Protocol of randomized controlled trial to evaluate the effect of moderate exercise training on the functional capacity of patients with an implantable cardioverter defibrillator in a tertiary care center in South India.

Background: Cardiac rehabilitation programs are planned to reduce the physiological and psychological stress of Cardiovascular Disease, decrease the risk of mortality secondary to CVD, improve cardiovascular function, and help patients to achieve their highest quality of life. However, data on the safety and efficacy of exercise training (ET) in patients with implantable cardioverter defibrillators (ICDs) is sparse. Exercise interventions in those with an ICD have not been extensively studied.

INDEPSO-ISPSM consensus on peritoneal malignancies - Enhanced recovery after surgery in cytoreductive surgery (CRS) with/without hyperthermic intraperitoneal chemotherapy (HIPEC).

Background: The role of enhanced recovery after surgery (ERAS) in cytoreductive surgery and/or Hyperthermic Intraperitoneal Chemotherapy HIPEC) is evolving, with promising results that improve patient outcomes. This consensus exercise was carried out to address and standardize components of the ERAS protocol pertinent to the Indian context.

Method: The modified Delphi method was employed with two rounds of voting.

Unveiling the toxicity of micro-nanoplastics: A systematic exploration of understanding environmental and health implications.

The surge in plastic production has spurred a global crisis as plastic pollution intensifies, with microplastics and nanoplastics emerging as notable environmental threats. Due to their miniature size, these particles are ubiquitous across ecosystems and pose severe hazards as they are ingested and bioaccumulate within organisms. Although global plastic production has reached an alarming 400.

Modulation of copper-induced neurotoxicity by monoisoamyl 2,3-dimercaptosuccinic acid loaded nanoparticles through inhibition of mitophagy and reduction of oxidative stress in SH-SY5Y cells.

Copper (Cu) dysregulation, often stemming from ATP7B gene mutations, exacerbates neurological disorders like Huntington's, Alzheimer's, and Parkinson's diseases. Monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA) shows promise in mitigating Cu induced neurotoxicity by chelating intracellular Cu ions, reducing oxidative stress, and restoring antioxidant enzyme function. However, challenges such as poor bioavailability hinder its therapeutic efficacy.

Microbial amidases: Characterization, advances and biotechnological applications.

The amidases (EC 3.5.1.

Robustness of machine learning predictions for Fe-Co-Ni alloys prepared by various synthesis methods.

Developing high-performance alloys is essential for applications in advanced electromagnetic energy conversion devices. In this study, we assess Fe-Co-Ni alloy compositions identified in our previous work through a machine learning (ML) framework, which used both multi-property ML models and multi-objective Bayesian optimization to design compositions with predicted high values of saturation magnetization, Curie temperature, and Vickers hardness. Experimental validation was conducted on two promising compositions synthesized using three different methods: arc melting, ball milling followed by spark plasma sintering (SPS), and chemical synthesis followed by SPS.

Enhancing glaucoma diagnosis: Generative adversarial networks in synthesized imagery and classification with pretrained MobileNetV2.

The disease affects the optic nerve and represents the principle reasons of irreversible vision loss, mostly asymptomatic and uncontrolled. Consequently, early and accurate diagnosis is critical to prevent or reduce its effect, however, conventional diagnostic techniques often fail to provide concrete results. In this regard, we present a new approach built on Generative Adversarial Networks (GAN) and MobileNetV2 pretrained architecture for diagnosing glaucoma.

Corrigendum to "Clothing design solutions for children with developmental disabilities: A scoping review protocol" [MethodsX Volume 13 (2024) 102974].

[This corrects the article DOI: 10.1016/j.mex.

Numerical and experimental methods for the assessment of a human finger-inspired soft pneumatic actuator for gripping applications.

