Synthesis, crystal structure and Hirshfeld analysis of a novel supra-molecular compound [Co(tsc)][Co(cit)](NO)·4HO.

A new cobalt complex, bis-[tris-(amino-thio-urea)cobalt(III)] bis-[2-(carb-oxy-methyl)-2-hy-droxy-butane-dioato]cobalt(II) tetra-nitrate tetra-hydrate, [Co(CHNS)][Co(CHO)](NO)·2HO, designated as [Co(tsc)][Co(cit)](NO)·4HO, was synthesized. Two crystallographically independent cobalt centers are present. In the first, the central metal atom is chelated by three thio-semicarbazide ligands in a bidentate fashion whereas the second, positioned on a crystallographic inversion center, is hexa-coordinated by two citrate anions in a distorted octa-hedral geometry.

Crystal structure, Hirshfeld surface analysis, DFT and mol-ecular docking studies of 4'-(benz-yloxy)-[1,1'-biphen-yl]-3-carb-oxy-lic acid.

In the title compound, CHO, intra-molecular C- H⋯O hydrogen bonds are observed. The dihedral angles between the aromatic benzoic acid ring and the two adjacent aromatic rings are 26.09 (4) and 69.

Breast cancer preclinical models: a vital resource for comprehending disease mechanisms and therapeutic development.

A significant obstacle in translating innovative breast cancer treatments from bench to bed side is demonstrating efficacy in preclinical settings prior to clinical trials, as the heterogeneity of breast cancer can be challenging to replicate in the laboratory. A significant number of potential medicines have not progressed to clinical trials because preclinical models inadequately replicate the complexities of the varied tumor microenvironment. Consequently, the variety of breast cancer models is extensive, and the selection of a model frequently depends on the specific inquiry presented.

Melioidosis of the Parotid Gland: Lessons Learned from a Fatal Case.

Meliodosis is an infectious disease also called whitemore's disease that can be fatal and is caused by the bacteria . This facultative intracellular aerobic gram-negative bacterium is typically transmitted through direct contact with contaminated water or soil (Currie et al. in Seminars in Respiratory and Critical Care Medicine 36:111-125, 2015).

Extra Skeletal Ewing's Sarcoma of Sino Nasal Tract-A Rare Entity a Case Report.

Ewing's sarcoma is a rare and highly malignant tumour predominantly affecting the bones. Extra skeletal Ewing's sarcoma of Sino nasal tract, encompassing the nasal cavity and paranasal sinuses is an exceedingly rare location for this tumour. We present a case of a 16 year-old boy who presented with right nasal obstruction, epistaxis and right facial swelling since 3 months.

A Systematic Review of Treatment Protocols in Auricular Pseudocysts.

A systematic review of literature on treatment modalities available with respect to efficacy, complications and recurrences so as to guide the clinician to better treat this enigmatic condition. A systematic search of PubMed, Google Scholar, Ovid and Cochrane databases. Articles in English that described or compared treatment were included.

Round Window Membrane Visibility and its Implications in Cochlear Implant Surgery.

With increasing number of patients with residual hearing being implanted, there is a renewed interest in round window (RW) as the preferred route for electrode insertion to reduce intracochlear trauma. The degree of round window membrane (RWM) visibility and its orientation might hamper the accessibility of RW for electrode insertion. This study is an attempt to identify the various factors affecting the accessibility of RW for electrode insertion.

Endoscopic Dacryocystorhinostomy - Comparative Outcomes of Powered vs. Non - Powered Instrument Techniques in a Tertiary Care Hospital.

This study compares the outcomes and complications associated with Powered and Non - Powered instrument techniques in patients undergoing Endoscopic Dacryocystorhinostomy (Endo DCR). An Observational, longitudinal study was carried out on 146 cases of Chronic Dacryocystitis who were divided into two equal groups. One group underwent Endo DCR by powered instruments (Powered group - PG) and the other group by non-powered technique (Non Powered group - NPG).

Comparing the Efficacy of Fentanyl Nasal Packing on Postoperative Pain in Patients Undergoing Nasal Surgeries Versus Normal Saline Pack-A Randomized Control Trial.

Nasal packing following nasal procedures are commonly used to reduce post operative bleeding and pain. Removal of nasal pack may be associated with mucosal injury which may cause delayed recovery. Various aspects of post-operative pain management have been studied.

Impact of Cochlear Implant on the Quality of Life in Post Lingual Deafened Adult Population in Tertiary Care Centre.

Unlabelled: In India, 7-8% of the population is affected by post lingual deafness, which can lead to job dissatisfaction, depression, social withdrawal, and educational challenges. Despite the benefits, cochlear implantation in Northern India remains underutilized. This study examines the impact of cochlear implants on post lingual deafness, along with their etiology and indications.

A Rare Case of Anterior Cervical Triangle Soft Tissue Tumour: Hibernoma.

Hibernomas are infrequent brown adipose tissue neoplasms. The thighs, shoulder, neck, and back are the most common places they appear. These are benign lipomatous neoplasms.

Role of Mahendra Maneuver in Sinusitis and Eustachian Tube Dysfunction.

The article titled "Role of the Maneuver in Sinusitis and Eustachian Tube Dysfunction" explores the efficacy of a novel technique known as the Maneuver. Sinusitis and Eustachian tube dysfunction are prevalent respiratory conditions often linked to impaired mucociliary flow and poor nasal clearance. Traditional maneuvers such as the Toynbee and Valsalva techniques provide temporary relief by forcefully opening the Eustachian tube but carry risks of injury and complications and does not work for sinusitis.

