Anticorrosion properties of ionic liquid functionalized graphene oxide epoxy composite coating on the carbon steel for CCUS environment.

The adoption of carbon capture, utilization, and storage (CCUS) technology is increasingly prevalent, driven by the global initiative to conserve energy and reduce emissions. Nevertheless, CCUS has the potential to induce corrosion in equipment, particularly in high-pressure environments containing carbon dioxide (CO). Therefore, anti-corrosion protection is necessary for the metal utilized for CO production and storage equipment.

A scientometric analysis of highly cited papers in Indian spine research (1995-2024): navigating the impact.

Purpose: The spine research within India has seen significant advancement, yet detailed examinations of its impact and evolution still need to be made sparse. To conduct a comprehensive scientometric review of the most frequently cited papers in Indian spine research from 1995 to 2024, aiming to map the field's evolution and its global impact.

Methods: Utilizing the Scopus database, a search was performed with keywords related to spine research, identifying 105 highly cited papers.

Recent advancements in the understanding of the alterations in mitochondrial biogenesis in Alzheimer's disease.

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by progressive memory loss and cognitive decline. The processes underlying the pathophysiology of AD are still not fully understood despite a great deal of research. Since mitochondrial dysfunction affects cellular energy metabolism, oxidative stress, and neuronal survival, it is becoming increasingly clear that it plays a major role in the development of AD.

Changes in physical characteristics of extreme rainfall events during the Indian summer monsoon based on downscaled and bias-corrected CMIP6 models.

We identified a set of bias-corrected and downscaled Coupled Model Intercomparison Project 6 (CMIP6) models capable of accurately simulating the observed mean Indian summer monsoon rainfall, extreme rain events (EREs) and their respective interannual variability. The future changes in EREs projected by these models for four climate change scenarios-Shared Socioeconomic Pathways (SSPs), 1-2.6, 2-4.

Co-linear Hexa-Mirror-Based Multi-Periodic Structured Illumination Microscopy.

Structured illumination microscopy (SIM) is a robust wide-field optical nanoscopy technique. Several approaches are implemented to improve SIM's resolution capability (∼2-fold). However, achieving a high resolution with a large field of view (FOV) is still challenging.

Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy.

Aberrations emerging in mitochondrial homeostasis are restrained by mitophagy to control mitochondrial integrity, bioenergetics signaling, metabolism, oxidative stress, and apoptosis. The mitophagy-accompanied mitochondrial processes that occur in a dysregulated condition act as drivers for cancer occurrence. In addition, the enigmatic nature of mitophagy in cancer cells modulates the cellular proteome, creating challenges for therapeutic interventions.

Unveiling the silent defenders: mycobacterial stress sensors at the forefront to combat tuberculosis.

The global escalation in tuberculosis (TB) cases accompanied by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of ( emphasizes the critical requirement for novel potent drugs. The demonstrates extraordinary adaptability, thriving in diverse conditions, and always finds itself in win-win situations regardless of whether the environment is favorable or unfavorable; no matter the magnitude of the challenge, it can endure and survive. This review aims to uncover the role of multiple stress sensors of that assist bacteria in remaining viable within the host for years against various physiological stresses offered by the host.

Endoscopic Step-Up Approach in Management of Necrotizing Pancreatitis.

The endoscopic step-up approach in the management of necrotizing pancreatitis involves sequential steps of intervention at different time points in the clinical course of the disease. EUS -guided drainage of walled-off necrosis is the first step of the endoscopic step-up approach. Lumen-apposing metal stents are preferred over plastic stents for safe and effective drainage because of their wide caliber.

Neurotoxic Effects and Cognitive Decline Induced by Aniline Blue Dye in an In-Vivo Zebrafish Model.

Aniline Blue is a synthetic dye extensively used in various industries, including textiles, plastics, and biological research due to its effective staining properties. However, its environmental and health impacts, particularly its neurotoxic effects, are poorly understood. While the dye has been associated with carcinogenicity and organ toxicity, the neurobehavioral consequences of Aniline Blue exposure remain underexplored.

