A novel RFE-GRU model for diabetes classification using PIMA Indian dataset.

Diabetes is a long-term condition characterized by elevated blood sugar levels. It can lead to a variety of complex disorders such as stroke, renal failure, and heart attack. Diabetes requires the most machine learning help to diagnose diabetes illness at an early stage, as it cannot be treated and adds significant complications to our health-care system.

Optimization of energy management in Malaysian microgrids using fuzzy logic-based EMS scheduling controller.

The microgrid (MG) faces significant security issues due to the two-way power and information flow. Integrating an Energy Management System (EMS) to balance energy supply and demand in Malaysian microgrids, this study designs a Fuzzy Logic Controller (FLC) that considers intermittent renewable sources and fluctuating demand patterns. FLC offers a flexible solution to energy scheduling effectively assessed by MATLAB/Simulink simulations.

Unveiling the Dissociation Mechanism of Diglycine Perchlorate.

Determining the dissociation mechanism of perchlorate materials remains a top priority to address sustainability, handling, processing, and synthesis issues of new and existing high-energy density materials vital to many industrial processes. We determined the dissociation mechanism of diglycine perchlorate (DGPCl) using vibrational spectroscopy, which unveiled the formation of ammonium perchlorate (AP) and carbon at high temperatures. Our studies establish that DGPCl shows multiple phase transitions upon heating.

Infants of diabetic mothers: epidemiology, pathophysiology, fetal heartassessment, structural and functional heart consequences: A narrative review.

Infants of diabetic mothers are neonates born to a woman who had periodic hyperglycaemia during pregnancy. Consequently, infants of diabetic mothers are at higher risks of illness besides morbidity and mortality due to teratogenic effects on the fetal cardiovascular system, causing most frequent CHDs. The primary purpose of this review is to present, on this topic, a better-comprehended review covering pertinent material and data to be informed of severe risks to a newborn's cardiac system and function.

Development of a Phototriggered Diradical Phosphoamination Strategy of Alkenes.

Aminophosphonates serve as extremely important moieties with respect to their activities in biological systems. However, incorporating a Nitrogen and Phosphorus moiety by conventional techniques in ionic mode is usually associated with extensive prefunctionalization of the substrates, employing harsh conditions and reagents that limit the viability of these methods. Introducing both of these components as radicals may be a viable option.

Placental Proteomics Reveals an Elevated Level of Aldo-Keto Reductase 1-B1, Highlighting Its Potential Role in Spontaneous Preterm Birth.

Preterm birth (PTB) refers to the delivery of a baby before the completion of 37 weeks of gestation. It is a significant global health issue with implications for both mothers and neonates. The placenta is a transient organ crucial in the sustenance of pregnancy until parturition; its dysfunction is associated with different adverse pregnancy outcomes, including PTB.

Growing old before growing rich: a scoping review on ageing-related policy interventions from the WHO Southeast Asian Region.

Background: WHO Southeast Asian Region (WHO SEARO) is home to 1.94 billion people accounting for one-fourth of the global population.

Objective: The primary objective of this scoping review is to describe the various policy interventions implemented in countries of the WHO SEARO to address the consequences of ageing.

Novel inclusion in the silvery hair syndromes: unravelling the mystery behind the silvery hair of homocystinuria.

Homocystinuria is a disorder of methionine metabolism leading to abnormal accumulation of homocysteine and its metabolites in blood and urine. This condition presents with a wide range of cutaneous and systemic features. This case report focuses on the particular cutaneous finding of silvery hair in this patient and its examination under a microscope that reveals an unusual and not yet reported finding of melanin clumps.

Research output in orthopedics and sports medicine from Latin America.

No Abstract available.

Knot-knot chronicles: unveiling the G-quadruplexes.

G-quadruplex structures (GQSes) are the intricate molecular knots or marvels that play diverse roles in various cellular processes, such as replication, transcription, and translation, which regulate gene expression. Even though GQSes can be found throughout the genome, they are more prevalent in certain genomic regions like promoters and 5'-UTRs. This review discusses the functionality of GQSes across various regions of the genome and draws attention to the intriguing world of DNA and RNA GQSes.

Microplastics can alter structural configurations of human non-canonical G-quadruplex DNA.

Microplastics (MP) with a diameter of less than 150 μm can enter the lymph and bloodstream systems, induce cellular toxicity and damage DNA. G-quadruplexes (GQs) are tetraplex DNA secondary structures found in the human genomes that play important roles in replication, transcription and genomic integrity. Comprehending the biological and molecular processes underlying the activities of MPs could aid in estimating potential hazards to humans.

The potential therapeutic role of berberine in treating epilepsy focusing on temporal lobe epilepsy: State of art and ongoing perspective.

Epilepsy is a neurological disease characterized by unprovoked recurrent epileptic seizures. Temporal lobe epilepsy (TLE) is the commonest type of focal epilepsy in adults that resist to the conventional anti-seizure medications (ASMs). Interestingly, ASMs do not affect the epileptogenesis and progression of disease.

Tuning the properties of soy protein isolate-based adhesive using various sustainable additives.