Petrous Bone Cholesteatoma- A Comprehensive Management Algorithm and Outcomes.

Unlabelled: Background: Petrous bone cholesteatoma (PBC) is a challenging condition involving the development of an epidermoid cyst within the petrous portion of the temporal bone. Advances in radiological imaging and skull base surgery have refined the management of PBC. Methods: An ambispective descriptive study was conducted on patients diagnosed with PBC between 2021 and 2024.

A Rare Case of Non-Invasive Fungal Sinusitis Caused by Scedosporium Apiospermum in an Immunocompetent Patient.

Unlabelled: Fungal sinusitis are very often caused by Aspergillus spp. Dematiaceae spp. and mucomycoses.

Role of Intraoperative Neuromonitoring to Identify External Branch of Superior Laryngeal Nerve During Thyroidectomy.

To evaluate the role of Intraoperative neuromonitoring (IONM) in visual and functional identification of external branch of superior laryngeal nerve (EBSLN) during thyroidectomy operation, 2. To identify the anatomical variations of EBSLN according to Cernea classification. This is a prospective observational study done on 30 patients who underwent thyroidectomy operation at the Department of Otorhinolaryngology in a tertiary medical institute.

Assessment of the Ultrasonological Findings of Goitrogenous Lesions.

Benign swellings of the thyroid gland are a common occurrence, frequently seen in surgical practice. Regardless of their appearance, however, it is a must to ultrasonologically analyse them in order to confirm their morphology and pick up any warning signs which might point towards a malignant transformation. In this particular study, we analyzed the morphological features (ultrasonological) associated with benign goitrogenous lesions.

Navigating Diagnostic Uncertainty: A Neck Swelling in an Elderly Patient Prompting Reflection on Over-investigation.

A brief communication report highlighting a 69-year-old male with a history of chronic conditions who presented with a persistent neck swelling following an upper respiratory tract infection. Despite multiple benign findings from various diagnostic procedures, the patient's anxiety about a potential malignancy led to repeated investigations, culminating in a left-sided neck dissection. The case underscores the challenges of managing patient-driven demands for certainty in an era of defensive medicine, where physicians may feel compelled to order excessive tests.

Evaluation of Accuracy of Clinical and Preoperative HRCT Diagnostic Findings with Intraoperative Findings in Patients of Cholesteatoma.

Cholesteatoma is a progressive and destructive middle ear disease that can lead to severe complications such as hearing loss, bone erosion, and even intracranial infections if left untreated. Accurate preoperative evaluation is crucial for the successful surgical management of this condition. High-Resolution Computed Tomography (HRCT) has become the gold standard in evaluation of extent of cholesteatoma due to its ability to reveal anatomical details of the middle ear.

Comparative Evaluation of Bilateral Earlobe Cleft Repair with and Without Platelet Rich Plasma Injection- In vivo Randomized Study.

Unlabelled: Earlobe clefts have been the major concern for aesthetic repair in the present situation. The advent of platelet-rich plasma (PRP) for enhancement of healing has never been treated for cleft earlobe repair. This study aims to compare and evaluate the efficacy of wound healing with and without platelet-rich plasma injection in bilateral earlobe cleft lobe repair.

Composite Ganglioneuroma and Schwannoma of the Cervical Sympathetic Chain: A Case Report.

Neurogenic tumors are benign tumors arising from nerve sheath or autonomic ganglion cells. Tumors arising from autonomic ganglion cells include neuroblastomas, ganglioneuromas, and ganglioneuroblastomas. Ganglioneuroma (GN) is a rare entity (1 per million).

Malignant Melanoma of External Auditory Canal: A Rare Case Report.

Malignant melanoma (MM) is predominantly seen in the skin, but it can also be seen in the eyes, ear, gastrointestinal tract, genital tract and mucous membrane of the oral cavity. MM of the ear accounts 1-4% of all cutaneous melanomas. In ear, pinna is the most common site.

Cervical Lymph Node Metastasis of Unknown Origin and Remote Primary at a Tertiary Cancer Centre in North India: Case Series with Review of Literature.

Carcinoma of unknown primary site represents a heterogeneous group of malignancies that present with lymph node or distant metastases, for which diagnostic work-up fails to identify the site of origin. Their incidence relative to total head and neck cancers ranges from as low as 1.7 to 2.

Nodular Goitre Posing as a Follicular Carcinoma with Extrathyroidal Extension: A Diagnostic Dilemma - A Case Report.

Nodular goitre caused by thyroid hyperplasia is a benign condition arising from abnormalities in thyroid gland physiology, resulting from an imbalance between thyroid-stimulating hormone, thyrotropin-releasing hormone, and the follicular epithelium of the thyroid gland. The histopathological characteristics of this hyperplasia can resemble well-differentiated follicular carcinoma of the thyroid. Here, we present the case of a 66-year-old man with clinicopathological features suggestive of follicular carcinoma with extrathyroidal extension.

Unifocal Conventional Papillary Thyroid Carcinoma with Coexisting Caseating Granulomatous Inflammation in India.

Thyroid cancer remains one of the leading endocrine malignancies with Conventional Papillary Thyroid Carcinoma (CVPTC) being the most commonly reported cancer. Caseating granulomatous inflammation is an unusual presentation in the thyroid even in places with high incidence of tuberculosis. The association of CVPTC with caseating granulomatous inflammation is infrequent.