Permanent Left Bundle Branch Area DF-4 Defibrillator Lead Implantation-Feasibility, Procedural Caveats, Safety, and Follow-Up.

Introduction: Permanent implantation of a DF-4 implantable cardiac defibrillator (ICD) lead in the left bundle branch area (LBBA-ICD) is the next paradigm in amalgamating cardiac resynchronization therapy (CRT) and defibrillation. We systematically investigated feasibility/success rate, procedural caveats, and complications associated with a permanent DF-4 LBBA ICD implant and pertinent data at short-term follow-up.

Methods: We prospectively attempted implantation of 7 Fr Durata (Abbott, Chicago, IL, USA) single coil DF-4 ICD lead at the LBBA using a fixed-curve non-deflectable CPS locator delivery sheath.

Alternative and Sustainable Route to Explore a New Class of Amidines by Photochemical Synergistic Effect of Copper/Nitroxyl Radical Catalysis via Halogen-Atom Transfer.

Amidines are a vital class of bioactive compounds and often necessitate multiple components for their synthesis. Therefore, exploring efficient and sustainable methodologies for their synthesis is indispensable. Herein, we disclose an alternative and greener method for synthesizing an unexplored new class of amidines through the photochemical synergistic effect of copper/nitroxyl radical catalysis.

Penicillin Allergy Management in India and Sri Lanka: Current Challenges.

Data regarding Penicillin allergy labels (PALs) from India and Sri Lanka are sparse. Emerging data suggests that the proportion of patients declaring an unverified PAL in secondary care in India and Sri Lanka (1%-4%) is lesser than that reported in High Income Countries (15%-20%). However, even this relatively small percentage translates into a large absolute number, as this part of the world accounts for approximately 25% of the global population.

Exploring cyanobacteria from diverse habitats of the Konkan region of India, unveiling novel species of the genera Desikacharya, Pseudoaliinostoc, and Chlorogloeopsis using a polyphasic approach.

The Indian subcontinent has emerged as a natural habitat to several cyanobacterial taxa which have been explored and described in the past few years using a polyphasic approach. Various new genera and species of Nostoc morphotypes, heteropolar unbranched as well as branched heterocytous cyanobacteria, have been described from various parts of India such as the central mainland, temperate hill stations of extreme northern India, and the biodiversity hotspots of northeast India. Konkan, a small strip of land bounded by Arabian sea on the west and Sahyadri mountains on the east, has various habitats such as coastal beds, old monuments, freshwater lakes, and rivers; however, this region has been less charted in modern cyanobacterial systematics, relative to others.

Integrating a greener RP-HPLC method and chemical pattern recognition for the identification of L. and its common adulterants in Indian markets.

This work deals with the development of a greener RP-HPLC method and chemical pattern recognition for the identification of L. collected from different natural sources and samples traded as '' in Indian herbal drug markets. The simultaneous quantification of α- and β-asarone was performed using 0.

Crystallisation Based Deracemisation and Chiral Resolution of Small Molecules.

Enantiomeric separation of chiral molecules is pivotal for exploring fundamental questions about life's origin and many other fields. Crystallisation is an important platform for the separation of chiral molecules, elegantly applied to many systems, for instance, the formation of conglomerates, where the enantiomers crystallise as separate phases. Many approaches have been proposed to explore crystallisation-driven enantiomeric separation with fewer insights into the complex pathways associated with the separation processes.

The Songdo consensus: Development of minimum reporting standards for studies of intervention in idiopathic anal fistula using a modified nominal group technique.

Aim: Cryptoglandular anal fistulas carry a substantial burden to quality of life. Surgery is the only effective curative treatment but requires balancing fistula healing against pain, wounds and continence impairment. Sphincter-preserving procedures do exist but demonstrate variable rates of success.

Trauma-Induced Stress Distribution in Primary Incisors Restored With Preformed Zirconia Crowns: 3D Finite Element Analysis.

Background/aims: Preformed zirconia crowns have emerged as the preferred choice for restoring damaged primary incisors. However, they differ from natural teeth in their biophysical properties and can potentially alter the overall response of crowned teeth to a traumatic load. This in silico study aimed to compare the response of three different traumatic loading conditions for the (i) natural (M1) and (ii) zirconia-restored tooth models (M2) models.

Curcumin: A Potential Detoxifier Against Chemical and Natural Toxicants.

The human body gets exposed to a variety of toxins intentionally or unintentionally on a regular basis from sources such as air, water, food, and soil. Certain toxins can be synthetic, while some are biological. The toxins affect the various parts of the body by activating numerous pro-inflammatory markers, like oxidative stresses, that tend to disturb the normal function of the organs ultimately.

Development of Synthetic Antimicrobial Peptides Based on Genomic Analysis of Streptococcus salivarius.