Optimized pure cellulose from rice straw using low alkali concentration for sustainable nanocellulose and nanohydrogel production with enhanced dye reduction.

Conversion of rice straw into nanocellulose offers a sustainable approach to agricultural waste management, yielding an industrially important product with potential applications. This work focuses on effectively extracting pure cellulose from both widely used Basmati and Parmal rice straw (BRS and PRS) using less alkali concentrations (3-5 % NaOH). The process was optimized via Box Behnken design at 90-150 °C temperatures for 90-150 min, which resulted in 88.

Determination of enzyme kinetic parameters of fast-acting Schizosaccharomyces pombe Ulp1 catalytic domain using Forster resonance energy transfer (FRET) assay.

The SUMO fusion technology has immensely contributed to the soluble production of therapeutics and other recombinant proteins in E. coli. The structure-based functionality of SUMO protease has remained the primary determinant for choosing SUMO as a solubility enhancer tag.

Effectiveness of rotavirus vaccine following introduction in the childhood immunization program in Northeast India.

Background: Rotavirus diarrhoea is a major cause of mortality and morbidity in children under five years of age. The WHO has recommended vaccination against this agent especially in countries with high mortality rates. As India accounts for almost a quarter of worldwide rotaviral diarrhoea cases, the government has introduced indigenously manufactured vaccines in the national immunization schedule which has been implemented in four phases.

The key vulnerabilities and therapeutic opportunities in the USP7-p53/MDM2 axis in cancer.

The MDM2/MDMX-p53 circuitry is essential for controlling the development, apoptosis, immune response, angiogenesis, senescence, cell cycle progression, and proliferation of cancer cells. Research has demonstrated that USP7 exerts strong control over p53, MDM2, and MDMX stability, with multiple mediator proteins influencing the USP7-p53-MDM2/MDMX axis to modify p53 expression level and function. In cases where p53 is of the wild type (Wt-p53) in tumors, inhibiting USP7 promotes the degradation of MDM2/MDMX, leading to the activation of p53 signaling.

PDE4 inhibitor rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer.

Aberrant activation of the hedgehog (Hh) signaling pathway positively correlates with progression, invasion and metastasis of several cancers, including breast cancer. Although numerous inhibitors of the Hh signaling pathway are available, several oncogenic mutations of key components of the pathway, including Smoothened (Smo), have limited their capability to be developed as putative anti-cancer drugs. In this study, we have modulated the Hh signaling pathway in breast cancer using a specific FDA-approved phosphodiesterase 4 (PDE4) inhibitor rolipram.

Antimicrobial biodegradable packaging films from phosphorylated starch: A sustainable solution for plastic waste.

This study focused on developing biodegradable packaging films based on starch as an alternative to non-biodegradable such as petroleum-derived synthetic polymers. To improve its physicochemical properties, potato starch was chemically modified through phosphorylation. Starch phosphorylation was carried out using cyclic 1,3-propanediol phosphoryl chloride (CPPC), produced phosphorylated starch (PS), and analyzed using Fourier transform infrared (FT-IR), X-ray diffraction (XRD), Nuclear magnetic resonance (NMR), and Thermogravimetric analysis (TGA).

Named reaction in carbohydrate chemistry: A review.

Central to the synthetic organic chemist's armoury are the organic/inorganic reagents which are employed to effect a broad range of structural changes. Herein, we report a collection of 29 organic named reactions applicable in the carbohydrate chemistry, arranged in alphabetical order. In this contribution, we have displayed general schemes, examples and probable reaction mechanism for each chemical reaction.

A review on the role of nanocomposites for desulfurization of liquid transportation fuels.

Stringent sulfur removal regulations from transportation fuels from typical levels of 500 ppm to ultra-low levels of 10 ppm (BS-6 standard) present a critical challenge for the crude processing industry. This research thoroughly investigates emerging desulfurization technologies, with a focus on nanocomposite (NC) materials that exhibit exceptional sulfur removal efficiency. Advanced nanocomposite catalysts, such as (TBA)PWFe@TiO@PVA, have near-complete removal rates of 96-99% for complicated sulfur compounds like dibenzothiophene (DBT) and derivatives.

