Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis.

Osteoarthritis, the most common arthritic condition, is an age-related progressive disease characterized by the loss of cartilage and synovial inflammation in the knees and hips. Development of pain, stiffness, and considerably restricted mobility of the joints are responsible for the production of matrix metalloproteinases and cytokines. Although several treatments are available for the management of this disease condition, they possess limitations at different levels.

Anti-furfurative comparison of Kesh Kanti-Herbal Shampoos and synthetic shampoos against Malassezia furfur for dandruff management.

Malassezia furfur is the primary etiological agent of dandruff (Pityriasis capitis). Although herbal shampoos are preferred for their natural, mild ingredients over synthetic counterparts, they are often perceived as less effective in managing flaky scalp conditions or furfuration causing dandruff. The study compares the antifungal efficacy of herbal and synthetic shampoos against M.

Eustress responses of Musa acuminata cv. red banana using LED spectra.

This study examined the impacts of different LED spectra on the growth of in vitro cultures of Musa acuminata cv. red banana and their biochemical profile, including the antioxidant enzymes catalase and ascorbate peroxidase, photosynthetic pigment and accumulation of total carbohydrate content. The far-red LEDs significantly increase shoot elongation (10.

Selective fluoride ion sensing using novel quinoline chemosensor insights into kinetics and molecular logic gate functions.

CQHC, a novel colorimetric fluorescent sensor, developed for the selective sensing of ions and well characterised, including SC-XRD. It demonstrated selective sensing for Co, Zn, Hg and F using absorbance titration at 420 nm, 446 nm and the binding constants estimated follows the order F > Co > Hg > Zn. On light of this, molecular logic gate was built for CQHC's selective multi-ion detection.

Study of blood flow patterns in a stenosed artery through the combined effect of body acceleration and generalized womersley solution.

Stenosis causes the narrowing of arteries due to plaque buildup, which impedes blood flow and affects flow dynamics. This work numerically analyzes flow fluctuations in stenosed arteries under realistic physiological conditions (resting and exercise) and external body acceleration. The artery is inclined at angle , and blood rheology is modeled using a generalized power-law fluid.

Efficient adsorptive removal of Congo Red dye using activated carbon derived from Spathodea campanulata flowers.

This report investigates the preparation, characterization, and application of activated carbon derived from Spathodea campanulata flowers (SCAC) to remove Congo Red (CR) dye from aqueous streams. SCAC was synthesized using orthophosphoric acid activation which yielded a mesoporous material with a specific surface area of (986.41 m/g), significantly exceeding values reported for flower-derived activated carbons in the available literature.

Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores.

Correct classification of type 1 (T1D) and type 2 diabetes (T2D) is challenging due to overlapping clinical features and the increasingly early onset of T2D, particularly in South Asians. Polygenic risk scores (PRSs) for T1D and T2D have been shown to work relatively well in South Asians, despite being derived from largely European-ancestry samples. Here we used PRSs to investigate the rate of potential misclassification of diabetes amongst British Bangladeshis and Pakistanis.

Dietary Chia (Salvia hispanica L.) seeds oil supplementation augments growth performance and gut microbial composition in Labeo rohita fingerlings.

The present study investigates the supplemental effects of chia seed oil (CSO) on the growth performance and modulation of intestinal microbiota in Labeo rohita fingerlings. Four diets were formulated with graded levels of CSO: 1.0%, 2.

Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach.

Triple-negative breast cancer (TNBC) is one of the most fatal malignancies in the world, accounting for 42% of all deaths due to metastasis. The significant development is hindered by the multi-drug resistance and poor patient compliance. PIK3CA gene mutation is one of the important causes of TNBC, which causes dysregulation of the cell cycle and cell proliferation.

Conformational diversity in class C GPCR positive allosteric modulation.

The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate. The architecture of mGlu receptor comprises an extracellular Venus-Fly Trap domain (VFT) connected to the transmembrane domain (7TM) through a Cysteine-Rich Domain (CRD). The binding of L-glutamate in the VFTs and subsequent conformational change results in the signal being transmitted to the 7TM inducing G protein binding and activation.

MiRNAs as major players in brain health and disease: current knowledge and future perspectives.

MicroRNAs are regulators of gene expression and their dysregulation can lead to various diseases. MicroRNA-135 (MiR-135) exhibits brain-specific expression, and performs various functions such as neuronal morphology, neural induction, and synaptic function in the human brain. Dysfunction of miR-135 has been reported in brain tumors, and neurodegenerative and neurodevelopmental disorders.

Tissue fibrosis in cardiorenal syndrome: crosstalk between heart and kidneys.

Cardiorenal syndrome (CRS) is represented as an intricate dysfunctional interplay between the heart and kidneys, marked by cardiorenal inflammation and fibrosis. Unlike other organs, the repair process in cardiorenal injury involves a regenerative phase characterized by proliferation and polyploidization, followed by a subsequent pathogenic phase of fibrosis. In CRS, acute or chronic cardiorenal injury leads to hyperactive inflammation and fibrotic remodeling, associated with injury-mediated immune cell (Macrophages, Monocytes, and T-cells) infiltration and myofibroblast activation.

