Trends in drug repurposing: Advancing cardiovascular disease management in geriatric populations.

Drug repurposing is a promising strategy for managing cardiovascular disease (CVD) in geriatric populations, offering efficient and cost-effective solutions. CVDs are prevalent across all age groups, with a significant increase in prevalence among geriatric populations. The middle-age period (40-65 years) is critical due to factors like obesity, sedentary lifestyle, and psychosocial stress.

Surface receptor-targeted Protein-based nanocarriers for drug delivery: Advances in cancer therapy.

Significant progress has been made in cancer therapy with protein-based nanocarriers targeted directly to surface receptors for drug delivery. The nanocarriers are a potentially effective solution for the potential drawbacks of traditional chemotherapy, such as lack of specificity, side effects, and development resistance. Peptides as nanocarriers have been designed based on their biocompatible, biodegradable, and versatile functions to deliver therapeutic agents into cancer cells, reduce systemic toxicity, and maximize therapy efficacy through utilizing targeted ligands such as antibodies, amino acids, vitamins, and other small molecules onto protein-based nanocarriers and thus ensuring that drugs selectively accumulate in the cancer cells instead of healthy organs/drug release at a target site without effects on normal cells, which inherently caused less systemic toxicity/off-target effect.

Role of Injectable Platelet-Rich Fibrin in the Management of Soft and Hard Tissue Periodontal Regeneration in Dentistry: Protocol for a Systematic Review.

Background: Injectable platelet-rich fibrin (i-PRF) has the capacity to release great amounts of several growth factors, as well as to stimulate increased fibroblast migration and the expression of collagen, transforming growth factor β, and platelet-derived growth factor. Consequently, i-PRF can be used as a bioactive agent to promote periodontal tissue regeneration.

Objective: We aim to compare and evaluate the effectiveness of i-PRF in periodontal tissue regeneration.

Extension for Community Healthcare Outcomes-Palliative Care in Africa and Quality of Life, Symptoms, Patient Experience, and Caregiver Distress Among Patients With Cancer.

Purpose: In this study, we aimed to evaluate the association between the Extension for Community Healthcare Outcomes-Palliative Care (ECHO-PC; ECHO Model-Based comprehensive educational and telementoring intervention) for health care professionals (HCPs) and change in patient-reported quality-of-life (QOL; Functional Assessment of Cancer Therapy-General [FACT-G]) among patients with advanced cancer. We also examined the association between ECHO-PC and changes in symptom distress (Edmonton Symptom Assessment Scale [ESAS]), patient experience and satisfaction, and caregiver distress scores.

Methods: ECHO-PC Clinic sessions were conducted twice a month for 1 year by an interdisciplinary team of PC clinicians at the MD Anderson Cancer Center, with participation of experts in PC in sub-Saharan Africa, using standardized curriculum on the basis of PC needs in the region.

A Potent Bis-Heteroleptic Ruthenium(II) Complex-Based Chalcogen Bonding Receptor for Selective Sensing of Phosphates.

The incorporation of a selenoimidazolium-based chalcogen bond (ChB) donor into a bis-heteroleptic Ru(II) complex (Ru-Se) has been designed for the first time to explore its anion-sensing properties and understand its selectivity to specific classes of anions. Photophysical studies demonstrate the receptor's selectivity toward phosphates, while H NMR displays its ability to recognize both I and HPO among the different halides and oxoanions through ChB interaction in CHCN and dimethyl sulfoxide- solvents, respectively. Additionally, microscopic studies such as DLS and TEM reveal that the selective turn-on sensing of HPO and HPO compared to I is driven by supramolecular aggregation behavior.

Retraction Note: Empirical evidence of effects of stringency amid Covid-19 pandemic spread.

[This retracts the article DOI: 10.1007/s00500-022-06986-0.].

Retraction Note: Machine learning-based self-sensing of the stiffness of shape memory coil actuator.

[This retracts the article DOI: 10.1007/s00500-022-06818-1.].

Retraction Note: Biserial targeted feature projection based radial kernel regressive deep belief neural learning for covid-19 prediction.

[This retracts the article DOI: 10.1007/s00500-022-06943-x.].

Retraction Note: Mathematical analysis of COVID-19 pandemic by using the concept of SIR model.

[This retracts the article DOI: 10.1007/s00500-021-06133-1.].

Retraction Note: Early diagnosis of COVID-19-affected patients based on X-ray and computed tomography images using deep learning algorithm.

[This retracts the article DOI: 10.1007/s00500-020-05275-y.].

