Improving the binding affinity of plastic degrading cutinase with polyethylene terephthalate (PET) and polyurethane (PU); an in-silico study.

Plastic pollution is a worrying problem, and its degradation is a laborious process. Although enzymatic plastic breakdown is a sustainable method, drawbacks such as numerous plastic kinds of waste make the degradation challenging. Therefore, a multi-plastic degrading (MPD) enzyme becomes necessary.

Deep eutectic solvent-assisted carbon quantum dots from biomass : A fluorescent sensor for nanomolar detection of dual analytes mercury (Ⅱ) and glutathione.

Deep eutectic solvents (DESs) have attracted significant attention in recent years due to its environment friendly characteristics and its participation in the multi-heteroatom doping of carbon quantum dots (CQDs). In this work, we present a simple, fast, and environment-friendly microwave synthesis approach for the synthesis of DES-assisted nitrogen and chloride co-doped CQDs (N,Cl-CQDs) using a choline chloride-urea based DES. A biomass-based precursor, i.

Impact of position of bolster on outcome of prone PCNL-A randomized clinical trial.

Objective: To determine whether the position of the bolster affects the access tract (supracostal/infracostal) for a superior calyceal puncture during prone PCNL and its effect on pleural complications.

Materials And Methods: It was a randomized clinical trial. Patients in whom superior calyceal puncture was done were divided into two groups by systematic sampling method, group 1 (horizontal bolster) and group 2 (vertical bolster), 50 patients in each group.

Confronting food insecurity through agricultural interventions: the Farmer FIRST program in India.

Introduction: Nutrition-sensitive agricultural interventions are crucial in addressing malnutrition and promoting food security. The Farmer, Farm, Innovation, Resources, Science, and Technology (FIRST) Program is a national-level agricultural intervention program that was started in 2016 by the Indian Council of Agricultural Research (ICAR). Its primary objective is to transform the lives and livelihoods of Indian farmers, with a focus on income and livelihood security.

Undesirable occupants of bone marrow creating a menace: A 4.5-year audit from a tertiary care centre in Eastern India.

Background: Bone marrow (BM) in addition to being the origin of primary hematological malignancies is also commonly involved in metastatic solid tumors. Bone marrow examination includes aspiration and biopsy, and it is a well-known procedure not only to diagnose hematological malignancies but also for staging and prognosis of various solid tumors. The presence of metastasis in the bone marrow is of grave prognostic significance and it is imperative to rule out marrow involvement in any malignancy where curative treatment is considered.

A study to compare and correlate the effect of a yogic lifestyle on Framingham, Q RISK 3, and WHO risk scores among high-risk cardiovascular subjects.

Background: Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels. Yoga is a low-cost, easily accessible lifestyle modification program that holds as an approach to decreasing cardiometabolic risk factors and increasing exercise self-efficacy among high-risk subjects. This study aimed to assess the impact of the yogic lifestyle (including diet) on cardiovascular risk scores by using the Framingham (FRS), QRISK3 score, and World Health Organization (WHO) CVD risk prediction charts at baseline, three months, and six months.

Haemolytic anemia in a patient of Chronic myeloid leukemia: an unrecognized side-effect of Hydroxyurea?

Hydroxyurea (HU) is frequently used in the treatment of various myeloproliferative neoplasms (MPN) where it reduces cell proliferation by impairing DNA synthesis leading to decreased hematopoiesis. Herein we report a case of a 65-year-old female who was diagnosed with Chronic myeloid leukemia and developed severe hemolytic anemia requiring multiple packed red blood cell (RBC) transfusions while being treated with hydroxyurea. The haemolysis persisted until discontinuation of the drug.

Hypophosphatemia in pregnancy: A case report.

Autosomal hypophosphatemic rickets though a rare genetic disorder can lead to significant discomfort to the patient resulting in clinical deterioration and a poor quality of life. We describe a case of a 33-year-old woman G2P1001 at 6 weeks of gestation with complaints of myalgia and bony pains. Keeping her history of bony pains and fractures in mind, she was further evaluated.

