Integration of Three-Dimensional Scanning and Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) Technology in Routine Prosthodontic Practice: A Cross-Sectional Study in Kerala.

Background: Digital dentistry has transformed all aspects of dentistry, especially prosthodontics, and is increasingly used for diagnosis, treatment planning, execution, student training, and research. This study aimed to assess the perception, attitude, and practice of digital technology in prosthodontics among dental professionals in Kerala, India.

Materials And Methods: A cross-sectional, questionnaire-based study was conducted among dental professionals in Kerala.

Clinical and Hematological Characteristics of Vitamin B12 Deficiency and Evaluation of the Therapeutic Response to Vitamin B12 Supplementation.

Background Vitamin B12 deficiency, or cobalamin deficiency, is common among populations with low consumption of animal-based products, mainly in India, due to religious and socioeconomic factors, which significantly increase the deficiency rate. The condition has been characterized by a wide range of clinical and hematological symptoms, mainly affecting the blood and nervous system. This study aims to assess the clinical and hematological characteristics of patients with vitamin B12 deficiency and assess the therapeutic response to supplementation with vitamin B12.

Optimizing Premenopausal Hormone Receptor-Positive Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer Management in India: Insights From Expert Consensus.

This research aims to optimize adjuvant ovarian function suppression (OFS) for premenopausal Indian women with hormone receptor-positive (HR+) /human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (eBC). To address specific challenges identified in clinical practice, a comprehensive questionnaire consisting of 21 statements was developed. These statements were reviewed and validated by a scientific committee, ensuring their accuracy and relevance to the study's objectives.

Correlation Between Serum Vitamin D and Calcium Levels and the Risk of Dental Caries in Children in Western Maharashtra, India.

Background Vitamin D and calcium are necessary for tooth health, and a lack of these can cause substantial changes. Dental caries, or tooth decay, is a common childhood illness that causes pain, difficulty chewing, and a lower quality of life. There is a scarcity of research on the correlation between vitamin D and calcium levels and dental caries risk among children in western Maharashtra.

Efficacy of Bacillus clausii UBBC-07 and Bacillus coagulans Unique IS-2 in Mitigating Pulmonary Parameters in Patients With Moderate COVID-19 Symptoms.

Probiotics have shown efficacy in preventing and reducing infections caused by common viruses, including rotavirus, norovirus, hepatitis, human papillomavirus (HPV), human immunodeficiency virus (HIV), and herpes simplex virus (HSV). A randomized, double-blind, placebo-controlled, three-arm parallel-group study was conducted on 56 patients with moderate COVID-19 symptoms. Patients were randomly assigned to one of the three groups: standard treatment combined with UBBC-07, standard treatment combined with Unique IS-2, or standard treatment with a placebo.

The Translation and Adaptation of the Labour Force Survey Disability Module (LFS-DM) Into Hindi.

Background and objective Disability assessments are crucial for identifying barriers faced by individuals with disabilities, particularly in countries like India, where disability is often underreported. The Labour Force Survey Disability Module (LFS-DM) is a widely used tool for disability assessment. It is available in English, and Indian Hindi-speaking people who are not proficient in English may face difficulties in responding to it.

Assessment of the Operational Aspects of Health and Wellness Centers in Randomly Selected Blocks of Eastern India.

Introduction Launched in 2018, by the Government of India, the Health and Wellness Centers (HWCs) initiative under the Ayushman Bharat program aims to transform India's primary healthcare system. This study evaluates the functioning of Health and Wellness Centres (HWCs) in random blocks of Patna, Bihar, focusing on service availability, infrastructure, manpower challenges, and overall effectiveness in meeting healthcare needs. Methodology The assessment aimed to understand the current state of functioning of 16 HWCs and identify areas for improvement through a Strengths, Weaknesses, Opportunities, Threats (SWOT) analysis.

A Complex Presentation of Multiple Myeloma With Renal Complications in a Young Female: Diagnostic Challenges and Treatment Approach.

A previously healthy 30-year-old woman experienced worsening back pain, fatigue, weakness, loss of appetite, and facial puffiness. After 18 months of these symptoms, she was diagnosed with multiple myeloma, which was also damaging her kidneys. The treatment involved a combination of medications and blood transfusions, leading to improved kidney function.

Serum metabolomic signatures of patients with rare neurogenetic diseases: an insight into potential biomarkers and treatment targets.

