Effectiveness of different combinations of phenoxetol and formaldehyde on preservation of histological features in human cadaveric tissues.

Background: Fixation preserves the tissues in a close to the life-like state by preventing its autolysis and putrefaction. Formalin has long been considered the close to ideal fixative for histological studies. With the awareness of occupational hazards, a few researchers have tried phenoxetol as a secondary preservative which offered comparable histological results to that of formalin.

Real world experience on patterns of usage and toxicity profile of immunotherapy drugs in Indian patients: A prospective observational study.

Background: Immune checkpoint inhibitors (ICIs) are now considered revolutionary agents in the treatment of various cancers. Prospective data are limited on the patterns of usage and toxicity profile of these drugs. We planned this study for addressing the same in Indian patients.

Comparison of clinicodemographic characteristics in patients with selective serotonin reuptake inhibitors poisoning: A cross-sectional study.

Background: Our objective of this study was to evaluate patients of Selective Serotonin Reuptake Inhibitors (SSRIs) overdose and compare the toxicological effects of citalopram overdose with other SSRIs in adult poisoning cases.

Methods: This cross-sectional study focused on acute, known-type SSRI ingestions. Demographic and toxicological data were collected on the patients.

Video bronchoscopic electrocautery fulguration of endobronchial carcinoids: Case series from an Indian tertiary care center.

Carcinoid tumors are slow-growing tumors noticed in the tracheobronchial tree and pulmonary parenchyma. Generally, these tumors are slow growing with minimum risk of distant metastasis, but the atypical type of carcinoids has greater malignant potential with lower survival rates. The primary and most effective treatment for all pulmonary carcinoid tumors is surgical resection if no contraindications to surgery exist.

Renal limited sarcoidosis presenting with acute kidney injury.

Sarcoidosis is a multisystem granulomatous disease of unknown etiology, characterized by noncaseating epithelioid granuloma, multinucleate giant cells, and tissue destruction. While lung and lymph node involvement is common, isolated renal involvement is rare. We report the case of a 55-year-old female patient, with renal limited sarcoidosis, who presented with worsening sensorium and acute kidney injury.

The role of cation-exchange resins in hyperkalemia management.

Hyperkalemia, characterized by elevated serum potassium levels, poses significant health risks, including life-threatening cardiac arrhythmias. The management of hyperkalemia has evolved, incorporating calcium polystyrene sulfonate (CPS) and newer agents such as sodium zirconium cyclosilicate (SZC) and patiromer alongside traditional treatments. This review provides a comprehensive examination of current management strategies for hyperkalemia, focusing on the comparative effectiveness, safety profiles, and patient preferences concerning CPS, SZC, and patiromer.

Sochureki, the different saw- scaled viper: Challenges are many!

Snake bite is a major cause of mortality in the Indian subcontinent. The condition is fraught with the problem of under reporting. Most bites in India are caused by the "Big 4 species," based on this, the anti-snake venom (ASV) is also sourced from these species only.

Challenges to Achieving Surgical Equity in Slums.

There is a critical lack of surgical data on individuals who live in urban slums, which hampers the allocation of healthcare resources and the provision of preventative measures. The complex interplay of factors affecting surgical care in slums, such as trust deficits, mental health concerns, and socioeconomic barriers, necessitates a distinct academic approach. We propose that researchers should consider "slum surgical health" as an area of study separate from urban health or slum health.

Impact of mechanical engineering innovations in biomedical advancements.

Abstract: The principal objective of the present paper is to meticulously review the family of biomaterials used in implants. A spectrum of applications of biomaterials in the perspective of prosthesis is also presented. This paper also emphasises on the review of the recent advancements in the field of biomedical implants with respect to mechanical engineering perspective.

Assessment of antimicrobial efficacy of leather coating using chitosan modified TiO-CuO nanocomposites.

