Navigating a Giant Thyroglossal cyst: A Compelling Case Study.

Thyroglossal duct cysts are congenital neck cysts, formed as a result of the failure of the thyroglossal duct to involute during embryogenesis. We present a case of a 55- year-old male who presented with a history of a large anterior neck mass measuring 11 x 8.5 cm.

Management of a Huge Arteriovenous Malformation of the Tongue with the Submandibular Gland Flap: A Case Report.

AVMs commonly manifest in childhood or adolescence, and can occur at any area of the body. The management could be conservative or surgical. Surgical excision of a tongue AVM requires adequate reconstruction and Submandibular gland proves to be an excellent modality for the same.

"Golden Hour" in Road Traffic Accident Victims: Hurdles and Impact on Mortality.

Introduction Road traffic accident (RTA)-related death and disability are alarming health issues globally, which are rapidly increasing in developing countries. Timely presentation to a health center and prompt medical care are needed to prevent mortality and morbidity related to RTAs. This study was conducted to find out the hurdles in the golden hour arrival of RTA victims and to study its impact on RTA mortality at a tertiary health institute.

Prevalence and Correlates of Osteoporosis and Metabolic Syndrome Among Patients With Chronic Obstructive Pulmonary Disease at a Rural Tertiary Healthcare Center in India.

Background Chronic obstructive pulmonary disease (COPD) results from chronic inflammation triggered by various risk factors. This inflammation can also impact other organ systems. COPD patients often have comorbidities such as osteoporosis and metabolic syndrome.

Exploring the potential anti-senescence effects of soybean-derived peptide Soymetide in mice hippocampal neurons via the Wnt/β-catenin pathway.

Soybean-based foods enhance cognitive functions by influencing hippocampal mechanisms. These salutary effects have so far been attributed to isoflavones present in soybeans. Considering cellular senescence contributes to cognitive decline and that no specific soy-derived peptides are known for their potential to mitigate senescence, we examined the efficacy of a thirteen amino acid soy-derived peptide, Soymetide, on a doxorubicin-induced senescence mice model.

Unveiling the cancer epidemic in India: a glimpse into GLOBOCAN 2022 and past patterns.

Background: The Global Cancer Observatory (GLOBOCAN) 2022 estimates highlight cancer as a significant global health problem. In the South-East Asia-region, India ranks third in terms of cancer incidence, second for mortality, and 121 in terms of crude rates globally. As cancer risks increase with age, particularly affecting older individuals, this study explores the current cancer burden in India by analyzing the cancer landscape across different age groups, determining the population's risk of cancer diagnosis and death, and projecting the future cancer burden aligned with past mortality patterns.

Comprehensive in-silico characterization and expression pattern of calmodulin genes under various abiotic and biotic stresses in Indian mustard ().

Unlabelled: Calcium (Ca⁺) as a secondary messenger has a multidimensional role, including the growth and development of plants and the adaptive response to stress conditions. Calmodulin (CaM), a calcium-binding protein, uniquely binds with these Ca⁺ ions and transmits Ca⁺ signals. Calmodulin proteins have been well-reported in various plants for playing a role in abiotic and biotic stress signaling; however, a comprehensive analysis of the genes of Indian mustard () has not been studied much.

Eavesdropping the pivotal defensive representatives of plant-thrips interaction.

The substantial economic impact of thrips on crop yield and productivity enthused us to review comprehensive research findings associated with plant-thrips interaction. An attempt has been made to summarize a broad spectrum of knowledge on thrips infestation in different crops regarding defensive traits including plant morphological features, biochemical alterations and transcriptional profiling of defensive genes along with effective thrips management strategies. Thrips feeding mechanism involves puncturing the outer (epidermal) layer of host tissue and evoking the plant defence mechanism.

Comparative translational reprogramming of during mechanical wounding.

Unlabelled: (soybean) is a highly protein-rich legume that also contains oils and vitamins. Unfortunately, soybean faces many biotic and abiotic stresses including heat, drought, pests, wounds, infections, and salinity, which limits the crop productivity. Among these, mechanical wounding (MW) causes significant harm to plants, creates a passage for invading pathogens, and disrupts plant metabolism.

Comparative efficacy of advanced and traditional wound dressings in post-operative orthopaedic care for hip and knee surgeries: A randomized controlled trial.

Background: This randomized controlled study aimed to evaluate the efficacy of three advanced dressings (Aquacel Ag®, Opsite® Post-Op, and Mepilex Border Post-Op®) versus traditional dressings in post-operative care for patients undergoing orthopaedic hip or knee surgeries.

Methods: Conducted between August and December 2022 at a tertiary care orthopaedic centre, 314 patients were randomized into four groups. Group A received Aquacel Ag®, Group B received Opsite® Post-Op, Group C received Mepilex Border Post-Op®, and Group D received traditional dressings.

Outcomes of COVID-19-associated mucormycosis epidemic in India: A prospective 2-year follow-up study.

Objectives: The objective of this study was to study the various outcomes among coronavirus disease 2019 (COVID-19)-associated mucormycosis (CAM) in terms of morbidity and mortality.

Methods: A prospective study was done on 107 patients (60 male, 47 female) in the Department of Otolaryngology and Head and Neck Surgery, Government Medical College, Patiala, India, diagnosed with CAM from April 2021 to August 2021. The patients were managed both medically and surgically.

Mechanistic investigation on cellular internalization triggering structure-induced conformational modulation of boron-nitrogen luminogens.