Introduction: To further advance our understanding of Muscular Dystrophies (MDs) and Spinocerebellar Ataxias (SCAs), it is necessary to identify the biological patterns associated with disease pathology. Although progress has been made in the fields of genetics and transcriptomics, there is a need for proteomics and metabolomics studies. The present study aimed to be the first to document serum metabolic signatures of MDs (DMD, BMD, and LGMD 2A) SCAs (SCA 1-3), from a South Asian perspective.

Taxonomic notes on the genus Breuning & de Jong, 1941 (Coleoptera, Cerambycidae) with a generic and specific synonym.

Taxonomic notes on the genus Breuning & de Jong, 1941 are presented. The genus Breuning, 1966 is synonymized with , and Breuning, 1966 is recognized as a junior synonym of Breuning & de Jong, 1941. Additionally, is redescribed, and Breuning, 1973 is formally reported from China, Vietnam, Thailand, and India for the first time.

Advancing tuberculosis elimination in India: A qualitative review of current strategies and areas for improvement in tuberculosis preventive treatment.

Tuberculosis (TB), caused by , remains a global health challenge, despite being preventable and curable. The global goal to end TB by 2030, with India targeting a 90% reduction in TB incidence by 2025, demands comprehensive interventions in prevention, early detection, treatment, and capacity building. This study analyzes the 2023 Global TB Reports, published articles, guidelines, and data to explore India's current TB landscape.

Influence of Smartphone Usage on development of Sexuality among Late Adolescent Boys in Health Sciences Colleges of South India.

Background: Better affordability of data plans and an increase in "budget" smartphones have resulted in an exponential rise in internet and smartphone users. The ease of access to sexually explicit material (SEM) coupled with adolescents' impulsivity makes them prone to excessive SEM exposure and may affect the development of sexuality via the perceived realism of such content. This study was done to study the influence between problematic smartphone usage (PSU) and sexuality development among late adolescent boys.

Comparative study between efficacy of topical tofacitinib 2% ointment versus topical clobetasol propionate 0.05% ointment in hand eczema at a tertiary hospital in central India.

Background: Hand eczema is a prevalent dermatological condition that significantly impacts the quality of life of affected individuals. Topical corticosteroids, such as Clobetasol Propionate, are commonly employed for management, but concerns regarding long-term use and potential side effects necessitate exploration of alternative treatments. This study protocol outlines a randomized controlled trial comparing the efficacy of topical Tofacitinib 2% ointment with Clobetasol Propionate 0.

A Scoping Review of Existing Policy Instruments to Tackle Overweight and Obesity in India: Recommendations for a Social and Behaviour Change Communication Strategy.

Background: The Indian government is committed to addressing various manifestations of malnutrition, including overweight and obesity, inorder to improve individual health and well-being. The scoping review aims to map existing national policy instruments (programmes, schemes, regulations and guidelines) addressing overweight and obesity in India and analysing them for Social and Behaviour Change Communication (SBCC) strategies.

Methods: Systematic identification and selection of policy instruments using 'Arksey and O'Malley' framework was conducted from central government ministry websites, between March and June 2023.

Emotion analysis of EEG signals using proximity-conserving auto-encoder (PCAE) and ensemble techniques.

Emotion recognition plays a crucial role in brain-computer interfaces (BCI) which helps to identify and classify human emotions as positive, negative, and neutral. Emotion analysis in BCI maintains a substantial perspective in distinct fields such as healthcare, education, gaming, and human-computer interaction. In healthcare, emotion analysis based on electroencephalography (EEG) signals is deployed to provide personalized support for patients with autism or mood disorders.

Irreversible electroporation for metastatic pancreatic carcinoma with liver metastasis: What does the evidence say.

Irreversible electroporation is a promising non-thermal ablation method that has been shown to increase overall survival in locally advanced pancreatic cancer in some studies. However, higher quality studies with proper controls and randomization are required to establish its superiority when added with neoadjuvant chemotherapy over the current management of choice, which is chemotherapy alone. Further studies are required before establishment of any survival benefit in metastatic pancreatic carcinoma, and such evidence is lacking at present.

Accidental Autoerotic Deaths and Mental Disorder: A Scoping Review.