This research investigates the microbial inactivation potential of ternary TiO-CuO-chitosan nanocomposites (TCC NCs) applied as surface coatings on cowhide leather. Initially, bare TiO nanoparticles (NPs) and binary TiO-CuO (TC) NCs, with varying CuO NPs content, were prepared using an sol-gel method. These binary TC NCs were then modified with chitosan at varying weight percentages (2%, 4%, 6%, and 8%).

High energy density solid state symmetric supercapacitors using ionic liquid dispersed Li ion-perovskites.

The study reports solid-state ceramic supercapacitors (SSCs) assembled using a novel composite electrolyte based on Li ion conducting perovskite-type LLTO (LiLaTiO) and an ionic liquid (EMIM BF). Small amounts of various ionic liquids (ILs) were added to LLTO to enhance the ionic conductivity and improve electrode compatibility. The optimal composition with approximately ∼6 wt% EMIM BF in LLTO exhibited a high ionic conductivity of around ∼10 Ω cm at room temperature, nearly three orders of magnitude higher than that of the pristine LLTO.

The Efficacy of Platelet-Rich Plasma in the Repair of Tympanic Membrane Perforation.

 Platelet-rich plasma (PRP) contains high platelet concentration and growth factors that help in rapid wound healing, hemostasis, and decreased scarring. It has been used in various conditions to aid in healing, but its use in ear, nose, and throat (ENT) is not yet common.  To compare the outcome of using PRP with myringoplasty with that of myringoplasty alone in the repair of tympanic membrane perforations.

Effectiveness of RESET care program: A real-world-evidence on managing non-alcoholic fatty liver disease through digital health interventions.

Background: Non-alcoholic fatty liver disease (NAFLD) management requires sustainable lifestyle modifications. This study aimed to evaluate the effectiveness of the RESET care plan, a comprehensive program that is an integrated personalized diet, exercise, and cognitive behavior therapy, delivered MyTatva's digital health application enabled through a body composition analyzer (BCA) and smartwatch.

Aim: To evaluates the effectiveness of the comprehensive program delivered MyTatva's digital health app enabled through internet of thing devices.

High metabolic dysfunction-associated steatotic liver disease prevalence in type 2 diabetes: Urgent need for integrated screening and lifestyle intervention.

This letter discusses the recent study by Mukherjee , which identifies a significant prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) among newly diagnosed type 2 diabetes mellitus (T2DM) patients in Bihar, India, and underscores the pressing need for integrated MASLD management within T2DM care. With 72.3% of the study cohort affected by MASLD, implementing routine liver function tests and ultrasound screenings is recommended as a standard practice in diabetes care, especially in regions with high prevalence rates.

Ultrasonographic view of fluid bronchogram secondary to endobronchial obstruction: A case report.

Background: Ultrasound has become an important aspect of emergency medicine due to its wide availability and portability for bedside investigations. Understanding some important ultrasound findings can aid in diagnosis and management.

Key Findings: We present a case of a 65-year-old smoker who presented with shortness of breath and hemoptysis and was in respiratory failure upon arrival in the emergency department.

A Cross-sectional Study of the Length of Stay of Persons with Mental Illnesses and Revenue to a Government Tertiary Neuropsychiatric Hospital Under Ayushman Bharat.

Background: Ayushman Bharat Pradhan Mantri Jan Arogya Yojana (AB-PMJAY) is a health insurance scheme launched by the Government of India (GOI) in 2018 to cover the in-patient (IP) treatment expenditures, including mental illness treatment expenditures, for 500 million Indians. AB-PMJAY pays 100% of treatment expenditures for persons below the poverty line (BPL) and 30% for people above the poverty line (APL). Ayushman Bharat Arogya Karnataka (ABAK) trust implements this scheme in Karnataka, a southern Indian state.

Physiological, Psychological, and Functional Health Determinants of Depressive Symptoms Among the Elderly in India: Evaluation of Classification Performance of XGBoost Models.