Exploring the effects of electron donor (D) and acceptor (A) functional groups in tuning the condensed state properties has been a challenging yet efficient approach to reveal promising materials for cutting-edge applications. Herein, a series of boron-nitrogen (BN) incorporated organic congeners (NBNMe2, NBOMe, NBF, NBCl, NBBr, NBCN, NBPy) appended with functional groups having various degrees of D/A characteristics were developed and their potential in controlling supramolecular assembly and condensed state luminescence features (>90 nm redshift in ) was explored. Despite the minor structural engineering in BN-based small molecules, they effectively modulated conformational orientation and molecular packing, leading to the directed growth of distinct and highly ordered self-assembly patterns, , nanosheets, nanospheres, nanowires, and nanorods.

Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress - a brief review.

Oxidative stress is considered as the root-cause of different pathological conditions. Transition metals, because of their redox-active states, are capable of free radical generation contributing oxidative stress. Hemoglobin and myoglobin are two major heme proteins, involved in oxygen transport and oxygen storage, respectively.

Retraction: Bismuth-based nanoparticles and nanocomposites: synthesis and applications.

[This retracts the article DOI: 10.1039/D4RA05637J.].

Onion peel derived carbon nanoparticles incorporated polysulfone membranes: enhanced dye removal from water.

The ongoing discharge of hazardous dyes from industrial processes has intensified global water pollution, posing serious threats to aquatic ecosystems and human health. Addressing this challenge, our study explores the potential of bio-based carbon nanomaterials (CNM), synthesized from onion peel biowaste and designated as ON11, as effective agents in dye removal. These CNMs were incorporated into a mixed matrix membrane (MMM), using polysulfone (PSU) as the membrane substrate, to enhance dye adsorption.

Green energy production: hydroprocessing of waste plastic to diesel fuel using bimetal of Mn/Zn supported on activated carbon.

This research introduces a Mn/Zn-activated carbon (AC) bimetallic catalyst for hydroprocessing polypropylene pyrolysis oil (PPO) into hydroprocessed polypropylene pyrolysis oil blend (HPPO-B), which closely mimics commercial diesel. Under optimized conditions (70 bar, 350 °C), the catalyst efficiently converts PPO into iso-alkanes, -alkanes, and aromatics, achieving a 95% compositional match with diesel. HPPO-B meets European EN590 diesel standards, with viscosity (3.

Lipid-based nanoformulations in onychomycosis therapy: addressing challenges of current therapies and advancing treatment.

Onychomycosis significantly impacts approximately 20% of the global population. The physical barriers of the nail structure make fungal infections a persistent therapeutic challenge. Traditional approaches, including topical and oral antifungal agents, have limitations such as toxicities, low nail permeability, adverse effects, and high recurrence rates.

Stability-Indicating RP-HPLC Method Development and Validation for Determination of Impurities in Loperamide Hydrochloride Capsules Dosage Form.

A quality by design (QbD)-based high-resolution, stability-indicating high-performance liquid chromatography (HPLC) method was developed for determining impurities in loperamide hydrochloride (LPH) tablet dosage forms. Using this method, eight known impurities were qualified, and three degradants were quantified with excellent peak resolution. Mobile Phase-A consisted of 0.

Vaccine to Nano-Vaccine: Novel Technique to Treat Rheumatoid Arthritis.

Autoimmune diseases are a class of diseases wherein the immune system of the body targets itself through autoreactive T cells and autoantibodies. Autoimmune diseases are classified as organ-specific autoimmune diseases and systemic autoimmune diseases. Organ-specific autoimmune diseases such as primary biliary cirrhosis, Hashimoto's Thyroiditis (HT), Type 1 Diabetes mellitus (T1D), and Graves' Disease (GD) are characterized by a unique immune system response to autoantigens in a single organ.

Advancements in Nanoparticle-Based Targeted Drug Delivery Systems for Breast Cancer.

Cancer is a leading cause of death and life-threatening disease globally. It is connected to persistent tissue damage and unregulated cellular proliferation. In females, breast cancer plays a crucial role in death rates.

Revealing the Future of Pharmacovigilance in Precision Pharmaceutical Monitoring.

The growing popularity of personalized medicine presents new hazards and difficulties for pharmacovigilance. This implies that it needs to modify its current approach. This research examines how drug safety monitoring for certain medications evolves over time.

Targeting Anaplastic Lymphoma Kinase in Oncology: Identification and Computational Validation of Novel Inhibitors for Anaplastic Large Cell Lymphoma, Non-small Cell Lung Cancer, and Neuroblastoma.

Background: Anaplastic Lymphoma Kinase (ALK) is implicated in several cancers, including anaplastic large cell lymphoma, non-small cell lung cancer, and neuroblastoma. Targeted inhibition of ALK represents a promising therapeutic strategy.

Aims: This study aimed to identify and evaluate potential ALK inhibitors using virtual screening and computational analyses to determine their binding stability, affinity, and dynamic behavior, ultimately assessing their potential as therapeutic agents for ALK-driven cancers.

Pre-clinical Safety Study of Cold Atmospheric Plasma (CAP) Produced by an Inbuilt CAP Device and ROS Mediated Apoptotic Activity in Human Skin Melanoma Cells.

Introduction: In recent decades, Cold Atmospheric Plasma (CAP) has become increasingly popular in healthcare for managing diseases, especially skin cancer. This study aimed to assess the preclinical safety of an indigenously developed dielectric barrier discharge-CAP device and its cytotoxic efficacy against melanoma cells while adhering to OECD 402 guidelines for acute dermal toxicity study. The safety evaluation includes ex vivo studies on mouse peritoneal exudates and in vivo acute dermal toxicity tests on Wistar rats.