The tireless voyage of the resilient little red blood cell.

The little red blood cell, through its relentless journey, is a powerful symbol of testament and determination and serves as a reminder to humans to persevere and never give up, no matter what challenges they may face all along the way.

Role of AIM2 and cGAS-STING signaling in high fat high carbohydrate diet-induced gut dysbiosis associated neurodegeneration.

Aims: Gut dysbiosis modulates CNS complications and cognitive decline through the gut-brain axis. The study aims to investigate the molecular mechanisms involved in gut dysbiosis-associated cognitive changes and the potential effects of probiotics in high fat-high carbohydrate diet-induced gut dysbiosis-associated neurodegeneration.

Materials And Methods: We used high fat, high-carbohydrate diet (HFHCD) and high-fat diet (HFD) to induce gut dysbiosis-associated neurodegeneration in C57BL/6 mice.

Perspective: Can growth monitoring and promotion accurately diagnose or screen for inadequate growth of individual children? A critical review of the epidemiological foundations.

Growth monitoring and promotion (GMP), the process of periodic anthropometric measurements to assess the adequacy of individual child growth, is implemented across low- and middle-income countries (LMICs). The epidemiological foundations of GMP (i.e.

Magnesium chloride-infused chitosan-poly (vinyl alcohol) electrolyte films: A versatile solution for energy storage devices.

The potential of advanced energy storage devices lies in using solid biodegradable polymer electrolytes. This study is focused on a solid blend polymer electrolyte (SBPE) film based on chitosan (CS)-poly (vinyl alcohol) (PVA) blend matrix doped with magnesium chloride (MgCl) salt via solution casting. The interaction of MgCl was verified via X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy.

The bioconjugates of curcumin, zingerone and [6]-shogaol with low molecular weight chitosan: Synthesis, characterization and in vitro anticancer activity in HepG2 cells.

The synthesis of bioconjugates of curcumin, zingerone, and [6]-shogaol with low molecular weight chitosan (LMWC) is presented. The unconjugated forms of these compounds exhibit low water solubility, poor stability, limited bioavailability, and low target specificity, whereas the synthetic conjugates demonstrate improved physical properties. The synthesis was achieved by forming succinates & then reacting with LMWC.

Enhanced photocatalytic dye detoxification by banana peel derived enzyme inherited ZnO/g-CN nanocomposite: Validation by soil health and seed germination analyses.

Development of bio-supported photocatalysts has become a pressing need in the field of environmental remediation. This work reports the synthesis of bio-enzyme (from banana peels) inherited (ZnO/g-CN) nanocomposite by simple soft chemical method and its photocatalytic degradation ability against the mixed dye (Methylene blue (MB) + Rhodamine-B (RhB)) under UV irradiation. Synthesized nanoparticles were characterized using experimental techniques XRD, FESEM, TEM, EDAX, XPS, UV-vis-NIR spectroscopy and FTIR.

Clinical practices on acute acquired comitant esotropia: A consensus statement proposed by the Council of Asia-Pacific Strabismus and Pediatric Ophthalmology Society.

Acute acquired comitant esotropia (AACE) is a concomitant strabismus characterized by sudden onset, mostly associated with diplopia. The prevalence of AACE has significantly increased, and various management approaches have been recommended in recent years. This study by the Council of Asia-Pacific Strabismus and Pediatric Ophthalmology Society aimed to provide an overview of the clinical features, etiology and the nonsurgical and surgical treatment recommendations for the condition to equip strabismus specialists with the most updated knowledge.

Ameliorative role of bioactive compounds against lead-induced neurotoxicity.

Lead (Pb) is an environmental toxin ubiquitously present in the human environment due to anthropogenic activities and industrialization. Lead can enter the human body through various sources and pathways, such as inhalation, ingestion and dermal contact, leading to detrimental health effects. The majority of lead that enters the body is removed by urine or feces; however, under chronic exposure conditions, lead is not efficient, as lead is absorbed and transferred to numerous organs, such as the brain, liver, kidney, muscles, and heart, and it is ultimately stored in mineralizing tissues such as bones and teeth.

Early muscular training and immobilization in external rotation could reduce the recurrence rate in first-time shoulder dislocators among young rugby athletes.

Background: Among rugby players, anterior shoulder dislocation is challenging to treat during the in-season period. It often leads to recurrent shoulder instability and requires prolonged rest post-surgery. No studies have determined the effectiveness of immobilization, early muscle strength training, or both in preventing reinjury in this population.

Gymnema saponin-induced lipid flip-flop identifies rigid membrane phenotype of methicillin resistant S. aureus and enhances it's antibiotic susceptibility.

Our previous study revealed that lipid flip-flop inducing phytochemicals from Gymnema sylvestre increase membrane permeability of antimicrobials in S. aureus. However, their lipid flipping and membrane permeabilizing effect on methicillin resistant S.