Background: In the oral environment, the production of bacteriocins or antimicrobial peptides (AMPs) plays a crucial role in maintaining ecological balance by impeding the proliferation of closely related microorganisms. This study aims to conduct in silico genome screening of Streptococcus salivarius to identify potential antimicrobial compounds existing as hypothetical peptides, with the goal of developing novel synthetic antimicrobial peptides.

Methods: Draft genomes of various oral Streptococcus salivarius strains were obtained from the NCBI database and subjected to analysis using bioinformatic tools, viz.

Biogenic Synthesis and Characterization of Silver Nanoparticles With Cyanobacterium Oscillatoria salina Using Against MDR Pathogenic Bacteria and Their Antiproliferative and Toxicity Study.

The biosynthesis of silver nanoparticles (AgNPs) using cyanobacteria has gained significant attention due to its cost-effective and eco-friendly advantages in green synthesis. Additionally, biogenic AgNPs show great potential for biological applications, particularly in combating infections caused by drug-resistant bacteria and fungi. This study synthesized using the cyanobacterium Oscillatoria salina (Os-AgNPs).

Pre-operative subjective functional capacity and postoperative outcomes in adult non-cardiac surgery: a systematic review and meta-analysis.

Introduction: Assessment of functional capacity is an essential part of peri-operative risk stratification. Subjective functional capacity is easier to examine than objective tests of patient fitness. However, the association between subjective functional capacity and postoperative outcomes has not been established.

Unveiling Cannabinoids and Terpenes Diversity in Cannabis sativa L. from Northern India for Future Breeding Strategies.

Cannabis sativa L. is an important medicinal plant with high commercial value. In recent years, the research interest in cannabidiol (CBD) and terpene-rich cannabis has been rapidly expanding due to their high therapeutic potential.

Substituent-driven ESIPT in Chromeno-pyrroloquinoline probe for differentiating normal and cancer cells.

Despite significant advancements in the structural flexibility and functional diversity of fluorescent molecular sensors, the chromophores often require complex synthetic processes and are typically designed to perform only a specific function. Herein, we have demonstrated the unique features of fluorophores based on a fused coumarin-indole scaffold, which are synthetically available via a one-step reaction. Four fluorophores (ICH, ICEst, ICOMe, and ICNMe2) with varying substituents were synthesized and characterized.

Two case reports of biliary stent infections by extensively drug-resistant Escherichia coli carrying bla at a tertiary-care hospital in West Bengal, India.

Background: Rising antimicrobial resistance (AMR) is an acute public health emergency impeding the clinical efficacy of surgical interventions. Biliary stent placement is one of the routine surgical procedures that rarely lead to infections that are empirically managed by broad-spectrum β-lactams and fluoroquinolones. Critical priority pathogens, such as carbapenem-resistant Escherichia coli challenge treatment outcomes and infection prevention.

Leaching of rare earth elements from phosphogypsum via citric acid medium: optimization through central composite design and kinetics studies.

Due to limited resources of rare earth elements (REEs) and their high demand, these are subjected to supply constraints. So it is important to recover REEs from potential secondary resources. Phosphogypsum is the waste generated on an enormous scale (300 million metric tons per year) from the fertilizer industry.

Clinical efficacy of photobiomodulation therapy in dental implant stability and crestal bone loss in implants placed in healed sites: a systematic review and meta-analysis of randomized clinical trials.

This systematic review and meta-analysis aimed to compare the effect of photobiomodulation (PBM) therapy on implant stability and crestal bone loss placed in healed sites. The present systematic review and meta-analysis were conducted according to PRISMA (The Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Two investigators carried out the electronic search of Pubmed, Google Scholar, and Ebscohost for published literature from 2012 till March 2024.

Impact of nocturnal road traffic noise and annoyance on self-reported insomnia symptoms: policy intervention in noise-polluted environments.

Chronic exposure to traffic noise is associated with increased stress and sleep disruptions. Research on the health consequences of environmental noise, specifically traffic noise, has primarily been conducted in high-income countries (HICs), which have guided the development of noise regulations. The relevance of these findings to policy frameworks in low- and middle-income countries (LMICs) remains uncertain.

Targeting breast cancer stem cells in ER-positive breast cancer by repurposing the benzoporphyrin derivative verteporfin as a YAP/TAZ small molecule inhibitor.

Background: Current treatment strategies for hormone-dependent breast cancers, including adjuvant endocrine therapy, often fail due to persistence of breast cancer stem cells (brCSCs), which are significant contributors to tumor recurrence and treatment resistance. Therefore, gaining deeper insights into the molecular regulators driving breast cancer aggressiveness is important. Moreover, given the complexities and expenses involved in developing new pharmacological agents, the strategic repurposing of existing FDA-approved drugs to target these key molecular pathways presents a compelling approach for identifying novel therapeutic interventions aimed at mitigating tumor refractoriness.