive insights. However, the co-precipitation of COFs in the membranes often brings trade-offs to commission long-life electrochemical energy storage solutions. Herein, a durable and ionically miscible dual-ion exchange membrane based on triazine organic framework (TOF) is designed for alkaline redox flow batteries (RFB).

Pd(II)-catalyzed cyclization of alkyne-tethered malononitriles nitrile insertion.

Herein, we have developed a Pd(II)-catalyzed cyclization of prochiral alkyne-tethered malononitriles to access five-membered carbocycles having a nitrile-containing all-carbon quaternary center. The reaction pathway involves a -acetoxypalladation, nitrile group insertions into the carbon-palladium bond and sequential deacetylation followed by -acetylation. Initial studies on asymmetric cyclization were also performed with chiral Pyox ligands.

Role of Artificial Intelligence in Drug Discovery to Revolutionize the Pharmaceutical Industry: Resources, Methods and Applications.

Traditional drug discovery methods such as wet-lab testing, validations, and synthetic techniques are time-consuming and expensive. Artificial Intelligence (AI) approaches have progressed to the point where they can have a significant impact on the drug discovery process. Using massive volumes of open data, artificial intelligence methods are revolutionizing the pharmaceutical industry.

Transcriptional engineering for value enhancement of oilseed crops: a forward perspective.

Plant-derived oils provide 20%-35% of dietary calories and are a primary source of essential omega-6 (linoleic) and omega-3 (α-linolenic) fatty acids. While traditional breeding has significantly increased yields in key oilseed crops like soybean, sunflower, canola, peanut, and cottonseed, overall gains have plateaued over the past few decades. Oilseed crops also experience substantial yield losses in both prime and marginal agricultural areas due to biotic and abiotic stresses and shifting agro-climates.

A Contemporary Insight Into the Seroepidemiology of Herpes Simplex Virus Infection in the Sub-Himalayan Region: Seroepidemiology of HSV Infection in North India.

Infection by human herpes simplex virus type 1 and type 2 (HSV-1/2) is common globally though with wide regional variability. Seroepidemiology of HSV-1/2 infections is of utmost importance in formulating control strategies, but there is a paucity of data from many regions of India. This study aimed to determine the prevalence of anti-HSV-1/2 antibodies in Uttarakhand and adjoining areas and to study its pattern and distribution in different subgroups.

Confronting allergies: strategies for combating pollution and safeguarding our health.

Increasing evidence demonstrates a robust link between environmental pollutants and allergic reactions, with air and indoor pollution exacerbating respiratory allergies and climate change intensifying seasonal allergies. Comprehensive action, including government regulations, public awareness, and individual efforts, is essential to mitigate pollution's impact on allergies and safeguard public health and ecological balance. Recent findings indicate a strong correlation between environmental pollutants and allergic reactions, with air pollution from vehicular emissions and industrial activities exacerbating respiratory allergies like asthma and allergic rhinitis.

From Sevagram to National Health Policy: Dr. Sushila Nayar's Contributions to Rural Healthcare and Medical Education in India.

Dr. Sushila Nayar (1914-2001) was a pioneering figure in Indian public health whose work spanned from grassroots initiatives to national policy formation. This review article traces Dr.

Navigating Challenges in Adult Airway Foreign Body Extraction: Retrospective Insights From Flexible Bronchoscopy.

Background Airway foreign body aspiration is an emergency predominantly observed in children and the elderly. However, it also occurs in adults, presenting with a variety of symptoms. Both rigid and flexible bronchoscopies are employed for foreign body retrieval.

Factors Affecting Visual Outcomes Following Scleral-Fixated Intraocular Lens Implantation at a Tertiary Care Center in Eastern India.

Background: Lens implantation becomes a major concern in patients lacking posterior capsular support, but various methods are available for rehabilitation. In such patients, scleral-fixated intraocular lens (SFIOL) implantation is preferred due to its fewer complications and better simulation of the natural lens position. In this non-randomized retrospective clinical study, we aimed to assess visual outcomes after sutureless SFIOL implantation in aphakic patients and factors affecting visual outcomes.