The increasing demand for soft robotic systems in agricultural, biomedical and other applications has driven the development of actuators that can mimic the flexibility and adaptability of human muscles. Several studies have explored the design and implementation of soft actuators for robotic applications, however, there is a need for soft actuators demonstrating delicate gripping capabilities but also excel in specific biomedical applications, such as therapeutic massaging. The objective of this work is to develop a multi-finger soft pneumatic actuator mimicking human fingers for Ayurvedic therapeutic massaging and gripping applications.

From Lab to Limb: Unraveling Translational Insights and Significance of Animal Models in Lower Extremity Transplantation.

The advancements in medicine throughout the twentieth century have been largely attributed to animal studies. The initial step in researching an animal disease is to establish a model closely resembling the clinical circumstances in humans. Consequently, an excellent animal model is essential for almost any experimental research.

Therapeutic doses of efzofitimod demonstrate efficacy in pulmonary sarcoidosis.

Background: In a phase 1b/2a clinical trial of efzofitimod in patients with corticosteroid-requiring pulmonary sarcoidosis, treatment resulted in dose-dependent improvement in key end-points. We undertook a analysis pooling dose arms that achieved therapeutic concentrations of efzofitimod (Therapeutic group) those that did not (Subtherapeutic group).

Methods: Peripheral blood mononuclear cells incubated with tuberculin-coated beads were exposed to varying concentrations of efzofitimod in an assay to determine concentrations that inhibited granuloma formation.

BanglaBlend: A large-scale nobel dataset of bangla sentences categorized by saint and common form of bangla language.

In the vibrant linguistic landscape of Bengali, spoken by millions in Bangladesh and India, the gap between saintly and common terms is culturally and computationally significant. Recognising this, we introduce BanglaBlend, a pioneering dataset created to capture these stylistic distinctions. BanglaBlend comes with 7350 annotated sentences, 3675 in saintly form and 3675 in common form, covering a crucial need in natural language processing (NLP) resources for Bangla.

Transient anterior chamber intraocular lens opacification by triamcinolone acetonide following intravitreal injection.

Background: Pseudophakic cystoid macular edema (CME) following primary anterior-chamber intraocular lens (ACIOL) implantations is commonly seen. Intravitreal triamcinolone acetonide (IVTA) injections have shown significant improvement in visual acuity and retinal thickness in refractory pseudophakic CME. Pseudohypopyon following IVTA injection is a known entity.

Adie's pupil and systemic manifestations: a rare unilateral presentation.

We present a case of a young woman who presented with blurring of vision in her right eye, worsening on near work. Detailed ophthalmic and neurological evaluation was done, which revealed light near dissociation, vermiform iris movements, constriction to diluted pilocarpine with absent deep tendon reflexes. Laboratory investigation indicated mild iron deficiency anemia and reduced vitamin D3 level.

Enhancing prosthetic hand control: A synergistic multi-channel electroencephalogram.

Electromyogram (EMG) has been a fundamental approach for prosthetic hand control. However it is limited by the functionality of residual muscles and muscle fatigue. Currently, exploring temporal shifts in brain networks and accurately classifying noninvasive electroencephalogram (EEG) for prosthetic hand control remains challenging.

Usefulness of Comprehensive Genomic Profiling in Clinical Decision-Making in Oncology: A Systematic Review.

Biologic factors limiting responsiveness to matched targeted therapies include genomic heterogeneity and complexity. Advanced tumors with unique molecular profiles can be studied by comprehensive genomic profiling (CGP) and enhance patient outcomes using principles of precision medicine. The clinical utility of CGP across all cancer types and different therapeutic interventions using overall survival (OS) and progression-free survival (PFS) data was studied in this systematic literature review.

Endoscopic endonasal dacryocystectomy.

Purpose: To report an exceptionally rare instance of Endoscopic endonasal dacryocystectomy.

Observations: Dacryocystectomy (DCT), a procedure of surgical extirpation of the lacrimal sac is normally approached by an external route. However, an endoscopic endonasal approach DCT is rare and usually reserved in cases where intellectual disabilities of a patient become a restrictive factor in maintenance of a healthy external wound.