Biolubricants from waste cooking oil: A review of extraction technologies, conversion techniques, and performance enhancement using natural antioxidants.

Effective management of agricultural and industrial by-products is essential for promoting circular economic practices and enhancing environmental sustainability. Agri-food wastes and waste cooking oil (WCO) represent two abundant residual streams with significant potential for sustainable biolubricant production. Valorizing biomass and WCO aligns with Sustainable Development Goal (SDG) 7, as it improves energy efficiency through enhanced lubricant performance and reduced energy loss.

Design, Synthesis, Biocompatibility, molecular docking and molecular dynamics studies of novel Benzo[b]thiophene-2-carbaldehyde derivatives targeting human IgM Fc Domains.

In this study, three novel derivatives of benzo[b]thiophene-2-carbaldehyde (BTAP1, BTAP2, and BTAP3) were successfully synthesized and comprehensively characterized using spectroscopic techniques including FTIR, UV-VIS, HNMR, and CNMR. Thermal analysis through TGA and DTA demonstrated remarkable thermal stability with a maximum threshold at 270 °C. Spectroscopic investigations revealed π → π* transitions in all compounds, attributed to the conjugated system comprising benzothiophene rings connected to bromophenyl/ aminophenyl/phenol rings via α, β-unsaturated ketone bridges.

Positive childhood experiences in mental health of young adults across adverse childhood experiences levels: A study from Delhi-NCR, India.

Background: While the impact of adverse childhood experiences (ACEs) on adult health outcomes has received substantial scientific attention, the role of positive childhood experiences (PCEs) has far less widely been explored, especially in low- and middle-income countries.

Objective: The present study aimed to understand the association of exposure to cumulative and individual PCEs with current depression, anxiety, stress, and well-being among young adults in Delhi-NCR, India, independently and across ACE exposure levels.

Participants And Setting: This cross-sectional study involved 1553 young adults (aged 18-25) of both sexes (70.

ST-CIRL: a reinforcement learning-based feature selection approach for enhanced anxiety classification.

A physiological signal-based Human-Computer Interaction (HCI) system provides a communication link between human emotional states and external devices. Accurately classifying these signals is vital for effective interaction, which requires extracting and selecting the most discriminative features to differentiate between various emotional states. This paper introduces the SMOTETomek-Correlated Interactive Reinforcement Learning (ST-CIRL) framework for anxiety classification, which leverages meta-descriptive statistics to enhance the state representation in the reinforcement learning process.

Elucidating the life history parameters of Culicoides oxystoma (Diptera: Ceratopogonidae) under varied substrate compositions and temperatures.

A comprehensive study was conducted on the life history parameters of an important vector Culicoides oxystoma Kieffer (Diptera: Ceratopogonidae), to standardize potential rearing procedures. Data on life history traits and rearing conditions are crucial for establishing laboratory colony and conducting vector competence-based studies utilizing specimens with a known rearing history. Six different substrate compositions were used to rear the larvae: S1: habitat mud containing cattle manure + nutrient broth + yeast, S2: yeast, S3: habitat mud containing cattle manure + nutrient broth, S4: nutrient broth, S5: sterile (habitat mud consisting cattle manure + nutrient broth + yeast) and S6: tap water.

EEG-derived brainwave patterns for depression diagnosis via hybrid machine learning and deep learning frameworks.

In the fields of engineering, science, technology, and medicine, artificial intelligence (AI) has made significant advancements. In particular, the application of AI techniques in medicine, such as machine learning (ML) and deep learning (DL), is rapidly growing and offers great potential for aiding physicians in the early diagnosis of illnesses. Depression, one of the most prevalent and debilitating mental illnesses, is projected to become the leading cause of disability worldwide by 2040.