An alternative approach to biokinetic modelling for phenol pollutant degradation and microbial growth using Genetic Programming.

Biokinetic models can optimise pollutant degradation and enhance microbial growth processes, aiding to protect ecosystem protection. Traditional biokinetic approaches (such as Monod, Haldane, etc.) can be challenging, as they require detailed knowledge of the organism's metabolism and the ability to solve numerous kinetic differential equations based on the principles of micro, molecular biology and biochemistry (first engineering principles) which can lead to discrepancies between predicted and actual degradation rates.

Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis.

Background: For decades, poor treatment options and low-quality evidence plagued care for patients with rifampin-resistant tuberculosis. The advent of new drugs to treat tuberculosis and enhanced funding now permit randomized, controlled trials of shortened-duration, all-oral treatments for rifampin-resistant tuberculosis.

Methods: We conducted a phase 3, multinational, open-label, randomized, controlled noninferiority trial to compare standard therapy for treatment of fluoroquinolone-susceptible, rifampin-resistant tuberculosis with five 9-month oral regimens that included various combinations of bedaquiline (B), delamanid (D), linezolid (L), levofloxacin (Lfx) or moxifloxacin (M), clofazimine (C), and pyrazinamide (Z).

Provision of Radiology Reports Simplified With Large Language Models to Patients With Cancer: Impact on Patient Satisfaction.

Purpose: To explore the perceived utility and effect of simplified radiology reports on oncology patients' knowledge and feasibility of large language models (LLMs) to generate such reports.

Materials And Methods: This study was approved by the Institute Ethics Committee. In phase I, five state-of-the-art LLMs (Generative Pre-Trained Transformer-4o [GPT-4o], Google Gemini, Claude Opus, Llama-3.

Analysis of trajectory transection rate on four-lane divided rural highway curves.

Objective: The study aims to develop continuous trajectory profiles along curves with minimal error. It also focuses on formulating a percentage trajectory transection rate model as a function of geometric parameters (e.g.

The Relationship between Removable Dental Prostheses and Brain Activity in Elderly Individuals: Systematic Review.

Background: There is an increasing body of literature associating edentulism with cognitive impairment. The aim of this systematic review was to summarize the available data, emphasizing the role of removable dental prostheses in preventing cognitive deterioration and promoting brain health in elderly individuals.

Aim: This systematic review investigates the relationship between the use of removable dental prostheses and physiological or adaptive changes at the cerebral level in partially and completely edentulous patients.

Patient-derived Organoids and Xenografts Uncover Therapeutic Vulnerabilities in Colorectal Signet Ring Cell Carcinomas.

Purpose: Identifying therapeutic targets for Signet Ring Cell Carcinoma (SRCC) of the colon and rectum is a clinical challenge due to the lack of Patient-Derived Organoids (PDO) or Xenografts (PDX). We present a robust method to establish PDO and PDX models to answer address this unmet need. We demonstrate that these models identify novel therapeutic strategies targeting therapy resistance and peritoneal metastasis.

Early weaning from invasive mechanical ventilation via high-flow nasal oxygen versus conventional weaning in patients with hypoxemic respiratory failure: a prospective randomized controlled study.

Objective: Although the efficacy of high-flow nasal oxygen therapy in delaying or avoiding intubation in patients with hypoxemic respiratory failure has been studied, its potential for facilitating early weaning from invasive mechanical ventilation remains unexplored.

Methods: In this randomized controlled trial, 80 adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation for > 48 hours were enrolled and divided into two groups: conventional weaning and early weaning via high-flow nasal oxygen. In the conventional weaning group, the spontaneous breathing trial was performed after the PaO2/FiO2 ratio was ≥ 200, whereas in the high-flow nasal oxygen group, the spontaneous breathing trial was conducted earlier when the PaO2/FiO2 ratio was 150 - 200.

Exploring the nature of stuttering through a behavioral-neuro-modulation intervention program in bilinguals with stuttering.

Purpose: Investigations on identifying the nature of stuttering present varying views. The argument remains whether the stuttering dysfluencies have a motor or a linguistic foundation. Though stuttering is considered a speech-motor disorder, linguistic factors are increasingly reported to play a role in stuttering.

Cellulose Nanofiber-Reinforced γ-AlOOH Aerogels for Enhanced Removal of Environmental Pollutants.

In this study, we report the modification of a monolithic γ-aluminum oxy-hydroxide (γ-AlOOH) aerogel with cellulose nanofibers (CNFs) using the sol-gel method via supercritical drying. The optimized 2% CNF (w/w) results in a monolithic CNF-γ-AlOOH that is amorphous in nature, along with C-C and C-O-C functional groups. Transmission electron microscopy (TEM) images of the as-synthesized CNF-γ-AlOOH showed CNF embedded in the γ-AlOOH aerogel.

The landscape of family medicine in India - A cross-sectional survey study.

Family medicine was recognized as a distinct specialty in India in the early 1980s, but it is at an early stage of implementation. There are few training programs, and little is known about family physicians' training, perceptions, and current practices. This paper describes the findings from the first national survey of family medicine in India.

Review of Indian studies on environmental impact assessment.