Influence of puberty on high intensity exercise induced skeletal muscle damage and inflammatory response in sedentary boys.

The present investigation examined the influence of age and pubertal transition on magnitude of muscle damage and inflammatory response following high intensity incremental treadmill running till volitional exhaustion in sixty-four sedentary prepubertal ( ​= ​32) and postpubertal ( ​= ​32) boys who were randomly recruited in the study. Muscle damage and inflammatory markers like creatine kinase (CK), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), aspartate aminotranferase (AST), C-Reactive Protein (CRP) and Interleukin-6 (IL-6) were estimated before and after exercise. Serum CK, LDH, AST, ALT, CRP and IL-6 levels significantly increased after exercise in both the groups in comparison to respective pre-exercise values.

New MUSA classification of adenomyosis: correlation of symptoms and clinical severity with direct and indirect features.

Introduction: To correlate the direct and indirect morphological uterus sonographic assessment (MUSA) features of adenomyosis with clinical symptoms severity.

Material And Methods: This observational prospective study was conducted at a tertiary care institute from April 2023 to March 2024, involving 254 women aged 18 to 45 years with a regular menstrual cycle and ultrasound-confirmed diagnosis of adenomyosis. Detailed clinicodemographic data were collected, including symptoms such as painful menses, heavy menstrual bleeding (HMB), chronic pelvic pain (CPP), and bowel/bladder symptoms.

How resistant is anammox biofilm against antibiotics: A special insight into anammox response towards fluoroquinolones.

Elevated concentrations of pharmaceutically active compounds (PhACs) in the water bodies are posing a serious threat to the aquatic microbiota and other organisms. In this context, anaerobic ammonium oxidizing (anammox) bacteria carry a great potential to degrade PhACs through their innate metabolic pathways. This study investigates the influence of short-term exposure to lower and higher concentrations (0.

Private equity renewable energy investments in India.

India is anticipated to grow its total energy consumption and CO emissions by more than any other country over the next two decades. India will have to attract around $400 billion in financing to realize its 500 GW target of renewable energy by 2030. Given complex renewable energy sector risks, rapidly scaling-up risk-friendly private equity financing will be critical to achieve India's target.

Navigating the nano-world future: Harnessing cellulose nanocrystals from green sources for sustainable innovation.

Cellulose nanocrystals (CNCs) are a class of materials that have received significant attention in recent years due to their unique properties and potential applications. CNCs are extracted from plant fibers and possess high strength, stiffness, and biocompatibility, making them attractive materials for use in various fields such as biomedical engineering, renewable energy, and nanotechnology. This provides an in-depth discussion of the extraction, characterization, and promising applications of CNCs.

Novel ionic liquid-infused PVA-based anion exchange membranes boosting bioelectricity yield from microbial fuel cells.

The goal of this research is to develop and characterize low-cost NHI doped polyvinyl alcohol (PVA)-4-ethyl-4-methylmorpholiniumbromide (ionic liquid) anion exchange membranes (AEM) and its application for membrane cathode assembly. Physical characterization like FTIR, POM, and XRD notified the functional groups, basic structure, and amorphosity of the produced membrane, and it was employed in single-chambered microbial fuel cells (sMFCs) as a separator. The membranes in terms of oxygen diffusion, proton conductivity, and ion exchange capabilities were evaluated.

Willingness to pay for cooking with electricity among rural households: The case of Southern Ethiopia.

One way to fulfill the worldwide goal of clean energy outlined in SDG 7 is by adopting modern and alternative energy sources, specifically through electric cooking. Most rural households in developing countries, however, lack access to a clean and affordable energy source; thus, a significant part of the population relies on solid fuels. This study investigates the factors influencing households' willingness to pay for electricity services for cooking in rural areas of Southern Ethiopia, where access to clean and affordable energy is limited.