Fallopian Tube Papilloma: A Systematic Review of Case Reports.

Fallopian tube papilloma (FTP) is one of the benign lesions of the oviduct and is a rare proliferative epithelial lesion. Low incidence and underreporting of the disease limit our knowledge of these lesions. These lesions cause a diagnostic dilemma and need to be differentiated from several other conditions of the fallopian tubes both benign and malignant.

Analysis of HAM-D Scores on Cognitive Functions and Heart Rate Variability in Patients with Major Depressive Disorder.

Background: Previous research has shown that Major Depressive Disorder (MDD) is accompanied by severe impairments in cognitive and autonomic processes, which may linger even when mood symptoms recover. This study aimed to analyse the relationship between depression severity, as measured by the Hamilton Depression Rating Scale (HAM-D), and how it affects heart rate variability (HRV) and cognitive function in patients with Major Depressive Disorder (MDD).

Methodology: The cross-sectional study was conducted at RUHS College of Medical Sciences and Associated Hospitals, Jaipur, from July 2022 to January 2023 on 90 subjects having major depressive disorder (MDD) of either sex in the 20-40 age group using the Hamilton score for depression (HAM D), Heart Rate Variability (HRV) measurements, and a battery of cognitive tests.

Deep learning driven silicon wafer defect segmentation and classification.

Integrated Circuits are made of various transistors that are embedded on a silicon wafer, these wafers are difficult to process and hence are prone to defects. Defecting these defects manually is a time consuming and labour-intensive task and hence automation is necessary. Deep Learning approach is better suited in this case as it is able to generalize defects if trained properly and can be a solution to segmentation and classification of defects automatically.

Indirect effect of psychological capital by using Partial Least Square (PLS) path analysis.

Understanding the relationship between Learned Helplessness (LH) and Psychological Capital (PsyCap) is essential for developing effective interventions for Indigenous adolescents. This study explored the role of PsyCap as a mediator in the link between LH and Psychological Well-Being (PWB). Total of 173 Indigenous adolescents (85 boys and 88 girls) from sixth to eleventh grade at government residential schools.

Binaural auditory beats vs music of choice as audio distraction behaviour guidance technique among children: A randomized controlled trial.

Background: Binaural beat is created by presenting two different pure-tone sine waves with less than a 30Hz difference dichotically. In dental settings, children listening to familiar music during treatments gain control over the anxiety caused by tools like the airotor or syringe, creating a comforting, familiar environment.

Aim: To evaluate and compare anxiety level during restorative treatment using No Music, Music of choice and Binaural Auditory Beats as Audio distraction behaviour guidance technique in children aged 6-12 years.

A Study on Quantification of the Effects of Heartfulness Meditation Intervention in Healthcare Professionals by Anchor-Based Method in Occupational Health Psychology.

Background: It's more important to measure the subjective perception of change after undergoing any behavioral or psychological intervention. Global rating of change method-anchor item-based is a method by which the change can be quantified and "minimum subjective perceived effect" (MSPE) can be calculated.

Aim: The current study was planned to quantify the effects of heartfulness meditation intervention in healthcare professionals by anchor-based method and compare the result with the pre-post-difference.

Application of Geographic Information System and Google Earth Engine for Spatial Analysis of Land Use by the Legacy Dumpsite at Raipur, Chhattisgarh: A Time Series Analysis.

Background: Legacy dump sites pose health and environmental risks. Challenges such as difficulty in monitoring and the impact of policy changes towards remediation efforts remain enigmatic due to complexities.

Objectives: Hence this study aimed to use Geographic Information System (GIS) and Google Earth historical imagery to monitor changes in legacy dump site located at Sarona in Raipur and to assess the impact of waste management strategies being implemented currently.

Polymorphisms in DNA Repair Genes as Biomarkers of Susceptibility for Pesticide-Induced DNA Damage among Agricultural Workers: A Review.