Environmental clearance in India is a legal instrument that determines potential environmental implication of organized projects in India. It entails an assessment of sensitive projects, focal points, and proposals that have potential and likely effects on social, environmental, and economic matters before they are commenced. The intended goal of this procedure is to detect negative effects on local societies, the environment in this case, so as to foster sustainable development.

Assessing the role of Alnus nepalensis D. Don in stabilizing landslide and its potential distribution: a case study from Uttarakhand, Western Himalaya.

The rising frequency and severity of landslides in the vulnerable Himalayan region of India threaten human settlements and critical infrastructure. This growing issue demands urgent action and innovative strategies to mitigate risks and bolster the resilience of affected communities and infrastructure in this fragile area. The research explores the use of Alnus nepalensis for slope stabilization, illustrated by a case study near Ukhimath, Uttarakhand, India, and elucidates the potential ecological niche of Alnus in the temperate region of Uttarakhand using well-dispersed species occurrence records along with environment.

Treatment outcomes among children and adolescents with extensively drug-resistant (XDR) and pre-XDR tuberculosis: Systematic review and meta-analysis.

Extensively drug-resistant (XDR) and pre-XDR- tuberculosis (TB) account for approximately a third of pediatric MDR-TB cases globally. Clinical management is challenging; recommendations are based on limited evidence. We assessed the clinical outcomes for children and adolescents treated for XDR-and pre-XDR-TB.

Correction: Understanding COVID-19 vaccine hesitancy in Meghalaya, India: Multiple correspondence and agglomerative hierarchical cluster analyses.

[This corrects the article DOI: 10.1371/journal.pgph.

Ruthenium-Catalyzed Intramolecular Allene-alkyne Cascade Cyclization: Access to the Sulfone-cyclopenta[]naphthalene Core.

A ruthenium-catalyzed intramolecular cascade cyclization of allene-alkyne has been achieved. This method offers a streamlined and atom-economical approach for the construction of sulfone bearing 1-cyclopenta[]naphthalenes, an important structural scaffold that exists in biologically active compounds. Our approach, backed by mechanistic insights from deuterium labeling, DFT calculations, and potential for reaction scale-up, presents synthetic chemists with an invaluable tool for efficiently producing a distinct carbon framework in a one-pot manner.

Inactivation of , and multidrug-resistant with dielectric barrier discharged cold atmospheric plasma: a comparative study with antimicrobial drugs.

Cold atmospheric plasma (CAP) has emerged as a promising technology for neutralizing microbes, including multidrug-resistant strains. This study investigates CAP's potential as an alternative to traditional antimicrobial drugs for microbial inactivation. In the era of increasing antimicrobial resistance, there is a persistent need for alternative antimicrobial strategies.

Intermediate-Term Outcomes and Complications of Ahmed Glaucoma Valve in Type 1 Keratoprostheses.

Purpose: To evaluate intermediate-term outcomes and complications associated with Ahmed glaucoma valve (AGV) implantation in eyes with type 1 keratoprosthesis (KPro).

Methods: We retrospectively reviewed records of 43 eyes of 43 Indian patients with type 1 KPro and AGV from 2009 to 2021 with a minimum of 6-months of follow-up. Five eyes that had AGV before KPro were excluded, leaving 38 eyes for analysis.

Exotic Synchronization in Continuous Time Crystals Outside the Symmetric Subspace.

Exploring continuous time crystals (CTCs) within the symmetric subspace of spin systems has been a subject of intensive research in recent times. Thus far, the stability of the time-crystal phase outside the symmetric subspace in such spin systems has gone largely unexplored. Here, we investigate the effect of including the asymmetric subspaces on the dynamics of CTCs in a driven dissipative spin model.

Precise Measurement of the e^{+}e^{-}→D_{s}^{+}D_{s}^{-} Cross Section at Center-of-Mass Energies from Threshold to 4.95 GeV.

Using the e^{+}e^{-} collision data collected with the BESIII detector operating at the BEPCII collider, at center-of-mass energies from the threshold to 4.95 GeV, we present precise measurements of the cross section for the process e^{+}e^{-}→D_{s}^{+}D_{s}^{-} using a single-tag method. The resulting cross section line shape exhibits several new structures, thereby offering an input for a future coupled-channel analysis and model tests, which are critical to understand vector charmonium-like states with masses between 4 and 5 GeV.

NH-MIL-125(Ti) and its functional nanomaterials - a versatile platform in the photocatalytic arena.

Titanium (Ti)-based MOFs are promising materials known for their porosity, stability, diverse valence states, and a lower conduction band (CB) than Zr-MOFs. These features support stable ligand-to-metal charge transfer (LMCT) transitions under photoirradiation, enhancing photocatalytic performance. However, Ti-MOF structures remain a challenge owing to the highly volatile and hydrophilic nature of ionic Ti precursors.

Assessing the role of education level on climate change belief, concern and action: a multinational survey of healthcare professionals in nephrology.

Background: Climate change poses a significant risk to kidney health, and countries with lower national wealth are more vulnerable. Yet, citizens from lower-income countries demonstrate less concern for climate change than those from higher-income countries. Education is a key covariate.