Purpose Of The Review: Accidental autoerotic death, more commonly known as "autoerotic asphyxia," is an extreme paraphilic behavior wherein individuals induce cerebral hypoxia during self-stimulated sexual activities, often by constricting the neck or obstructing respiratory passages. Data on accidental deaths caused by autoerotic play is very low because of the non-disclosure of the mode/circumstances of death or non-paralleled forensic systems in many countries. There is a high likelihood of coexisting mental disorders with such behavior.

Zinc Doped Akermanite: A Promising Biomaterial for Orthopedic Application with Enhanced Bioactivity, Mechanical Strength, and Bacterial Study.

Incorporating zinc into biocompatible materials has been identified as a potential strategy for promoting bone regeneration and osteogenic activity during hard tissue regeneration. This work aimed to investigate the impact of zinc doping on the structure of akermanite, which was synthesized using the sol-gel combustion method, with the goal of improving the biological response. Powder XRD and FT-IR analysis confirmed the phase purity and the respective functional groups associated with Zn-doped akermanite.

An Investigation into the Synthesis and Characterization of Novel Tetrazole Derivatives for Application as Mild Steel Corrosion Inhibitors in a Solution of Hydrochloric Acid.

The objective of the study was to synthesize tetrazole molecules featuring nitro groups positioned at the para and meta locations. We aimed to assess their effectiveness in inhibiting corrosion of mild steel in a 1 M HCl solution at 298 K. Tetrazoles with 2,5-disubstitution were created using [3 + 2] cycloaddition and N-alkylation techniques, with a particular emphasis on synthesizing molecules that contain nitro groups.

Enhancing EMI Shielding Efficiency of Polyurethane Foam by Incorporating MWCNT-Decorated Hollow Glass Microspheres.

This work explores the enhancement of EMI shielding efficiency of polyurethane (PU) foam by loading multiwall carbon nanotube (MWCNTs)-decorated hollow glass microspheres (HGMs). MWCNT was coated onto the HGM surface by a simple solution casting technique. The coated HGM particles were loaded in PU foams, resulting in an even dispersion of MWCNT in the foam struts, thereby forming an interconnected conductive network in the polymer matrix.

Novel D-Ribofuranosyl Tetrazoles: Synthesis, Characterization, In Vitro Antimicrobial Activity, and Computational Studies.

The goal of this study was to synthesize and evaluate new antimicrobial compounds. We specifically focused on the development of 2,5-disubstituted tetrazole derivatives containing the O-methyl-2,3-O-isopropylidene-(D)-ribofuranoside groups through N-alkylation reactions. The synthesized compounds were characterized using H and C nuclear magnetic resonance (NMR) spectroscopy.

Synthesis, Characterization, and Antimicrobial Activity of Urea-Containing α/β Hybrid Peptides against and Methicillin-Resistant .

The insertion of β-amino acids and replacement of the amide bond with a urea bond in antimicrobial peptide sequences are promising approaches to enhance the antibacterial activity and improve proteolytic stability. Herein, we describe the synthesis, characterization, and antibacterial activity of short αβ cationic hybrid peptides LA-Orn-βAcc-PEA, ; LA-Lys-βAcc-PEA, ; and LA-Arg-βAcc-PEA, in which a C12 lipid chain is conjugated at the N terminus of peptide through urea bonds. Further, we evaluated all the peptides against both and methicillin-resistant (MRSA) and their multidrug resistant (MDR) clinical isolates.

UVREK: Development and Analysis of an Expression Profile Knowledgebase of Biomolecules Induced by Ultraviolet Radiation Exposure.

Humans encounter diverse environmental factors which can have impact on their health. One such environmental factor is ultraviolet (UV) radiation, which is part of the physical component of the exposome. UV radiation is the leading cause of skin cancer and is a significant global health concern.

Bis(diiminate)-Supported Bimetallic Complexes: Tri-Coordinated Zinc for Nitrile and Carbodiimide Hydroboration.

We report the synthesis and characterization of bis(diiminate)-supported tricoordinated zinc complexes () and demonstrate the catalytic activity of one representative compound in the hydroboration of nitriles and carbodiimides using pinacolborane (HBpin). Experimental and theoretical studies were performed to elucidate the reaction mechanism. Our findings indicate that the hydroboration reaction initiates with the formation of a tricoordinated zinc hydride intermediate, followed by the subsequent attack of nitriles and carbodiimides.