Pesticides induce oxidative DNA damage and genotoxic effects such as DNA single-strand breaks (SSBs), double-strand breaks (DSBs), DNA adducts, chromosomal aberrations, and enhanced sister chromatid exchanges. Such DNA damage can be repaired by DNA repair mechanisms. In humans, single nucleotide polymorphisms (SNPs) are present in DNA repair genes involved in base excision repair (BER) (, and nucleotide excision repair (NER) (, , , and ), and double-strand break repair (DSBR) ( and ).

Unveiling the Hepatic Harbinger: Assessing the Fatty Liver Index as a Predictor of Metabolic Syndrome in Female Healthcare Workers.

Background: Female healthcare workers have unique occupational stressors and lifestyle factors that may increase their risk of metabolic disorders. This study aimed to investigate the utility of the fatty liver index (FLI) as a predictor of metabolic syndrome among female employees in the healthcare sector.

Methods: This cross-sectional study included 450 female healthcare workers aged ≥18 years, employed in various roles at a tertiary healthcare facility in Gujarat.

Global and Indian Scenarios of Fatal and Non-fatal Occupational Injuries: A Secondary Data Analysis.

Introduction: Fatal and non-fatal occupational injuries are one of the most important public health problems all over the world. Its number greatly varies from country to country over the years. Worldwide approximately 4% of global gross domestic product (GDP) is lost due to occupational injuries.

A Randomized Controlled Trial to Compare the Effectiveness of Smart Dynamic Fabric Actuator with Exercises in Chronic Musculoskeletal Leg Pain Associated with Prolonged Standing in a Hospital Setting.

Background: There are adverse effects on the health outcomes of workers whose occupation involves prolonged standing, such as lower back pain, leg pain, cardiovascular diseases, fatigue, discomfort, and pregnancy-related health outcomes. The effectiveness of massage therapy as an intervention for managing leg pain associated with prolonged standing needs to be addressed.

Aims: This study aimed to evaluate the smart dynamic fabric actuator's effectiveness in treating chronic musculoskeletal leg pain in persons with occupations involving prolonged standing.

Effort-Reward Imbalance and Its Association with Musculoskeletal Pain among Information Technology Professionals.

Context: Psychosocial factors at the workplace play a significant role in the development of work stress and are associated with cardiovascular diseases, diabetes mellitus, and musculoskeletal disorders. Imbalance due to high effort and low reward at the workplace among information technology (IT) professionals can lead to work stress.

Aim: To assess the effort-reward imbalance (ERI) among IT professionals and its association with musculoskeletal pain.

Driving into Diabetes: Risk Assessment among Interstate Truck Drivers in West Bengal.

Diabetes mellitus has led to a huge increase in its number over recent decades. Due to their occupation, truck drivers are predisposed to higher risk of lifestyle disorders. Hence, this study intended to assess their risk of developing diabetes mellitus with respect to IDRS (Indian Diabetes Risk Score).

Ergonomic Risk Assessment Using the Rapid Entire Body Assessment (REBA) Tool among Cleaners: A Cross-Sectional Study.

Context: Cleaning consists of different activities such as mopping, sweeping, swabbing, dusting, disposing of trash, and buffing. These different physical activities of the cleaners can change the body's normal biomechanics, possibly leading to the development of musculoskeletal disorders over time.

Aims: This study aimed to check the ergonomic risk and its relationship with age, BMI, and work experience among cleaners.

Relationship Between Subjectively Assessed Physical Activity (GPAQ) and Quality of Life (WHOQOL-BREF) of Aging Employees in JIPMER, Puducherry: A Cross-Sectional Analytical Study.

Background: Physical activity appears to be one of the most important strategies for preventing physical and mental disorders. Regular physical activity (PA) may prolong life and appears to be a preventative measure against genetic and molecular aging.

Aim: To find the relationship between aging adults' quality of life (QOL) and PA.