This work investigates the adhesive property of Soy Protein Isolate(SPI)polymer solution by studying mechanical properties of composites formed using waste wood granules and SPI solutions. To improve the adhesive strength of SPI solution, Carboxymethyl Cellulose Sodium(NaCMC)was mixed (in the weight ratios of 9:1 and 8:2) due to its strong gel formation capabilities. The adhesive performance of these composites was further investigated in the presence and absence of non-toxic additives, including sorbitol (SOR) and stearic acid (SA).

Sustainable oxalic acid treatment of lignocellulosic fibers for ensuring improved performance of treated fibers based bio PBS composites.

Plant-based macromolecules such as lignocellulosic fibers are one of the promising bio-resources to be utilized as reinforcement for developing sustainable composites. However, due to their hydrophilic nature and weak interfacial bonding with polymer matrices, these fibers are mostly incompatible with biopolymers. The current research endeavor explores the novel eco-friendly oxalic acid (CHO.

Nano-structured polyaniline in biocatalysis: Manifesting simultaneous competence of polyaniline nanofibers and nanotubes as immobilization matrices for laccase mediated synthesis of drug intermediates.

Customized nano-biocatalysts of laccase have been made using nano-structured polyaniline viz. nano-fibers and nano-tubes, as immobilization supports and a simultaneous comparison between them has been made. Laccases are poly-phenol oxidases having tremendous utility concerning wider areas of application especially in the field of organic and drug syntheses.

Advancements in understanding the role and mechanism of sirtuin family (SIRT1-7) in breast cancer management.

Breast cancer (BC) is the most prevalent type of cancer in women worldwide and it is classified into a few distinct molecular subtypes based on the expression of growth factor and hormone receptors. Though significant progress has been achieved in the search for novel medications through traditional and advanced approaches, still we need more efficacious and reliable treatment options to treat different types and stages of BC. Sirtuins (SIRT1-7) a class III histone deacetylase play a major role in combating various cancers including BC.

Unravelling a new focus of Spotted Fever Rickettsioses as causative agents of acute undifferentiated febrile illness in Odisha, A state in eastern Costal India.

Spotted fever group Rickettsia (SFGR) infections remain largely under-investigated as causative agents of acute undifferentiated febrile illness (AUFI) in resource-limited settings. Few studies are available on the prevalence of SFGR infections in India, especially in eastern India. In a cross-sectional study conducted in 192 hospitalized adult and paediatric patients with AUFI, the frequency of SFGR using sequential PCR targeting genes encoding citrate synthase gene (gltA), 17 kDa lipoprotein precursor antigen (17kDa), outer membrane proteins A and B (omp A & omp B) was 6.

Identification of ABHD6 as a lysophosphatidylserine lipase in the mammalian liver and kidneys.

Lysophosphatidylserine (lyso-PS) is a potent hormone-like signaling lysophospholipid, which regulates many facets of mammalian biology and dysregulation in its metabolism is associated with several human neurological and autoimmune diseases. Despite the physiological importance and causal relation with human pathophysiology, little is known about the metabolism of lyso-PS in tissues other than the nervous and immune systems. To address this problem, here, we attempted to identify one (or more) lipase(s) capable of degrading lyso-PS in different mammalian tissues.

"Comparison of the efficacy of Erich arch bars, IMF screws and SMART Lock Hybrid arch bars in the management of mandibular fractures- A Randomized clinical study".

Purpose: The purpose of this study was to assess and compare the efficacy of Erich Arch Bar (EAB), Inter Maxillary Fixation (IMF) screws and SMART Lock Hybrid arch bar (HABs) in the treatment of mandibular fractures.

Materials And Methods: A prospective randomized clinical study was carried out in the Department of Dentistry at ESIC Hospital in Hyderabad from August 2021 to August 2023. The study comprised of three groups (EAB group (31), IMF screw group (33) and HABs group (29)).

Novel therapeutic targets for cardiorenal syndrome.

Cardiorenal syndrome (CRS) is an interdependent dysfunction of the heart and kidneys, where failure in one organ precipitates failure in the other. The pathophysiology involves sustained renin-angiotensin-aldosterone-system (RAAS) activation, mitochondrial dysfunction, inflammation, fibrosis, oxidative stress and tissue remodeling, culminating in organ dysfunction. Existing therapies targeting the RAAS, diuretics and other agents have limitations, including diuretic resistance and compensatory sodium reabsorption.

Interactions between lncRNAs and cyclins/CDKs complexes; key players in determining cancer cell response to CDKs inhibitors.

Transcription takes place over a significant portion of the human genome. However, only a small portion of the transcriptome, roughly 1.2%, consists of RNAs translated into proteins; the majority of transcripts, on the other hand, comprise a variety of RNA families with varying sizes and functions.

Mechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease.

Neurodegenerative disorders (NDDs) have been prevalent for more than a decade, and the number of individuals affected per year has increased exponentially. Among these NDDs, Alzheimer's disease, which causes extreme cognitive impairment, and Parkinson's disease, characterized by impairments in motor activity, are the most prevalent. While few treatments are available for clinical practice, they have minimal effects on reversing the neurodegeneration associated with these debilitating diseases.