Background: Depression among the elderly is a growing public health concern, especially in India. This study aimed to investigate the predictive validity of physiological, psychological, and functional health factors in classifying the level of depressive symptoms among the elderly using the extreme gradient boosting (XGBoost) technique. Additionally, we compared the performance of models trained on original and resampled data.

Factors Influencing Pregnant Women's Participation in Randomised Clinical Trials in India: A Qualitative Study.

Objective: To explore factors affecting participation of pregnant women in randomised clinical trials in Belagavi, Karnataka, India.

Design: A qualitative study using semi-structured in-depth interviews and focus group discussions as data collection methods.

Setting: Primary, secondary and tertiary health facilities and their community catchment areas in Belagavi district.

Advancements in hyperpigmentation management: exploring conventional methods, phytoconstituents, novel approaches, and instrumental techniques.

Hyperpigmentation is a common dermatological condition characterized by the darkening of patches of skin compared to the surrounding areas. It can occur in individuals of all skin types and ethnicities, and is caused by an overproduction or accumulation of melanin, the pigment responsible for the color of our skin, hair, and eyes. This comprehensive overview aims to delve into the various types, causes, risk factors, clinical manifestations, diagnosis, and treatment options for hyperpigmentation.

Targeted therapy in TNBC: Exploring the role of antibody-drug conjugates with a focus on sacituzumab govitecan.

Objectives: To underscore the prevalence and mortality of breast cancer and review advancements in metastatic TNBC management, with a particularly focus on the role of antibody-drug conjugates (ADCs), emphasizing the safety and therapeutic potential of Sacituzumab govitecan (SG) as a groundbreaking ADC.

Data Sources: This review gathers scientific data from the past decade, sourced from PUBMED, ClinicalTrials.gov, and Google Scholar to retrieve relevant studies focused on SG in metastatic TNBC treatment.

Probing the nature of intramolecular (sp)C-H⋯Cu(I) interactions in organo thione copper(I) cages.

The assessment of copper(I) and hydrogen interactions is challenging and should be approached with caution. In this paper, we report an assessment of multiple copper(I) and hydrogen interactions in two unique copper(I) thione cages. Copper(I) -heterocyclic thione cages [{Cu(-Br)(-L1)}] (1) and [{Cu(-I)(-L1)}] (2) were synthesized and characterized with proximity enforced Cu⋯H interactions.

Ultrafast broadband spectroscopy of widely spread excitonic features in WSe nanosheets.

The performance of an optoelectronic device is largely dependent on the light harvesting properties of the active material as well as the dynamic behaviour of the photoexcited charge carriers upon absorption of light. Recently, atomically thin two-dimensional transition metal dichalcogenides (2D TMDCs) have garnered attention as highly prospective materials for advanced ultrathin solar cells and other optoelectronic applications, owing to their strong interaction with electromagnetic radiation, substantial optical conductivity, and impressive charge carrier mobility. WSe is one such extremely promising solar energy material.

Total Synthesis of (+)-7,7'-Bistaxodione via Late-Stage Electrochemical Dimerization.

The first asymmetric total synthesis of the tetraterpenoid (+)-7,7'-bistaxodione () via a unique late-stage electrochemical oxidative dimerization of a diterpenoid quinone methide tumor Inhibitor (+)-taxodione () has been described. The naturally occurring monomer was synthesized from aromatic abietane diterpenoid, ferruginol (1e) . Further, an efficient convergent synthetic route toward the naturally occurring aromatic abietane terpenoids has been shown via a Lewis acid-mediated diastereoselective cationic epoxy-ene cyclization.

Modified Uvular Repair in Children Undergoing Palatoplasty.

Background: Paucity exists in the literature on uvular repair while documenting palatoplasty techniques for children with cleft palate.

Solution: We propose a modified approach without losing any soft tissue structures, gaining better cosmetic outcome, and possibly having functional gains postoperatively.

What We Did That Is New: The proposed technique provides better cosmesis for the structures postoperatively and enhances the palatoglossal arch, which may prevent the spillage of saliva to the oropharyngeal region.