Assessment and Correlation of TP53 With Histological Parameters of Oral Squamous Cell Carcinoma.

Background Oral squamous cell carcinoma is a common problem among tobacco chewers and related products in developing countries like India. Histopathological examination evaluates and confirms the diagnosis of oral SCC. Clinical examination and molecular profiling by histopathological examination (HPE) are important prognostic tools used in clinical practice.

Prone Position Video Laryngoscopy for the Successful Intubation of Penetrating Back Injury: A Report of Two Cases.

Airway management in the prone position presents significant challenges and carries the risk of encountering a difficult airway situation. Here, we present two adults who sustained traumatic knife injuries to the back and required surgical intervention. Due to the potential life-threatening complications associated with dislodging the knife, traditional supine and lateral decubitus positions were not feasible for airway management.

Unprecedented Co-occurrence: Identification of a Pathogenic Genetic Variant in the KMT2B Gene in a Wilson Disease Patient with a Pathogenic ATP7B Mutation.

The pathophysiology of dystonia in Wilson disease (WD) is complex and poorly understood. Copper accumulation in the basal ganglia, disrupts dopaminergic pathways, contributing to dystonia's development via neurotransmitter imbalance. Despite advances in diagnosis and management, WD with dystonia remains a challenging condition to treat.

Modulation of Autophagy and Nitric Oxide Signaling via Glycyrrhizic Acid and 7-Nitroindazole in MPTP-induced Parkinson's Disease Model.

Background: Parkinson's disease (PD) is characterized by dopaminergic (DA) neuron loss, Lewy body build-up, and motor dysfunction. One of the primary pathogenic mechanisms of PD development is autophagy dysfunction and nitric oxide-mediated neurotoxicity.

Purpose: The current study focuses on autophagy and nitric oxide (NO) signaling roles in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated PD mice and their protection by their modulators.

Self-esteem and Locus of Control as Predictors of Academic Achievement: A Study Among Graduate Students.

Background: Earlier researchers have explored the individual impacts of locus of control and self-esteem on academic as well as nonacademic success. But limited attention was given to their interplay within a university context. By integrating these variables into a unified framework, a more comprehensive understanding of the learning processes of university students can be achieved, which can further help in developing strategies to improve the overall learning outcome and come out as successful individuals.

Assessment of heat-killed expressing Chikungunya virus E2 protein as a candidate vaccine for dual protection against Chikungunya virus and .

The Chikungunya virus (CHIKV) is a mosquito-borne virus with a long history of recurring epidemics transmitted through mosquitoes. The rapid spread of CHIKV has intensified the need for potent vaccines. Escherichia coli (), a vital part of human gut microbiota, is utilized in recombinant DNA technology for cloning.

Applications of MR Finger printing derived T1 and T2 values in Adult brain: A Systematic review.

Introduction: Magnetic resonance imaging (MRI) is essential for brain imaging, but conventional methods rely on qualitative contrast, are time-intensive, and prone to variability. Magnetic resonance finger printing (MRF) addresses these limitations by enabling fast, simultaneous mapping of multiple tissue properties like T1, T2. Using dynamic acquisition parameters and a precomputed signal dictionary, MRF provides robust, qualitative maps, improving diagnostic precision and expanding clinical and research applications in brain imaging.

Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges.

The field of three dimensional (3D) bioprinting has witnessed significant advancements, with bioinks playing a crucial role in enabling the fabrication of complex tissue constructs. This review explores the innovative bioinks that are currently shaping the future of 3D bioprinting, focusing on their composition, functionality, and potential for tissue engineering, drug delivery, and regenerative medicine. The development of bioinks, incorporating natural and synthetic materials, offers unprecedented opportunities for personalized medicine.

A bird's-eye view of the biological mechanism and machine learning prediction approaches for cell-penetrating peptides.

Cell-penetrating peptides (CPPs) are highly effective at passing through eukaryotic membranes with various cargo molecules, like drugs, proteins, nucleic acids, and nanoparticles, without causing significant harm. Creating drug delivery systems with CPP is associated with cancer, genetic disorders, and diabetes due to their unique chemical properties. Wet lab experiments in drug discovery methodologies are time-consuming and expensive.