Retraction Note: A deep neural network for the classification of epileptic seizures using hierarchical attention mechanism.

[This retracts the article DOI: 10.1007/s00500-022-07122-8.].

Retraction Note: Dynamic multi-variant relational scheme-based intelligent ETL framework for healthcare management.

[This retracts the article DOI: 10.1007/s00500-022-06938-8.].

Retraction Note: Securing health care data through blockchain enabled collaborative machine learning.

[This retracts the article DOI: 10.1007/s00500-023-08330-6.].

Retraction Note: Performance evaluation of deep learning techniques for lung cancer prediction.

[This retracts the article DOI: 10.1007/s00500-023-08313-7.].

Retraction Note: Time-series data prediction problem analysis through multilayered intuitionistic fuzzy sets.

[This retracts the article DOI: 10.1007/s00500-022-07053-4.].

Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect.

The global priorities in the field of infectious diseases are constantly changing. While emerging viral infections have regularly dominated public health attention, which has only intensified after the COVID-19 pandemic, numerous bacterial diseases have previously caused, and continue to cause, significant morbidity and mortality-deserving equal attention. Three potentially life-threatening endemic bacterial diseases (leptospirosis, melioidosis, and rickettsioses) are a huge public health concern especially in low- and middle-income countries.

Virtual reality based audio visual brainwave entrainment to improve learning in children with attention deficit hyperactive disorder.

Attention deficit/hyperactive disorder is increasing in prevalence among children all over the world which affects the children's communication, learning, and behavior, which in turn affects the quality of life. The depolarization of neurons is modulated by neural stimulation which triggers activity-based mechanisms of neuroplasticity. An external periodic stimulus that can modify the oscillations of the brain through synchronization is called entrainment.

Protective effects of herbal compounds against cyclophosphamide-induced organ toxicity: a pathway-centered approach.

Cyclophosphamide is a key component of numerous chemotherapeutic protocols, demonstrating broad-spectrum efficacy against various malignancies and non-cancerous conditions. This review examines CPM's metabolic pathways, therapeutic applications, and its resulting organ-specific toxicities. Despite its clinical benefits in treating nephrotic syndrome, encephalomyelitis, breast cancer, ovarian cancer, and other diseases, CPM is associated with significant adverse effects on the kidneys, liver, heart, lungs, and intestines.

Synergistic SERS Enhancement of Highly Sensitive and Reusable rGO-Ag-ZrO Thin Film Nanocomposite to Detect Synthetic Textile Dyes.

The textile industry is one of the main industries that benefited from the industrial revolution. Therefore, discharging of dyes from textile, paper, plastic, and rubber industries is inevitable. This colored wastewater prevents sunlight penetration and highly affects water sources.

Use of Machine Learning to Predict Individual Postprandial Glycemic Responses to Food Among Individuals With Type 2 Diabetes in India: Protocol for a Prospective Cohort Study.

Background: Type 2 diabetes (T2D) is a leading cause of premature morbidity and mortality globally and affects more than 100 million people in the world's most populous country, India. Nutrition is a critical and evidence-based component of effective blood glucose control and most dietary advice emphasizes carbohydrate and calorie reduction. Emerging global evidence demonstrates marked interindividual differences in postprandial glucose response (PPGR) although no such data exists in India and previous studies have primarily evaluated PPGR variation in individuals without diabetes.

Noninvasive Anemia Detection and Hemoglobin Estimation from Retinal Images Using Deep Learning: A Scalable Solution for Resource-Limited Settings.

Purpose: The purpose of this study was to develop and validate a deep-learning model for noninvasive anemia detection, hemoglobin (Hb) level estimation, and identification of anemia-related retinal features using fundus images.

Methods: The dataset included 2265 participants aged 40 years and above from a population-based study in South India. The dataset included ocular and systemic clinical parameters, dilated retinal fundus images, and hematological data such as complete blood counts and Hb concentration levels.

Yeast Eukaryotic Initiation Factor 4B Remodels the MRNA Entry Site on the Small Ribosomal Subunit.

Eukaryotic Initiation Factor 4 (eIF4) is a group of factors that activates mRNA for translation and recruit 43S preinitiation complex (PIC) to the mRNA 5' end, forming the 48S PIC. The eIF4 factors include mRNA 5' cap-binding protein eIF4E, ATP-dependent RNA helicase eIF4A, and scaffold protein eIF4G, which anchors eIF4A and eIF4E. Another eIF4 factor, eIF4B, stimulates the RNA helicase activity of eIF4A and facilitates mRNA recruitment.